Targeting IL-6 and RANKL signaling inhibits prostate cancer growth in bone

Effects of Bone-Targeted Agents on Cancer Progression and Mortality

(2012) R. Coleman et al.   JNCI-Journal of the National Cancer Institute

Denosumab Treatment of Prostate Cancer With Bone Metastases and Increased Urine N-Telopeptide Levels After Therapy With Intravenous Bisphosphonates: Results of a Randomized Phase II Trial

(2012) Karim Fizazi et al.   JOURNAL OF UROLOGY

Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study

(2011) Karim Fizazi et al.   LANCET

Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial

(2011) Matthew R Smith et al.   LANCET

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis

(2010) Li Laine Ooi et al.   BONE

The bone remodeling environment is a factor in breast cancer bone metastasis

(2010) Li Laine Ooi et al.   BONE

Establishment of an HS23 stromal cell-dependent myeloma cell line: fibronectin and IL-6 are critical

(2010) Akira Sakai et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Osteoblasts are a major source of inflammatory cytokines in the tumor microenvironment of bone metastatic breast cancer

(2010) Karen M. Bussard et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Expression pattern of receptor activator of NFκB (RANK) in a series of primary solid tumors and related bone metastases

(2010) Daniele Santini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization

(2010) Tomoyuki Igawa et al.   NATURE BIOTECHNOLOGY

Vitamin D deficiency promotes prostate cancer growth in bone

(2010) Yu Zheng et al.   PROSTATE

Implications of Serum Bone Turnover Markers in Prostate Cancer Patients With Bone Metastasis

(2010) Naoto Kamiya et al.   UROLOGY

Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo

(2009) Roland Axmann et al.   ARTHRITIS AND RHEUMATISM

Tumor Self-Seeding by Circulating Cancer Cells

(2009) Mi-Young Kim et al.   CELL

Humanized Anti-Interleukin-6 Receptor Antibody Suppresses Tumor Angiogenesis and In vivo Growth of Human Oral Squamous Cell Carcinoma

(2009) S. Shinriki et al.   CLINICAL CANCER RESEARCH

Interleukin-6 in the Bone Marrow Microenvironment Promotes the Growth and Survival of Neuroblastoma Cells

(2008) T. Ara et al.   CANCER RESEARCH

Bone resorption increases tumour growth in a mouse model of osteosclerotic breast cancer metastasis

(2008) Yu Zheng et al.   CLINICAL & EXPERIMENTAL METASTASIS

Change in Markers of Bone Metabolism with Chemotherapy for Advanced Prostate Cancer: Interleukin-6 Response Is a Potential Early Indicator of Response to Therapy

(2008) Kathleen M. Woods Ignatoski et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH