Review
Immunology
Pauline Ginsberg, Ulf Panzer, Nariaki Asada
Summary: The discovery of tissue-resident memory T cells has brought new understanding to human tissue-specific immunity. These cells remain in peripheral tissues after activation and clonal expansion, providing quick immunological responses upon re-encounter with antigens. However, recent studies have shown that tissue-resident memory T cells might worsen autoimmune diseases like lupus nephritis and ANCA-associated glomerulonephritis. Understanding renal tissue-resident memory T cells could lead to new therapeutic targets for autoimmune kidney diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Simin Jamaly, Mehrdad Rakaee, Reza Abdi, George C. Tsokos, Kristin Andreassen Fenton
Summary: Kidney involvement in patients with systemic lupus erythematosus (SLE) leads to significant morbidity and mortality, with lupus nephritis (LN) pathogenesis involving diverse mechanisms driven by autoimmune response elements. This alters the biology of kidney resident cells, with processes in the glomeruli and interstitium potentially proceeding independently but with inevitable crosstalk. Various cells and molecules play a role in the injury and damage of the kidney, and targeting these components therapeutically may prevent or reverse kidney failure. Additionally, tertiary lymphoid structures in the kidneys of patients with lupus nephritis have been associated with poorer renal outcomes, formed by a complex interaction of immune cells and kidney resident cells.
AUTOIMMUNITY REVIEWS
(2021)
Article
Plant Sciences
Chen Cheng, Rongrong Zhu, Mingjian Liu, Hao Yang, Fangfang Guo, Qunqun Du, Xiaolan Wang, Minmin Li, Gaopeng Song, Renan Qin, Shuwen Liu
Summary: This study aimed to explore the efficacy and potential mechanisms of Kunxian capsule (KXC) through pharmacological network, in vitro and in vivo studies. It was found that KXC inhibits renal damage and T-cell infiltration in lupus nephritis by blocking the JAK1-STAT1 pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Bing Wu, Yanwei Wu, Chen Fan, Chunlan Feng, Haoyu Wang, Fang Bai, Jianping Zuo, Wei Tang
Summary: Heme plays an important role in the pathogenesis of systemic lupus erythematosus (SLE), and supplementation of heme can significantly improve lupus symptoms, reduce proteinuria levels, and alleviate organ enlargement.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Ti Zhang, Mengmeng Wang, Jiaxun Zhang, Xiaopian Feng, Zhengzhao Liu, Zhen Cheng
Summary: In patients with lupus nephritis, the number of tubulointerstitial CD8+T cells correlates with clinicohistologic impairment, and levels exceeding 130/mm(2) are independently associated with an unfavorable kidney outcome.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rakesh Mishra, Ramalingam Bethunaickan, Celine C. Berthier, Zhengzi Yi, Joshua J. Strohl, Patricio T. Huerta, Weijia Zhang, Anne Davidson
Summary: The study found significant disruption of renal circadian rhythms in mice with lupus nephritis, affecting multiple renal pathways including homeostasis, metabolism, and blood pressure regulation. Induction of remission therapy partially reversed this circadian dysregulation.
MOLECULAR MEDICINE
(2021)
Review
Rheumatology
Rhea Bhargava, Hao Li, George C. Tsokos
Summary: This review provides an overview of recent advances in understanding the pathogenesis of lupus nephritis, particularly focusing on the roles of resident kidney cells. It emphasizes the potential of cell targeted approaches in preventing and treating this disease.
CURRENT OPINION IN RHEUMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Savino Sciascia, Martina Cozzi, Alice Barinotti, Massimo Radin, Irene Cecchi, Roberta Fenoglio, Daniele Mancardi, Georgia Wilson Jones, Daniela Rossi, Dario Roccatello
Summary: Fibrosis is a pathological process that can affect the kidney, leading to persistent inflammation or long-term injury. Recently, there has been increasing attention on interstitial fibrosis and tubular atrophy as markers of injury severity, predictors of treatment response, and prognostic factors for renal outcome in lupus nephritis (LN). This review explores the mechanisms of fibrogenesis in LN and the importance of the chronicity index in predicting treatment response and renal prognosis. Understanding the cellular and molecular pathways involved in fibrosis in LN could help identify individuals at higher risk of chronic kidney disease and develop new therapeutic strategies for lupus patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Ioannis Parodis, Julius Lindblom, Nursen Cetrez, Leonardo Palazzo, Henri Ala, Frederic A. Houssiau, Christopher Sjoewall, Brad H. Rovin
Summary: In this study, we evaluated the efficacy of belimumab in preventing de novo renal flares and identified factors associated with renal flare occurrence. We found that Asian origin, positive baseline anti-double stranded DNA levels, and increasing mean prednisone dose during follow-up were associated with de novo renal flares.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Immunology
Elena Litvinova, Carine Bounaix, Guillaume Hanouna, Jennifer Da Silva, Laura Noailles, Lucie Beaudoin, Michael Padden, Nessrine Bellamri, Agnes Lehuen, Eric Daugas, Renato C. Monteiro, Heloise Flament
Summary: This study found that the frequency of MAIT cells is significantly reduced in the blood of patients with severe lupus nephritis (LN), and these cells also undergo changes in function and phenotype. The study also found that patients who achieve complete renal remission after immunosuppressive therapy have higher frequencies of MAIT cells and lower expression of proliferation marker Ki-67 and granzyme B (GzB).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Tomohiro Koga, Kunihiro Ichinose, George C. Tsokos
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs. Immune abnormalities contribute to the expression of the disease, with elements of the immune system instigating cellular damage. Correcting immune aberrations and preventing organ damage are both important.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Xinxia Lu, Liangao Wang, Meng Wang, Yuejin Li, Qinqin Zhao, Yanjun Shi, Yujing Zhang, Yingjie Wang, Wei Wang, Long Ji, Haifeng Hou, Dong Li
Summary: This study evaluated the performance of IgG N-glycosylation in diagnosing lupus nephritis (LN) in female systemic lupus erythematosus (SLE) patients. The results showed that specific glycans and anemia were associated with LN. These IgG N-glycans can serve as potential biomarkers to differentiate LN among SLE patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hsin-Yuan Chen, Yi-Fen Chiang, Yong-Han Hong, Tzong-Ming Shieh, Tsui-Chin Huang, Mohamed Ali, Hsin-Yi Chang, Kai-Lee Wang, Shih-Min Hsia
Summary: Quercetin has beneficial effects on inhibiting fibrosis and inflammation in lupus nephritis models, as shown in both in vivo and in vitro experiments. It improves renal function, inhibits fibrosis- and inflammation-related markers, and ameliorates renal cell pyroptosis via the IL33/ST2 pathway.
Article
Rheumatology
Gaelle Tilman, Emilie Dupre, Laura Watteyne, Charlotte Anne Baert, Delphine Nolf, Fatima Benhaddi, Fanny Lambert, Aurelie Daumerie, Caroline Bouzin, Sophie Lucas, Nisha Limaye
Summary: The presence of p16(INK4a)-positive cells, a marker of cellular senescence, is associated with renal disease severity in both human and mouse models of lupus nephritis.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Immunology
Ying Ding, Xiaojuan Yu, Lihua Wu, Ying Tan, Zhen Qu, Feng Yu
Summary: The study found that C4d deposition in renal tissues was common among patients with lupus nephritis (LN), with tubular basement membrane C4d deposition being associated with disease activity, and arteriolar C4d deposition being associated with renal microvascular lesions (RVLs) and worse renal outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yan Chen, Wing-Kuk Au, Daniel Chan, Ko-Yung Sit, Zhe Zhen, Kar-Lal Ho, Debbie Wong, Lai-Ming Ho, Desmond Yap, Yui-Ming Lam, Chu-Pak Lau, Hung-Fat Tse, Tak-Mao Chan, Kai-Hang Yiu
INTERNATIONAL HEART JOURNAL
(2018)
Article
Transplantation
Desmond Y. H. Yap, Lorraine P. Y. Kwan, Maggie K. M. Ma, Maggie M. Y. Mok, Gary C. W. Chan, Tak Mao Chan
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2019)
Review
Immunology
Maggie K. M. Ma, Susan Yung, Tak Mao Chan
Article
Transplantation
Desmond Y. H. Yap, Chun Hay Tam, Susan Yung, Sunny Wong, Colin S. O. Tang, Temy M. Y. Mok, Catherine K. Y. Yuen, Maggie K. M. Ma, Chak Sing Lau, Tak Mao Chan
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2020)
Article
Rheumatology
Meggan Mackay, Maria Dall'Era, Joanna Fishbein, Kenneth Kalunian, Martin Lesser, Jorge Sanchez-Guerrero, Deborah M. Levy, Earl Silverman, Michelle Petri, Cristina Arriens, Edmund J. Lewis, Stephen M. Korbet, Fabrizio Conti, Vladimir Tesar, Zdenka Hruskova, Eduardo F. Borba, Eloisa Bonfa, Tak Mao Chan, Manish Rathi, K. L. Gupta, Vivekanand Jha, Sarfaraz Hasni, Melissa R. West, Neil Solomons, Frederic A. Houssiau, Juanita Romero-Diaz, Juan Mejia-Vilet, Brad H. Rovin
ARTHRITIS & RHEUMATOLOGY
(2019)
Article
Urology & Nephrology
Brad H. Rovin, Neil Solomons, William F. Pendergraft, Mary Anne Dooley, James Tumlin, Juanita Romero-Diaz, Lidia Lysenko, Sandra V. Navarra, Robert B. Huizinga
KIDNEY INTERNATIONAL
(2019)
Article
Rheumatology
Chao Li, Desmond Y. H. Yap, Gavin Chan, Yu-bing Wen, Hang Li, Colin Tang, Xue-mei Li, Xue-wang Li, Tak Mao Chan
JOURNAL OF RHEUMATOLOGY
(2019)
Review
Rheumatology
K. M. Thong, T. M. Chan
Article
Urology & Nephrology
Sing Leung Lui, Desmond Yap, Vincent Cheng, Tak Mao Chan, Kwok Yung Yuen
Article
Medicine, Research & Experimental
Jessica Y. S. Chu, Mel K. M. Chau, Caleb C. Y. Chan, Andrew C. P. Tai, Kwok Fan Cheung, Tak Mao Chan, Susan Yung
MOLECULAR THERAPY-NUCLEIC ACIDS
(2019)
Article
Gastroenterology & Hepatology
Lung-Yi Mak, Sze-Hang Liu, Desmond Yat-Hin Yap, Wai-Kay Seto, Danny Ka-Ho Wong, James Fung, Tak-Mao Chan, Ching-Lung Lai, Man-Fung Yuen
DIGESTIVE DISEASES AND SCIENCES
(2019)
Article
Immunology
Desmond Y. H. Yap, Colin Tang, James Y. Y. Fung, Wai-Kay Seto, Maggie K. M. Ma, Bo Ying Choy, Tak Mao Chan
TRANSPLANT INFECTIOUS DISEASE
(2019)
Article
Multidisciplinary Sciences
Shan-Shan Li, Carman K. M. Ip, Matthew Y. H. Tang, Maggie K. S. Tang, Yin Tong, Jiangwen Zhang, Ayon Ahmed Hassan, Abby S. C. Mak, Susan Yung, Tak-Mao Chan, Philip P. Ip, Cheuk Lun Lee, Philip C. N. Chiu, Leo Tsz On Lee, Hung-Cheng Lai, Jin-Zhang Zeng, Ho Cheung Shum, Alice S. T. Wong
NATURE COMMUNICATIONS
(2019)