Structural and Antigenic Definition of Hepatitis C Virus E2 Glycoprotein Epitopes Targeted by Monoclonal Antibodies

Human Monoclonal Antibody MBL-HCV1 Delays HCV Viral Rebound Following Liver Transplantation: A Randomized Controlled Study

(2013) R. T. Chung et al.   AMERICAN JOURNAL OF TRANSPLANTATION

An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission

(2013) Alexander W. Tarr et al.   HEPATOLOGY

Glycan Shifting on Hepatitis C Virus (HCV) E2 Glycoprotein Is a Mechanism for Escape from Broadly Neutralizing Antibodies

(2013) Homer Pantua et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus

(2013) L. Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of glycoprotein E2 from bovine viral diarrhea virus

(2013) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-hepatitis C virus E2 (HCV/E2) glycoprotein monoclonal antibodies and neutralization interference

(2012) Giuseppe Sautto et al.   ANTIVIRAL RESEARCH

HCV Proteins and Immunoglobulin Variable Gene (IgV) Subfamilies in HCV-Induced Type II Mixed Cryoglobulinemia: A Concurrent Pathogenetic Role

(2012) Giuseppe Sautto et al.   Clinical & Developmental Immunology

High Titer and Avidity of Nonneutralizing Antibodies against Influenza Vaccine Antigen Are Associated with Severe Influenza

(2012) Kelvin K. W. To et al.   Clinical and Vaccine Immunology

Characterization of epitopes recognized by monoclonal antibodies: experimental approaches supported by freely accessible bioinformatic tools

(2012) Nicola Clementi et al.   DRUG DISCOVERY TODAY

Mass spectrometric analysis of hepatitis C viral envelope protein E2 reveals extended microheterogeneity of mucin-type O-linked glycosylation

(2012) Joachim Bräutigam et al.   GLYCOBIOLOGY

Phage Display-based Strategies for Cloning and Optimization of Monoclonal Antibodies Directed against Human Pathogens

(2012) Nicola Clementi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toward a Hepatitis C Virus Vaccine: the Structural Basis of Hepatitis C Virus Neutralization by AP33, a Broadly Neutralizing Antibody

(2012) J. A. Potter et al.   JOURNAL OF VIROLOGY

Structure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site 412 to 423 in Complex with Antibody AP33

(2012) L. Kong et al.   JOURNAL OF VIROLOGY

Amino Acid Residue-Specific Neutralization and Nonneutralization of Hepatitis C Virus by Monoclonal Antibodies to the E2 Protein

(2012) H. Duan et al.   JOURNAL OF VIROLOGY

Cooperativity in Virus Neutralization by Human Monoclonal Antibodies to Two Adjacent Regions Located at the Amino Terminus of Hepatitis C Virus E2 Glycoprotein

(2012) Z. Keck et al.   JOURNAL OF VIROLOGY

Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1

(2012) L. Kong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

(2012) E. Giang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape?

(2012) Mancini Nicasio et al.   Viruses-Basel

Influenza B-Cells Protective Epitope Characterization: A Passkey for the Rational Design of New Broad-Range Anti-Influenza Vaccines

(2012) Nicola Clementi et al.   Viruses-Basel

Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies Its Role in Cell Entry

(2012) Kamel El Omari et al.   Cell Reports

The role of neutralizing antibodies in hepatitis C virus infection

(2011) V. C. Edwards et al.   JOURNAL OF GENERAL VIROLOGY

Hepatitis C virus resistance to protease inhibitors

(2011) Philippe Halfon et al.   JOURNAL OF HEPATOLOGY

Neutralizing Monoclonal Antibodies against Hepatitis C Virus E2 Protein Bind Discontinuous Epitopes and Inhibit Infection at a Postattachment Step

(2011) M. C. Sabo et al.   JOURNAL OF VIROLOGY

Hepatitis C Patient-Derived Glycoproteins Exhibit Marked Differences in Susceptibility to Serum Neutralizing Antibodies: Genetic Subtype Defines Antigenic but Not Neutralization Serotype

(2011) A. W. Tarr et al.   JOURNAL OF VIROLOGY

Naturally Occurring Antibodies That Recognize Linear Epitopes in the Amino Terminus of the Hepatitis C Virus E2 Protein Confer Noninterfering, Additive Neutralization

(2011) A. W. Tarr et al.   JOURNAL OF VIROLOGY

Mapping a Region of Hepatitis C Virus E2 That Is Responsible for Escape from Neutralizing Antibodies and a Core CD81-Binding Region That Does Not Tolerate Neutralization Escape Mutations

(2011) Z.-Y. Keck et al.   JOURNAL OF VIROLOGY

Cell Culture Replication of a Genotype 1b Hepatitis C Virus Isolate Cloned from a Patient Who Underwent Liver Transplantation

(2011) George Koutsoudakis et al.   PLoS One

Structural Basis for Broad Neutralization of Hepatitis C Virus Quasispecies

(2011) Pascal Lapierre et al.   PLoS One

A Prime-Boost Strategy Using Virus-Like Particles Pseudotyped for HCV Proteins Triggers Broadly Neutralizing Antibodies in Macaques

(2011) P. Garrone et al.   Science Translational Medicine

Characterization of antibody-mediated neutralization directed against the hypervariable region 1 of hepatitis C virus E2 glycoprotein

(2010) G. Vieyres et al.   JOURNAL OF GENERAL VIROLOGY

The variable regions of hepatitis C virus glycoprotein E2 have an essential structural role in glycoprotein assembly and virion infectivity

(2010) K. McCaffrey et al.   JOURNAL OF GENERAL VIROLOGY

Role of N-Linked Glycans in the Functions of Hepatitis C Virus Envelope Proteins Incorporated into Infectious Virions

(2010) F. Helle et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Hypervariable Region 1 Modulates Receptor Interactions, Conceals the CD81 Binding Site, and Protects Conserved Neutralizing Epitopes

(2010) D. Bankwitz et al.   JOURNAL OF VIROLOGY

Neutralizing Antibody-Resistant Hepatitis C Virus Cell-to-Cell Transmission

(2010) C. L. Brimacombe et al.   JOURNAL OF VIROLOGY

Intracytoplasmic stable expression of IgG1 antibody targeting NS3 helicase inhibits replication of highly efficient hepatitis C Virus 2a clone

(2010) Partha K Chandra et al.   Virology Journal

The Disulfide Bonds in Glycoprotein E2 of Hepatitis C Virus Reveal the Tertiary Organization of the Molecule

(2010) Thomas Krey et al.   PLoS Pathogens

Identification and Characterization of Broadly Neutralizing Human Monoclonal Antibodies Directed against the E2 Envelope Glycoprotein of Hepatitis C Virus

(2009) T. J. Broering et al.   JOURNAL OF VIROLOGY

The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and Infection

(2009) I. Benedicto et al.   JOURNAL OF VIROLOGY

Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity

(2009) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential neutralization efficiency of hemagglutinin epitopes, antibody interference, and the design of influenza vaccines

(2009) W. Ndifon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein

(2008) A. M. Owsianka et al.   JOURNAL OF GENERAL VIROLOGY

Dissecting the role of putative CD81 binding regions of E2 in mediating HCV entry: Putative CD81 binding region 1 is not involved in CD81 binding

(2008) Katharina B Rothwangl et al.   Virology Journal