Article
Hematology
F. H. J. Kaptein, L. J. M. Kroft, G. Hammerschlag, M. K. Ninaber, M. P. Bauer, M. Huisman, F. A. Klok
Summary: Pulmonary infarction occurs due to occlusion of distal pulmonary arteries, leading to ischemia, hemorrhage and necrosis. It is mainly caused by acute pulmonary embolism, but specific management strategies and impact are unclear, requiring further research to fill knowledge gaps.
THROMBOSIS RESEARCH
(2021)
Article
Respiratory System
Gudula J. A. M. Boon, Yvonne M. Ende-Verhaar, Roisin Bavalia, Lahassan H. El Bouazzaoui, Marion Delcroix, Olga Dzikowska-Diduch, Menno Huisman, Katarzyna Kurnicka, Albert T. A. Mairuhu, Saskia Middeldorp, Piotr Pruszczyk, Dieuwertje Ruigrok, Peter Verhamme, Hubert W. Vliegen, Anton Vonk Noordegraaf, Joris W. J. Vriend, Frederikus A. Klok
Summary: The study validated a simple screening strategy for early exclusion of CTEPH after acute PE, reducing the need for echocardiography in the majority of patients and resulting in a substantially shorter diagnostic delay compared to current practice.
Article
Critical Care Medicine
Parth Rali, Daniel Sacher, Belinda Rivera-Lebron, Rachel Rosovsky, Jean M. Elwing, Jonathan Berkowitz, Bushra Mina, Bhavinkumar Dalal, George A. Davis, David M. Dudzinski, Alicia Duval, Eugene Ichinose, Christopher Kabrhel, Aniruddh Kapoor, Ka U. Lio, Robert Lookstein, Michael McDaniel, Roman Melamed, Soophia Naydenov, Shalom Sokolow, Kenneth Rosen Field, Victor Tapson, Eduardo Bossone, Brent Keeling, Richard Channick, Charles B. Ross
Summary: The management paradigm for acute pulmonary embolism has evolved with the availability of advanced treatment modalities, coinciding with the development of pulmonary embolism response teams. Interhospital transfer of critically ill PE patients is a current unmet need, requiring medical optimization, defined roles of emergency services, and responsibilities of referring and receiving centers.
Article
Respiratory System
Samira Marin-Romero, Aitor Ballaz-Quincoces, Covadonga Gomez-Cuervo, Pablo Javier Marchena-Yglesias, Patricia Lopez-Miguel, Iria Francisco-Albesa, Jose Maria Pedrajas-Navas, Marina Lumbierres, Miguel Angel Aibar-Arregui, Juan Bosco Lopez-Saez, Montserrat Perez-Pinar, Carlos Baeza-Martinez, Antoni Riera-Mestre, Marisa Peris-Sifre, Jose Antonio Porras-Ledantes, Juan Criado-Garcia, Teresa Elias-Hernandez, Remedios Otero, Maria Barca-Hernando, Alfonso Muriel, Frederikus A. Klok, Luis Jara-Palomares
Summary: A symptom screening programme conducted via phone calls for PE survivors with dyspnoea NYHA/WHO scale >= II significantly increased the diagnosis rate of CTEPH. Implementing simple strategies can help diagnose CTEPH earlier.
Article
Medicine, General & Internal
Ann-Sophie Eggers, Alaa Hafian, Markus H. Lerchbaumer, Gerd Hasenfuss, Karl Stangl, Burkert Pieske, Mareike Lankeit, Matthias Ebner
Summary: Although the effect of infections on adverse outcome risk in patients with pulmonary embolism (PE) remains unclear, clinically relevant infections requiring antibiotic treatment were found in almost half of the patients and carried a similar prognostic effect as an increase in one risk class of the European Society of Cardiology (ESC) risk stratification algorithm. Elevated levels of C-reactive protein (CRP) and procalcitonin (PCT) were independent predictors of adverse outcome.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Yu Liu, Ming Xie, Xiaoli Gao, Ran Liu
Summary: A meta-analysis evaluated the diagnostic value of circulating microRNA-134 levels for APE, finding that levels were higher in APE patients compared to controls and had diagnostic potential, but further research is needed for validation.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Review
Hematology
Mateo Porres-Aguilar, Rachel P. Rosovsky, Belinda N. Rivera-Lebron, Scott Kaatz, Debabrata Mukherjee, Javier E. Anaya-Ayala, David Jimenez, Carlos Jerjes-Sanchez
Summary: Pulmonary embolism response teams (PERTs) are multidisciplinary teams that have changed the approach to complex acute pulmonary embolism (PE) cases. PERTs are positively impacting the treatment paradigm for acute PE through global adoption by the healthcare community.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Critical Care Medicine
Stefano Barco, Anna C. Mavromanoli, Karl-Friedrich Kreitner, Alexander C. Bunck, Roman J. Gertz, Sebastian Ley, Luca Valerio, Frederikus A. Klok, Felix Gerhardt, Stephan Rosenkranz, Stavros Konstantinides
Summary: This study found that 15% of patients with acute pulmonary embolism (PE) showed signs of chronic PE or chronic thromboembolic pulmonary hypertension (CTEPH) on CT pulmonary angiography (CTPA). Specific radiologic parameters, such as intravascular webs, arterial narrowing or retraction, dilated bronchial arteries, and right ventricular hypertrophy, could help identify preexisting CTEPH. Early diagnosis of CTEPH can be facilitated by targeted follow-up strategies and risk-adapted CTEPH screening based on these parameters.
Article
Radiology, Nuclear Medicine & Medical Imaging
Diletta Cozzi, Chiara Moroni, Edoardo Cavigli, Alessandra Bindi, Cosimo Caviglioli, Peiman Nazerian, Simone Vanni, Vittorio Miele, Maurizio Bartolucci
Summary: CTPA findings can predict 30-day mortality of patients with APE in the Emergency Department, particularly the quantification of right ventricular strain, which is associated with troponin I levels and echocardiographic signs of right-heart dysfunction. The study suggests that a dilated coronary sinus may have additional prognostic value in predicting mortality.
Article
Critical Care Medicine
Timothy A. Morris, Timothy M. Fernandes, Richard N. Channick
Summary: Long-term dyspnea and exercise intolerance are common problems after acute pulmonary embolism. This article presents a stepwise approach to evaluating post-pulmonary embolism patients, using a hierarchy of clinically validated diagnostic tests. The algorithm, represented by the acronym SEARCH, includes symptom screening, exercise testing, arterial perfusion, resting echocardiography, confirmatory chest imaging, and hemodynamics measured by right heart catheterization. The article illustrates the algorithm with a patient in a pulmonary embolism follow-up clinic.
Article
Medicine, General & Internal
Brett J. Carroll, Sebastian E. Beyer, Colby Shanafelt, Christopher Kabrhel, Parth Rali, Belinda Rivera-Lebron, Rachel Rosovsky, Charles B. Ross, Duane S. Pinto, Eric A. Secemsky
Summary: This study evaluated patients with acute pulmonary embolism and compared the characteristics, treatment, and outcomes of transferred and non-transferred patients. Transferred patients had higher-risk features, more frequently received advanced therapy, and had higher definite pulmonary embolism-related mortality.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Critical Care Medicine
Ana Jaureguizar, David Jimenez, Behnood Bikdeli, Pedro Ruiz-Artacho, Alfonso Muriel, Victor Tapson, Raquel Lopez-Reyes, Beatriz Valero, Gili Kenet, Manuel Monreal
Summary: This study investigated the association between heart rate and pulmonary embolism outcomes and found that a higher heart rate is associated with increased all-cause and PE-related mortality. Modifying the heart rate cutoff in the simplified Pulmonary Embolism Severity Index (sPESI) and the Bova score can improve the prognostication of patients with PE.
Article
Cardiac & Cardiovascular Systems
Raquel Morillo, David Jimenez, Behnood Bikdeli, Carmen Rodriguez, Andres Tenes, Yugo Yamashita, Takeshi Morimoto, Takeshi Kimura, Gemma Vidal, Nuria Ruiz-Gimenez, Olivier Espitia, Manuel Monreal
Summary: The study evaluates the utility of a modified simplified Pulmonary Embolism Severity Index (sPESI) in elderly patients with acute symptomatic pulmonary embolism, and concludes that the new model has higher sensitivity for predicting short-term mortality in this population. Safe outpatient therapy may benefit a minority of these patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Alisha Jamil, Hillary Johnston-Cox, Steven Pugliese, Ashwin S. Nathan, Paul Fiorilli, Sameer Khandhar, Mitchell D. Weinberg, Jay Giri, Taisei Kobayashi
Summary: This document focuses on risk stratification of pulmonary embolism, review of current interventional therapies, the role of clinical endpoints in assessing the effectiveness of different interventional therapies, and the role of mechanical circulatory support in the complex management of this disease.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Review
Medicine, General & Internal
Antonio Leidi, Stijn Bex, Marc Righini, Amandine Berner, Olivier Grosgurin, Christophe Marti
Summary: Risk stratification plays a crucial role in the management of acute pulmonary embolism, helping to determine the appropriate diagnostic and therapeutic strategies. Patients are categorized into low-risk, intermediate-risk, and intermediate-high-risk groups based on clinical parameters and markers of right ventricular dysfunction and myocardial injury. This classification guides the choice of treatment and helps identify patients who may benefit from more aggressive approaches.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Jose S. Possomato-Vieira, Jessica S. Chimini, Maria L. S. da Silva, Carlos A. Dias-Junior
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2018)
Article
Pharmacology & Pharmacy
Victor Hugo Goncalves-Rizzi, Jose Sergio Possomato-Vieira, Regina Aparecida Nascimento, Mayara Caldeira-Dias, Carlos Alan Dias-Junior
EUROPEAN JOURNAL OF PHARMACOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Jose Sergio Possomato-Vieira, Victor Hugo Goncalves-Rizzi, Regina Aparecida do Nascimento, Rodrigo Roldao Wandekin, Mayara Caldeira-Dias, Jessica Sabbatine Chimini, Maria Luiza Santos da Silva, Carlos A. Dias-Junior
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Pharmacology & Pharmacy
Jessica Sabbatine Chimini, Jose Sergio Possomato-Vieira, Maria Luiza Santos da Silva, Carlos A. Dias-Junior
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2019)
Article
Pharmacology & Pharmacy
Regina A. Nascimento, Jose S. Possomato-Vieira, Victor H. Goncalves-Rizzi, Gisele F. Bonacio, Elen Rizzi, Carlos A. Dias-Junior
EUROPEAN JOURNAL OF PHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Gabriela Palma Zochio, Jose Sergio Possomato-Vieira, Jessica Sabbatine Chimini, Maria Luiza Santos da Silva, Carlos Alan Dias-Junior
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2019)
Article
Cell Biology
Regina A. Nascimento, Jose S. Possomato-Vieira, Giselle E. Bonacio, Elen Rizzi, Carlos A. Dias-Junior
Article
Cardiac & Cardiovascular Systems
Edileia Souza-Paula, Leticia C. C. Polonio, Gabriela P. Zochio, Katiussia Pinho da Silva, Helio Kushima, Carlos A. Dias-Junior
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Jose Sergio Possomato-Vieira, Ana Carolina Palei, Caroline Cristina Pinto-Souza, Ricardo Cavalli, Carlos Alan Dias-Junior, Valeria Sandrim
Summary: This study measured plasma H2S levels in healthy pregnant women, gestational hypertensive patients, and preeclamptic patients. It found that H2S levels were elevated in preeclampsia and further increased in gestational hypertension, with a negative correlation with nitrite. This suggests that increased H2S may be a compensatory mechanism for reduced NO in hypertensive disorders of pregnancy.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Review
Obstetrics & Gynecology
Priscila Rezeck Nunes, Lucas Cezar Pinheiro, Laisla Zanetoni Martins, Carlos Alan Dias-Junior, Ana Carolina Taveiros Palei, Valeria Cristina Sandrim
Summary: S-nitrosylation is a process in which nitric oxide reacts with free thiol groups in proteins, modulating cellular functions and acting as a mediator in endothelial cells. Deficits in NO bioavailability have been associated with pregnancy-related disorders. Studying the role of S-nitrosylation in preeclampsia can provide insights into its pathophysiology and potential drug treatments.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Pharmacology & Pharmacy
Thalita L. A. Rocha, Teubislete F. Borges, Serginara D. Rodrigues, Laisla Z. Martins, Maria L. S. da Silva, Gisele F. Bonacio, Elen Rizzi, Carlos A. Dias-Junior
Summary: The study aimed to investigate the effects of sevoflurane and isoflurane on vascular function, nitric oxide (NO) bioavailability, and biomarkers of oxidative stress and inflammation. The results showed that sevoflurane anesthesia impaired vasocontraction, reduced NO bioavailability and cytokines, and increased MMP-2 activity, while isoflurane anesthesia did not have these effects.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cristal Jesus Toghi, Laisla Zanetoni Martins, Leonardo Lopes Pacheco, Edileia Souza Paula Caetano, Bruna Rahal Mattos, Elen Rizzi, Carlos Alan Dias-Junior
Summary: Pravastatin can protect rats from oxidative stress-induced activation of matrix metalloproteinases (MMPs) and improve endothelial function, thereby alleviating symptoms in pre-eclamptic rats.
Article
Biochemistry & Molecular Biology
Laisla Zanetoni Martins, Maria Luiza Santos da Silva, Serginara David Rodrigues, Saskia Estela Biasotti Gomes, Laura Molezini, Elen Rizzi, Marcelo Freitas Montenegro, Carlos Alan Dias-Junior
Summary: Preeclampsia is a maternal hypertension disorder associated with vascular dysfunction and fetal and placental growth restrictions. Placental ischemia is suggested as the primary trigger of preeclampsia, and sodium nitrite may attenuate its effects by reducing blood pressure, preventing fetal and placental weight loss, counteracting vascular hyper-reactivity, and partially restoring NO and MMP-2 activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Serginara David Rodrigues, Maria Luiza Santos da Silva, Laisla Zanetoni Martins, Saskia Estela Biasotti Gomes, Noemia A. P. Mariani, Erick J. R. Silva, Helio Kushima, Bruna Rahal Mattos, Elen Rizzi, Carlos Alan Dias-Junior
Summary: This study found that isoflurane anesthesia can protect the endothelial function of patients with pregnancy hypertension, possibly involving endothelium-derived NO.
Article
Biochemistry & Molecular Biology
Priscilla Bianca de Oliveira, Gabriela Palma Zochio, Edileia Souza Paula Caetano, Maria Luiza Santos da Silva, Carlos Alan Dias-Junior
Summary: The study investigated the role of perivascular adipose tissue (PVAT)-derived hydrogen sulfide (H2S) in vasodilation in pregnancy hypertension-induced endothelial dysfunction. The results showed that PVAT-derived H2S stimulated with the amino acid L-cysteine may be an alternative method to induce vasorelaxation in endothelial dysfunction related to pregnancy hypertension.
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)