Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors

NKT Cells in Tumor Immunity: Opposing Subsets Define a New Immunoregulatory Axis

(2014) J. A. Berzofsky et al.   JOURNAL OF IMMUNOLOGY

Critical Role for the Chemokine Receptor CXCR6 in Homeostasis and Activation of CD1d-Restricted NKT Cells

(2014) E. Germanov et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Programmed Death-1/Programmed Death Ligand 1 Interaction Regulates the Induction and Maintenance of Invariant NKT Cell Anergy

(2014) W.-S. Chang et al.   JOURNAL OF IMMUNOLOGY

Accumulation of Activated Invariant Natural Killer T Cells in the Tumor Microenvironment after α-Galactosylceramide-Pulsed Antigen Presenting Cells

(2012) Kaoru Nagato et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Targeting NKT cells and PD-L1 pathway results in augmented anti-tumor responses in a melanoma model

(2011) Kevin Durgan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Activated iNKT cells promote Vγ9Vδ2-T cell anti-tumor effector functions through the production of TNF-α

(2011) Famke L. Schneiders et al.   CLINICAL IMMUNOLOGY

Human NKT cells direct the differentiation of myeloid APCs that regulate T cell responses via expression of programmed cell death ligands

(2011) Subramanya Hegde et al.   JOURNAL OF AUTOIMMUNITY

Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity

(2011) Jessica J. O’Konek et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin Combined with TGF-  Converts Human Invariant NKT Cells into Suppressive Foxp3+ Regulatory Cells

(2011) L. Moreira-Teixeira et al.   JOURNAL OF IMMUNOLOGY

Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals

(2011) Patrick J Brennan et al.   NATURE IMMUNOLOGY

Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria

(2011) Yuki Kinjo et al.   NATURE IMMUNOLOGY

Engagement of glycosylphosphatidylinositol-anchored proteins results in enhanced mouse and human invariant natural killer T cell responses

(2010) Lisa A. Mannik et al.   IMMUNOLOGY

Early activation of invariant natural killer T cells in a rheumatoid arthritis model and application to disease treatment

(2010) Aurore Miellot-Gafsou et al.   IMMUNOLOGY

Autoreactive natural killer T cells: promoting immune protection and immune tolerance through varied interactions with myeloid antigen-presenting cells

(2010) Subramanya Hegde et al.   IMMUNOLOGY

NKT Cell-Dependent Regulation of Secondary Antigen-Specific, Conventional CD4+ T Cell Immune Responses

(2010) Y. Shin et al.   JOURNAL OF IMMUNOLOGY

Diverse Endogenous Antigens for Mouse NKT Cells: Self-Antigens That Are Not Glycosphingolipids

(2010) B. Pei et al.   JOURNAL OF IMMUNOLOGY

Regulation of Secondary Antigen-Specific CD8+ T-Cell Responses by Natural Killer T Cells

(2009) C. Hong et al.   CANCER RESEARCH

Combination therapy ofin vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma

(2009) Naoki Kunii et al.   CANCER SCIENCE

Invariant Natural Killer T Cells Regulate Breast Cancer Response to Radiation and CTLA-4 Blockade

(2009) K. A. Pilones et al.   CLINICAL CANCER RESEARCH

Natural Killer T Cells and Autoimmune Disease

(2009) Lan Wu et al.   CURRENT MOLECULAR MEDICINE

The Contrasting Roles of NKT Cells in Tumor Immunity

(2009) Jay Berzofsky et al.   CURRENT MOLECULAR MEDICINE

Multiple tissue-specific isoforms of sulfatide activate CD1d-restricted type II NKT cells

(2009) Maria Blomqvist et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NKT cell immune responses to viral infection

(2009) Marlowe S Tessmer et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Vα24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages

(2009) Liping Song et al.   JOURNAL OF CLINICAL INVESTIGATION

CD1d Activation and Blockade: A New Antitumor Strategy

(2009) M. W. L. Teng et al.   JOURNAL OF IMMUNOLOGY

CD1d-Based Combination Therapy Eradicates Established Tumors in Mice

(2009) M. W. L. Teng et al.   JOURNAL OF IMMUNOLOGY

Cytokine-Dependent Modification of IL-12p70 and IL-23 Balance in Dendritic Cells by Ligand Activation of V 24 Invariant NKT Cells

(2009) Y. Uemura et al.   JOURNAL OF IMMUNOLOGY

A Phase I-II Study of  -Galactosylceramide-Pulsed IL-2/GM-CSF-Cultured Peripheral Blood Mononuclear Cells in Patients with Advanced and Recurrent Non-Small Cell Lung Cancer

(2009) S. Motohashi et al.   JOURNAL OF IMMUNOLOGY

Enrichment of Human CD4+ V 24/V 11 Invariant NKT Cells in Intrahepatic Malignant Tumors

(2009) G. Bricard et al.   JOURNAL OF IMMUNOLOGY

Human NKT cells promote monocyte differentiation into suppressive myeloid antigen-presenting cells

(2009) Subramanya Hegde et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity

(2009) C. Guillonneau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-galactosylceramide is an effective mucosal adjuvant for repeated intranasal or oral delivery of HIV peptide antigens

(2009) Amy N. Courtney et al.   VACCINE

Recognition of Lyso-Phospholipids by Human Natural Killer T Lymphocytes

(2009) Lisa M. Fox et al.   PLOS BIOLOGY

Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer

(2008) D. H. Chang et al.   BLOOD

Type I NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma

(2008) G. J. Renukaradhya et al.   BLOOD

A novel immunoregulatory axis of NKT cell subsets regulating tumor immunity

(2008) Jay A. Berzofsky et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Ascites Specific Inhibition of CD1d-Mediated Activation of Natural Killer T Cells

(2008) T. J. Webb et al.   CLINICAL CANCER RESEARCH

Generation of Antitumor Invariant Natural Killer T Cell Lines in Multiple Myeloma and Promotion of Their Functions via Lenalidomide: A Strategy for Immunotherapy

(2008) W. Song et al.   CLINICAL CANCER RESEARCH

Insufficient ex vivo expansion of Vα24+ natural killer T cells in malignant lymphoma patients related to the suppressed expression of CD1d molecules on CD14+ cells

(2008) O. Imataki et al.   CYTOTHERAPY