Article
Nutrition & Dietetics
Deepti K. Sharma, Paul H. Anderson, Howard A. Morris, Peter M. Clifton
Summary: The study finds that intake of 1000 mg calcium from milk or calcium carbonate is effective in acutely suppressing bone resorption in postmenopausal women, regardless of visceral fat levels.
JOURNAL OF NUTRITION
(2022)
Editorial Material
Endocrinology & Metabolism
Dured Dardari
Summary: The pathophysiology of Charcot neuroarthropathy (CN) involves unclear mechanisms, particularly in terms of the onset of inflammation and bone remodeling factor disruption leading to bone lysis. This study suggests a potential link between this inflammation and the rapid correction of chronic hyperglycemia, which is associated with treatment-induced neuropathy of diabetes (TIND). The findings contribute to a better understanding of the mysterious physiopathology of CN.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Nutrition & Dietetics
Gerard Karsenty
Summary: Together, loss- and gain-of-function experiments have identified osteocalcin as a hormone with wide-ranging effects in rodents and primates. It influences energy metabolism, steroidogenesis, neurotransmitter biosynthesis, male fertility, electrolyte homeostasis, cognition, the stress response, and exercise capacity. This review focuses on the regulation of energy metabolism by osteocalcin, while also touching on its other functions and proposing a potential common theme with bone's structural functions.
ANNUAL REVIEW OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Zijing Ran, Xiaomei Xue, Lin Han, Robert Terkeltaub, Tony R. Merriman, Ting Zhao, Yuwei He, Can Wang, Xinde Li, Zhen Liu, Lingling Cui, Hailong Li, Aichang Ji, Shuhui Hu, Jie Lu, Changgui Li
Summary: The decrease in serum urate level is positively associated with reduced visceral fat area in male gout patients, suggesting a potential benefit of urate-lowering therapy in promoting loss of visceral fat.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qiang Chang, Jie Huang, Liming He, Fengna Xi
Summary: This study demonstrates a simple electrochemical immunosensor based on gold nanoparticles electrodeposited on chitosan-reduced graphene oxide composite modified electrode for sensitive detection of bone metabolism biomarker BGP. The immobilized AuNPs provide binding sites for anti-BGP antibodies, resulting in reduced electrochemical signal when BGP is present. The electrochemical detection is fast and ultrasensitive, with a detection limit of 20 ag ml(-1), and it is also reliable for detecting BGP in human serum.
FRONTIERS IN CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Juan J. Lopez-Gomez, Jose L. Perez-Castrillon, Isabel Garcia de Santos, Maria Perez-Alonso, Olatz Izaola-Jauregui, David Primo-Martin, Daniel A. De Luis-Roman
Summary: This study examined the differences in bone metabolism between postmenopausal women with and without obesity, and compared the risk of fracture at five years between these groups.
Article
Endocrinology & Metabolism
Wen-bin Zheng, Jing Hu, Di-Chen Zhao, Bing-Na Zhou, Ou Wang, Yan Jiang, Wei-Bo Xia, Xiao-ping Xing, Mei Li
Summary: Osteogenesis imperfecta (OI) patients commonly exhibit obesity, glucolipid metabolic abnormalities, and reduced grip strength. Circulating osteocalcin and undercarboxylated osteocalcin may play an important role in regulating glucose metabolism and muscle function in children with OI.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Sport Sciences
Bronwen Lundy, Alannah K. A. Mckay, Nikita C. Fensham, Nicolin Tee, Bryce Anderson, Aimee Morabito, Megan L. R. Ross, Marc Sim, Kathryn E. Ackerman, Louise M. Burke
Summary: Although acute exercise increases bone turnover markers, the impact of subsequent sessions and preexercise calcium intake remains unclear. This study found that preexercise intake of calcium-rich foods can stabilize blood calcium levels and reduce markers of bone resorption during exercise. These practical strategies can be integrated into athletes' sports nutrition plans to safeguard long-term bone health and reduce the risk of bone stress injuries.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Review
Biochemistry & Molecular Biology
Angelos Dimas, Anastasia Politi, Alexandra Bargiota, Theodoros Panoskaltsis, Nikolaos F. Vlahos, Georgios Valsamakis
Summary: Fetal exposure to adverse environmental factors during intrauterine life can affect the development and future metabolic health of the offspring. Maternal bone turnover is implicated in fetal growth and neonatal body composition and metabolic wellbeing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Jyotirmaya Behera, Jessica Ison, Michael J. Voor, Neetu Tyagi
Summary: Recent evidence suggests that physical exercise has a positive impact on skeletal development and can protect against bone loss and deterioration. This study investigated the effects of exercise on bone mass and mechanical quality in mice with type 2 diabetes mellitus. The results showed that diabetes leads to a decrease in Irisin, which further contributes to bone loss through inflammation. Exercise, along with certain interventions, can restore Irisin levels and improve bone formation in diabetic mice. This study demonstrates that exercise-induced skeletal Irisin can ameliorate diabetes-associated glucose intolerance and bone loss.
Article
Endocrinology & Metabolism
Lara H. Sattgast, Adam J. Branscum, Natali Newman, Steven W. Gonzales, Mary Lauren Benton, Erich J. Baker, Kathleen A. Grant, Russell T. Turner, Urszula T. Iwaniec
Summary: IGF-1 plays a role in bone turnover and chronic alcohol consumption can reduce levels of bone turnover markers and disrupt the normal relationship between IGF-1 and these markers.
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Aysegul Gulbahar, Gamze Sinem Caglar, Tufan Arslanca
Summary: The study aimed to investigate the predictive value of Visceral Adiposity Index (VAI) for cardiovascular disease (CVD) and its relationship with electrolytes. The results showed a significant correlation between VAI and patients with Metabolic Syndrome (MetS), but VAI was not predictive of 10-year CVD risk.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Laura Braud, Maria Pini, Donald F. Stec, Sylvie Manin, Genevieve Derumeaux, David E. Stec, Roberta Foresti, Roberto Motterlini
Summary: The up-regulation of Sirt1 levels specifically in the visceral adipose tissue of Nrf2(-/-) mice is a key adaptive mechanism that mitigates glucose intolerance induced by nutritional stress.
Review
Agriculture, Dairy & Animal Science
Agata Wawrzyniak, Krzysztof Balawender
Summary: This article examines the development, structure, and remodeling of bone tissue. As an essential component of the skeleton, bone provides support and protection and maintains the concentration of calcium and phosphate in body fluids. Bone metabolism involves the balance of bone formation and resorption, regulated by various factors. Secretion of biologically active substances in bone tissue also influences bone function and metabolism.
Article
Agriculture, Dairy & Animal Science
Niklas A. Karst, Xaver Sidler, Annette Liesegang
Summary: Mastitis metritis agalactia (MMA) is a common post-partum disease in sows that negatively affects their longevity and health of both sows and piglets. This study aimed to investigate the impact of MMA on bone and fat metabolism, with the hypothesis that MMA can be predicted by measuring ketone bodies and bone markers. The results showed that sows with MMA had poorer body condition scores, increased serum CTX-I, decreased serum OC, and elevated levels of pro-inflammatory cytokines, suggesting a more negative effect on bone metabolism compared to healthy sows post-partum.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Yu-Jin Kwon, Hye Sun Lee, Go Eun Park, Hyung-Mi Kim, Jung Joo Lee, Woo Jeong Kim, Ji-Won Lee
Summary: This study aimed to investigate the association between total protein intake and all-cause mortality in patients with chronic kidney disease (CKD). The results showed that higher protein intake was not significantly associated with mortality in CKD patients. Further research is needed to determine optimal protein intake levels and the impact of dietary protein sources on health outcomes and mortality in CKD.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Yu-Jin Kwon, Hye-Sun Lee, Goeun Park, Hyung-Mi Kim, Ji-Won Lee
Summary: This study aimed to investigate the association between dietary fiber intake and all-cause and cardiovascular disease mortality in individuals with pre-existing chronic conditions, especially in Asian countries. The results showed that higher dietary fiber intake was significantly associated with a lower risk of all-cause and cardiovascular disease mortality.
Article
Nutrition & Dietetics
Yu-Jin Kwon, Da-In Sung, Ji-Won Lee
Summary: This study investigated the association between dietary patterns and adherence to Mediterranean diet (MD) with premenstrual syndrome (PMS) in Korean women. The results showed that low adherence to MD and a higher bread/snack dietary pattern were associated with an increased risk of PMS.
Article
Multidisciplinary Sciences
Yea-Chan Lee, Young Kyung You, Sungsoo Lee, Duk Hwan Moon, Ji-Won Lee
Summary: The purpose of this study was to evaluate the effectiveness of monitoring skin blood flow in assessing blood perfusion during endoscopic lumbar sympathectomy (ELS) in patients with plantar hyperhidrosis. Retrospective analysis of 30 patients undergoing surgical treatment for plantar hyperhidrosis showed that monitoring skin blood flow via laser doppler flowmetry (LDF) improved the accuracy of ELS.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Youhyun Song, Hye Sun Lee, Goeun Park, Sang-Wook Kang, Ji Won Lee
Summary: This study aimed to investigate the risk of dyslipidemia in patients with thyroid cancer (TC) compared to the general population without TC. The results showed no significant difference in dyslipidemia risk between TC patients and the general population, both in prospective and retrospective analyses.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
A-Ra Cho, Kyung-Won Hong, Yu-Jin Kwon, Ja-Eun Choi, Hye-Sun Lee, Hyung-Mi Kim, Soong June Bae, Sung Gwe Ahn, Joon Jeong, Ji-Won Lee
Summary: This pilot randomized controlled trial investigated the effects of two obesity-related gene variants and a Mediterranean diet intervention on weight loss and metabolic parameters in overweight or obese breast cancer patients. The results showed that the gene variants did not influence weight loss or metabolic improvements within the Mediterranean diet intervention. However, in the control group, one of the gene variants was associated with increased intake of saturated fatty acids and trans fat. The study suggests that the Mediterranean diet may have a protective role against the effects of certain gene variants.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Yu-Jin Kwon, Hye Sun Lee, Goeun Park, Juyeon Yang, Hyung-Mi Kim, Ji-Won Lee
Summary: This study investigated the association between dietary zinc intake and total deaths, cancer, and cardiovascular disease death. The results showed that dietary zinc intake was inversely associated with all-cause mortality and cardiovascular disease mortality, but not with cancer mortality. These findings suggest that recommending optimal dietary zinc intake is beneficial for human health.
Article
Nutrition & Dietetics
Yu-Jin Kwon, Hye Sun Lee, Goeun Park, Ji-Won Lee
Summary: There is inconclusive evidence regarding the association between dietary sodium, potassium, and the sodium-to-potassium ratio and all-cause and cardiovascular disease mortality. This study found that sodium intake was not associated with all-cause mortality, while potassium intake was inversely associated with all-cause mortality.
FRONTIERS IN NUTRITION
(2022)
Article
Oncology
Jiin Ryu, Eun-Young Lee, Jihee Min, Sujin Yeon, Ji-Won Lee, Sang Hui Chu, Hyangkyu Lee, Seung Il Kim, Jee Ye Kim, Seho Park, Justin Y. Jeon
Summary: This 12-month randomized controlled trial investigates the effects of tailored home-based exercise programs on short-term and long-term physiological outcomes in patients with breast cancer. The study found that exercise interventions customized to patients' treatment phase, surgery type, and physical function can improve shoulder function, body composition, and insulin resistance. These findings provide guidance for the development of effective exercise programs for patients with breast cancer post-operatively.
Article
Dentistry, Oral Surgery & Medicine
Hyun-Jeong Lee, Ji-Won Lee, Sue Kim, Yu-Jin Kwon
Summary: This study found that TyG, TyG-BMI, TyG-WC, and TyG-WHtR are significantly associated with the risk of periodontitis, and TyG-WHtR has the highest predictive performance.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Behavioral Sciences
Youhyun Song, Dasom Lee, Ja-Eun Choi, Ji Won Lee, Kyung-Won Hong
Summary: In this study, genome-wide association studies revealed genetic loci associated with left-handedness and ambidexterity, which were replicated with previously reported variants. These findings are linked to brain development, neurological processes, and neuropsychiatric diseases, providing intriguing insights for future neurological research.
BRAIN AND BEHAVIOR
(2023)
Article
Primary Health Care
Joon Hyung Lee, Jae Yong Shira, Ji Won Lee
Summary: This study investigated the association between urinary cotinine levels and blood pressure in Korean adults exposed to secondhand smoke. The results showed that in female participants, urinary cotinine levels were positively associated with systolic and diastolic blood pressure. However, there was no association between blood pressure and urinary cotinine levels in male participants.
KOREAN JOURNAL OF FAMILY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sanghoon Kim, Ji-Won Lee, Yaeji Lee, Youhyun Song, John A. Linton
Summary: This study found a correlation between the triglyceride-glucose (TyG) index and mean low-density lipoprotein (LDL) particle size. The results showed that the TyG index cutoff value for sdLDL particle predominance was close to the cutoff value of diabetes risk in Koreans.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Hematology
Dong-Wook Chun, Yae-Ji Lee, Jun-Hyuk Lee, Ji-Won Lee
Summary: This study found that an increasing trajectory of AIP is associated with a higher risk of incident CVD. Monitoring and managing the trajectory of AIP may be a preventive strategy for CVD.
THROMBOSIS JOURNAL
(2023)
Article
Pediatrics
Ehn-Young Kim, Hye-Won Lee, Ji-Won Lee, Yu-Jin Kwon, Nak-Hoon Son
Summary: The study aimed to analyze the trends in serum uric acid (SUA) levels among Korean children and adolescents over a 5-year period, considering factors such as age, sex, obesity, and abdominal obesity. The study utilized nationally representative data from the Korea National Health and Nutritional Examination Survey conducted from 2016 to 2020. The findings showed a significant increase in SUA levels among boys with obesity or abdominal obesity, indicating the need for further research on the health outcomes associated with SUA in this population.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)
