Editorial Material
Anesthesiology
A. Ni Eochagain
Summary: The case presented involves a patient who developed cryoshock during a cryoablative procedure for hepatocellular carcinoma. Cryoshock, a rare complication of cryoablation, can lead to multiorgan failure and coagulopathy with a mortality rate of up to 40%. The main mechanism appears to involve cytokine release and the mainstay of treatment is organ support.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Genetics & Heredity
Keqiang Ma, Hongsheng Wu, Lei Ji
Summary: This study focused on developing prognostic and diagnostic models for hepatocellular carcinoma (HCC) based on hepatitis B virus (HBV)-related genes. Through analysis of gene expression profiles and clinical data, several genes related to HCC were identified, and prognostic and diagnostic models were constructed. The results suggest that these genes can serve as reliable biomarkers for HCC, providing new insights for improving prognosis, diagnosis, and treatment outcomes.
FRONTIERS IN GENETICS
(2023)
Article
Virology
Oguntope Adeorike Sobajo, Judith Uche Oguzie, Benjamin Adegboyega, Philomena Eromon, Christian Happi, Isaac Komolafe, Onikepe Folarin
Summary: This study investigated the prevalence of mutations in the hepatitis B virus genes in a population in southwest Nigeria. It found a high prevalence of immune escape mutations and BCP/PC mutants, which have implications for diagnosis, vaccine efficacy, and management of HBV in the country.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyo-Jin Kang, Haeryoung Kim, Dong Ho Lee, Bo Yun Hur, Yoon Jung Hwang, Kyung-Suk Suh, Joon Koo Han
Summary: This study evaluated the gadoxetate-enhanced MRI findings and prognostic significance of the proliferative class of hepatocellular carcinoma (HCC) after surgery. The proliferative class was associated with poor overall survival, increased rates of intrahepatic and extrahepatic metastasis, and specific predictive factors such as rim arterial phase hyperenhancement on MRI and high serum alpha-fetoprotein levels.
Article
Virology
Danli Yang, Jun Zou, Guiwen Guan, Xiaoyu Feng, Ting Zhang, Guixin Li, Hui Liu, Huiling Zheng, Jingyuan Xi, Guangxin Yu, Lizhong Dai, Fengmin Lu, Xiangmei Chen
Summary: This study systematically investigated the effect of A1762T/G1764A mutations on HBV replication and its underlying mechanisms. The results showed that these mutations enhance the replication ability of HBV and affect the expression levels of related RNA and proteins. In vitro and in vivo experiments confirmed that these mutations promote HBV replication and revealed their regulatory role in RNA transcription.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Ju A. Son, Hye Ri Ahn, Donglim You, Geum Ok Baek, Moon Gyong Yoon, Jung Hwan Yoon, Hyo Jung Cho, Soon Sun Kim, Suk Woo Nam, Jung Woo Eun, Jae Youn Cheong
Summary: Investigating molecular markers for predicting HCC recurrence revealed novel gene signatures, potentially serving as prognostic indicators for patients.
Article
Oncology
Xianmo Wang, Huawei Yi, Jiancheng Tu, Wen Fan, Jiahao Wu, Li Wang, Xiang Li, Jinrong Yan, Huali Huang, Rong Huang
Summary: Hepatitis B-infected hepatocellular carcinoma is a common cancer with high incidence and mortality rates. The study identified ASF1B as an independent prognostic factor in HBV-infected hepatocellular carcinoma, and its high expression is associated with poor prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Masaki Kaibori, Kengo Yoshii, Kosuke Matsui, Hideyuki Matsushima, Hisashi Kosaka, Hidekazu Yamamoto, Takayoshi Nakajima, Kazunori Aoi, Takashi Yamaguchi, Katsunori Yoshida, Mitsugu Sekimoto
Summary: The aim of this study was to investigate the prognostic impact of ABO blood types on the survival of Japanese patients with HCC who underwent surgical resection. The results showed that patients with blood type A had significantly lower recurrence-free survival and overall survival compared to non-type A patients. Hence, ABO blood type may have a prognostic impact on HCC patients after hepatectomy.
Article
Biochemistry & Molecular Biology
Lili Zhou, Shaohuai Xia, Yaoyao Liu, Qiang Ji, Lifeng Li, Xuan Gao, Xiaodi Guo, Xin Yi, Feng Chen
Summary: This study established a model based on lipid metabolism to stratify HBV-related HCC into high-risk and low-risk groups, and found that the low-risk group had longer survival times. Furthermore, the study identified gene mutations and genomic instability in the high-risk group, while the low-risk group showed characteristics in immune cell infiltration and lipid metabolism.
LIPIDS IN HEALTH AND DISEASE
(2023)
Review
Cell Biology
Anna Sloutskin, Hila Shir-Shapira, Richard N. Freiman, Tamar Juven-Gershon
Summary: The core promoter region is an active regulatory module in transcriptional programs, controlling developmental genes through downstream regions like the DPE. Promoter-dependent basal transcription machinery emphasizes the importance of specialized transcription complexes in driving embryonic development and morphogenesis. Enhancer specificity and transcription burst size are regulated by the core promoter content, highlighting its importance in developmental gene expression networks.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Surgery
Alessandro D. Mazzotta, Alina Pascale, Luis Cano, Olivier Rosmorduc, Marc-Antoine Allard, Antonio Sa Cunha, Rene Adam, Daniel Cherqui, Eric Vibert, Nicolas Golse
Summary: This study evaluated the impact of the number of nodules on the prognosis of liver transplant candidates, finding that patients with >=5 nodules had lower survival rates, suggesting the exclusion of high-risk patients.
TRANSPLANT INTERNATIONAL
(2021)
Article
Oncology
I-Cheng Lee, Hao-Jan Lei, Gar-Yang Chau, Yi-Chen Yeh, Chi-Jung Wu, Chien-Wei Su, Teh-la Huo, Yee Chao, Han-Chieh Lin, Ming-Chih Hou, Yi-Hsiang Huang
Summary: The study found that in patients with HBV-related HCC undergoing surgical resection under NUCs therapy, factors such as HBsAg levels, cirrhosis, and other markers were associated with recurrence and mortality at different time intervals. The pre-operative HBsAg level was identified as an important predictor for long-term recurrence and survival.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Dongsub Jeon, Won-Mook Choi, Jin-Sun Kim, Yusun Jung, Su-Yeon Lee, Haeng Ran Seo, Kang Mo Kim
Summary: This study found that serum sorbitol dehydrogenase (SORD) levels were associated with the length of recurrence-free survival after surgical resection for HCC, with higher SORD levels (>= 15 ng/mL) being linked to a shorter recurrence-free survival. When combined with AFP levels, SORD levels could better predict the prognosis in HCC patients.
Article
Virology
Yang Liu, Dmytro Kornyeyev, Lindsey May, Dong Han, Thomas Aeschbacher, Silvia Chang, Ross Martin, Hongmei Mo, Becket Feierbach
Summary: The existing cell culture-based methods for studying HBV have limitations and cannot achieve long-term viral passage. This study developed a robust in vitro long-term viral passage system by subjecting an HBV genotype A clinical isolate to multiple rounds of UV treatment and passing it through an optimized primary human hepatocyte (PHH)/human fibroblast coculture system. This passage system can be used to study the entire life cycle of HBV and has the potential for in vitro drug-resistance selection upon further optimization.
JOURNAL OF VIROLOGY
(2022)
Article
Cell Biology
Sagarika Banerjee, Zhi Wei, Tian Tian, Dipayan Bose, Natalie N. C. Shih, Michael D. Feldman, Thaer Khoury, Angela De Michele, Erle S. Robertson
Summary: Alterations to the natural microbiome are linked to different diseases, and the presence or absence of specific microbes is directly related to disease outcomes. The study found that different subtypes of breast cancer have specific viromes and microbiomes, with ER+ and TN tumors showing the most and least diverse microbiome, respectively. Specific microbial signatures allowed discrimination between different BC subtypes and correlated with clinical outcomes.
CELL DEATH & DISEASE
(2021)
Article
Agriculture, Dairy & Animal Science
Yanru Wang, Gaoqian Li, Xinjiang Zhang, Yuanyuan Zheng, Suling Guo, Dan Guo, Xinghui Zhang, Xingtang Dou, Taiyu Hui, Chang Yue, Jiaming Sun, Suping Guo, Zhixian Bai, Weidong Cai, Yixing Fan, Zeying Wang, Wenlin Bai
Summary: N-6-methyladenosine (m(6)A) is the most common internal modification of mRNA and lncRNA in eukaryotes. This study identified important m(6)A-modified genes involved in cashmere fineness and fiber growth using high-throughput sequencing methods. A comparison between male and female Liaoning Cashmere Goat skin tissues revealed differentially expressed m(6)A-modified genes, and some of these genes were validated to be associated with cashmere fineness.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Wenlin Bai, Xihua Zou, Peixuan Li, Jia Ye, Yang Yang, Li Yan, Wei Pan, Lianshan Yan
Summary: A novel millimeter-Wave joint radar and communication system based on photonic spectrum-spreading phase-coding is proposed. The system combines photonic microwave phase-coding and spectrum-spreading multiplexing techniques to achieve high range resolution for radar detection and high capacity for wireless communication. The spectrum-spreading multiplexing orthogonalizes the radar signal and communication data, reducing mutual interferences and improving the performance of both radar and communication.
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
(2022)
Article
Clinical Neurology
Sidan Du, Ying Huang, Yifei Ma, Yao Qin, Jing Cui, Wenlin Bai, Hongjuan Han, Rong Zhang, Hongmei Yu
Summary: This study investigates the potential mediating role of rapid eye movement sleep behavior disorder (RBD), depression, and anxiety in the association between dopaminergic replacement therapy (DRT) and impulse control disorders (ICDs) in Parkinson's disease (PD) patients. The results suggest that improvements in depression and RBD partially explain the aggravation of ICDs, while anxiety plays a mediating role. Therefore, monitoring changes in RBD, depression, and anxiety related to hyperdopaminergic status is crucial for preventing ICDs in PD patients.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Yao Qin, Hongjuan Han, Yang Li, Jing Cui, Haixia Jia, Xiaoyan Ge, Yifei Ma, Wenlin Bai, Rong Zhang, Durong Chen, Fuliang Yi, Hongmei Yu
Summary: In this study, the trajectory of reversion from MCI to NC or near-NC and patterns of postreversion were explored. Participants who experienced reversion remained at increased risk for progression to MCI or dementia over the longer term and recurrent reversions were observed. Age, independence level, APOE, cognition, daily activity ability, depression, and neuropsychiatric symptoms were significant predictors of bidirectional transitions. These findings provide valuable insights for future research and proactive management plans.
Article
Environmental Sciences
Yiran Sun, Jiayu Pei, Xi Chen, Mengwen Lin, Yun Pan, Yingying Zhang, Wenlin Bai, Xingfan Zhou, Wenping Zhang
Summary: This study aimed to investigate the effect of CPF on depressive-like behavior in mice and the role of gut microbiota in this behavior. The results showed that CPF caused depressive-like behaviors with pathological changes in the hippocampus and colon. CPF also induced changes in gut microbiota, including 49 differential bacteria. Correlation analysis demonstrated that 18 differentially abundant bacteria were correlated with CPF-induced depression.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Minglin Wang, Han Dai, Shengda Sheng, Yanlei Liu, Shuyi Zhang, Wenlin Bai, Huiling Xue
Summary: This study investigated the role of miRNAs in cashmere growth by analyzing the expression of miRNAs in SHFs. The results showed that the early anagen phase is crucial for miRNA regulation of cashmere growth. Furthermore, differential expression analysis identified several miRNAs that are involved in SHF development, regeneration, and regression. The study also discovered a potential novel role of miR-143-3p in cashmere growth through its direct repression of Itga6 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Optics
W. E. N. L. I. N. Bai, P. E. I. X. U. A. N. LI, X. I. H. U. A. Zou, N. I. N. G. Y. U. A. N. Zhong, W. E. Pan, L. I. A. N. S. H. A. N. Yan, B. I. N. Luo
Summary: This paper proposes and experimentally demonstrates a millimeter-wave joint radar-communication (JRC) system with super-resolution, using optical heterodyne upconversion and self-coherent detection downconversion techniques. The system is based on a designed coherent dual-band constant envelope linear frequency modulation-orthogonal frequency division multiplexing (LFM-OFDM) signal with opposite phase modulation indexes. The self-coherent detection enables the de-chirping of the MMW radar and frequency downconversion reception of MMW communication, achieving real-time decomposition of radar and communication information. Furthermore, a super-resolution radar range profile is realized through the coherent fusion processing of the dual-band JRC signals.
Article
Agriculture, Dairy & Animal Science
Ronghuan Yin, Ronglan Yin, Man Bai, Yixing Fan, Zeying Wang, Yubo Zhu, Qi Zhang, Taiyu Hui, Jincheng Shen, Siyu Feng, Wenlin Bai
Summary: This study investigates the effects of N6-Methyladenosine modification-circRNA-zinc finger protein 638 (m6A-circRNA-ZNF638) on the induced activation of secondary hair follicle (SHF) stem cells in cashmere goats. The study analyzes the m6A modification of ZNF638 in SHF stem cells and evaluates the effects of circRNA-ZNF638 on the induced activation of SHF stem cells through overexpression and knockdown experiments. The study also analyzes the competitive binding between miR-361-5p and circRNA-ZNF638/Wnt5a 3'- untranslated region.
Article
Medical Laboratory Technology
Wenlin Bai, Hui Wang, Ruiling Fang, Mengwen Lin, Yao Qin, Hongjuan Han, Jing Cui, Rong Zhang, Yifei Ma, Durong Chen, Wenping Zhang, Li Wang, Hongmei Yu
Summary: The effect of abnormal OGTT0h+1h+2h on macrosomia was significantly greater than other OGTT characteristics, especially for those with pre-pregnancy BMI >= 24 kg/m2.
CLINICA CHIMICA ACTA
(2023)
Article
Medical Informatics
Fuliang Yi, Hui Yang, Durong Chen, Yao Qin, Hongjuan Han, Jing Cui, Wenlin Bai, Yifei Ma, Rong Zhang, Hongmei Yu
Summary: Due to class imbalance, the diagnosis of Alzheimer's disease (AD) using machine learning (ML) is challenging. This study aimed to construct an interpretable framework, XGBoost-SHAP, to handle the imbalance in AD progression and achieve multiclassification of AD stages.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Article
Engineering, Electrical & Electronic
Wenlin Bai, Peixuan Li, Xihua Zou, Ningyuan Zhong, Wei Pan, Xiong Deng, Lianshan Yan
Summary: In this study, a multiband integrated sensing and communication (ISAC) system using optical frequency upconversion and coherent receiving techniques for millimeter-wave (MMW) high-capacity wireless communication and high-resolution sensing functions is proposed and experimentally demonstrated. A photonic MMW frequency upconverter generates MMW multiband ISAC signals which are then processed by a coherent photonic MMW de-chirper for radar signal processing and data fusion. Communication receiving and demodulation are achieved by coherent receiving technology for multiband/multiuser scenarios. Experimental results show a communication data rate of 16 Gbit/s and a two-dimension radar imaging with 3.75-cm range resolution. After multiband data fusion, an ultra-high resolution of 8.6-mm is successfully achieved for radar ranging and imaging.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Peixuan Li, Lizhi Zhu, Hui Wang, Wei Pan, Ningyuan Zhong, Wenlin Bai, Lianshan Yan, Xihua Zou
Summary: This study proposes a blind frequency-domain nonlinear equalization approach for millimeter-wave fiber-wireless intermediate-frequency over fiber (IFoF) mobile fronthaul systems. It achieves symbol-by-symbol channel tracking and has advantages in terms of computational complexity, transmission capacity, and equalization performance.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Peixuan Li, Wenlin Bai, Xihua Zou, Ningyuan Zhong, Wei Pan, Lianshan Yan
Summary: We propose a cost-effective millimeter-level resolution photonic multiband radar system using a single MZM driven by a 1-GHz-bandwidth LFM signal. It achieves an approximately 8.5 mm range resolution through coherence-processing-free multiband data fusion.
2023 OPTICAL FIBER COMMUNICATIONS CONFERENCE AND EXHIBITION, OFC
(2023)
Article
Engineering, Electrical & Electronic
Zhang Hui, Li Peixuan, Zou Xihua, Bai Wenlin, Pan Wei, Yan Lianshan
Summary: Exploiting microwave photonic techniques to generate and distribute high-frequency millimeter-wave signals has significant potential. In this study, a broadband m-RoF uplink fronthaul transmission system was experimentally validated using a simple cascaded modulator topology and an ultrawideband Mach-Zehnder modulator. Subharmonic downconversion of the mm-wave signals was achieved, enabling high-speed and high-capacity transmission.
LASER & OPTOELECTRONICS PROGRESS
(2022)
Article
Agriculture, Dairy & Animal Science
Junyin Zhao, Jincheng Shen, Zeying Wang, Man Bai, Yixing Fan, Yubo Zhu, Wenlin Bai
Summary: Circular RNAs (circRNAs) are stable RNA molecules that can function as miRNA sponges to regulate gene expression. In this study, we found that circRNA-0100 was highly expressed in the hair follicle bulge of cashmere goats and promoted the differentiation of SHF stem cells into hair lineage. Our results demonstrated that circRNA-0100 sequesters miR-153-3p to enhance KLF5 expression, thereby promoting the differentiation of SHF stem cells into hair lineage in cashmere goats. This study provides novel scientific evidence for understanding the molecular regulatory mechanisms involved in the differentiation of SHF stem cells into hair lineage in cashmere goats.
ARCHIVES ANIMAL BREEDING
(2022)
