Article
Biochemistry & Molecular Biology
Hanan Kamel M. Saad, Alawiyah Awang Abd Rahman, Azly Sumanty Ab Ghani, Wan Rohani Wan Taib, Imilia Ismail, Muhammad Farid Johan, Abdullah Saleh Al-Wajeeh, Hamid Ali Nagi Al-Jamal
Summary: Iron homeostasis is regulated by hepcidin, which is influenced by factors such as iron stores, hypoxia, inflammation, and erythropoiesis. Beta-thalassemia patients exhibit iron deficiency, iron overload, and ineffective erythropoiesis. Recent research has identified new diagnostic markers and therapeutic targets for beta-thalassemia.
Article
Cell Biology
Corbin R. Azucenas, T. Alex Ruwe, John P. Bonamer, Bo Qiao, Tomas Ganz, Mika Jormakka, Elizabeta Nemeth, Bryan Mackenzie
Summary: Fpn is a protein expressed in the plasma membrane of macrophages, enterocytes, and hepatocytes, which mediates the transfer of cellular iron into the blood plasma. Research has shown that human Fpn does not transport manganese, but mouse Fpn may be involved in manganese metabolism. Comparative analysis of mouse and human Fpn revealed that they share identical properties in terms of substrate profile, calcium dependence, optimal pH, and hepcidin sensitivity.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Genetics & Heredity
Patryk Slusarczyk, Katarzyna Mleczko-Sanecka
Summary: The production and breakdown of red blood cells involves significant iron recycling processes. Specialized macrophages are key in handling red blood cells, but there is still limited understanding of the mechanistic details of this process.
Article
Nutrition & Dietetics
Ethan Baratz, Olga Protchenko, Shyamalagauri Jadhav, Deliang Zhang, Pierre-Christian Violet, Samantha Grounds, Minoo Shakoury-Elizeh, Mark Levine, Caroline C. Philpott
Summary: Oral supplementation of vitamin E can reduce liver iron stores in mice by suppressing the iron-and redox-sensing transcription factor Nrf2, leading to enhanced iron efflux through liver FPN. Iron depletion may indirectly enhance the antioxidative effects of vitamin E.
JOURNAL OF NUTRITION
(2023)
Article
Hematology
Mariateresa Pettinato, Alessandro Dulja, Silvia Colucci, Valeria Furiosi, Franca Fette, Andrea U. U. Steinbicker, Martina U. U. Muckenthaler, Antonella Nai, Alessia Pagani, Laura Silvestri
Summary: The expression of the iron regulatory hormone hepcidin in hepatocytes is regulated by the BMP-SMAD pathway through specific receptors and ligands. The immunophilin FKBP12 acts as a hepcidin inhibitor by blocking the ALK2 receptor and its activity can be modulated by the drug Tacrolimus. FKBP12 regulates the BMP-SMAD pathway by modulating receptor interactions and ligand responsiveness.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Fisheries
Teresa Kaminska-Gibas, Joanna Szczygiel, Annemiek Blasweiler, Lukasz Gajda, Ebru Yilmaz, Patrycja Jurecka, Ludmila Kolek, Marek Ples, Ilgiz Irnazarow
Summary: Iron uptake, transport, and storage involve multiple proteins, including ferroportin (fpn). This study identified two functional fpns in common carp with distinct expression patterns.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Elena Gammella, Margherita Correnti, Gaetano Cairo, Stefania Recalcati
Summary: Body iron levels are regulated by hepcidin, which controls the presence of ferroportin (FPN) on cell surface. Disruption of this regulation can lead to disorders related to iron-deficiency or overload. Recent evidence suggests that FPN may also play a crucial role in local iron control, potentially causing tissue damage despite unchanged systemic iron homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Bruce E. Holbein, Christian Lehmann
Summary: Iron is essential for various biological processes but can be toxic in excess. Dysregulation of iron metabolism has been linked to a range of diseases, including infections, cancer, and neurological disorders. Current therapies for iron dysregulation have limitations, but new iron chelators and hepcidin agonists show promise. Harnessing iron-driven reactive oxygen species generation and ferroptosis may offer selective cancer cell destruction. This review discusses iron requirements, regulation, and dysregulation in diseases, as well as potential new therapies.
Article
Biochemistry & Molecular Biology
Maria G. Ledesma-Colunga, Ulrike Baschant, Heike Weidner, Tiago C. Alves, Peter Mirtschink, Lorenz C. Hofbauer, Martina Rauner
Summary: In this study, the authors investigated the role of transferrin receptor 2 (Tfr2) in the pathogenesis of inflammatory arthritis. They found that Tfr2-deficient mice developed more severe joint inflammation and bone erosion compared to control mice. Further experiments suggested that Tfr2 deficiency promoted macrophage polarization towards a pro-inflammatory state, contributing to the progression of arthritis.
Article
Multidisciplinary Sciences
Stella Ekaputri, Eun-Kyung Choi, Manuela Sabelli, Luisa Aring, Kelsie J. Green, Juoae Chang, Kai Bao, Hak Soo Choi, Shigeki Iwase, Jonghan Kime, Elena Corradini, Antonello Pietrangelo, Martin D. Burke, Young Ah Seo
Summary: This study shows that hinokitiol can serve as a surrogate transmembrane iron transporter and restore normal iron physiology in FPN1-deficient animals or primary cells from patients. It redistributes iron from the liver to red blood cells, increases hemoglobin and hematocrit, and activates the regulated ferritin proteolysis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Developmental Biology
Chang Cao, Mark D. Fleming
Summary: Fetal development relies on adequate iron supply by the placenta, and the iron transporter Fpn1 plays an essential role in this process. Using gene manipulation techniques, we created a specific Cre mouse model, which provides direct evidence for the essential role of Fpn1 in placental iron transport.
Article
Plant Sciences
Leah J. Kim, Kaitlyn M. Tsuyuki, Fengling Hu, Emily Y. Park, Jingwen Zhang, Jennifer G. Iraheta, Ju-Chen Chia, Rong Huang, Avery E. Tucker, Madeline Clyne, Claire Castellano, Angie Kim, Daniel D. Chung, Christopher T. DaVeiga, Elizabeth M. Parsons, Olena K. Vatamaniuk, Jeeyon Jeong
Summary: This study reveals the essential role of Arabidopsis ferroportin 3 (FPN3) in maintaining optimal iron homeostasis in mitochondria and chloroplasts. Lack of FPN3 leads to disrupted iron levels and abnormal ultrastructure in mitochondria, affecting plant growth under iron-deficient conditions.
Article
Biology
Mehdi Chaib, Bilal B. Hafeez, Hassan Mandil, Deidre Daria, Ajeeth K. Pingili, Sonam Kumari, Mohammed Sikander, Vivek K. Kashyap, Guo-Yun Chen, Emmanuel Anning, Manish K. Tripathi, Sheema Khan, Stephen Behrman, Murali M. Yallapu, Meena Jaggi, Liza Makowski, Subhash C. Chauhan
Summary: This study discovers that a probiotic-derived siderophore, ferrichrome, can remodel tumor-associated macrophages, increase CD8+ T cell infiltration, and significantly reduce tumor burden in pancreatic cancer. Ferrichrome also enhances the efficacy of anti-PD-L1 therapy, providing a potential novel combination therapy for pancreatic cancer treatment.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ana C. Moreira, Tania Silva, Goncalo Mesquita, Ana Cordeiro Gomes, Clara M. Bento, Joao V. Neves, Daniela F. Rodrigues, Pedro N. Rodrigues, Agostinho A. Almeida, Paolo Santambrogio, Maria Salome Gomes
Summary: In Mycobacterium avium infection, macrophage FTH1 plays a key role in iron redistribution by regulating the level of available iron in tissues, thereby influencing resistance to infection and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Betty Berezovsky, Jana Frydlova, Iuliia Gurieva, Daniel W. Rogalsky, Martin Vokurka, Jan Krijt
Summary: The study aimed to investigate the expression of ferroportin protein under various treatments affecting systemic hepcidin. The results showed that the expression of heart ferroportin protein is regulated by both systemic hepcidin and heart non-heme iron content.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Lucy Mupfumi, Cheleka A. M. Mpande, Tim Reid, Sikhulile Moyo, Sanghyuk S. Shin, Nicola Zetola, Tuelo Mogashoa, Rosemary M. Musonda, Ishmael Kasvosve, Thomas J. Scriba, Elisa Nemes, Simani Gaseitsiwe
Article
Immunology
Kadimo Nthobatsang, Tshimologo Lone Ncenga, Chipo Mwangi-Woto, Tuelo J. Wedu, Tebogo Gabatlhaolwe, Sikhulile Moyo, Richard Marlink, Ishmael Kasvosve, Lesego Gabaitiri, Modisa S. Motswaledi
Summary: The study found that the RH2 blood group may be a critical host genetic factor determining susceptibility to HIV infection, with RH2-negative individuals being more likely to be HIV positive than heterozygotes. RH2-positive patients had higher CD4(+) cell counts, lower viral loads, and slower rates of CD4(+) decline compared to RH2-negative individuals.
Article
Oncology
Leabaneng Tawe, Surbhi Grover, Nicola Zetola, Erle S. Robertson, Simani Gaseitsiwe, Sikhulile Moyo, Ishmael Kasvosve, Giacomo M. Paganotti, Mohan Narasimhamurthy
Summary: The study revealed a high promoter methylation rate of multiple tumor suppressor genes in cervical cancer patients, which was associated with increased risk of cervical cancer. Methylation of the RARB gene showed the strongest association with cervical cancer, and both cervical cancer and promoter methylation of RARB and DAPK1 genes were associated with increasing age.
FRONTIERS IN ONCOLOGY
(2021)
Article
Virology
Kaelo K. Seatla, Dorcas Maruapula, Wonderful T. Choga, Tshenolo Ntsipe, Nametso Mathiba, Mompati Mogwele, Max Kapanda, Bornapate Nkomo, Dinah Ramaabya, Joseph Makhema, Mompati Mmalane, Madisa Mine, Ishmael Kasvosve, Shahin Lockman, Sikhulile Moyo, Simani Gaseitsiwe
Summary: Limited real-world outcomes data on treatment-experienced HIV-1 C patients failing Integrase Strand Transfer Inhibitor-based regimens were studied. Resistance to DTG was more common in patients exposed to RAL cART, and individuals with 4-class drug resistance mutations plus integrase T97 and E157Q mutations had worse outcomes. Frequent viral load monitoring and genotypic resistance testing are necessary for HIV-1 C diagnosed individuals with treatment experience.
Article
Genetics & Heredity
Savannah Mwesigwa, Lesedi Williams, Gaone Retshabile, Eric Katagirya, Gerald Mboowa, Busisiwe Mlotshwa, Samuel Kyobe, David P. Kateete, Eddie Mujjwiga Wampande, Misaki Wayengera, Sununguko Wata Mpoloka, Angella N. Mirembe, Ishmael Kasvosve, Koketso Morapedi, Grace P. Kisitu, Adeodata R. Kekitiinwa, Gabriel Anabwani, Moses L. Joloba, Enock Matovu, Julius Mulindwa, Harry Noyes, Gerrit Botha, Chester W. Brown, Graeme Mardon, Mogomotsi Matshaba, Neil A. Hanchard
Summary: The study found that viral co-infection in pediatric HIV infection is associated with disease progression, with Anelloviridae potentially linked to long-term non-progression status, and Torque teno virus (TTV) associated with reduced immune activation.
NPJ GENOMIC MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Monkgomotsi J. Maseng, Leabaneng Tawe, Prisca K. Thami, Kaelo K. Seatla, Sikhulile Moyo, Axel Martinelli, Ishmael Kasvosve, Vladimir Novitsky, Max Essex, Gianluca Russo, Simani Gaseitsiwe, Giacomo M. Paganotti
Summary: The study aimed to investigate the impact of CYP2B6 genotype and haplotype variation on the risk of developing EFV/NVP drug resistance mutations in HIV patients in Botswana. Results showed an association between EFV/NVP resistance and the CYP2B6 516G allele, indicating the importance of assessing CYP2B6 genetic profiles in HIV-infected patients to improve virologic outcomes.
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2021)
Article
Genetics & Heredity
Samuel Kyobe, Savannah Mwesigwa, Grace P. Kisitu, John Farirai, Eric Katagirya, Angella N. Mirembe, Lesego Ketumile, Misaki Wayengera, Fred Ashaba Katabazi, Edgar Kigozi, Edward M. Wampande, Gaone Retshabile, Busisiwe C. Mlotshwa, Lesedi Williams, Koketso Morapedi, Ishmael Kasvosve, Jacqueline Kyosiimire-Lugemwa, Betty Nsangi, Masego Tsimako-Johnstone, Chester W. Brown, Moses Joloba, Gabriel Anabwani, Lukhele Bhekumusa, Sununguko W. Mpoloka, Graeme Mardon, Mogomotsi Matshaba, Adeodata Kekitiinwa, Neil A. Hanchard
Summary: A study on two African pediatric populations found associations between specific HLA alleles and HIV-1 LTNP, especially in the HLA-C region. Novel haplotype associations were also observed, highlighting the value of multi-ethnic populations in genetic studies and offering insights for ongoing vaccine research in HIV-1.
FRONTIERS IN GENETICS
(2021)
Article
Microbiology
Kaelo K. Seatla, Dorcas Maruapula, Wonderful T. Choga, Olorato Morerinyane, Shahin Lockman, Vladimir Novitsky, Ishmael Kasvosve, Sikhulile Moyo, Simani Gaseitsiwe
Summary: This study found a high conservation of the HIV-1 nef gene 3'PPT motif in 'real-world' patients, with no differences observed based on VL suppression or INSTI-based cART failure. Future research should explore other HIV-1 regions for associations with DTG failure.
Article
Infectious Diseases
Leabaneng Tawe, Wonderful T. Choga, Giacomo M. Paganotti, Ontlametse T. Bareng, Tlhalefo D. Ntereke, Pleasure Ramatlho, Doreen Ditshwanelo, Simani Gaseitsiwe, Ishmael Kasvosve, Doreen Ramogola-Masire, Omenge E. Orang'o, Erle Robertson, Nicola Zetola, Sikhulile Moyo, Surbhi Grover, Aaron C. Ermel
Summary: This study investigated the variation of human papillomavirus (HPV) genotypes in Africa and found co-infection of HPV and HIV. The study found a significantly higher prevalence of high-risk HPV genotypes in the Botswana population and significant differences in genetic diversity between HIV-positive and HIV-negative women.
BMC INFECTIOUS DISEASES
(2022)
Article
Medical Laboratory Technology
Mokgadi G. Manake, Pleasure Ramatlho, Tlhalefo D. Ntereke, Leabaneng Tawe, Zackary A. Bango, Isaac K. Quaye, Giacomo M. Paganotti, Ishmael Kasvosve
Summary: This research examined the impact of the FPN Q248H mutation, prevalent in Botswana, on susceptibility to Plasmodium falciparum malaria. Through genotyping 264 samples and estimating parasite concentrations, a potential association between FPN Q248H mutation and malaria susceptibility was identified.
CLINICA CHIMICA ACTA
(2021)
Article
Medicine, General & Internal
Monkgomotsi J. Maseng, Leabaneng Tawe, Prisca K. Thami, Sikhulile Moyo, Ishmael Kasvosve, Vladimir Novitsky, Max Essex, Gianluca Russo, Simani Gaseitsiwe, Giacomo M. Paganotti
Summary: This study investigated the association between CYP2B6 516G>T variation and NNRTI toxicity in Botswana. The results showed that CYP2B6 516 variation was not associated with NNRTI toxicity, and no other factors were found to be associated with toxicity.
Review
Pharmacology & Pharmacy
Keneuoe Cecilia Nthontho, Andrew Khulekani Ndlovu, Kirthana Sharma, Ishmael Kasvosve, Daniel Louis Hertz, Giacomo Maria Paganotti
Summary: Breast cancer is a leading cause of cancer death in low- and middle-income countries, especially among sub-Saharan African women. This review summarizes the impact of genetic variation on treatment outcomes for breast cancer drugs, with a focus on the importance of African genetic diversity.
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Nametso Kelentse, Sikhulile Moyo, Kesaobaka Molebatsi, Olorato Morerinyane, Shatho Bitsang, Ontlametse T. Bareng, Kwana Lechiile, Tshepo B. Leeme, David S. Lawrence, Ishmael Kasvosve, Rosemary Musonda, Mosepele Mosepele, Thomas S. Harrison, Joseph N. Jarvis, Simani Gaseitsiwe
Summary: This study investigated CSF viral escape and HIV-1 viral load in individuals treated for HIV-associated cryptococcal meningitis. The results showed a decreasing trend of CSF viral escape during antifungal treatment, indicating the potential of antifungal therapy in reversing CSF viral escape.
Article
Infectious Diseases
Nametso Kelentse, Sikhulile Moyo, Wonderful T. Choga, Kwana Lechiile, Tshepo B. Leeme, David S. Lawrence, Ishmael Kasvosve, Rosemary Musonda, Mosepele Mosepele, Thomas S. Harrison, Joseph N. Jarvis, Simani Gaseitsiwe
Summary: This study compared the patterns of HIV-1 drug resistance mutations between the cerebrospinal fluid (CSF) and plasma of individuals with HIV-associated cryptococcal meningitis. The results showed high concordance in HIV-1 drug resistance mutations between the CSF and plasma, suggesting intercompartmental mixing and possibly a lack of compartmentalization. Some individuals also harbored minority HIV-1 drug resistance mutations.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Felicity Gopolang, Fales Zulu-Mwamba, Davy Nsama, Annika Kruuner, Dailes Nsofwa, Ishmael Kasvosve, Royce Gomo, Tiny Motlhabane, Bhavna Chohan, Olusegun Soge, Daniel Osterhage, Nancy Campbell, Michael Noble, Ann Downer, Jean-Frederic Flandin, Anya Nartker, Catherine Koehn, Linda K. Nonde, Aaron Shibemba, Clement B. Ndongmo, Martin Steinau, Lucy A. Perrone
Summary: This professional development program enhanced the organizational leadership and management competencies of laboratory managers and quality officers through a blended learning approach and practical application projects, resulting in significant improvement in accreditation scores for multiple laboratories, with five laboratories ultimately achieving International Organization for Standardization 15189 accreditation.
AFRICAN JOURNAL OF LABORATORY MEDICINE
(2021)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)