Current State of Type 1 Diabetes Immunotherapy: Incremental Advances, Huge Leaps, or More of the Same?

Polyclonal Adaptive Regulatory CD4 Cells That Can Reverse Type I Diabetes Become Oligoclonal Long-Term Protective Memory Cells

(2014) E. Godebu et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cells Genetically Engineered to Express IL-10 Induce Long-Lasting Antigen-Specific Tolerance in Experimental Asthma

(2014) E. Henry et al.   JOURNAL OF IMMUNOLOGY

B Lymphocyte Depletion by CD20 Monoclonal Antibody Prevents Diabetes in Nonobese Diabetic Mice despite Isotype-Specific Differences in Fc R Effector Functions

(2014) Y. Xiu et al.   JOURNAL OF IMMUNOLOGY

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Ex Vivo-Expanded Natural CD4+CD25+ Regulatory T Cells Synergize With Host T-Cell Depletion to Promote Long-Term Survival of Allografts

(2010) G. Xia et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Immune Reconstitution Following Rabbit Antithymocyte Globulin

(2010) S. Gurkan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Immunological efficacy of heat shock protein 60 peptide DiaPep277TM therapy in clinical type I diabetes

(2010) V. A. L. Huurman et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response

(2010) Mikael Chéramy et al.   CLINICAL IMMUNOLOGY

Immune Intervention in Children with Type 1 Diabetes

(2010) Johnny Ludvigsson et al.   Current Diabetes Reports

Reversal of New-Onset Diabetes through Modulating Inflammation and Stimulating β-Cell Replication in Nonobese Diabetic Mice by a Dipeptidyl Peptidase IV Inhibitor

(2010) Lei Tian et al.   ENDOCRINOLOGY

Reversal of Autoimmunity by Boosting Memory-like Autoregulatory T Cells

(2010) Sue Tsai et al.   IMMUNITY

Blocking interleukin-1β in acute and chronic autoinflammatory diseases

(2010) C. A. Dinarello   JOURNAL OF INTERNAL MEDICINE

A Short Pulse of IL-4 Delivered by DCs Electroporated With Modified mRNA Can Both Prevent and Treat Autoimmune Diabetes in NOD Mice

(2010) Rémi J Creusot et al.   MOLECULAR THERAPY

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

(2010) Lionel Apetoh et al.   NATURE IMMUNOLOGY

Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells

(2010) Roopali Gandhi et al.   NATURE IMMUNOLOGY

Suppression of Allergic Inflammation by Allergen-DNA-modified Dendritic Cells Depends on the Induction of Foxp3+Regulatory T Cells

(2010) Kui Wu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Lymphoid tissue-specific homing of bone marrow-derived dendritic cells

(2009) R. J. Creusot et al.   BLOOD

Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity

(2009) Béatrice Regnault et al.   BMC Medical Genomics

Predictive Characteristics of Diabetes-Associated Autoantibodies Among Children With HLA-Conferred Disease Susceptibility in the General Population

(2009) Heli T.A. Siljander et al.   DIABETES

Antigen-Based Therapy for the Treatment of Type 1 Diabetes

(2009) J. Tian et al.   DIABETES

New Definition for the Partial Remission Period in Children and Adolescents With Type 1 Diabetes

(2009) H. B. Mortensen et al.   DIABETES CARE

Immunotherapy for the Prevention and Treatment of Type 1 Diabetes: Human trials and a look into the future

(2009) M. Rewers et al.   DIABETES CARE

No Effect of the Altered Peptide Ligand NBI-6024 on  -Cell Residual Function and Insulin Needs in New-Onset Type 1 Diabetes

(2009) M. Walter et al.   DIABETES CARE

Etanercept Treatment in Children With New-Onset Type 1 Diabetes: Pilot randomized, placebo-controlled, double-blind study

(2009) L. Mastrandrea et al.   DIABETES CARE

Diagnosis and Classification of Diabetes Mellitus

(2009)   DIABETES CARE

Thymus-specific deletion of insulin induces autoimmune diabetes

(2009) Yong Fan et al.   EMBO JOURNAL

Prevention of Type 1 Diabetes

(2009) Diane K. Wherrett et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

CD8+T cells specific for β cells encounter their cognate antigens in the islets of NOD mice

(2009) Shuguang Pang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

(2009) Carlos E. B. Couri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy

(2009) Tihamer Orban et al.   JOURNAL OF AUTOIMMUNITY

Cutting Edge: Normal Regional Lymph Node Enrichment of Antigen-Specific Regulatory T Cells with Autoimmune Disease-Suppressive Capacity

(2009) K. M. Wheeler et al.   JOURNAL OF IMMUNOLOGY

Novel Human Transitional B Cell Populations Revealed by B Cell Depletion Therapy

(2009) Arumugam Palanichamy et al.   JOURNAL OF IMMUNOLOGY

Immunomodulation by chronobiologically-based glucocorticoids treatment for multiple sclerosis relapses

(2009) Lea Glass-Marmor et al.   JOURNAL OF NEUROIMMUNOLOGY

Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes

(2009) Linda Yip et al.   NATURE IMMUNOLOGY

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-1β and the Autoinflammatory Diseases

(2009) Charles A. Dinarello   NEW ENGLAND JOURNAL OF MEDICINE

Etiopathogenesis of type 1 diabetes mellitus: prognostic factors for the evolution of residual β cell function

(2009) Sergio A Dib et al.   Diabetology & Metabolic Syndrome

Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice

(2008) Rémi J. Creusot et al.   CLINICAL IMMUNOLOGY

Thymic Stromal Lymphopoietin and Thymic Stromal Lymphopoietin-Conditioned Dendritic Cells Induce Regulatory T-Cell Differentiation and Protection of NOD Mice Against Diabetes

(2008) G. Besin et al.   DIABETES

A Microsphere-Based Vaccine Prevents and Reverses New-Onset Autoimmune Diabetes

(2008) B. Phillips et al.   DIABETES

 -Cell Mass and Type 1 Diabetes: Going, Going, Gone?

(2008) E. Akirav et al.   DIABETES

Special regulatory T cell review: The resurgence of the concept of contrasuppression in immunoregulation

(2008) Thomas Lehner   IMMUNOLOGY

Protective role of interleukin-10-producing regulatory dendritic cells against murine autoimmune gastritis

(2008) Masamoto Torisu et al.   JOURNAL OF GASTROENTEROLOGY

Alloantigen-Pulsed Host Dendritic Cells Induce T-Cell Regulation and Prolong Allograft Survival in a Rat Model of Hindlimb Allotransplantation

(2008) Yur-Ren Kuo et al.   JOURNAL OF SURGICAL RESEARCH

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

(2008) Kirsti Näntö-Salonen et al.   LANCET

Dendritic cells transduced with lentiviral-mediated RelB-specific ShRNAs inhibit the development of experimental autoimmune myasthenia gravis

(2008) Yong Zhang et al.   MOLECULAR IMMUNOLOGY

GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes

(2008) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

The TrialNet Natural History Study of the Development of Type 1 Diabetes: objectives, design, and initial results

(2008) Jeffrey L Mahon et al.   PEDIATRIC DIABETES

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

(2008) Y. Onishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice

(2008) C. Louvet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curative and   cell regenerative effects of  1-antitrypsin treatment in autoimmune diabetic NOD mice

(2008) M. Koulmanda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic cells in islets of Langerhans constitutively present   cell-derived peptides bound to their class II MHC molecules

(2008) B. Calderon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of circadian rhythm on the efficacy of the hepatitis B vaccination

(2008) Oguz Karabay et al.   VACCINE

The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus

(2008) Marc Y Donath et al.   Nature clinical practice. Endocrinology & metabolism