Article
Biochemistry & Molecular Biology
Renata Vargas Sinatora, Eduardo Federighi Baisi Chagas, Fernando Otavio Pires Mattera, Luciano Junqueira Mellem, Ana Rita de Oliveira dos Santos, Larissa Pires Pereira, Ana Luiza de Carvalho Aranao, Elen Landgraf Guiguer, Adriano Cressoni Araujo, Jesselina F. dos Santos Haber, Leila Campos Guissoni, Sandra Maria Barbalho
Summary: This study investigated the relationship between inflammatory biomarkers and metabolic syndrome in postmenopausal women and found that increased deposition of visceral fat leads to increased production of inflammatory cytokines. The IL-10/TNF-alpha ratio was found to be accurate in diagnosing metabolic syndrome in this population.
Review
Nutrition & Dietetics
Celia Bauset, Ana Martinez-Aspas, Sara Smith-Ballester, Alicia Garcia-Vigara, Aitana Monllor-Tormos, Fawzi Kadi, Andreas Nilsson, Antonio Cano
Summary: Menopause leads to a decrease in estrogen levels and an increase in fat content, increasing the risk of metabolic syndrome. Nut ingestion may help reduce the risk of metabolic syndrome, especially by improving lipid and carbohydrate metabolism.
Article
Cell Biology
Maysa O. A. Oliveira, Alvaro R. Leonco, Vinicius B. Pavani, Isadora R. Barbosa, Maria M. Campos
Summary: Periodontal disease (PD) and metabolic syndrome (MS) can negatively influence each other, increasing the risk for cardiovascular diseases (CVD). This study found that omega-3 supplementation can have beneficial effects in inhibiting inflammation, improving blood glucose and triglyceride levels in the context of co-induced PD and MS.
Review
Biochemistry & Molecular Biology
Hye Gyeong Jeong, Hyuntae Park
Summary: Menopause is a crucial stage in a woman's life and is strongly associated with metabolic diseases. The symptoms experienced during perimenopause can be distressing for women, and managing these factors can improve postmenopausal women's health.
Article
Nutrition & Dietetics
Anna Maria Cybulska, Daria Schneider-Matyka, Mateusz Bosiacki, Dariusz Chlubek, Mariusz Panczyk, Elzbieta Grochans
Summary: This study evaluated the relationship between element levels and the risk of metabolic syndrome in perimenopausal women. The results showed that low blood potassium levels were associated with an increased risk of metabolic syndrome, while higher copper levels were observed in overweight women, negatively correlating with total cholesterol, LDL, and systolic blood pressure.
Article
Reproductive Biology
Hong Zhang, Lu Zheng, Chuwei Li, Jun Jing, Zhou Li, Shanshan Sun, Tongmin Xue, Kemei Zhang, Mengqi Xue, Chun Cao, Lei Ouyang, Zhang Qian, Rui Xu, Zhaowanyue He, Rujun Ma, Li Chen, Bing Yao
Summary: This study aimed to explore how omega-3 polyunsaturated fatty acids (PUFAs) alleviate ovarian dysfunction and insulin resistance in mice with dehydroepiandrosterone-induced polycystic ovary syndrome (PCOS) by modulating gut microbiota. The results indicated that oral supplementation with omega-3 PUFAs improved PCOS phenotype and alleviated DHEA-induced gut dysbiosis by increasing the abundance of beneficial bacteria. Furthermore, the gut microbiota played a key role in improving adipose tissue morphology and function. Therefore, omega-3 supplementation may be a promising therapeutic approach for treating PCOS by modulating gut microbiota and alleviating ovarian dysfunction and insulin resistance.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Maria Magdalena Quetglas-Llabres, Margalida Monserrat-Mesquida, Cristina Bouzas, Cristina Gomez, David Mateos, Tomas Ripoll-Vera, Josep A. Tur, Antoni Sureda
Summary: Studies have found that MetS patients with low adherence to MDP have higher levels of glycated haemoglobin A1c and triglycerides, as well as lower levels of HDL cholesterol. Those with low adherence to MDP also have higher plasma levels of pro-inflammatory markers, lower antioxidant enzyme activity, and more severe cellular oxidative stress responses. Patients with higher adherence to MDP showed less altered anthropometric parameters, blood biochemical profile, and better oxidative and inflammatory status.
Review
Food Science & Technology
Ellencristina da Silva Batista, Susana Castelo Branco Ramos Nakandakari, Adelino Sanchez Ramos da Silva, Jose Rodrigo Pauli, Leandro Pereira de Moura, Eduardo Rochete Ropelle, Enilton A. Camargo, Dennys Esper Cintra
Summary: This article provides a detailed mechanistic proposal for understanding the role of omega-3 fatty acids in the inflammatory environment, including their modulation of prostaglandins and leukotrienes, recognition by G protein-coupled receptors, and insulin-sensitizing effects.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Gladys P. Velarde, Naila Choudhary, Katia Bravo-Jaimes, Carmen Smotherman, Saadia Sherazi, Dale F. Kraemer
Summary: The study found that high-intensity atorvastatin had a significant impact on lipogenesis and apolipoproteins in women with metabolic syndrome, but did not lower levels of inflammatory, thrombotic and platelet activity markers. Further research is needed to explore the use of statins for primary prevention in these patients.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Orthopedics
N. E. J. Jansen, E. Molendijk, D. Schiphof, J. B. J. van Meurs, E. H. G. Oei, M. van Middelkoop, S. M. A. Bierma-Zeinstra
Summary: Metabolic syndrome (MetS) and its components are associated with progression of knee osteoarthritis (OA) MRI features, but no interaction was found between MetS and menopausal transition and MRI features.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Nutrition & Dietetics
Mengjun Wang, Junliang Liu, Zhao Zhang, Haixiong Zhang, Ning Wang, Xi Chen, Xuemei Han, Qian Lu, Shanshan Chi
Summary: Dietary intervention may help decrease IL-6 levels in patients with MetS, but it does not significantly affect IL-1 beta, TNF-alpha, or CRP levels.
FRONTIERS IN NUTRITION
(2022)
Article
Agriculture, Dairy & Animal Science
Gitit Kra, Jayasimha Rayalu Daddam, Uzi Moallem, Hadar Kamer, Radka Kocvarova, Alina Nemirovski, G. Andres Contreras, Joseph Tam, Maya Zachut
Summary: This study found that dietary supplementation of omega-3 fatty acids during the transition period can reduce the activation of the endocannabinoid system (ECS) and affect metabolic and inflammatory markers in postpartum dairy cows. Omega-3 supplementation resulted in reduced feed intake and alterations in ECS components in blood, adipose tissue, and liver, leading to modulations in lipid metabolism and inflammation in dairy cows.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Pediatrics
Natasha A. Schvey, Lisa M. Shank, Marian Tanofsky-Kraff, Sophie Ramirez, Deborah R. Altman, Taylor Swanson, Alex G. Rubin, Nichole R. Kelly, Sarah LeMay-Russell, Meghan E. Byrne, Megan N. Parker, Miranda M. Broadney, Sheila M. Brady, Susan Z. Yanovski, Jack A. Yanovski
Summary: Research did not find any association between weight-based teasing and worsened cardiometabolic health among youth in two different samples. Longitudinal studies are needed to further explore the relationship between weight stigma and health outcomes in young people.
Article
Psychology, Developmental
Sarah A. Keim, Abigail Jude, Katie Smith, Aiman Q. Khan, Daniel L. Coury, Joseph Rausch, Shivika Udaipuria, Megan Norris, Lindsay R. Bartram, Anita R. Narayanan, Lynette K. Rogers
Summary: This study is a double-blind, randomized controlled trial that tested the effect of fatty acid supplementation in children aged 2-6 years with recently diagnosed Autism Spectrum Disorder (ASD). The results showed that the FA supplement increased levels of omega-3 and omega-6 fatty acids and reduced IL-2 levels. The treatment was well tolerated and had a high adherence rate.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Review
Food Science & Technology
Yongjin Wang, Yandan Wang, Qayyum Shehzad, Yijia Su, Lirong Xu, Le Yu, Wei Zeng, Zhongxiang Fang, Gangcheng Wu, Wei Wei, Qingzhe Jin, Hui Zhang, Xingguo Wang
Summary: This systematic review and meta-analysis summarized available randomized controlled trials (RCTs) on the effects of omega-3 polyunsaturated fatty acids (PUFAs) supplementation on patients with metabolic syndrome (MetS) and related cardiovascular diseases (CVDs). The results showed that omega-3 PUFAs supplementation significantly reduced triglyceride, total cholesterol, blood pressure, inflammatory markers, and increased high-density lipoprotein levels.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Oncology
Idam de Oliveira-Junior, Eliana Aguiar Petri Nahas, Ana Cristina Cherem, Jorge Nahas-Neto, Rene Aloisio da Costa Vieira
Summary: Breast cancer is the most common type of cancer among women worldwide. Sentinel lymph node biopsy (SLNB) for T1 and T2 with negative axillae (N0) is accepted, but patients with T3-T4b tumors with N0 often undergo unnecessary axillary lymph node dissection. The study found that SLNB in T3/T4b tumors is safe and effective, with no association with ipsilateral axillary relapse.
Article
Biochemistry & Molecular Biology
Jonas Bernardes de Lima Filho, Leticia Freire, Eliana Aguiar Petri Nahas, Fabio Lera Orsatti, Claudio Lera Orsatti
FRONTIERS IN MOLECULAR BIOSCIENCES
(2020)
Article
Sport Sciences
Marcelo A. S. Carneiro, Gersiel N. de Oliveira Junior, Jairo F. R. de Sousa, Eddie F. C. Murta, Claudio L. Orsatti, Marcia A. Michelin, Edilson S. Cyrino, Fabio L. Orsatti
Summary: This study compared the effects of resistance training at different loads on postmenopausal women. The results showed that lower-load resistance training was more effective in increasing muscle mass, while there were no significant differences in inflammatory biomarkers, muscular strength, and physical performance between the two training groups.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2022)
Article
Nutrition & Dietetics
Marcelo A. S. Carneiro, Gersiel N. de Oliveira Junior, Jairo F. R. de Sousa, Claudio L. Orsatti, Eddie F. C. Murta, Marcia A. Michelin, Edilson S. Cyrino, Fabio L. Orsatti
Summary: The study aimed to investigate the impact of whole-body resistance training on various indicators in postmenopausal women. Results showed that load intensity does not determine the effect of resistance training on obesity-related indicators, body fat, and physical performance, although higher load intensity showed better improvements in extracellular heat shock proteins and the 400-meter walking test.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Oncology
Benedito Souza Almeida-Filho, Michelle Sako Omodei, Daniel A. B. Buttros, Eduardo Carvalho-Pessoa, Carla Priscila Carvalho-Pessoa, Heloisa De Luca Vespoli, Eliana Aguiar Petri Nahas
Summary: This study aimed to investigate the association between vitamin D concentration at diagnosis and overall survival, disease-free survival, and cancer-specific survival in postmenopausal women treated for breast cancer. The study found that vitamin D deficiency and insufficiency at diagnosis were independently associated with lower survival rates.
Article
Geriatrics & Gerontology
Fabio Lera Orsatti, Paulo Ricardo Prado Nunes, Marcelo Augusto da Silva Carneiro, Claudio Lera Orsatti, Markus Vinicius Campus Souza
Summary: This study found that there is heterogeneity in muscle strength response to resistance training in postmenopausal women, and the factors that contribute to this heterogeneity are training frequency and insulin resistance.
EXPERIMENTAL GERONTOLOGY
(2022)
Editorial Material
Obstetrics & Gynecology
Ana Lucia Ribeiro Valadares, Jaime Kulak Junior, Lucia Helena Simoes da Costa Paiva, Elizabeth Jeha Nasser, Celia Regina da Silva, Eliana Aguiar Petri Nahas, Luiz Francisco Cintra Baccaro, Marcio Alexandre Hipolito Rodrigues, Marco Aurelio Albernaz, Maria Celeste Osorio Wender, Maria Celia Mendes, Rita de Cassia de Maio Dardes, Rodolfo Strufaldi, Rogerio Cesar Bocardo, Luciano de Melo Pompei
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2022)
Article
Endocrinology & Metabolism
Claudio Lera Orsatti, Fabio Lera Orsatti, Thaiz Geovana Bezerra, Ana Quevedo, Eliana Aguiar Petri Nahas
Summary: This study aims to determine whether higher levels of circulating IL-15 are positively associated with improvement in insulin resistance. In a 9-month follow-up, postmenopausal women were divided into a higher IL-15 group and a lower IL-15 group, and it was found that the higher IL-15 group showed improvements in insulin resistance and insulin levels.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Eneida B. Schmitt, Claudio L. Orsatti, Luciana Cangussu, Flavia N. Bueloni-Dias, Priscila F. Poloni, Daniel Spadoto-Dias, Eliana A. P. Nahas
Summary: The aim of this study was to evaluate the effect of vitamin D supplementation alone on the adipokine profile of postmenopausal women. 160 women were randomly assigned to either oral supplementation with 1,000 IU cholecalciferol/d or a placebo. After 9 months, vitamin D supplementation was associated with increased adiponectin and decreased resistin levels, suggesting a beneficial effect on the adipokine profile of postmenopausal women with vitamin D deficiency.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Article
Obstetrics & Gynecology
R. Bonassi Machado, L. de Melo Pompei, E. A. P. Nahas, J. Nahas-Neto, L. da Costa-Paiva, S. Y. O. Del Debbio, M. Badalotti, M. C. O. Wender, A. M. Cruz
Summary: This study evaluated the efficacy and safety of oral ultra-low-dose continuous combination of 17 beta-estradiol (17β-E2) and norethisterone acetate (NETA) in postmenopausal Brazilian women. The group treated with 0.5 mg 17β-E2/0.1 mg NETA showed a significant reduction in the frequency and severity of vasomotor symptoms compared to the placebo group. Adverse events were comparable between the groups, but there were more complaints of vaginal bleeding in the 0.5 mg 17β-E2/0.1 mg NETA group.
Article
Endocrinology & Metabolism
Raissa Holanda Melo, Ana Gabriela Pontes, Lucia Regina Marques Gomes Delmanto, Flavia Neves Bueloni-Dias, Heloisa De Luca Vespoli, Eliana Aguiar Petri Nahas
Summary: HbA1c showed high sensitivity and specificity in the diagnosis of prediabetes in young women with PCOS, compared to OGTT.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Luiz Francisco Cintra Baccaro, Lucia Helena Simoes da Costa Paiva, Elizabeth Jeha Nasser, Ana Lucia Ribeiro Valadares, Celia Regina da Silva, Eliana Aguiar Petri Nahas, Jaime Kulak Junior, Marcio Alexandre Hipolito Rodrigues, Marco Aurelio Albernaz, Maria Celeste Osorio Wender, Maria Celia Mendes, Rita de Cassia de Maio Dardes, Rodolfo Strufaldi, Rogerio Cesar Bocardo, Luciano de Melo Pompei
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2022)
Article
Obstetrics & Gynecology
Camila Miranda, Vinicius Faria Borges de Morais, Fernanda Maria Martins, Danyelle Cristina Silva Pelet, Claudio Lera Orsatti, Luciana Mendes Cangussu-Oliveira, Eliana Aguiar Petri Nahas, Samarita Beraldo Santagnello, Rodolfo Ferreira de Paula, Markus Vinicius Campos Souza, Fabio Lera Orsatti
Summary: The study verified that absolute ALM (<15 kg) is the most suitable parameter for predicting osteoporosis in postmenopausal women based on LMM. ALM and ALM index were associated with osteoporosis at the lumbar spine, while only ALM was associated with osteoporosis at the femoral neck.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)
Article
Obstetrics & Gynecology
Ludmila M. N. Bercaire, Mario Cavagna, Nilka F. Donadio, Andressa R. Rocha, Rafael Portela, Vanessa R. Alves, Thamara B. B. Santos, Felipe Cavagna, Artur Dzik, Luiz H. Gebrim, Eliana A. P. Nahas
JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA
(2020)
Article
Obstetrics & Gynecology
Rogerio Bonassi Machado, Luciano de Melo Pompei, Rosires Andrade, Eliana Nahas, Cristina Guazzelli, Maria Celeste Wender, Achilles Machado Cruz
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2020)