Article
Public, Environmental & Occupational Health
Yinan Ren, Mingye Zhao, Dachuang Zhou, Qian Xing, Fangfang Gong, Wenxi Tang
Summary: This study evaluated the cost-effectiveness of colorectal cancer screening in China and found that FIT screening can save costs, while colonoscopy is cost-effective. In specific regions, high-income areas could consider strategies with more frequent electronic colonoscopy.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Gastroenterology & Hepatology
Kevin Selby, Christopher D. Jensen, Theodore R. Levin, Jeffrey K. Lee, Joanne E. Schottinger, Wei K. Zhao, Douglas A. Corley, Chyke A. Doubeni
Summary: The study investigated a CRC screening program conducted throughout the year, finding that over 800,000 individuals participated in the screening, with 40% having prior endoscopy, 20% completing FIT immediately after receiving the kit, resulting in 82% of those eligible being screened by the end of the year.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Diana G. Redwood, Tuan A. Dinh, John B. Kisiel, Bijan J. Borah, James P. Moriarty, Ellen M. Provost, Frank D. Sacco, James J. Tiesinga, David A. Ahlquist
Summary: The study aimed to evaluate the cost-effectiveness of multitarget stool DNA testing (MT-sDNA) compared with colonoscopy and fecal immunochemical testing (FIT) for Alaska Native adults. Results showed that MT-sDNA demonstrated significant cost-effectiveness in different adherence scenarios, with clear advantages in terms of QALYs savings.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Oncology
Anton Gies, Tobias Niedermaier, Laura Fiona Gruner, Thomas Heisser, Petra Schrotz-King, Hermann Brenner
Summary: FOBTs show lower sensitivities in detecting early-stage colorectal cancer, particularly T1 cancers. Further research should focus on improving the detection of early-stage cancer.
Article
Gastroenterology & Hepatology
Briton Lee, Erin Keyes, Carly Rachocki, Barbara Grimes, Ellen Chen, Eric Vittinghoff, Uri Ladabaum, Ma Somsouk
Summary: The mailed FIT program significantly increased colorectal cancer screening over multiple years. Patients in the intervention group were more likely to complete the FIT and had a longer duration of screening. However, the completion rate in the second intervention cycle was lower for patients who did not complete the FIT in the first cycle.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Saray Duran-Sanchon, Lorena Moreno, Javier Gomez-Matas, Josep M. Auge, Miquel Serra-Burriel, Miriam Cuatrecasas, Leticia Moreira, Anna Serradesanferm, Angels Pozo, Jaume Grau, Maria Pellise, Meritxell Gironella, Antoni Castells
Summary: The miRFec algorithm can effectively identify individuals at highest risk for advanced colorectal neoplasia and differentiate patients with colorectal cancer from those with non-advanced adenomas or normal colonoscopy. By incorporating this algorithm, 34% of colonoscopies could be avoided, increasing the effectiveness and efficiency of FIT-based CRC screening programs.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Arthur Kooyker, Lucie de Jonge, Esther Toes-Zoutendijk, Manon Spaander, Hanneke van Vuuren, Ernst Kuipers, Folkert van Kemenade, Chris Ramakers, Evelien Dekker, Iris Nagtegaal, Monique van Leerdam, Iris Lansdorp-Vogelaar
Summary: FIT-based screening is effective in detecting early-stage colorectal cancer, and this effectiveness is maintained even with repeat screening. Increasing the FIT cut-off value significantly reduces the number of detected cancers, but the majority of detected cancers are still diagnosed at an early stage.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Gonzalo Hijos-Mallada, Alberto Lue, Raul Velamazan, Nuria Saura, Carlos Abril, Marta Lorenzo, Mercedes Navarro, Eduardo Chueca, Samantha Arechavaleta, Fernando Gomollon, Angel Lanas, Carlos Sostres
Summary: In the CRC screening program, FIT was found to be the best fecal marker for the diagnosis of CRC and advanced adenoma. None of the other biomarkers explored or their combinations provided a better diagnostic accuracy than FIT alone. Only transferrin showed an acceptable diagnostic accuracy.
FRONTIERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Arthur I. Kooyker, Esther Toes-Zoutendijk, Annemieke W. J. Opstal-van Winden, Maaike Buskermolen, Hanneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, Chris Ramakers, Evelien Dekker, Iris D. Nagtegaal, Harry J. de Koning, Manon C. W. Spaander, Iris Lansdorp-Vogelaar, Monique E. van Leerdam
Summary: The colonoscopy-related mortality within the Dutch FIT-based CRC screening program was estimated to range from 0.23 to 0.91 per 10,000 FIT-positive participants undergoing colonoscopy, with 50% of likely colonoscopy-related causes of death being cardiovascular events.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Jean-Francois Bretagne, Aurore Carlo, Christine Piette, Chloe Rousseau, Mathilde Cosson, Astrid Lievre
Summary: Switching from gFOBT to FIT in a mature population-based colorectal cancer screening program led to a dramatic decrease in the cumulative incidence rates of interval cancers, with FIT demonstrating significantly higher sensitivity compared to gFOBT.
BRITISH JOURNAL OF CANCER
(2021)
Article
Public, Environmental & Occupational Health
Tingting Yao, Qin Sun, Kangwei Xiong, Yuan Su, Qian Zhao, Chenhong Zhang, Lijiu Zhang, Xuejun Li, Haiming Fang
Summary: This study compares different testing strategies for colorectal cancer screening, including multi-target fecal DNA testing, quantitative and qualitative fecal immunoassay tests (FITs). The efficacy of these strategies was examined in different populations, and it was found that single testing strategy is more suitable for general population screening, while combined testing strategy is more suitable for high-risk populations screening.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Olusegun Alatise, Anna J. Dare, Patrick A. Akinyemi, Fatimah B. Abdulkareem, Samuel A. Olatoke, Gregory C. Knapp, T. Peter Kingham
Summary: Colorectal cancer screening with qualitative fecal immunochemical tests in Nigeria is feasible and acceptable to average-risk asymptomatic participants. However, the low positive predictive value for advanced neoplasia and high endoscopy burden investigating false positives suggests it might not be an appropriate screening tool in this setting.
LANCET GLOBAL HEALTH
(2022)
Article
Multidisciplinary Sciences
Miriam P. van der Meulen, Esther Toes-Zoutendijk, Manon C. W. Spaander, Evelien Dekker, Johannes M. G. Bonfrer, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, M. F. van Velthuysen, Maarten G. J. Thomeer, Harriet van Veldhuizen, Harry J. de Koning, Iris Lansdorp-Vogelaar, Monique E. van Leerdam
Summary: The participation rate in FIT screening is lower for individuals with a lower socioeconomic status (SES), but they have a higher detection rate for advanced neoplasia. Screening has the potential to reduce health inequalities in CRC mortality.
Article
Gastroenterology & Hepatology
Simon Ladefoged Rasmussen, Christian Torp-Pedersen, Kare Andersson Gotschalck, Ole Thorlacius-Ussing
Summary: This study aimed to assess the effects of antithrombotic treatment on the fecal immunochemical test (FIT)-based Danish national screening program for colorectal cancer (CRC). The results showed that individuals receiving antithrombotic treatment had a higher proportion of positive FIT results, and the detection rate of CRC was slightly lower among patients on antithrombotic treatment. Moreover, the positive predictive value (PPV) for CRC or high risk adenomas was decreased nearly twofold in patients treated with nonvitamin K oral anticoagulants (NOACs).
Article
Oncology
P. H. A. Wisse, W. de Klaver, F. van Wifferen, L. Meiqari, M. Bierkens, M. J. E. Greuter, B. Carvalho, M. E. van Leerdam, M. C. W. Spaander, E. Dekker, V. M. H. Coupe, M. de Wit, G. A. Meijer
Summary: This study aims to validate the relative sensitivity of mtFIT compared to FIT in colorectal cancer (CRC) screening, and predict the lifetime health effects and costs using the Adenoma and Serrated Pathway to Colorectal CAncer model. The results of this study will provide important clinical utility information for the Dutch national CRC screening program.
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)