Journal
CLINICA CHIMICA ACTA
Volume 437, Issue -, Pages 14-18Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2014.06.015
Keywords
Autoantibodies; Autoimmune disease; Pre-clinical phase
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Funding
- National Natural Science Foundation of China [81273282, 81302541]
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The presence of autoantibodies is characteristic of autoimmune diseases. It is widely accepted that autoantibodies provide crucial diagnostic and prognostic information for autoimmune diseases. Indeed, numerous studies have demonstrated that the appearance of autoantibodies precedes the clinical onset of autoimmune diseases. We performed a literature review regarding the appearance of autoantibodies that preceded the clinical onset of autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, primary biliary cirrhosis, inflammatory bowel disease, and multiple sclerosis. Herein we review and comment on the major findings of these studies. (C) 2014 Elsevier B.V. All rights reserved.
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