Systematic, evidence-based discovery of biomarkers at the NCI

Antibody-Based Detection of ERG Rearrangement-Positive Prostate Cancer

(2015) Kyung Park et al.   NEOPLASIA

Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis

(2012) Wen Cai Zhang et al.   CELL

Beyond PSA: The Next Generation of Prostate Cancer Biomarkers

(2012) J. R. Prensner et al.   Science Translational Medicine

A Reproducible and High-Throughput HPLC/MS Method To Separate Sarcosine from α- and β-Alanine and To Quantify Sarcosine in Human Serum and Urine

(2011) Tamra E. Meyer et al.   ANALYTICAL CHEMISTRY

Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression

(2011) John R Prensner et al.   NATURE BIOTECHNOLOGY

Therapeutic Targeting of SPINK1-Positive Prostate Cancer

(2011) B. Ateeq et al.   Science Translational Medicine

Urine TMPRSS2:ERG Fusion Transcript Stratifies Prostate Cancer Risk in Men with Elevated Serum PSA

(2011) S. A. Tomlins et al.   Science Translational Medicine

The Emergence of lncRNAs in Cancer Biology

(2011) J. R. Prensner et al.   Cancer Discovery

A Prospective, Multicenter, National Cancer Institute Early Detection Research Network Study of [-2]proPSA: Improving Prostate Cancer Detection and Correlating with Cancer Aggressiveness

(2010) L. J. Sokoll et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Performance of the Prostate Cancer Antigen 3 (PCA3) Gene and Prostate-Specific Antigen in Prescreened Men: Exploring the Value of PCA3 for a First-line Diagnostic Test

(2010) Monique J. Roobol et al.   EUROPEAN UROLOGY

Randomized Clinical Trials With Biomarkers: Design Issues

(2010) B. Freidlin et al.   JNCI-Journal of the National Cancer Institute

Cancer Biomarkers: Can We Turn Recent Failures into Success?

(2010) E. P. Diamandis   JNCI-Journal of the National Cancer Institute

Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma

(2010) Nallasivam Palanisamy et al.   NATURE MEDICINE

TMPRSS2-ERG Gene Fusion Is Not Associated with Outcome in Patients Treated by Prostatectomy

(2009) Anuradha Gopalan et al.   CANCER RESEARCH

Oncogenic gene fusions in epithelial carcinomas

(2009) John R Prensner et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

(2009) Arun Sreekumar et al.   NATURE

The use of PCA3 in the diagnosis of prostate cancer

(2009) Daphne Hessels et al.   Nature Reviews Urology

Induced Chromosomal Proximity and Gene Fusions in Prostate Cancer

(2009) R.-S. Mani et al.   SCIENCE

Biomarkers for Prostate Cancer

(2008) Danil V. Makarov et al.   Annual Review of Medicine

The Role of SPINK1 in ETS Rearrangement-Negative Prostate Cancers

(2008) Scott A. Tomlins et al.   CANCER CELL

A First-Generation Multiplex Biomarker Analysis of Urine for the Early Detection of Prostate Cancer

(2008) B. Laxman et al.   CANCER RESEARCH

Clinical Utility of the PCA3 Urine Assay in European Men Scheduled for Repeat Biopsy

(2008) Alexander Haese et al.   EUROPEAN UROLOGY

Pivotal Evaluation of the Accuracy of a Biomarker Used for Classification or Prediction: Standards for Study Design

(2008) Margaret S. Pepe et al.   JNCI-Journal of the National Cancer Institute

PCA3: A Molecular Urine Assay for Predicting Prostate Biopsy Outcome

(2008) Ina L. Deras et al.   JOURNAL OF UROLOGY

The cancer biomarker problem

(2008) Charles L. Sawyers   NATURE