Antigen-Based Immune Therapeutics for Type 1 Diabetes: Magic Bullets or Ordinary Blanks?

Autoimmunity to Both Proinsulin and IGRP Is Required for Diabetes in Nonobese Diabetic 8.3 TCR Transgenic Mice

(2014) B. Krishnamurthy et al.   JOURNAL OF IMMUNOLOGY

Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes

(2011) S. Fourlanos et al.   DIABETES

The immunotherapeutic potential of dendritic cells in type 1 diabetes

(2010) G. Mukherjee et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes

(2010) S. I. Mannering et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group

(2010) J. B. Matthews et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society

(2010) R. Mallone et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response

(2010) Mikael Chéramy et al.   CLINICAL IMMUNOLOGY

Failure to Preserve  -Cell Function With Mycophenolate Mofetil and Daclizumab Combined Therapy in Patients With New- Onset Type 1 Diabetes

(2010) P. A. Gottlieb et al.   DIABETES CARE

Immunotherapy of Type 1 Diabetes: Where Are We and Where Should We Be Going?

(2010) Xunrong Luo et al.   IMMUNITY

Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice

(2010) Mercedes Rodriguez Garcia et al.   JOURNAL OF CLINICAL INVESTIGATION

Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients

(2010) Jason L. Gaglia et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloid-Derived Suppressor Cells Prevent Type 1 Diabetes in Murine Models

(2010) B. Yin et al.   JOURNAL OF IMMUNOLOGY

Genetics, pathogenesis and clinical interventions in type 1 diabetes

(2010) Jeffrey A. Bluestone et al.   NATURE

Measurement of CD8+T Cell Responses in Human Type 1 Diabetes

(2009) Emanuela Martinuzzi et al.   Annals of the New York Academy of Sciences

Lymphoid tissue-specific homing of bone marrow-derived dendritic cells

(2009) R. J. Creusot et al.   BLOOD

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Validity and Reproducibility of Measurement of Islet Autoreactivity by T-Cell Assays in Subjects With Early Type 1 Diabetes

(2009) K. C. Herold et al.   DIABETES

Effects of Exenatide Alone and in Combination With Daclizumab on  -Cell Function in Long-Standing Type 1 Diabetes

(2009) K. I. Rother et al.   DIABETES CARE

No Effect of the Altered Peptide Ligand NBI-6024 on  -Cell Residual Function and Insulin Needs in New-Onset Type 1 Diabetes

(2009) M. Walter et al.   DIABETES CARE

Functional islet-specific Treg can be generated from CD4+CD25− T cells of healthy and type 1 diabetic subjects

(2009) S. Alice Long et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy

(2009) Tihamer Orban et al.   JOURNAL OF AUTOIMMUNITY

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study

(2008) S. L. Thrower et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization

(2008) Peter Achenbach et al.   Current Diabetes Reports

Recognition of Human Proinsulin Leader Sequence by Class I-Restricted T-Cells in HLA-A*0201 Transgenic Mice and in Human Type 1 Diabetes

(2008) A. Toma et al.   DIABETES

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes

(2008) A. L. Putnam et al.   DIABETES

 -Cell Mass and Type 1 Diabetes: Going, Going, Gone?

(2008) E. Akirav et al.   DIABETES

CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

(2008) Ania Skowera et al.   JOURNAL OF CLINICAL INVESTIGATION

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

(2008) Kirsti Näntö-Salonen et al.   LANCET

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE

GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes

(2008) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extent of Beta Cell Destruction Is Important but Insufficient to Predict the Onset of Type 1 Diabetes Mellitus

(2008) David J. Klinke   PLoS One

Effect of Adjunct Metformin Treatment in Patients with Type-1 Diabetes and Persistent Inadequate Glycaemic Control. A Randomized Study

(2008) Søren Søgaard Lund et al.   PLoS One

Selective delivery of   cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice

(2008) A. Mukhopadhaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA