Article
Ophthalmology
Bhavya Gorimanipalli, Sumitha Muthu, Rohit Shetty, Reshma Raghunath Ranade, Pooja Khamar
Summary: The effectiveness of vision therapy (VT) in treating patients with chronic presumed refractory dry eye disease (DED) and concurrent nonstrabismic binocular vision anomalies (NSBVAs) was evaluated in this study. A total of 32 patients were prospectively evaluated and showed significant improvement in binocular vision parameters and symptoms after VT. It is important to diagnose and treat NSBVAs in patients with DED to ensure complete relief of symptoms and patient satisfaction.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Zhang Zhang, Xinrong Zou, Wenwen Xue, Pei Zhang, Shanshan Wang, Haidong Zou
Summary: The study investigated the ocular surface commensal bacteria profiles of patients with diabetes mellitus and dry eye disease, revealing differences in microbial composition between the groups. Patients with diabetes mellitus and dry eye disease had a more complex microbial composition compared to other groups, with unique core genera identified in each group. The findings provide insights into the microbial profile of dry eye disease in patients with diabetes mellitus.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Han Qiao, Zhuo Xu, Mengchi Sun, Shuwen Fu, Fangxue Zhao, Danping Wang, Zhonggui He, Yinglei Zhai, Jin Sun
Summary: In this study, RBM liposomal eye drops were designed and optimized for the treatment of dry eye disease (DED). The RBM liposomes showed better stability, slow-release rate, and longer residence time on the ocular surface compared to suspensions. They reduced the drug dose and irritation to the ocular surface while maintaining the same efficacy and increasing the concentration in the cornea and aqueous humor.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Medicine, General & Internal
Shuo Yang, Yaying Wu, ChunYang Wang, Xiuming Jin
Summary: This review summarizes the various ion-channels related to dry eye, their functions, and distribution. It also discusses the research results of different compounds targeting these channels. Further understanding the relationship between ion-channels and dry eye is crucial for targeted drug therapy.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Dongkyu Jeon, Ikhyun Jun, Ho K. Lee, Jinhong Park, Bo-Rahm Kim, Kunhi Ryu, Hongchul Yoon, Tae-im Kim, Wan Namkung
Summary: The study identified Cact-3 as a novel CFTR activator that can stimulate chloride secretion in ocular epithelium and alleviate symptoms in a dry eye disease mouse model. This suggests that Cact-3 could be a potential drug candidate for the treatment of dry eye disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Daniele Gaudenzi, Tommaso Mori, Salvatore Crugliano, Antonella Grasso, Carlo Frontini, Antonella Carducci, Siddharth Yadav, Roberto Sgrulletta, Emiliano Schena, Marco Coassin, Antonio Di Zazzo
Summary: Dry eye disease (DED) is a common condition that leads patients to seek medical attention. Accurate diagnosis is important for relieving patient discomfort and preventing long-term ocular surface damage. Currently, subjective tests may result in variations in diagnosis. However, the use of anterior segment optical coherence tomography (AS-OCT) and ocular hygrometer provide fast, accurate, and cost-effective diagnostic methods.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Bhubanananda Sahu, Isha Chug, Hemant Khanna
Summary: The eye is a crucial area for the development of gene therapies, with the FDA approval of the first gene-therapy drug for a form of congenital blindness sparking numerous studies to develop gene therapies for other eye diseases. Research has revealed new insights into the benefits and limitations of drug-delivery routes to different parts of the eye.
Review
Biochemistry & Molecular Biology
Maurizio Rolando, Stefano Barabino
Summary: Dry eye disease is a multifactorial condition that is caused by reduced tear secretion, increased tear water evaporation, or the production of poor-quality tears. Recent studies have found that vitamin D supplementation may be an effective alternative therapy for patients with DED who do not respond to conventional treatments, possibly due to its positive effect on modulating immune and inflammatory responses. This review focuses on the pathogenesis and treatment of DED, with a special emphasis on the potential role of systemic administration of vitamin D as a therapeutic approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chang Ho Yoon, Jin Suk Ryu, Jung Hwa Ko, Joo Youn Oh
Summary: This study revealed that aberrant fucosylation plays a crucial role in the pathogenesis of dry eye disease (DED) and may serve as a novel target for DED therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ana Lopez-Machado, Natalia Diaz-Garrido, Amanda Cano, Marta Espina, Josefa Badia, Laura Baldoma, Ana Cristina Calpena, Eliana B. Souto, Maria Luisa Garcia, Elena Sanchez-Lopez
Summary: The study developed lactoferrin-loaded liposomes coated with hyaluronic acid, which showed potential in reversing dry eye symptoms and possessing anti-inflammatory efficacy without causing ocular irritation. This innovative nanotechnological tool could offer a promising approach in the treatment of Dry Eye Disease.
Review
Biochemistry & Molecular Biology
Youssof Eshac, Rachel L. Redfern, Vinay Kumar Aakalu
Summary: The ocular surface is responsible for maintaining a clear moist refractive surface and protecting the eye from exogenous pathogens, with antimicrobial peptides playing a crucial role in the immune response during both healthy states and dry eye diseases. These peptides have various functions such as neutralizing microbial threats, promoting wound healing, and modulating immunity, making them potential therapeutic targets for ocular surface diseases and dry eye.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Louis Tong, Florentin Constancias, Aihua Hou, Song Lin Chua, Daniela I. Drautz-Moses, Stephan Christoph Schuster, Liang Yang, Rohan B. H. Williams, Staffan Kjelleberg
Summary: The study describes the conjunctival microbiome in people with mild dry eye in Singapore and found that the microbial composition was similar to age-matched controls. Age was identified as an important factor that affects the composition of the conjunctival microbiome, and the relative abundance of specific microorganisms may vary according to the host environment.
FRONTIERS IN MEDICINE
(2022)
Article
Nutrition & Dietetics
Dalia Ng, Juan Carlos Altamirano-Vallejo, Alejandro Gonzalez-De La Rosa, Jose Navarro-Partida, Jorge Eugenio Valdez-Garcia, Ricardo Acosta-Gonzalez, Juan Carlos Martinez Camarillo, Andres Bustamante-Arias, Juan Armendariz-Borunda, Arturo Santos
Summary: Polyphenols have shown potential in preventing and treating chronic diseases due to their antioxidant, anti-inflammatory, neuroprotective, and anti-angiogenic effects. However, their limited stability and bioavailability pose challenges. In this study, an oral formulation containing polyphenols and omega-3 fatty acids, along with a surfactant, was evaluated for its safety and efficacy in patients with dry eye disease (DED). The formulation demonstrated improved symptoms and tear film status in patients with mild to moderate DED.
Review
Microbiology
Qingyu An, Haidong Zou
Summary: People with diabetes mellitus are at a higher risk of developing dry eye disease (DED). The ocular surface microbiota (OSM) differs significantly between patients with DED and healthy people, indicating that OSM dysbiosis may contribute to the pathogenesis of DED. The high-glucose environment and subsequent pathological changes can cause OSM dysbiosis, leading to ocular surface inflammation and tear composition alterations.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Immunology
Yun Qi, Yong Wan, Tianhui Li, Ming Zhang, Yu Song, Yaguang Hu, Yining Sun, Li Li
Summary: In this study, differences in the composition and function of the ocular microbiome were observed between patients with dry eye concomitant with autoimmune disease and those without autoimmune disease, suggesting potential variations in pathogenesis and disease severity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Ophthalmology
Mehmet Tetikoglu, Zafer Yueksel, Serdar Aktas, Haci Murat Sagdik, Fatih Ozcura
INTERNATIONAL OPHTHALMOLOGY
(2018)
Article
Ophthalmology
Haci Murat Sagdik, Fatma Ucar, Mehmet Tetikoglu, Serdar Aktas, Fatih Ozcura, Havva Kocak, Salim Neselioglu, Funda Eren
INTERNATIONAL OPHTHALMOLOGY
(2018)
Editorial Material
Obstetrics & Gynecology
Berna Haliloglu Peker, Erdin Ilter, Hakan Peker, Aygen Celik, Ali Gursoy, Onur Gunaldi
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2018)
Article
Anesthesiology
Talat Ercan Serifsoy, Serkan Tulgar, Onur Selvi, Ozgur Senturk, Erdin Ilter, Berna Haliloglu Peker, Zeliha Ozer
JOURNAL OF CLINICAL ANESTHESIA
(2020)
Article
Obstetrics & Gynecology
Hakan Peker, Berna Haliloglu Peker
Summary: The study compared the morphological characteristics of pelvis and urethra in nulliparous pregnant women with and without stress urinary incontinence (SUI) using 3D high-frequency endovaginal ultrasound (3D-EVUS). Women with SUI were found to have longer levator hiatus transverse diameter, shorter anteroposterior diameter, and wider symphysis angle compared to those without SUI. Additionally, a rhabdosphincter volume of less than 1.26 cm(3) was found to be a sensitive and specific predictor of SUI in nulliparous pregnant women.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Ophthalmology
Orhan Altunel, Saadet Gultekin Irgat, Fatih Ozcura
Summary: Our results objectively demonstrate early nuclear lens density changes using Scheimpflug images in eyes with n-AMD that were treated with repeated ranibizumab injections for 12 months.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Obstetrics & Gynecology
Sule Gokyildiz Surucu, Burcu Avcibay Vurgec, Derya Kaya Senol, Ebru Gozuyesil, Dilek Bilgic, Cemile Onat Koroglu, Gulseren Daglar, Nilgun Avci, Gulsen Cayir, Berna Haliloglu Peker, Nezihe Kizilkaya Beji, Hakan Peker, Onay Yalcin
Summary: This study aimed to explore the relationships between women's sexual functions, sexual quality of life, and depression in the pregnancy and postpartum periods. The results showed high rates of sexual dysfunction among participants during these periods, with a decrease in sexual quality of life as pregnancy progressed but a significant increase in the postpartum period. Depression symptoms were found to be associated with increased sexual dysfunction and decreased sexual quality of life in both pregnancy and postpartum periods, with an improvement in sexual quality of life as depressive symptoms decreased, especially in the sixth month postpartum.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Ophthalmology
Saadet Gultekin Irgat, Fatih Ozcura
Summary: This study found that intravitreal aflibercept treatment is highly effective in improving visual acuity and central macular thickness in patients with macular edema caused by branch retinal vein occlusion, regardless of the presence of serous retinal detachment.
ARQUIVOS BRASILEIROS DE OFTALMOLOGIA
(2023)
Letter
Ophthalmology
Fatih Ozcura
INTERNATIONAL OPHTHALMOLOGY
(2022)
Letter
Ophthalmology
Fatih Ozcura, Saadet Gultekin Irgat
ARQUIVOS BRASILEIROS DE OFTALMOLOGIA
(2020)
Letter
Medicine, General & Internal
Fatih Ozcura, Saadet Gultekin Irgat
EURASIAN JOURNAL OF MEDICINE
(2020)
Letter
Ophthalmology
Fatih Ozcura
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2020)
Letter
Ophthalmology
Fatih Ozcura, Volkan Dayanir
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2018)
Article
Ophthalmology
Mehmet Tetikoglu, Muhammed Mustafa Kurt, Haci Murat Sagdik, Serdar Aktas, Medine Asli Yildirim, Fatih Ozcura
CUTANEOUS AND OCULAR TOXICOLOGY
(2018)
Letter
Ophthalmology
Fatih Ozcura, Nilgun Yildirim
JOURNAL OF OPTOMETRY
(2018)