Article
Environmental Sciences
Pallavi Gautam, Anand Kumar Pandey, Ankush Gupta, Suresh Kumar Dubey
Summary: Imidacloprid, a widely used insecticide, has toxic effects on non-targeted organisms. This study investigated the potential of Sphingobacterium sp. InxBP1 in degrading imidacloprid through genomic, proteomic, bioinformatic, and metabolomic analyses. The findings identified genes and enzymes involved in the oxidative degradation of imidacloprid, as well as their affinity and binding to the degradation intermediates. The metabolomic study validated the proposed degradation mechanism. These findings suggest that Sphingobacterium sp. InxBP1 can be utilized in developing in-situ remediation technologies for imidacloprid.
ENVIRONMENTAL POLLUTION
(2023)
Review
Genetics & Heredity
Serena Dato, Paolina Crocco, Nicola Rambaldi Migliore, Francesco Lescai
Summary: The omics approach provides new opportunities in understanding the mechanisms of aging, by combining single-cell analysis with systems biology tools to investigate perturbed networks during aging and disease. High-throughput technologies like next-generation sequencing, proteomics, and metabolomics offer a unique opportunity to study biological markers during aging with high accuracy and specificity. Integration, interpretation, and sharing of high-throughput data continue to be major challenges in aging research, highlighting the need for the development of methods focused on integrating different data types. Emphasis on bioinformatics collaboration, diversity, data sharing, and community-driven portable methods is essential for future advancements in aging research.
FRONTIERS IN GENETICS
(2021)
Review
Chemistry, Medicinal
Abdullahi Tunde Aborode, Wireko Andrew Awuah, Tatiana Mikhailova, Toufik Abdul-Rahman, Samantha Pavlock, Mrinmoy Kundu, Rohan Yarlagadda, Manas Pustake, Ines Filipa da Silva Correia, Qasim Mehmood, Parth Shah, Aashna Mehta, Shahzaib Ahmad, Abiola Asekun, Esther Patience Nansubuga, Shekinah Obinna Amaka, Anastasiia Dmytrivna Shkodina, Athanasios Alexiou
Summary: This article reviews effective technologies for natural source drug discovery and aids in a more precisely targeted pharmaceutical approach, including RNA interference or CRISPR technology.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Amjad M. Husaini, Syed Anam ul Haq, Alberto Jose Lopez Jimenez
Summary: Saffron is a unique plant with complex cellular processes regulated at multiple levels. Understanding the interactions between different biological activities is challenging due to its sterility and lack of a whole-genome sequence. Omics-based technologies are immensely helpful in overcoming these limitations and developing a better understanding of saffron biology, leading to improved phenotypes in saffron plants.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Oncology
Zijian Zou, Wei Sun, Yu Xu, Wanlin Liu, Jingqin Zhong, Xinyi Lin, Yong Chen
Summary: Sarcomas are rare mesenchymal neoplasms with unique genetic characteristics, and their diagnosis relies heavily on pathological examination. Advanced treatments and multi-omics approaches have shown promise in improving outcomes and understanding sarcomas, but further research is needed to optimize their clinical application.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Alexander Arsov, Kaloyan Petrov, Penka Petrova
Summary: This article discusses the potential of microbial production of butanol as a new fuel and the challenge of butanol toxicity to microbes. Modern omics approaches have made significant progress in addressing the issue of low butanol tolerance, but a strain capable of both synthesis and tolerance at commercializable concentrations has yet to be discovered or produced.
BIOTECHNOLOGY ADVANCES
(2021)
Review
Food Science & Technology
Karolinny Cristiny de Oliveira Vieira, Hevelin Regiane Augusto da Silva, Isabela Poletto Masselli Rocha, Emmanuel Barboza, Lizziane Kretli Winkelstroter Eller
Summary: Outbreaks and deaths related to Foodborne Diseases (FBD) are constantly occurring worldwide, largely due to consumption of contaminated foodstuffs with pathogens. This review discusses the main omic techniques applied in foodborne pathogens and their potential in ensuring food safety. Omics have been shown to integrate variables that contribute to food safety and improve consumer health, costs, and product quality.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Multidisciplinary Sciences
Elif Everest, Ege Ulgen, Ugur Uygunoglu, Melih Tutuncu, Sabahattin Saip, Osman Ugur Sezerman, Aksel Siva, Eda Tahir Turanli
Summary: By combining genomic and proteomic data of MS patients, shared pathways were identified, suggesting that integrating multiple datasets can reduce false positive and negative results in genome-wide SNP associations.
Review
Cell Biology
Jia-Chen Liu, Shan-Shan Dong, Hui Shen, Dan-Yue Yang, Bin-Bin Chen, Xue-Ying Ma, Yi-Ran Peng, Hong-Mei Xiao, Hong-Wen Deng
Summary: Sarcopenia is a systemic disease characterized by muscle dysfunction, with its genetic architecture and molecular mechanisms still largely unclear. Recent advancements in multi-omics studies offer new insights into the pathogenesis of sarcopenia and may lead to new clinical applications.
AGEING RESEARCH REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Mengyuan Kan, Blanca E. Himes
Summary: Glucocorticoid drugs are widely used in the treatment of diseases, but there is still much to learn about their cell type-specific mechanisms and why patients respond differently. Recent studies have used genomics, transcriptomics, and other omics approaches to address these questions, but there are still knowledge gaps to be filled related to glucocorticoid action mechanisms.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Plant Sciences
Yamshi Arif, Priyanka Singh, Andrzej Bajguz, Pravej Alam, Shamsul Hayat
Summary: This review discusses the crucial role of silicon in plant development and stress responses, highlighting its interactions with plant hormones and antioxidants, as well as its application in 'omic approaches. Furthermore, it emphasizes the need for further research on the role of silicon during abiotic stress in plants for a better understanding at a broader level.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Biotechnology & Applied Microbiology
Ranjna Sirohi, Jaemin Joun, Hong Ii Choi, Vivek Kumar Gaur, Sang Jun Sim
Summary: This article discusses the potential of microalgae as an energy feedstock and the efforts to increase microalgae productivity using various omics techniques, with a particular focus on the application of genome sequencing and metabolic engineering in this field.
MICROBIAL CELL FACTORIES
(2021)
Review
Fisheries
Thao V. Nguyen, Andrea C. Alfaro, Craig Mundy, Jillian Petersen, Norman L. C. Ragg
Summary: The steady increase in global abalone aquaculture production has led to growing interest in applying new technologies, such as omics approaches, for abalone research. Omics techniques like genomics, transcriptomics, proteomics, and metabolomics are revealing key molecules and pathways in biological processes and identifying potential biomarkers. Integration of multiple omics approaches shows great potential in overcoming challenges and limitations to improve abalone production.
Review
Biochemistry & Molecular Biology
Theodore Alexandrov, Julio Saez-Rodriguez, Sinem K. Saka
Summary: Spatial omics is a rapidly growing field that integrates imaging and omics to obtain spatially resolved information. It has opened up new opportunities and challenges for method developers and provides a new window into spatial biology.
MOLECULAR SYSTEMS BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Qiaolifan Aerqin, Zuo-Teng Wang, Kai-Min Wu, Xiao-Yu He, Qiang Dong, Jin-Tai Yu
Summary: This review summarizes the progress made in the discovery of reliable Alzheimer's disease (AD) biomarkers using genomics, transcriptomics, proteomics, and metabolomics. The importance of these biomarkers in the diagnosis and treatment of AD is discussed.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Arancha Cebrian, Teresa Gomez del Pulgar, Maria Jose Mendez-Vidal, Maria Luisa Gonzalvez, Nuria Lainez, Daniel Castellano, Iciar Garcia-Carbonero, Emilio Esteban, Maria Isabel Saez, Rosa Villatoro, Cristina Suarez, Alfredo Carrato, Javier Munarriz-Ferrandiz, Laura Basterrechea, Mirta Garcia-Alonso, Jose Luis Gonzalez-Larriba, Begona Perez-Valderrama, Josefina Cruz-Jurado, Aranzazu Gonzalez del Alba, Fernando Moreno, Gaspar Reynes, Maria Rodriguez-Remirez, Valentina Boni, Ignacio Mahillo-Fernandez, Yolanda Martin, Andrea Viqueira, Jesus Garcia-Foncillas
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Marlid Cruz-Ramos, Laura del Puerto-Nevado, Binbin Zheng, Rafael Lopez-Bajo, Arancha Cebrian, Maria Rodriguez-Remirez, Laura Garcia-Garcia, Sonia Solanes-Casado, Jesus Garcia-Foncillas
JOURNAL OF GERIATRIC ONCOLOGY
(2019)
Article
Oncology
M. J. Fernandez-Acenero, M. Cruz, J. Sastre-Varela, J. Casal, M. A. Ceron Nieto, L. del Puerto-Nevado, J. Garcia-Foncillas, A. Cebrian
PATHOLOGY & ONCOLOGY RESEARCH
(2020)
Article
Cell Biology
Elsa Sanchez-Lopez, Zhenyu Zhong, Alexandra Stubelius, Shannon R. Sweeney, Laela M. Booshehri, Laura Antonucci, Ru Liu-Bryan, Alessia Lodi, Robert Terkeltaub, Juan Carlos Lacal, Anne N. Murphy, Hal M. Hoffman, Stefano Tiziani, Monica Guma, Michael Karin
Article
Endocrinology & Metabolism
Maria Rodriguez-Remirez, Laura del Puerto-Nevado, Maria Jesus Fernandez Acenero, Hakimeh Ebrahimi-Nik, Marlid Cruz-Ramos, Laura Garcia-Garcia, Sonia Solanes, Natalia Banos, Elena Molina-Roldan, Jesus Garcia-Foncillas, Arancha Cebrian
NEUROENDOCRINOLOGY
(2020)
Article
Microbiology
Tahl Zimmerman, Juan Carlos Lacal, Salam A. Ibrahim
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Endocrinology & Metabolism
Maria Rodriguez-Remirez, Laura del Puerto-Nevado, Maria Jesus Fernandez-Acenero, Marlid Cruz-Ramos, Laura Garcia-Garcia, Sonia Solanes, Elena Molina-Roldan, Jesus Garcia-Foncillas, Arancha Cebrian
NEUROENDOCRINOLOGY
(2020)
Article
Multidisciplinary Sciences
Tahl Zimmerman, Valerie Chasten, Juan Carlos Lacal, Salam A. Ibrahim
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Barbara Manzanares-Martin, Arancha Cebrian Aranda, Laura del Puerto-Nevado, Rafael Gonzalez, Sonia Solanes, Maria Auxiliadora Gomez-Espana, Jesus Garcia-Foncillas, Enrique Aranda
Summary: The study investigated the potential value of KIR genotyping in the clinical outcome of patients with KRAS mutant mCRC treated with cetuximab. The results demonstrated the immunomodulatory activity of cetuximab in KRAS mutant mCRC patients and identified KIR genotypes as an independent predictor of patient outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Pharmacology & Pharmacy
Juan Carlos Lacal, Tahl Zimmerman, Joaquin M. Campos
Summary: Choline kinase plays a crucial role in human tumors and specific compounds targeting it have been identified as potential anticancer agents. Some of these compounds have shown selective anticancer activity and have progressed to clinical trials. Additionally, ChoK alpha inhibitors are proposed as a novel therapeutic approach against various diseases.
Review
Biochemistry & Molecular Biology
Angel M. Cuesta, Eunate Gallardo-Vara, Juan Casado-Vela, Lucia Recio-Poveda, Luisa-Maria Botella, Virginia Albinana
Summary: Rare Diseases (RD), although individually may seem insignificant, collectively represent over 7000 different diseases that pose a life-threatening condition for patients. Drug repurposing, an alternative option in drug development, has been identified as a viable strategy to tackle RDs. Propranolol, initially prescribed for hypertension and other conditions, has shown promising therapeutic effects in RDs, including antiangiogenic, pro-apoptotic, vasoconstrictor, and anti-inflammatory properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Suriel Errasti Diaz, Mercedes Penalva, Lucia Recio-Poveda, Susana Vilches, Juan Casado-Vela, Julian Perez Perez, Luisa Maria Botella, Virginia Albinana, Angel M. Cuesta
Summary: Hereditary Hemorrhagic Telangiectasia (HHT) is a rare disorder characterized by vascular development abnormalities. This study identified a novel mutation in the ACVRL1/ALK1 gene, leading to reduced ALK1 protein levels. The mutation can be diagnosed using genetic sequencing, providing a simple diagnostic method for developing countries.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Juan Carlos Lacal, Rosario Perona, Javier de Castro, Arancha Cebrian
Summary: Lung cancer is a leading cause of mortality in developed countries. Immunotherapy has been proposed as a standard treatment for advanced non-small cell lung cancer (NSCLC), but there is a need for novel strategies to improve patient outcomes. Choline kinase alpha (ChoK alpha) has been identified as a potential target for cancer therapy. Combining ChoK alpha inhibitors with platinum-based chemotherapy may offer a new and effective treatment approach for NSCLC patients.
Review
Medicine, General & Internal
Virginia Albinana, Eunate Gallardo-Vara, Juan Casado-Vela, Lucia Recio-Poveda, Luisa Maria Botella, Angel M. Cuesta
Summary: Research on cancer therapies focuses on various processes influenced by the cellular and molecular microenvironment of the tumor. Different strategies, including the use of propranolol, have been tested to reduce malignancy and create a harmful microenvironment for the tumor. Propranolol has shown antitumoral properties and synergistic effects when used in combination with other drugs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Juan Manuel Corral, Laura del Puerto-Nevado, Mabel Cedeno, Anxo Rio-Vilarino, Ignacio Mahillo-Fernandez, Carlos Galeano, Natalia Banos, Jesus Garcia-Foncillas, Manuel Domine, Arancha Cebrian
Summary: This study found that high levels of Gal-1 and PLR were associated with poorer prognosis in SCLC patients, supporting their utility as clinical prognostic biomarkers. Additionally, an in vivo model suggested that inhibition of Gal-1 may be a novel potential therapy for this disease with very poor prognosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)