Article
Cardiac & Cardiovascular Systems
Kazunori Omote, Hidemi Sorimachi, Masaru Obokata, Yogesh N. Reddy, Frederik H. Verbrugge, Massar Omar, Hilary M. DuBrock, Margaret M. Redfield, Barry A. Borlaug
Summary: This study aimed to characterize the pathophysiology of pulmonary vascular disease in left heart disease (PH-LHD) and found that PH-LHD patients displayed distinct features, such as poorer left atrial function and more severe right ventricular dysfunction at rest, as well as more severe impairments in cardiac output and oxygen delivery during exercise. Further study is required to identify innovative treatments for the pulmonary vasculature in PH-LHD.
EUROPEAN HEART JOURNAL
(2022)
Article
Health Care Sciences & Services
Igor Volodarsky, Katerina Kerzhner, Dan Haberman, Valeri Cuciuc, Lion Poles, Alex Blatt, Elena Kirzhner, Jacob George, Gera Gandelman
Summary: Right heart catheterization is a diagnostic procedure used to diagnose pulmonary hypertension. It includes measuring blood pressure in heart chambers, estimating cardiac output, and calculating pulmonary vascular resistance. The thermodilution and indirect Fick methods are commonly used to evaluate cardiac output, but there is a discrepancy between the values obtained by the two methods.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Barry A. Borlaug, John Blair, Martin W. Bergmann, Heiko Bugger, Dan Burkhoff, Leonhard Bruch, David S. Celermajer, Brian Claggett, John G. F. Cleland, Donald E. Cutlip, Ira Dauber, Jean-Christophe Eicher, Qi Gao, Thomas M. Gorter, Finn Gustafsson, Chris Hayward, Jan van der Heyden, Gerd Hasenfuss, Scott L. Hummel, David M. Kaye, Jan Komtebedde, Joseph M. Massaro, Jeremy A. Mazurek, Scott McKenzie, Shamir R. Mehta, Mark C. Petrie, Marco C. Post, Ajith Nair, Andreas Rieth, Frank E. Silvestry, Scott D. Solomon, Jean-Noel Trochu, Dirk J. Van Veldhuisen, Ralf Westenfeld, Martin B. Leon, Sanjiv J. Shah
Summary: In heart failure patients, those with latent pulmonary vascular disease may worsen with atrial shunt therapy, while those without latent pulmonary vascular disease may benefit.
Article
Cardiac & Cardiovascular Systems
Sergio Caravita, Claudia Baratto, Aurora Filippo, Davide Soranna, Celine Dewachter, Antonella Zambon, Giovanni Battista Perego, Denisa Muraru, Michele Senni, Luigi P. Badano, Gianfranco Parati, Jean-Luc Vachiery, Marat Fudim
Summary: A study found that there is a latent pulmonary vascular disease among patients with heart failure with preserved ejection fraction. These patients have altered ventilatory control, increased pulmonary vascular reactivity, and poor prognosis.
JACC-HEART FAILURE
(2023)
Review
Biochemistry & Molecular Biology
Argen Mamazhakypov, Abdirashit Maripov, Akpay S. Sarybaev, Ralph Theo Schermuly, Akylbek Sydykov
Summary: Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure and vascular remodeling. Circulating osteopontin has been suggested as a biomarker of PH progression and right ventricular dysfunction. Preclinical studies have shown that osteopontin plays a role in PH pathogenesis by modulating various cellular processes. This article provides an overview of osteopontin regulation and its impact on pulmonary vascular remodeling, as well as the potential of targeting osteopontin for PH management.
Article
Cardiac & Cardiovascular Systems
Ghaleb Khirfan, Manshi Li, Xiaofeng Wang, Raed A. Dweik, Gustavo A. Heresi, Adriano R. Tonelli
Summary: PVRI appears to have a stronger association than PVR with disease severity markers in PAH, but both PVR and PVRI were similarly associated with hospitalizations and survival in the overall cohort. In obese patients, PVRI was a risk factor for first PAH hospitalization, while neither PVR nor PVRI were risk factors for mortality.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Respiratory System
Katherine Kearney, Eugene Kotlyar, Edmund M. T. Lau
Summary: Chronic heart failure syndrome is linked to pulmonary arterial hypertension and can lead to activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system. PAH is also associated with changes in skeletal and respiratory muscle functions, but exercise training can help reverse peripheral muscle dysfunction to some extent.
CLINICS IN CHEST MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Shih-Hung Hsiao, Chao-Sheng Hsiao, Kuan-Rau Chiou
Summary: The study assessed the prevalence and prognostic significance of systolic pulmonary regurgitation (PR) in patients with severe heart failure (HF), finding that systolic PR is associated with right ventricular dysfunction, high PVR, signs of low cardiac output, and pulmonary edema. It is independently linked to further cardiovascular events and significantly impacts cardiovascular outcomes.
Article
Cardiac & Cardiovascular Systems
Shih-Hung Hsiao, Chao-Sheng Hsiao, Kuan-Rau Chiou
Summary: This study evaluated the prevalence and prognostic significance of systolic pulmonary regurgitation (PR) in patients with severe heart failure (HF), revealing an association between systolic PR and high pulmonary vascular resistance (PVR) and right ventricular dysfunction, and a significant impact on cardiovascular outcomes.
Article
Cardiac & Cardiovascular Systems
Tadakatsu Inagaki, James T. Pearson, Hirotsugu Tsuchimochi, Daryl O. Schwenke, Shigeyoshi Saito, Takahiro Higuchi, Takeshi Masaki, Keiji Umetani, Mikiyasu Shirai, Yoshikazu Nakaoka
Summary: The study found impaired vasodilator responses in the right coronary artery of severe pulmonary hypertension rat models, which could be partially restored by endothelin-1 receptor antagonist treatment. This treatment improved RV function by attenuating right heart afterload and improving right coronary endothelial function, showing potential for preventing heart failure in severe PAH patients.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Salaheldin Ahmed, Abdulla Ahmed, Goran Radegran
Summary: Plasma levels of AMBP, LPL, and glyoxalase I may serve as potential biomarkers to distinguish HFpEF-PH from PAH, with a combination of these proteins yielding the largest AUC in discriminating between the two conditions. Further large-scale clinical studies are recommended to validate these findings.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Respiratory System
Jason Weatherald, Brianne Philipenko, David Montani, Pierantonio Laveneziana
Summary: CPET is a common tool for differential diagnosis of dyspnoea, with ventilatory inefficiency being a hallmark characteristic of pulmonary vascular diseases. Understanding the mechanisms and diagnostic implications of ventilatory inefficiency is crucial in managing patients with these conditions.
EUROPEAN RESPIRATORY REVIEW
(2021)
Article
Cardiac & Cardiovascular Systems
Nobutaka Kakuda, Eisuke Amiya, Masaru Hatano, Masaki Tsuji, Chie Bujo, Junichi Ishida, Hiroki Yagi, Akihito Saito, Koichi Narita, Yoshitaka Isotani, Kanna Fujita, Masahiko Ando, Shogo Shimada, Osamu Kinoshita, Minoru Ono, Issei Komuro
Summary: This study compared the hemodynamics and clinical events after heart transplantation in patients who received a left ventricular assist device as a bridge to transplantation, stratified by the severity of residual pulmonary vascular resistance. The results showed that patients with high residual pulmonary vascular resistance exhibited increased right and left atrial pressures and a higher occurrence of composite clinical events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Vladislav Chubuchny, Nicola Riccardo Pugliese, Claudia Taddei, Elisa Poggianti, Valentina Spini, Andrea Barison, Bruno Formichi, Edoardo Airo, Carolina Bauleo, Renato Prediletto, Luigi Emilio Pastormerlo, Michele Coceani, Marco Ciardetti, Christina Petersen, Emilio Pasanisi, Carlo Lombardi, Michele Emdin, Alberto Giannoni
Summary: The novel quantitative echocardiographic approach for the estimation of PAWP and PVR has high diagnostic accuracy in patients with heart failure and pulmonary hypertension, showing superior performance compared to previous recommendations and equations.
Review
Cardiac & Cardiovascular Systems
Miranda K. Culley, Stephen Y. Chan
Summary: This review discusses emerging concepts centered on endothelial senescence in pulmonary vascular disease. It proposes that endothelial senescence may serve as a unifying mechanism for pulmonary hypertension and highlights the link between aging and this disease. Additionally, it presents potential opportunities and barriers for targeting senescence in the diagnosis and treatment of pulmonary hypertension.
CIRCULATION RESEARCH
(2022)