Journal
CLEVELAND CLINIC JOURNAL OF MEDICINE
Volume 77, Issue 10, Pages 689-+Publisher
CLEVELAND CLINIC
DOI: 10.3949/ccjm.77gr.2010
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Autosomal dominant (early-onset) Alzheimer disease and the much more common sporadic Alzheimer disease share a common pathology but not necessarily a common pathophysiology. Common cardiovascular comorbidities are associated with increased risk for Alzheimer disease and offer opportunities for intervention. Class I evidence for prevention is extremely limited. The overall body of evidence suggests the best time to intervene is in midlife, not in old age.
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