RANKL Cytokine: From Pioneer of the Osteoimmunology Era to Cure for a Rare Disease

Investigation of osteoclastogenic signalling of the RANKL substitute LIGHT

(2013) F. Hemingway et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Dynamic visualization of RANKL and Th17-mediated osteoclast function

(2013) Junichi Kikuta et al.   JOURNAL OF CLINICAL INVESTIGATION

New regulation mechanisms of osteoclast differentiation

(2012) Tomoki Nakashima et al.   Annals of the New York Academy of Sciences

The development of denosumab for the treatment of diseases of bone loss and cancer-induced bone destruction

(2012) Carsten Goessl et al.   Annals of the New York Academy of Sciences

Osteocyte control of osteoclastogenesis

(2012) Charles A. O'Brien et al.   BONE

Receptor Activator of Nuclear Factor κB Ligand (RANKL) Protein Expression by B Lymphocytes Contributes to Ovariectomy-induced Bone Loss

(2012) Melda Onal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteopetrosis rescue upon RANKL administration toRankl−/−mice: A new therapy for human RANKL-dependent ARO

(2012) Nadia Lo Iacono et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteocyte RANKL: New insights into the control of bone remodeling

(2012) Jinhu Xiong et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Crystal Structure of Human RANKL Complexed with Its Decoy Receptor Osteoprotegerin

(2012) X. Luan et al.   JOURNAL OF IMMUNOLOGY

Developmentally Regulated Availability of RANKL and CD40 Ligand Reveals Distinct Mechanisms of Fetal and Adult Cross-Talk in the Thymus Medulla

(2012) G. E. Desanti et al.   JOURNAL OF IMMUNOLOGY

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

(2012) David L. Lacey et al.   NATURE REVIEWS DRUG DISCOVERY

New developments in osteoimmunology

(2012) Hiroshi Takayanagi   Nature Reviews Rheumatology

Osteocyte regulation of bone mineral: a little give and take

(2012) G. J. Atkins et al.   OSTEOPOROSIS INTERNATIONAL

RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor

(2012) Christopher A. Nelson et al.   STRUCTURE

Intercellular Cross-Talk Among Bone Cells: New Factors and Pathways

(2012) Natalie A. Sims et al.   Current Osteoporosis Reports

Distinct Developmental Requirements for Isolated Lymphoid Follicle Formation in the Small and Large Intestine

(2011) Kathryn A. Knoop et al.   AMERICAN JOURNAL OF PATHOLOGY

A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF

(2011) Eleni Douni et al.   HUMAN MOLECULAR GENETICS

The skeleton: a multi-functional complex organ. The role of key signalling pathways in osteoclast differentiation and in bone resorption

(2011) David J Mellis et al.   JOURNAL OF ENDOCRINOLOGY

RANKL/RANK—beyond bones

(2011) Reiko Hanada et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Paget's Disease of Bone: Evidence for Complex Pathogenetic Interactions

(2011) Pui Yan Jenny Chung et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Regulatory Mechanism of Osteoclastogenesis by RANKL and Wnt Signals

(2010) Naoyuki Takahashi   Frontiers in Bioscience-Landmark

Structural and Functional Insights of RANKL-RANK Interaction and Signaling

(2010) C. Liu et al.   JOURNAL OF IMMUNOLOGY

New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK/RANKL axis

(2010) J. C. Crockett et al.   OSTEOPOROSIS INTERNATIONAL

Structure-based development of a receptor activator of nuclear factor- B ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis

(2010) H. M. Ta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A single-center experience in 20 patients with infantile malignant osteopetrosis

(2009) Evelina Mazzolari et al.   AMERICAN JOURNAL OF HEMATOLOGY

RANK/RANKL: Regulators of Immune Responses and Bone Physiology

(2009) Andreas Leibbrandt et al.   Annals of the New York Academy of Sciences

Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-α

(2009) Atsuhiko Hikita et al.   Biochemistry and Cell Biology

Control of RANKL gene expression

(2009) Charles A. O'Brien   BONE

Evaluation of Pharmaceuticals With a Novel 50-Hour Animal Model of Bone Loss*

(2009) Yoshiya Tomimori et al.   JOURNAL OF BONE AND MINERAL RESEARCH

RANKL Is Necessary and Sufficient to Initiate Development of Antigen-Sampling M Cells in the Intestinal Epithelium

(2009) K. A. Knoop et al.   JOURNAL OF IMMUNOLOGY

Central control of fever and female body temperature by RANKL/RANK

(2009) Reiko Hanada et al.   NATURE

Expression of receptor activator of nuclear factor-κB ligand by B cells in response to oral bacteria

(2009) X. Han et al.   Oral microbiology and immunology

Soluble RANKL Induces High Bone Turnover and Decreases Bone Volume, Density, and Strength in Mice

(2008) S. A. J. Lloyd et al.   CALCIFIED TISSUE INTERNATIONAL

Infantile Malignant, Autosomal Recessive Osteopetrosis: The Rich and The Poor

(2008) Anna Villa et al.   CALCIFIED TISSUE INTERNATIONAL

The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator

(2008) Yu Hikosaka et al.   IMMUNITY

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

(2008) Taishin Akiyama et al.   IMMUNITY

Targeted Deletion of a Distant Transcriptional Enhancer of the Receptor Activator of Nuclear Factor-κB Ligand Gene Reduces Bone Remodeling and Increases Bone Mass

(2007) Carlo Galli et al.   ENDOCRINOLOGY