Article
Surgery
Anne M. Sescleifer, Caitlin A. Francoisse, Tamara A. Osborn, Jeffrey D. Rector, Alexander Y. Lin
Summary: By modifying patients' postoperative photographs, the study found that lip angle has a smaller impact on appearance ratings compared to scar severity. Although families are more concerned about scarring, clinically, the angle of the cleft lip repair is more likely to influence the perception of the surgical result.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Mohammad Khursheed Alam, Ahmed Ali Alfawzan, Fatema Akhter, Haytham Jamil Alswairki, Prabhat Kumar Chaudhari
Summary: This study investigated the variation between non-syndromic cleft lip and/or palate (NSCLP) and non-cleft (NC) subjects in relation to lip morphology (LM) and nasolabial angle (NLA). The results showed significant disparities in LM-1 and NLA between NSCLP and NC individuals.
APPLIED SCIENCES-BASEL
(2022)
Review
Dentistry, Oral Surgery & Medicine
Robert Frederick, Amy Claire Hogan, Natalie Seabolt, Rose Mary S. Stocks
Summary: This article emphasizes the benefits of a multidisciplinary team approach in the systemic management of patients with cleft lip and cleft palate, and suggests the addition of a registered dietitian to the care team. An ideal cleft palate care team should focus on a comprehensive, collaborative, and family-centered approach. While care teams may vary depending on context and location, there are still some key principles.
Article
Chemistry, Multidisciplinary
Natalia Kaczorowska, Marcin Mikulewicz
Summary: This paper examines cephalometric parameters in patients with cleft lip and palate and cleft lip, and compares the differences between these patient groups. The results show that cleft palate surgery has an effect on the forward growth of the maxilla.
APPLIED SCIENCES-BASEL
(2022)
Article
Cell Biology
Xiaofeng Li, Yu Tian, Ling Qiu, Shu Lou, Guirong Zhu, Yue Gao, Lan Ma, Yongchu Pan
Summary: This study utilized an expression quantitative trait locus (eQTL) dataset to identify multiple associations with the risk of non-syndromic cleft lip with or without cleft palate (NSCL/P). Functional annotation analysis showed that these risk loci were significantly enriched in transcription regulation and chromatin open regions on the genome. Additionally, these susceptible genes were closely related to cell fate determination, the pluripotency of stem cells, and Wnt signaling pathways.
Review
Genetics & Heredity
Arwa Babai, Melita Irving
Summary: Orofacial clefting is a common birth defect worldwide, presenting as cleft lip only, isolated cleft palate or cleft lip and palate. It has a diverse genetic background influenced by gene-gene and gene-environment interaction, resulting in syndromic and nonsyndromic orofacial clefts. Orofacial clefts cause significant physiological difficulties, impacting feeding, speech and language development, and other developmental aspects, leading to increased social and financial burden. The management of orofacial clefts requires a multidisciplinary team approach.
Article
Surgery
Amy S. Xue, Edward P. Buchanan, Larry H. Hollier
Summary: This article provides an overview of characteristics of unilateral cleft lip and nasal deformity, as well as its management options including presurgical orthopedics, operative techniques, and postsurgical care. Specific surgical techniques such as rotation-advancement and straightline repairs are discussed in detail, along with current concepts in primary cleft nose repair.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Health Care Sciences & Services
Chin-Han Chang, Chi-Hua Chang, Jui-Pin Lai, Shiu-Shiung Lin, Yu-Jen Chang
Summary: This study investigated the prevalence of tooth agenesis, tooth malformation, and eruption patterns of upper canines/first premolars in Taiwanese children. The results suggest a strong correlation between the patterns of dental anomalies and the cleft sites in cleft lip and cleft palate patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Chihiro Iwaya, Akiko Suzuki, Junichi Iwata
Summary: Cleft lip and palate is a common congenital birth defect with varied causes. Recent studies suggest that non-coding RNAs, specifically microRNAs, may play a role in the development of cleft lip and palate. This review examines the potential of microRNAs as causative mechanisms in humans and mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Otorhinolaryngology
David O'Neil Danis, Kevin Bachrach, Jacquelyn Piraquive, Alexander P. Marston, Jessica R. Levi
Summary: The study found an association between neonatal abstinence syndrome (NAS) and cleft lip and/or cleft palate (CLP), specifically isolated cleft palate, suggesting that prenatal exposure to opioids may be an environmental risk factor in the development of CLP.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Genetics & Heredity
Benjamin L. Green, Grace-Ann Fasaye, Sarah G. Samaranayake, Anna Duemler, Lauren A. Gamble, Jeremy L. Davis
Summary: Pathogenic and likely pathogenic variants in the CDH1 gene are associated with increased risk of gastric and breast cancers, as well as hereditary cleft lip and palate (CLP). This study aimed to determine the prevalence of CLP in families with these variants. The results showed a high prevalence of CLP in families carrying CDH1 variants, with no clear genotype-phenotype pattern. Genetic testing for CDH1 should be considered in families with CLP and a history of gastric or lobular breast cancer.
FRONTIERS IN GENETICS
(2022)
Article
Surgery
Amy S. Xue, Edward P. Buchanan, Larry H. Hollier
Summary: This article describes the characteristics and management of bilateral cleft lip and nasal deformity, including presurgical orthopedics, operative techniques, and postsurgical care.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Public, Environmental & Occupational Health
Jeong Yeop Ryu, Tae Hyun Park, Byung Chae Cho, Kang Young Choi
Summary: This study assessed the epidemiology of cleft lip with or without palate (CL/P) in South Korea from 2006 to 2018. The prevalence of CL/P was found to be 1.96 per 1000 live births, which is one of the highest worldwide. CL/P children had higher risks of premature births and mortality, with cardiovascular anomalies being the most common cause of death in syndromic CL/P.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Genetics & Heredity
Xi Cheng, Fengzhou Du, Xiao Long, Jiuzuo Huang
Summary: This article provides an overview of the genetic inheritance model of non-syndromic cleft lip with or without palate (NSCL/P), including both monogenic and polygenic perspectives. Representative genes and regions are presented, along with existing association studies and corresponding loci in the Chinese population. The potential of using polygenic risk scores for risk stratification of NSCL/P is highlighted, offering promising avenues for improved risk assessment and personalized interventions.
Review
Immunology
Elizabeth Gershater, Yuan Liu, Binglan Xue, Min Kyung Shin, Hyun Koo, Zhong Zheng, Chenshuang Li
Summary: Orofacial cleft disorders, particularly cleft lip and/or palate (CL/P), are common congenital disorders worldwide. This review examines the differences in microbiota between CL/P patients and healthy individuals at various anatomical locations. Pathogenic bacterial and fungal species were found to be prevalently and/or specifically detected in CL/P patients, which may aid in the development of CL/P-specific microbiota management strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Veterinary Sciences
Enio Moura, Jose L. Wagner, Silvana M. Cirio, Claudia T. Pimpao
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION
(2015)
Article
Veterinary Sciences
E. Moura, C. T. Pimpao
JOURNAL OF SMALL ANIMAL PRACTICE
(2017)
Article
Anatomy & Morphology
E. Moura, B. Thon, C. T. Pimpao
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2017)
Article
Genetics & Heredity
Enio Moura, Silvana M. Cirio, Jose A. Villanova
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2010)
Article
Veterinary Sciences
Enio Moura, Silvana M. Cirio
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION
(2010)
Review
Veterinary Sciences
Enio Moura, Isabel S. Rotenberg, Claudia T. Pimpao
TOPICS IN COMPANION ANIMAL MEDICINE
(2019)
Article
Veterinary Sciences
Enio Moura, Saulo Henrique Weber, Jair Rodini Engracia Filho, Claudia Turra Pimpao
TOPICS IN COMPANION ANIMAL MEDICINE
(2020)
Article
Veterinary Sciences
E. Moura, S. R. T. Daltro, D. M. Sas, J. R. Engracia Filho, M. R. Farias, C. T. Pimpao
Summary: Through targeted next-generation sequencing of the EDA gene in a male poodle with X-linked hypohidrotic ectodermal dysplasia, it was found that the cause of the dysplasia is not point variants, small deletions, or insertions in the exons and splice sites of the gene. Patients with XLHED phenotype may have other types of variants in the EDA gene or in other genes of the EDA signaling pathway.
JOURNAL OF SMALL ANIMAL PRACTICE
(2021)
Review
Veterinary Sciences
Enio Moura, Ubirajara Iobe Tasqueti, Rita Maria Venancio Mangrich-Rocha, Jair Rodini Engracia Filho, Marconi Rodrigues de Farias, Claudia Turra Pimpao
Summary: Inborn errors of metabolism are genetic disorders caused by a block in a metabolic pathway, affecting both humans and animals. They are individually rare diseases but relatively common as a group. Inbreeding in dog breeds increases the risk of disease recurrence due to the higher frequency of heterozygotes. Familiarity with this subject among general practitioners is significant in identifying new cases and increasing knowledge about inborn errors of metabolism.
TOPICS IN COMPANION ANIMAL MEDICINE
(2022)
Article
Developmental Biology
Enio Moura, Ubirajara Iobe Tasqueti, Antonia Maria R. B. Prado, Acir Jose S. Franco, Claudia Turra Pimpao
Summary: The study examines a pair of conjoined twin pigs with craniofacial duplication, presenting a similar pattern of abnormalities as human diprosopus and other species. The scarcity of detailed studies on craniofacial duplication in pigs and the lack of a definitive explanation on the etiology and pathogenesis of conjoined twins highlight the need for further research and publication of more cases.
BIRTH DEFECTS RESEARCH
(2023)
Review
Dermatology
E Moura, SM Cirio
VETERINARY DERMATOLOGY
(2004)
