Article
Dermatology
A. Lamberts, N. Kotnik, G. F. H. Diercks, J. M. Meijer, G. Di Zenzo, H. H. Pas, M. F. Jonkman, B. F. Gibbs, U. Raap, B. Horvath
Summary: Total IgE levels were elevated in a significant percentage of both NBP and BP patients, with IgE being present in both serum and skin. The study suggests a common IgE-dependent mechanism in both diseases, such as pruritus, but further research is needed to determine if IgE contributes to blister formation in BP.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Immunology
Roberto Maglie, Maria Efenesia Baffa, Francesca Montefusco, Carlo Pipito, Stefano Senatore, Marco Capassoni, Vincenza Maio, Marco Matucci Cerinic, Emiliano Antiga, Serena Guiducci
Summary: This article describes the unusual occurrence of bullous pemphigoid (BP) in a female patient with a concomitant history of generalized morphea and cutaneous and genital lichen sclerosus. The study provides a literature review on cases of BP in patients with localized scleroderma or lichen sclerosus and discusses the immunological mechanisms that may have contributed to the emergence of BP in the patient.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Carlo Alberto Maronese, Marzia Caproni, Chiara Moltrasio, Giovanni Genovese, Pamela Vezzoli, Paolo Sena, Giulia Previtali, Emanuele Cozzani, Giulia Gasparini, Aurora Parodi, Laura Atzori, Emiliano Antiga, Roberto Maglie, Francesco Moro, Elena Biancamaria Mariotti, Alberto Corra, Sabatino Pallotta, Biagio Didona, Angelo Valerio Marzano, Giovanni Di Zenzo
Summary: Bullous pemphigoid (BP) is an autoimmune disease that COVID-19 vaccines may induce. An Italian study collected data of BP patients associated with COVID-19 vaccines and found that these patients have similar characteristics to idiopathic BP, but with a slight male predominance and reduced humoral response to BP230.
FRONTIERS IN MEDICINE
(2022)
Article
Dermatology
W. Masmoudi, M. Vaillant, S. Vassileva, A. Patsatsi, G. Quereux, C. Moltrasio, C. Abasq, C. Prost-Squarcioni, D. Kottler, D. Kiritsi, N. Litrowski, P. Plantin, L. Friedrichsen, A. Zebrowska, S. Duvert-Lehembre, S. Hofmann, V Ferranti, F. Jouen, P. Joly, V Hebert
Summary: This study suggests cut-off values of 20-57 for BPDAI to distinguish mild, moderate and severe BP, and confirms that it is a robust tool to assess BP severity precisely. The intraclass correlation coefficient for BPDAI was high, and improvement in BPDAI score was correlated with decrease in anti-BP180 ELISA value.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Sascha Staender, Enno Schmidt, Detlef Zillikens, Ralf J. Ludwig, Khalaf Kridin
Summary: Some patients with bullous pemphigoid have mucosal involvement, which is associated with the absence of anti-BP230 antibodies and peripheral eosinophilia.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Article
Dermatology
Khalaf Kridin, Nina van Beek, Elena Buehler, Anne S. Kochan, Mahdy Ranjbar, Stefan Beissert, Detlef Zillikens, Claudia Guenther, Enno Schmidt
Summary: This retrospective cohort study evaluated the characteristics associated with refractory disease course and blindness among patients with mucous membrane pemphigoid (MMP) and the association of different treatment strategies with the prognostic outcome. The study found that MMP patients with anti-LAD-1 IgA and anti-DEJ IgG reactivity should be carefully monitored. While initial bilateral ocular disease and scarring ocular lesions were associated with blindness, patients initially presenting with unilateral and nonscarring ocular disease may still develop severe vision impairment.
Article
Immunology
Dario Didona, Luca Scarsella, Milad Fehresti, Farzan Solimani, Hazem A. Juratli, Manuel Goebel, Stefan Muehlenbein, Lily Holiangu, Josquin Pieper, Vera Korff, Thomas Schmidt, Cassian Sitaru, Ruediger Eming, Michael Hertl, Robert Pollmann
Summary: Bullous pemphigoid is an autoimmune disorder in elderly individuals characterized by serum IgG autoantibodies. Chronic pruritus in the elderly may be related to autoimmunity, and therapeutic application of clobetasol propionate ointment in BP patients has been shown to reduce BP180-specific T cells and improve symptoms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Florine Guerrois, Elsa Hassan, Thomas Bettuzzi, Vannina Seta, Claire Goulvestre, Lamia Jelti, Thibaut Belmondo, Pierre Wolkenstein, Selim Aractingi, Saskia Ingen-Housz-Oro, Nicolas Dupin
Summary: The study identified three different clusters of BP, including one corresponding to severe BP1801 BP230- BP with features common to mucous membrane pemphigoid.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Florine Guerrois, Elsa Hassan, Thomas Bettuzzi, Vannina Seta, Claire Goulvestre, Lamia Jelti, Thibaut Belmondo, Pierre Wolkenstein, Selim Aractingi, Saskia Ingen-Housz-Oro, Nicolas Dupin
Summary: This study identifies three different clusters of Bullous pemphigoid (BP), one of which has common features with mucous membrane pemphigoid. Understanding the different clinical and biological profiles of BP is crucial in the diagnosis and treatment of the disease.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
S. Staender, E. Schmidt, D. Zillikens, D. Thaci, R. J. Ludwig, K. Kridin
Summary: Patients with both BP and psoriasis present at a younger age with a milder disease phenotype, lower levels of pathogenic autoantibodies, and specific linear C3 deposits along the dermal-epidermal junction detected by direct immunofluorescence microscopy.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Immunology
Hiroshi Koga, Kwesi Teye, Arisa Sugawara, Masahiro Tsutsumi, Norito Ishii, Takekuni Nakama
Summary: Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease with a prominent role of T helper 2 (Th2) cells. IL-9 is elevated in the serum and lesions of BP, and could be a biomarker of BP.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Francesco Moro, Feliciana Mariotti, Anna Pira, Naomi De Luca, Biagio Didona, Gianluca Pagnanelli, Giovanni Di Zenzo
Summary: This article reports a case of a patient with multiple sclerosis and scleroderma who developed severe bullous pemphigoid. The disease may be triggered by an immune response to BP180 and BP230.
FRONTIERS IN MEDICINE
(2022)
Review
Immunology
Bianca Opelka, Enno Schmidt, Stephanie Goletz
Summary: Pemphigoid diseases are autoimmune skin blistering diseases characterized by autoantibodies against proteins of the cutaneous basement membrane zone. The interaction between autoantibodies and BP180 antigen leads to immune cell activation, inflammation, and blister formation. The clinical phenotype of the disease is influenced by the specificity of antibodies and epitopes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Marina Alexandre, Gerome Bohelay, Thomas Gille, Christelle Le Roux-Villet, Isaac Soued, Florence Morin, Frederic Caux, Sabine Grootenboer-Mignot, Catherine Prost-Squarcioni
Summary: In this study, the effectiveness of omalizumab (OMZ) in patients with refractory bullous pemphigoid and mucous membrane pemphigoid was evaluated. The results showed that OMZ induced a rapid improvement in symptoms, allowed disease control, and reduced concomitant therapies. This is the largest retrospective study on the use of OMZ in the treatment of bullous pemphigoid and mucous membrane pemphigoid.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Yen-Chi Shih, Huijie Yuan, Jia Shen, Jie Zheng, Meng Pan
Summary: The study found that anti-BP230 IgE is more frequently observed in topical-steroid-therapy-resistant patients with bullous pemphigoid, and it prefers the R1 domain of BP230, which is not included in commercially available testing kits. Detection of anti-BP230 IgE can serve as an indicator for initiating systemic steroid therapy.
JOURNAL OF DERMATOLOGY
(2021)