Review
Biochemistry & Molecular Biology
Itay Aizenbud, Asaf Wilensky, Galit Almoznino
Summary: Periodontal disease is a chronic inflammatory condition that leads to bone and tooth loss. It has been linked to various systemic diseases, including diabetes and obesity. These diseases are part of the metabolic syndrome cluster, which significantly increases the risk of cardiovascular diseases, diabetes, and stroke. This review aims to investigate the correlation between periodontal disease and the components and outcomes of the metabolic syndrome cluster, providing insights into the fundamental mechanisms that link each condition with the metabolic syndrome. Understanding this interplay can lead to more effective treatments considering the broader impact of managing periodontal disease on systemic disease treatment, and vice versa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Maryam Kazemi, Joy Y. Kim, Stephen A. Parry, Ricardo Azziz, Marla E. Lujan
Summary: The systematic review and meta-analysis revealed that Black women with polycystic ovary syndrome have a greater tendency for adverse cardiometabolic risk profile compared to White women, despite lower triglyceride levels. These findings emphasize the importance of considering these disparities in diagnostic, monitoring, and management practices in Black women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Grzegorz K. Jakubiak, Kamila Osadnik, Mateusz Lejawa, Tadeusz Osadnik, Marcin Golawski, Piotr Lewandowski, Natalia Pawlas
Summary: Metabolic syndrome is the coexistence of factors that increase the risk for type 2 diabetes and cardiovascular disease, and it is associated with oxidative stress. Among the components of metabolic syndrome, obesity and insulin resistance show the strongest association with oxidative stress.
Review
Chemistry, Medicinal
Azar Hosseini, Bibi Marjan Razavi, Maciej Banach, Hossein Hosseinzadeh
Summary: Quercetin, as an important flavonoid, has potential effects in improving symptoms of metabolic syndrome, but further research and clinical trials are needed to determine its true clinical value.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Paula N. Brandao-Lima, Gabrielli B. de Carvalho, Tanyara B. Payolla, Flavia M. Sarti, Regina M. Fisberg, Fiona C. Malcomson, John C. Mathers, Marcelo M. Rogero
Summary: This study evaluated the levels of 21 miRNAs in plasma according to MetS components and sex in adults. The results showed that miR-16 and miR-363 levels were reduced in women with MetS, while men with one or more risk factors showed higher levels of miR-let-7c and miR-30a. Individuals with raised waist circumference, blood pressure, low HDL-cholesterol concentrations, and high fasting plasma glucose and/or insulin resistance exhibited specific miRNA patterns in plasma. These findings suggest that plasma miRNA levels may serve as early biomarkers for the cardiometabolic components of MetS and highlight sex differences in individuals with MetS.
Article
Public, Environmental & Occupational Health
Ibrahim Mahmoud, Nabil Sulaiman
Summary: This study estimates the prevalence of MetS and its associated risk factors in the UAE. The results show a high burden of MetS, particularly among Emirati women and Asian non-Arab men. Aggressive intervention strategies are recommended to prevent the development of cardiovascular diseases.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Juha Auvinen, Joona Tapio, Ville Karhunen, Johannes Kettunen, Raisa Serpi, Elitsa Y. Dimova, Dipender Gill, Pasi Soininen, Tuija Tammelin, Juha Mykkanen, Katri Puukka, Mika Kahonen, Emma Raitoharju, Terho Lehtimaki, Mika Ala-Korpela, Olli T. Raitakari, Sirkka Keinanen-Kiukaanniemi, Marjo-Riitta Jarvelin, Peppi Koivunen
Summary: Lower Hb levels may be beneficial for metabolic health, associated with lower body mass index, better glucose tolerance and other metabolic profiles, lower inflammatory load, and blood pressure.
Review
Nutrition & Dietetics
Lucia Melguizo-Rodriguez, Victor J. Costela-Ruiz, Enrique Garcia-Recio, Elvira De Luna-Bertos, Concepcion Ruiz, Rebeca Illescas-Montes
Summary: The prevalence of hypovitaminosis D has been increasing in developed countries due to lifestyle changes and unhealthy habits. Scientific evidence shows an inverse relationship between vitamin D deficiency and metabolic syndrome (MetS), with supplementation helping improve outcomes in individuals with MetS. Maintaining optimal vitamin D concentrations is proposed as a preventive strategy against MetS.
Review
Peripheral Vascular Disease
Guanghong Jia, James R. Sowers
Summary: Insulin resistance and diabetes have been shown to increase the risk of developing hypertension, vascular stiffness, and cardiovascular disease. There are complex interactions and promotion mechanisms between these diseases, including inappropriate activation of the renin-angiotensin-aldosterone system and sympathetic nervous system.
Review
Endocrinology & Metabolism
Poli Mara Spritzer, Ramon Bossardi Ramos, Lucas Bandeira Marchesan, Monica de Oliveira, Enrico Carmina
Summary: A systematic review and meta-analysis of metabolic traits in Brazilian women with PCOS revealed that they have a worse metabolic profile than women without PCOS, with higher prevalence of obesity, metabolic syndrome and impaired glucose tolerance. The lipid profile was also more adverse in PCOS women.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Review
Endocrinology & Metabolism
Pablo Panico, Myrian Velasco, Ana Maria Salazar, Arturo Picones, Rosa Isela Ortiz-Huidobro, Gabriela Guerrero-Palomo, Manuel Eduardo Salgado-Bernabe, Patricia Ostrosky-Wegman, Marcia Hiriart
Summary: Exposure to arsenic in drinking water is a global health problem associated with an increased risk of developing metabolic diseases. Metabolic syndrome is a complex pathology that results from the interaction between environmental and genetic factors, and is linked to an increased risk of developing type 2 diabetes, cardiovascular diseases, and cancer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Reyna Rodriguez-Mortera, Russell Caccavello, Ricardo Hermo, Maria Eugenia Garay-Sevilla, Alejandro Gugliucci
Summary: In a study comparing obese adolescents to lean controls, it was found that obese participants exhibited higher levels of hepcidin, ferritin, and IL-6. Differences in iron metabolism markers were not significant between the two groups except for ferritin. Hepcidin levels in obese adolescents were more correlated with inflammation and metabolic alterations than with iron metabolism.
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, Chih-Yao Hou, Wei-Hsuan Hsu, You-Lin Tain
Summary: Metabolic syndrome (MetS) has developmental origins, which can be programmed by adverse early-life conditions. Early interventions have potential to prevent MetS, and mechanism-targeted strategies including antioxidants and probiotics are being explored. Further research is needed to determine insults, mechanisms, and reprogramming strategies for clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Ana Maria Garcia-Munoz, Ana I. Garcia-Guillen, Desiree Victoria-Montesinos, Maria Salud Abellan-Ruiz, Begona Alburquerque-Gonzalez, Fernando Canovas
Summary: Metabolic syndrome is linked to increased risks of cardiovascular disease and type 2 diabetes, further exacerbated by a sedentary lifestyle and situations like the COVID-19 pandemic. Recent studies suggest that consumption of polyphenol-rich fruits and vegetables has a protective effect in reducing cardiovascular risk. Hibiscus sabdariffa (HS) in combination with other plant extracts has been gaining attention for its potential in treating metabolic syndrome. A systematic review and meta-analysis of randomized clinical trials were conducted to examine the effects of HS with other plant extracts on metabolic syndrome prevention, revealing improvements in anthropometric parameters, blood pressure, and lipid profile.