Article
Biochemistry & Molecular Biology
Saska Djekic, Jelena Vekic, Aleksandra Zeljkovic, Jelena Kotur-Stevuljevic, Srdjan Kafedzic, Marija Zdravkovic, Ivan Ilic, Sasa Hinic, Milivoje Cerovic, Milica Stefanovic, Marija Mihajlovic, Aleksandar Neskovic, Natasa Bogavac-Stanojevic
Summary: The aim of this study was to assess the impacts of oxidative stress, inflammation, and the presence of sdLDL on the antioxidative function of HDL subclasses and the distribution of PON1 activity within HDL in patients with STEMI. The results showed significant differences in the proportions of HDL subclasses and the distribution of PON1 in STEMI patients compared to the control group. There were positive associations between sdLDL and PON1 activity within HDL subclasses. The increased oxidative stress and sdLDL in STEMI patients are closely related to the compromised antioxidative function of small HDL3 particles and the altered PON1 distribution within HDL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Hongjuan Tang, Zhicong Xiang, Longyu Li, Xiaofei Shao, Qin Zhou, Xu You, Chongxiang Xiong, Jing Ning, Tong Chen, David Deng, Hequn Zou
Summary: The study found that with the deterioration of metabolic disease, the distribution of HDL subclasses and related structural proteins also changed, while lymphocytes and inflammation factors gradually increased. The level of HDL2b was negatively associated with WBC, lymphocytes, and hs-CRP, and high levels of HDL3 and low levels of HDL2b increased the probability of having an unfavorable metabolic unhealth/obesity status. This suggests that HDL2b particles may play an anti-inflammatory role by negatively regulating lymphocyte activation and could be a potential therapeutic target for future metabolic diseases.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Abdolkarim Mahrooz, Yasaman Shokri, Atena Variji, Mehryar Zargari, Ahad Alizadeh, Ehsan Mehtarian
Summary: Developing laboratory assays to evaluate HDL functions and improving cardiovascular disease risk assessment by investigating new cardiometabolic risk factors based on substituting paraoxonase 1 (PON1) as a critical enzyme in the functionality of HDL for that of HDL-C may help predict the risk of coronary artery disease. The study found that the new cardiometabolic ratios remained significant as independent variables after multivariate adjustment, providing optimal discriminating cutoffs for CAD. Substituting PON1 activity for HDL-C in atherogenic lipid ratios can enhance CAD risk assessment by providing an index of HDL activity.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Immunology
Sverre Grover Aukrust, Kristine Bech Holte, Trine B. Opstad, Ingebjorg Seljeflot, Tore Julsrud Berg, Ragnhild Helseth
Summary: In patients with long-term T1DM, the levels of circulating NETs are not consistently associated with the presence of T1DM or the development of CAD. This suggests altered neutrophil function and reduced NETosis in T1DM.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Monika Frysz, Ingrid Gergei, Hubert Scharnagl, George Davey Smith, Jie Zheng, Deborah A. Lawlor, Markus Herrmann, Winfried Maerz, Jon H. Tobias
Summary: The study found that higher levels of sclerostin were associated with increased risk of diabetes and certain cardiovascular risk factors, as well as higher severity of coronary artery disease and cardiac mortality. However, these associations were partially explained by major cardiovascular risk factors.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Angelo Zinellu, Stefania Sedda, Arduino A. Mangoni
Summary: The presence of a pro-oxidant state in patients with schizophrenia may contribute to the higher risk of atherosclerosis and cardiovascular disease in this group. This study investigated the associations between paraoxonase-1 levels and oxidative stress in schizophrenia patients. The results suggest that alterations in paraoxonase-1 may reflect a pro-oxidant state in specific subgroups of patients with schizophrenia.
Article
Behavioral Sciences
Qian Xu, Raymond Tak Fai Cheung
Summary: This study investigated the effects of type 1 diabetes mellitus (T1DM) on cerebral ischemia-reperfusion injury (CIRI) in rats and the role of melatonin in protecting against CIRI in T1DM rats. The results showed that T1DM aggravated CIRI, while melatonin treatment attenuated CIRI in T1DM rats through anti-inflammatory and anti-apoptotic effects.
BRAIN AND BEHAVIOR
(2023)
Article
Pharmacology & Pharmacy
Teresa Buckner, Baohai Shao, Robert H. Eckel, Jay W. Heinecke, Karin E. Bornfeldt, Janet Snell-Bergeon
Summary: The study found that serum APOC3 is associated with insulin resistance and coronary artery calcification in patients with type 1 diabetes.
JOURNAL OF CLINICAL LIPIDOLOGY
(2021)
Article
Endocrinology & Metabolism
William B. Horton, Janet K. Snell-Bergeon
Summary: This study found that different HbA1c metrics were positively correlated with coronary artery calcium volume and pericardial adipose tissue volume, and they could independently predict cardiovascular events in individuals with type 1 diabetes. These associations persisted even after adjusting for multiple cardiovascular disease risk factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Pharmacology & Pharmacy
Qing-Rong Liu, Kanikkai Raja Aseer, Qin Yao, Xiaoming Zhong, Paritosh Ghosh, Jennifer F. O'Connell, Josephine M. Egan
Summary: CB2R may play important roles in autoimmune diabetes by regulating inflammasomes, intracellular autophagy, and extracellular vesicle release, which in turn regulate the function of pancreatic islets.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Sara Sokooti, Jose L. Flores-Guerrero, Lyanne M. Kieneker, Hiddo J. L. Heerspink, Margery A. Connelly, Stephan J. L. Bakker, Robin P. F. Dullaart
Summary: High-density lipoprotein (HDL) particles of larger size and lower levels of H4P are associated with a lower risk of developing type 2 diabetes (T2D), while higher levels of H2P are associated with a higher risk. Additionally, large HDL particles and H6P are inversely associated with T2D in nonobese individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Athina Trakaki, Peter Wolf, Wolfgang Weger, Thomas O. Eichmann, Hubert Scharnagl, Julia T. Stadler, Wolfgang Salmhofer, Eva Knuplez, Michael Holzer, Gunther Marsche
Summary: The study found that psoriasis patients had impaired HDL function at baseline compared to controls, but short-term and especially intermediate-term therapy with biologics markedly reduced HDL cholesterol efflux capacity and rendered HDL pro-inflammatory. However, it increased paraoxonase and lecithin-cholesterol acyltransferase activities. All biologics caused similar changes in HDL composition, subclass distribution and cholesterol efflux capacity.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Endocrinology & Metabolism
Damien Denimal, Sara Benanaya, Serge Monier, Isabelle Simoneau, Jean-Paul Pais de Barros, Wilfried Le Goff, Benjamin Bouillet, Bruno Verges, Laurence Duvillard
Summary: This study aimed to evaluate the association between lipidomic abnormalities in high-density lipoprotein (HDL) and impaired cholesterol efflux capacity and anti-inflammatory effect in type 2 diabetes (T2D) patients. The results showed that despite lipidomic abnormalities, the cholesterol efflux and anti-inflammatory capacities of HDL are preserved in T2D patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Tiantian Pang, Amy C. Alman, Heewon L. Gray, Arpita Basu, Lu Shi, Janet K. Snell-Bergeon
Summary: The inflammatory potential of diet may play a crucial role in the development of metabolic syndrome, especially in patients with type 1 diabetes mellitus. The study found that individuals with T1DM consumed more pro-inflammatory diets and had a greater risk of developing MetS compared to those without diabetes.
NUTRITION RESEARCH
(2021)
Article
Medicine, General & Internal
Aleksandra Cieluch, Aleksandra Uruska, Marcin Nowicki, Ewa Wysocka, Pawel Niedzwiecki, Agata Grzelka-Wozniak, Justyna Flotynska, Dorota Zozulinska-Ziolkiewicz
Summary: This study investigated the changes in serum apo AI and AII in newly diagnosed type 1 diabetes patients during insulin treatment, and their association with daily insulin requirement. The results showed a significant increase in apo concentration during the first year of T1DM, suggesting a need for reconsidering the lipid control criteria in T1DM.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Emergency Medicine
Hector Gonzalez-Pacheco, Rodrigo Gopar-Nieto, Gian-Manuel Jimenez-Rodriguez, Daniel Manzur-Sandoval, Julio Sandoval, Alexandra Arias-Mendoza
Summary: One rare but potentially life-threatening complication in COVID-19 patients is bilateral spontaneous pneumothorax, which requires early recognition to prevent potentially fatal consequences.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Letter
Rheumatology
Luis M. Amezcua-Guerra, Gustavo Rojas-Velasco, Malinalli Brianza-Padilla, Armando Vazquez-Rangel, Ricardo Marquez-Velasco, Francisco Baranda-Tovar, Rashidi Springall, Hector Gonzalez-Pacheco, Yaneli Juarez-Vicuna, Claudia Tavera-Alonso, Fausto Sanchez-Munoz, Marisol Hernandez-Salas
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Roxana Perez-Villavicencio, Javier Flores-Estrada, Martha Franco, Bruno Escalante, Oscar Perez-Mendez, Adriana Mercado, Rocio Bautista-Perez
Summary: This study investigated the effect of empagliflozin on sphingomyelin and its metabolites in diabetic and hypertensive rats. The results showed that empagliflozin decreased hyperglycemia in diabetic rats and reduced the levels of sphingomyelin and related substances. It also regulated the activity of certain enzymes. In hypertensive rats, empagliflozin mainly decreased the levels of sphingomyelin in the catabolic pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Paola del Carmen Guerra-de-Blas, Daniela Cruz-Gonzalez, Elena B. Martinez-Shio, Roberto Gonzalez-Amaro, Hector Gonzalez-Pacheco, Esther Layseca-Espinosa, Carlos D. Escobedo-Uribe, Adriana E. Monsivais-Urenda
Summary: This study evaluated the phenotype of DCs and the levels of Tregs in myocarditis patients and healthy controls, and found that circulating DCs in myocarditis patients displayed an activating phenotype, with increased levels of Tregs. The study also found that the increased levels of DCs and higher expression of costimulatory molecules correlated with worsened myocardial function and higher levels of acute phase reactants.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Maria Luna-Luna, Eric Niesor, Oscar Perez-Mendez
Summary: The cardioprotective role of high-density lipoproteins (HDL) may not only be explained by reverse cholesterol transport, but also by bidirectional lipid transport. HDL plays an important role in tissue repair and cell function restoration. This hypothesis is consistent with the beneficial effects of HDL against atherosclerosis and its capacity to induce insulin secretion.
Article
Biochemistry & Molecular Biology
Ryousuke Satou, Martha Franco, Courtney M. Dugas, Akemi Katsurada, L. Gabriel Navar
Summary: This study demonstrates the beneficial effects of immunosuppression by mycophenolate mofetil (MMF) on the augmentation of intrarenal angiotensinogen (AGT) in hypertension. MMF treatment attenuates the activation of renal macrophages and the production of pro-inflammatory cytokines, leading to the normalization of AGT levels and the amelioration of hypertensive kidney injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Hector Gonzalez-Pacheco, Rodrigo Gopar-Nieto, Diego Araiza-Garaygordobil, Jose Luis Briseno-Cruz, Guering Eid-Lidt, Jorge Arturo Ortega-Hernandez, Daniel Sierra-Lara, Alfredo Altamirano-Castillo, Salvador Mendoza-Garcia, Daniel Manzur-Sandoval, Klayder Melissa Aguilar-Montano, Heriberto Ontiveros-Mercado, Jorge Ivan Garcia-Espinosa, Pablo Esteban Perez-Pinetta, Alexandra Arias-Mendoza
Summary: The study applied the SCAI shock stages at the time of admission for risk stratification in STEMI patients and found a significant association between shock stages and 30-day mortality.
Article
Medicine, General & Internal
Benny Giovanni Cazarin-Santos, Nonanzit Perez-Hernandez, Rosalinda Posadas-Sanchez, Gilberto Vargas-Alarcon, Oscar Perez-Mendez, Juan Rodriguez-Silverio, Bladimir Roque-Ramirez, Veronica Marusa Borgonio-Cuadra, Jose Manuel Rodriguez-Perez
Summary: This study found an association between genetic variants and the development of subclinical atherosclerosis, with the rs3102735 polymorphism showing a protective effect and the GACC haplotype decreasing risk while the GACT haplotype increasing risk.
Article
Biochemistry & Molecular Biology
Ana L. Vega-Jasso, Luis M. Amezcua-Guerra, Hector Gonzalez-Pacheco, Julio Sandoval-Zarate, Cesar A. Gonzalez-Diaz, Jennifer Escobar-Alvarado, Jennifer D. Manzano-Luna, Malinalli Brianza-Padilla
Summary: This study investigated the involvement of adipokines in AMI patients, and found that both AMI patients and AMI patients with OSA exhibited elevated levels of adipokines. AMI patients with concomitant OSA also showed greater cardiac damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Jorge A. Ortega-Hernandez, Hector Gonzalez-Pacheco, Jardiel Arguello-Bolanos, Jose Omar Arenas-Diaz, Roberto Perez-Lopez, Mario Ramon Garcia-Arias, Rodrigo Gopar-Nieto, Daniel Sierra-Lara-Martinez, Diego Araiza-Garaygordobil, Daniel Manzur-Sandoval, Luis Alejandro Soliz-Uriona, Gloria Monserrath Astudillo-Alvarez, Jaime Hernandez-Montfort, Alexandra Arias-Mendoza
Summary: This study aimed to better understand the hemodynamic profiles of different phenotypes in acute myocardial infarction-CS (AMI-CS) and identify different outcomes associated with these phenotypes using pulmonary artery catheter (PAC) data. The results showed that the three different AMI-CS phenotypes had varying mortality rates and hemodynamic parameters, and the phenotypes remained statistically significant even after adjustments. These findings have important implications for patient prognosis assessment and treatment strategies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Emanuel Amezcua-Castillo, Hector Gonzalez-Pacheco, Arturo Saenz-San Martin, Pablo Mendez-Ocampo, Ivan Gutierrez-Moctezuma, Felipe Masso, Daniel Sierra-Lara, Rashidi Springall, Emma Rodriguez, Alexandra Arias-Mendoza, Luis M. Amezcua-Guerra
Summary: Atherosclerotic cardiovascular disease (CVD) is the leading cause of mortality worldwide, and inflammation plays a crucial role in the pathogenesis of coronary artery disease (CAD). C-reactive protein (CRP), as an inflammatory marker, has been widely used in cardiovascular risk assessment and therapeutic decision-making. Pharmacological interventions with anti-inflammatory properties have also shown promising effects in reducing cardiovascular risks and CRP levels.
Article
Biochemistry & Molecular Biology
Brianda Amezcua-Guerra, Luis M. Amezcua-Castillo, Jazmin A. Guerra-Lopez, Kietsee A. Diaz-Dominguez, Jose L. Sanchez-Gloria, Andres Cruz-Melendez, Adrian Hernandez-Diazcouder, Yaneli Juarez-Vicuna, Fausto Sanchez-Munoz, Fengyang Huang, Claudia Tavera-Alonso, Malinalli Brianza-Padilla, Elvira Varela-Lopez, Daniel Sierra-Lara, Alexandra Arias-Mendoza, Gabriela Fonseca-Camarillo, Ricardo Marquez-Velasco, Hector Gonzalez-Pacheco, Rashidi Springall, Luis M. Amezcua-Guerra
Summary: This study suggests that miR-133b and miR-126 may serve as potential diagnostic biomarkers for distinguishing patients with ST-segment elevation myocardial infarction (STEMI) from those presenting with nonischemic chest discomfort. However, microRNAs have no associations with inflammatory markers or cardiovascular risk scores, nor do they have associations with the occurrence of major adverse cardiovascular events.
Article
Medicine, Research & Experimental
Gilberto Vargas-Alarcon, Oscar Perez-Mendez, Rosalinda Posadas-Sanchez, Hector Gonzalez-Pacheco, Alexandra Arias -Mendoza, Galileo Escobedo, Teresa Juarez-Cedillo, Marva Arellano-Gonzalez, Jose Manuel Fragoso
Summary: This study found that ABO gene polymorphisms are associated with a lower risk of ACS, lower systolic blood pressure, and plasma lipid levels.
BIOMOLECULES AND BIOMEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Hector Gonzalez-Pacheco, Daniel Manzur-Sandoval, Rodrigo Gopar-Nieto, Amada Alvarez-Sangabriel, Carlos Martinez-Sanchez, Guering Eid-Lidt, Alfredo Altamirano-Castillo, Salvador Mendoza-Garcia, Jose Luis Briseno-Cruz, Francisco Azar-Manzur, Diego Araiza-Garaygordobil, Daniel Sierra-Lara, Gian Manuel Jimenez-Rodriguez, Emmanuel Adrian Lazcano-Diaz, Francisco Baranda-Tovar, Jessrel Sharon Valencia-Alvarez, Miguel Alejandro Cutz-Ijchajchal, Jose Carlos Penagos-Cordon, Paola Morejon-Barragan, Alexandra Arias-Mendoza
Summary: This study investigated the temporal trends, clinical features, and outcomes of patients with cardiogenic shock in a Mexican institution. Differences in etiology and clinical characteristics were observed between AMI-CS and non-AMI-CS patients, but both groups showed high in-hospital mortality rates.
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)