Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 135, Issue 2, Pages 400-410Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2014.396
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Funding
- Fundacao de Amparo a Pesquisa do Estado da Bahia (FAPESB) e/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [PPSUS SUS0025/2009]
- Pronex (FAPESB/CNPq) [738712006]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)/Programa Ciencias sem Fronteiras
- Oves Minnesfond
- Radiumhemmet research funds [121202]
- Swedish Cancer Society
- Swedish Research Council
- Swedish Institute
- INTAS
- Erasmus KI-UWM
- STINT
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In this study, we used proteomics and biological network analysis to evaluate the potential biological processes and components present in the identified proteins of biopsies from cutaneous leishmaniasis (CL) patients infected by Leishmania braziliensis in comparison with normal skin. We identified 59 proteins differently expressed in samples from infected and normal skin. Biological network analysis employing identified proteins showed the presence of networks that may be involved in the cell death mediated by cytotoxic T lymphocytes. After immunohistochemical analyses, the expression of caspase-9, caspase-3, and granzyme B was validated in the tissue and positively correlated with the lesion size in CL patients. In conclusion, this work identified differentially expressed proteins in the inflammatory site of CL, revealed enhanced expression of caspase-9, and highlighted mechanisms associated with the progression of tissue damage observed in lesions.
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