Article
Nutrition & Dietetics
Li Li, Qi Huang, Linjian Yang, Rui Zhang, Leili Gao, Xueyao Han, Linong Ji, Xiantong Zou
Summary: There is an association between non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) with levels of vitamin B12 and associated metabolites, while MMA and HCY may be associated with an increased risk for advanced fibrosis.
Article
Nutrition & Dietetics
Paulina Kreusler, Mandy Vogel, Anja Willenberg, Ronny Baber, Yvonne Dietz, Antje Koerner, Uta Ceglarek, Wieland Kiess
Summary: This study proposes age- and sex-specific percentiles for serum cobalamin and folate and analyzes the impact of sex, age, BMI, and SES on their concentrations in healthy children and adolescents. Folate concentrations decrease with age while cobalamin peaks between three and seven years of age. Female sex is associated with higher vitamin levels in older age groups.
Article
Geriatrics & Gerontology
L. Nalder, B. Zheng, G. Chiandet, L. T. Middleton, Celeste A. De Jager
Summary: The study found that older men and women are prone to vitamin B12 deficiency, which may have different negative effects on cognitive domains such as memory and attention. In addition, high BMI was also associated with poorer cognitive performance.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Nutrition & Dietetics
Sehoon Park, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: This study shows that a high blood homocysteine level causally decreases eGFR, while high folate levels are associated with an increase in eGFR. Future trials may reveal the importance of homocysteine-lowering interventions for the prevention of kidney function impairment.
Article
Nutrition & Dietetics
Audrey St-Laurent, Anne-Sophie Plante, Simone Lemieux, Julie Robitaille, Amanda J. MacFarlane, Anne-Sophie Morisset
Summary: This study investigated the folate and vitamin B12 levels in 79 French-Canadian pregnant women at different stages of pregnancy. It was found that the intake of folate and vitamin B12 in the diet was associated with the concentration of these biomarkers in the blood. The serum total folate concentrations were generally high, while the vitamin B12 concentrations were influenced by the body mass index of the pregnant women.
JOURNAL OF NUTRITION
(2023)
Review
Medical Laboratory Technology
Agata Sobczynska-Malefora, Edgard Delvin, Andrew McCaddon, Kourosh R. Ahmadi, Dominic J. Harrington
Summary: Vitamin B-12 is an essential cofactor in two metabolic pathways and is primarily obtained from animal-based foods. Deficiency in B-12 can mimic various illnesses and requires attention from different medical specialists for accurate diagnosis and treatment. Current tests and treatment options for B-12 deficiency have limitations that need to be addressed for better assessment and management.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2021)
Article
Medicine, General & Internal
Tsahi T. Lerman, Eytan Cohen, Tzippy Sochat, Elad Goldberg, Idan Goldberg, Ilan Krause
Summary: According to this study, there was no association found between the use of PPI medications and vitamin B12 deficiency or hyperhomocysteinemia. Patients receiving PPI medications had slightly higher levels of vitamin B12 and homocysteine, but these differences were not clinically significant.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Review
Food Science & Technology
Linnea Barebring, Christel Lamberg-Allardt, Birna Thorisdottir, Alfons Ramel, Fredrik Soderlund, Erik Kristoffer Arnesen, Bright I. Nwaru, Jutta Dierkes, Agneta Akesson
Summary: This systematic review aimed to assess the evidence for whether habitual or different levels of experimental intake of vitamin B12 from diet and supplements is sufficient to ensure adequate B12 status in groups most susceptible to vitamin B12 deficiency. The search yielded 18 included studies, and the conclusion was that the evidence is currently insufficient to determine if or which level of B12 intake is sufficient to maintain adequate status for all included populations.
FOOD & NUTRITION RESEARCH
(2023)
Article
Pediatrics
Ulrike Mutze, Magdalena Walter, Mareike Keller, Gwendolyn Gramer, Sven F. Garbade, Florian Gleich, Dorothea Haas, Roland Posset, Sarah C. Grunert, Julia B. Hennermann, Eva Thimm, Junmin Fang-Hoffmann, Steffen Syrbe, Jurgen G. Okun, Georg F. Hoffmann, Stefan Kolker
Summary: The study evaluated the clinical outcomes of infants with vitamin B-12 deficiency identified through newborn screening at 1.5 years old, finding that all affected infants achieved age-appropriate neurodevelopmental test results at 15 months without characteristic symptoms of vitamin B-12 deficiency. Most mothers of affected infants also had undiagnosed vitamin B-12 deficiency and received specific treatment.
JOURNAL OF PEDIATRICS
(2021)
Article
Clinical Neurology
Li Mu, Feng Yu, Jiejing Xia, XiaoE Lang, Anam Haque, Hanjing Emily Wu, Xiang Yang Zhang
Summary: This study reveals a close relationship between body mass index (BMI) and plasma homocysteine (Hcy) levels in patients with bipolar disorder (BD), indicating that Hcy may be an important indicator for BD-induced weight gain.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Pediatrics
Kuchana Suresh Kumar, Arushi Gahlot Saini, Savita Verma Attri, Bhavneet Bharti, Naveen Sankhyan, Prateek Bhatia
Summary: The study found a high prevalence of vitamin B12 deficiency in infants and their mothers, indicating an urgent need for population supplementation with vitamin B12.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Clinical Neurology
Guillaume Grzych, Sylvie Deheul, Emeline Gernez, Jean-Baptiste Davion, Dries Dobbelaere, Louise Carton, Isabelle Kim, Jean Claude Guichard, Marie Girot, Linda Humbert, Anas Bennis, Marie Joncquel, Vincent Chieux, Audrey Joly, Phenicia Nasserdine, Nathalie Trillot, Claire Douillard, Pascal Pigny, Celine Tard
Summary: Plasma homocysteine is consistently increased in chronic N2O consumption, while MMA increase and total vitamin B12 decrease are not always present. However, homocysteine and MMA are correlated with clinical severity, with MMA being a better marker of severity.
JOURNAL OF NEUROLOGY
(2023)
Article
Toxicology
Etienne Mondesert, Celine Eiden, Helene Peyriere, Aude Formoso, Lucas Corti, Jean-Paul Cristol, Stephanie Badiou
Summary: Misuse of inhaled nitrous oxide is a growing concern in France, as it affects the concentration of vitamin B-12 and leads to a range of clinical issues. Measurement of vitamin B-12, homocysteine, and methylmalonic acid concentrations can assist in diagnosing complex cases.
CLINICAL TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Jacob Selhub, Joshua W. Miller, Aron M. Troen, Joel B. Mason, Paul F. Jacques
Summary: This article proposes a hypothesis that excessive intake of folic acid depletes serum holotranscobalamin, decreasing active vitamin B-12 in the circulation and limiting its availability for tissues. The study provides evidence from observational and intervention studies, and suggests that further research is needed to elucidate the biochemical and physiological mechanisms underlying this interaction.
ADVANCES IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Yiping Liu, Taowei Zhong, Xinli Song, Senmao Zhang, Mengting Sun, Jianhui Wei, Jing Shu, Tubao Yang, Tingting Wang, Jiabi Qin
Summary: In this hospital-based case-control study, we found significant associations between genetic polymorphisms of the methionine synthase (MTR) gene at rs1805087 and rs2275565 and the risk of non-syndromic congenital heart disease (CHD). Additionally, we observed significant associations between three haplotypes and CHD risk.
SCIENTIFIC REPORTS
(2023)
Article
Sport Sciences
Fabio T. Montrezol, Rodolfo Marinho, Gloria de F. A. da Mota, Vania D'Almeida, Edilamar M. de Oliveira, Ricardo J. Gomes, Alessandra Medeiros
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2019)
Article
Nutrition & Dietetics
Janaina L. S. Donadio, Marcelo M. Rogero, Elvira M. Guerra-Shinohara, Fernando Barbosa, Charles Desmarchelier, Patrick Borel, Alan A. Sneddon, John E. Hesketh, Silvia M. F. Cozzolino
CLINICAL NUTRITION
(2019)
Article
Biology
Julia Ribeiro da Silva Vallim, Fernanda Gaspar do Amaral, Jose Cipolla-Neto, Vania D'Almeida
CHRONOBIOLOGY INTERNATIONAL
(2019)
Article
Biochemistry & Molecular Biology
Jose Aradjo de Oliveira-Silva, Joyce Umbelino Pintoyamamoto, Renata Bernardes de Oliveira, Vaneisse Cristina Lima Monteiro, Beatriz Jurkiewcz Frangipani, Sandra Obikawa Kyosen, Ana Maria Martins, Vania D'Almeida
GENETICS AND MOLECULAR BIOLOGY
(2019)
Article
Medicine, General & Internal
Clovis Paniz, Maylla Rodrigues Lucena, Juliano Felix Bertinato, Felipe Rebello Lourenco, Bruna Cipriano A. Barros, Guilherme Wataru Gomes, Maria Stella Figueiredo, Rodolfo Delfini Cancado, Vera Lucia Nascimento Blaia-D Avila, Christine M. Pfeiffer, Zia Fazili, Ralph Green, Valdemir Melechco Carvalho, Elvira Maria Guerra-Shinohara
JOURNAL OF INVESTIGATIVE MEDICINE
(2019)
Article
Clinical Neurology
Priscila Farias Tempaku, Marcos Leite Santoro, Lia Bittencourt, Vania D'Almeida, Sintia Iole Belangero, Sergio Tufik
Article
Physiology
Luana Cristina de Almeida Silva, Allan Chiaratti de Oliveira, Vanessa Cavalcante-Silva, Maria do Carmo Franco, Vania D'Almeida
EXPERIMENTAL PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Cinthia Castro do Nascimento, Odair Aguiar, Gustavo Monteiro Viana, Vania D'Almeida
Summary: Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disease caused by a mutation in the IDUA gene, leading to the accumulation of GAGs in cells and affecting cell and tissue physiology. Studies have shown damage in the testes of MPS I mice, with signs of cell injury and impaired substrate degradation pathways. Idua plays a critical role in maintaining testicular structure, potentially impacting spermatogenesis.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Cell Biology
Nicole Yolanda Ferreira, Cinthia Castro do Nascimento, Vanessa Goncalves Pereira, Flavia de Oliveira, Carla Cristina Medalha, Vanessa Cavalcante da Silva, Vania D'Almeida
Summary: Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disorder characterized by deficiency of an enzyme responsible for glycosaminoglycan degradation. Musculoskeletal impairment caused by the disease affects bone structure, leading to smaller and more fragile femurs in 3-month-old Idua -/- mice compared to controls, while 6-month-old Idua -/- mice show increased resistance to fracture possibly due to changes in bone matrix.
Article
Nutrition & Dietetics
Vanessa Cavalcante-Silva, Julia Ribeiro da Silva Vallim, Leandro Fernandes, Allan Chiaratti de Oliveira, Vania D'Almeida
Summary: Methionine supplementation during pregnancy and lactation had long-term effects on body composition and locomotor activity in female offspring, while no significant changes were observed in birth weight or organ weights in male offspring.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Environmental Sciences
Helton de Sa Souza, Camila Maria de Melo, Ronaldo Delmonte Piovezan, Rafael Eduardo Eustorgio Pinheiro Chagas Miranda, Miguel Araujo Carneiro-Junior, Bruno Moreira Silva, Ronaldo Vagner Thomatieli-Santos, Sergio Tufik, Dalva Poyares, Vania D'Almeida
Summary: A study found that resistance exercise training can improve sleep and inflammation status in sarcopenic patients, possibly by increasing anti-inflammatory markers.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biology
Julia Ribeiro da Silva Vallim, Gabriela Sant'Ana Lima, Heloisa Mayumi Suyama Tsuji, Beatriz Duarte Palma Xylaras, Sergio Tufik, Marcelo Demarzo, Vania D'Almeida
Summary: This study aimed to identify the sociodemographic factors associated with subjective well-being and describe the mediating behavioral variables. The findings showed that morningness, male gender, not working while studying, and practicing Pilates/yoga were associated with greater subjective well-being. Except for employment status, no direct effects were observed, highlighting the need for a multidimensional approach. The relationship between subjective well-being and sociodemographic factors exists only in the presence of behavioral mediators, specifically perceived stress, daytime sleepiness, symptoms of depression, sleep quality, and positive and negative affects. Future research should further investigate the impact of sleep, stress, and circadian preferences on this relationship.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Clinical Neurology
Guilherme Luiz Fernandes, Julia Ribeiro da Silva Vallim, Vania D'Almeida, Sergio Tufik, Monica Levy Andersen
Summary: Sleepiness is influenced by multiple factors including social jetlag and sleep variability. This study found that the effects of social jetlag on sleepiness may be mediated by sleep debt, highlighting the importance of circadian misalignment and sleep debt for sleep health on a population level.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Pediatrics
Sandra Obikawa Kyosen, Leny Toma, Helena Bonciani Nader, Marion Coting Braga, Vanessa Goncalves Pereira, Sueli Canossa, Joao Bosco Pesquero, Vania D'Almeida, Ana Maria Martins
REVISTA PAULISTA DE PEDIATRIA
(2019)
Review
Sport Sciences
Joao Gustavo Claudino, Tim J. Gabbett, Helton de Sa Souza, Mario Simim, Peter Fowler, Diego de Alcantara Borba, Marco Melo, Altamiro Bottino, Irineu Loturco, Vania D'Almeida, Alberto Carlos Amadio, Julio Cerca Serrao, George P. Nassis
BMJ OPEN SPORT & EXERCISE MEDICINE
(2019)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)