Article
Clinical Neurology
Young Jun Park, June Soo Kim, Kyoung-Min Park, Young Keun On, Seung-Jung Park
Summary: The presence of high-burden subclinical atrial fibrillation (SCAF) in permanent pacemaker patients without preexisting atrial fibrillation is closely associated with increased risks of composite adverse outcomes, especially progression to clinical AF and ischemic stroke. Therefore, prospective studies are warranted to investigate the optimal anticoagulation therapy for permanent pacemaker patients with both high-burden SCAF and high stroke risk.
Article
Medicine, General & Internal
Ameenathul M. Fawzy, Arnaud Bisson, Sid A. Bentounes, Alexandre Bodin, Julien Herbert, Gregory Y. H. Lip, Laurent Fauchier
Summary: This study found that patients with atrial fibrillation (AF) who have cardiac implantable electronic devices (CIEDs) are at higher risk of ventricular tachycardia (VT), ventricular fibrillation (VF), and cardiac arrests (CA) compared to patients without AF.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Gregory F. Michaud, William G. Stevenson
Summary: A 63-year-old healthy male with atrial fibrillation presents with symptoms of dyspnea and irregular heartbeat. Physical examination reveals high blood pressure, irregular pulse, and ECG confirms atrial fibrillation. Further evaluation and treatment plan are needed.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Giuseppe Boriani, Yuichiro Sakamoto, Gianluca Botto, Satoru Komura, Paolo Pieragnoli, Hitoshi Minamiguchi, Saverio Iacopino, Takahisa Noma, Tommaso Infusino, Yoshihide Takahashi, Domenico Facchin, Francesco De Rosa, Ennio Pisano, Sarah Meloni, Mauro Biffi
Summary: In dual-chamber pacemaker patients with atrial fibrillation history, the use of Reactive ATP is associated with a low incidence of persistent AF, highlighting that the positive results of the MINERVA trial were related to the effectiveness of Reactive ATP rather than to preventive pacing.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Cardiac & Cardiovascular Systems
Benedikt Linz, Julie Norup Hertel, Thomas Jespersen, Dominik Linz
Summary: Excessive alcohol consumption has detrimental effects on the cardiovascular system, including increasing the risk of atrial fibrillation (AF) and other cardiovascular diseases. Both acute and chronic effects of alcohol intake may contribute to the development of AF, involving changes in atrial refractoriness, conduction velocity, and atrial remodeling. Alcohol abstinence can reduce AF recurrence and risk factors, and improve overall cardiovascular health.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ange Maguy, Yuvaraj Mahendran, Jean-Claude Tardif, David Busseuil, Jin Li
Summary: This study explores the association between autoantibodies targeting cardiac ion channels and unexplained AF. They found a common autoantibody response against K(ir)3.4 protein in patients with AF, even before the development of clinically apparent AF. Functional studies and a mouse model of K(ir)3.4 autoimmunity support the causal relationship between K(ir)3.4 autoantibodies and AF.
Article
Geriatrics & Gerontology
Mert Ilker Hayiroglu, Tufan Cinar, Goksel Cinier, Gizem Yuksel, Levent Pay, Kivanc Keskin, Cahit Coskun, Gokcem Ayan, Vedat Cicek, Ahmet Ilker Tekkesin
Summary: This study investigated the occurrence of atrial fibrillation (AF) in octogenarians with dual-chamber permanent pacemakers (PPM) and its association with long-term mortality. The study found that diabetes, urea levels, albumin levels, paced QRS duration, and the frequency of atrial high-rate episodes (AHREs) were independently associated with a long-term risk of AF in these patients. Furthermore, left ventricular ejection fraction, left atrial anteroposterior diameter, and AHRE + AF were identified as independent risk factors for long-term mortality in octogenarians with dual-chamber PPM implants.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Medicine, General & Internal
Bianca J. J. M. Brundel, Xun Ai, Mellanie True Hills, Myrthe F. Kuipers, Gregory Y. H. Lip, Natasja M. S. de Groot
Summary: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is increasing in prevalence. Understanding the molecular mechanisms underlying AF is crucial for the development of personalized diagnostic tools and mechanism-based therapies. Co-creation with patients is essential for successful management of AF.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Multidisciplinary Sciences
Maarten Hulsmans, Maximilian J. Schloss, I-Hsiu Lee, Aneesh Bapat, Yoshiko Iwamoto, Claudio Vinegoni, Alexandre Paccalet, Masahiro Yamazoe, Jana Grune, Steffen Pabel, Noor Momin, Hana Seung, Nina Kumowski, Fadi E. Pulous, Daniel Keller, Constanze Bening, Ursula Green, Jochen K. Lennerz, Richard N. Mitchell, Andrew Lewis, Barbara Casadei, Oriol Iborra-Egea, Antoni Bayes-Genis, Samuel Sossalla, Chin Siang Ong, Richard N. Pierson, Jon C. Aster, David Rohde, Gregory R. Wojtkiewicz, Ralph Weissleder, Filip K. Swirski, George Tellides, George Tolis, Serguei Melnitchouk, David J. Milan, Patrick T. Ellinor, Kamila Naxerova, Matthias Nahrendorf
Summary: This study deciphered the role of immune and stromal cells in atrial fibrillation and identified SPP1(+) macrophages as potential targets for immunotherapy in atrial fibrillation.
Article
Cardiac & Cardiovascular Systems
Srikanth Perike, Francisco J. Gonzalez-Gonzalez, Issam Abu-Taha, Frederick W. Damen, Laurin M. Hanft, Ken S. Lizama, Anahita Aboonabi, Andrielle E. Capote, Yuriana Aguilar-Sanchez, Benjamin Levin, Zhenbo Han, Arvind Sridhar, Jacob Grand, Jody Martin, Joseph G. Akar, Chad M. Warren, R. John Solaro, Sang-Ging Ong, Dawood Darbar, Kerry S. Mcdonald, Craig J. Goergen, Beata M. Wolska, Dobromir Dobrev, Xander H. T. Wehrens, Mark D. McCauley
Summary: The study revealed that patients with AF have increased expression of PPP1R12C protein, leading to decreased atrial contractility. Overexpression of PPP1R12C in mice increases PP1c targeting to MLC2a, causing MLC2a dephosphorylation, and subsequently increasing AF inducibility.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Zhuanzhuan Wu, Chao Jiang, Jingye Li, Jing Du, Yu Bai, Xueyuan Guo, Wei Wang, Songnan Li, Chenxi Jiang, Nian Liu, Ribo Tang, Rong Bai, Caihua Sang, Deyong Long, Xin Du, Changsheng Ma, Jianzeng Dong
Summary: Family history of atrial fibrillation is a risk factor for postablation atrial tachyarrhythmia recurrence, especially in patients diagnosed with atrial fibrillation at age 50 or younger.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2021)
Article
Computer Science, Information Systems
Li Zhu, Viswam Nathan, Jilong Kuang, Jacob Kim, Robert Avram, Jeffrey Olgin, Jun Gao
Summary: Atrial Fibrillation (AF) is a significant cardiac rhythm disorder that can be detected and monitored using wearable sensors. This study developed a highly sensitive and specific AF detection algorithm, and comprehensively validated its performance in a real-world population. The research also demonstrated the robustness and accuracy of the algorithm in daily living scenarios.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Letter
Medicine, General & Internal
Isaac W. Leon-acuna, Takeki Suzuki
Summary: Andrade et al. found that initial catheter cryoballoon ablation strategy resulted in lower incidence of persistent atrial fibrillation and lower arrhythmia burden compared to antiarrhythmic drug therapy in patients with paroxysmal atrial fibrillation during 3 years of follow-up. The study builds upon the findings of the EARLY-AF trial and the STOP AF First trial. Due to the relatively small sample size (303 patients) and short follow-up period, it may be difficult to detect mortality benefits of cryoballoon ablation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Medicine, Research & Experimental
Chang Yi Li, Jing Rui Zhang, Wan Ning Hu, Song Nan Li
Summary: Atrial fibrillation (AF) is closely linked with fibrosis, which is a key factor in structural changes that impact the occurrence and persistence of AF. Despite the complexity of this process, advancements in technology now allow for non-invasive evaluation of fibrosis, facilitating the selection of personalized treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jo-Nan Liao, Su-Shen Lim, Tzeng-Ji Chen, Ta-Chuan Tuan, Shih-Ann Chen, Tze-Fan Chao
Summary: The modified Taiwan AF score based on age and clinical comorbidities can be used to predict incident AF in the Asian population. The risk of AF increases with higher scores.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)