Review
Biochemistry & Molecular Biology
Giovanna Gallo, Speranza Rubattu, Camillo Autore, Massimo Volpe
Summary: Natriuretic peptides (NPs) are important in regulating heart function and have beneficial effects in cardiovascular diseases. They serve as biomarkers for diagnosis and prognosis, and can guide treatment strategies for improved outcomes. Therapies based on the properties and regulation of NPs are being developed for heart failure, hypertension, and other cardiovascular conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Amera Halabi, Elizabeth Potter, Hilda Yang, Leah Wright, Julian W. Sacre, Jonathan E. Shaw, Thomas H. Marwick
Summary: This study investigated the association between clinical scores and biomarkers with subclinical LV dysfunction and evaluated their ability to identify patients who require echocardiography. The results showed a weak relationship between these assessment tools and subclinical LV dysfunction. They had limited ability to discriminate abnormal global longitudinal strain, diastolic function, and left ventricular mass.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Michael C. Wang, Bridget Dolan, Benjamin H. Freed, Lourdes Vega, Nikola Markoski, Amy E. Wainright, Bonnie Kane, Laura E. Seegmiller, Katharine Harrington, Alana A. Lewis, Sanjiv J. Shah, Clyde W. Yancy, Ian J. Neeland, Hongyan Ning, Donald M. Lloyd-Jones, Sadiya S. Khan
Summary: The FIT-HF pilot study aims to assess the feasibility of a quantitative risk-based strategy for enrolling participants into a pharmacist-led prevention program to reduce heart failure risk. Participants will undergo various screenings and interventions over a 1-year period, with the primary outcome being change in BNP levels at 1-year follow-up. Feasibility will be evaluated through monitoring retention rates.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Hitoshi Nakagawa, Takuya Kumazawa, Kenji Onoue, Yasuki Nakada, Tomoya Nakano, Satomi Ishihara, Naoto Minamino, Hiroshi Hosoda, Nobuhisa Iwata, Tomoya Ueda, Ayako Seno, Taku Nishida, Tsunenari Soeda, Satoshi Okayama, Makoto Watanabe, Rika Kawakami, Yoshihiko Saito
Summary: The study showed that overexpression of NEP in cardiomyocytes leads to increased degradation of natriuretic peptides in the heart, resulting in an exaggerated hypertrophic and fibrotic response to pressure overload.
Article
Cardiac & Cardiovascular Systems
Toru Kondo, Azmil H. Abdul-Rahim, Atefeh Talebi, William T. Abraham, Akshay S. Desai, Kenneth Dickstein, Silvio E. Inzucchi, Lars Kober, Mikhail N. Kosiborod, Felipe A. Martinez, Milton Packer, Mark Petrie, Piotr Ponikowski, Jean L. Rouleau, Marc S. Sabatine, Karl Swedberg, Michael R. Zile, Scott D. Solomon, Pardeep S. Jhund, John J. McMurray
Summary: A simple risk model can be used to identify HFrEF patients without AF who have a high risk of stroke, allowing for targeted use of prophylactic anticoagulant therapy.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Frederik H. Verbrugge, Kazunori Omote, Yogesh N. Reddy, Hidemi Sorimachi, Masaru Obokata, Barry A. Borlaug
Summary: Patients with HFpEF and normal NP levels exhibit mild diastolic dysfunction and preserved cardiac output reserve during exercise, despite marked elevation in filling pressures. These patients have higher morbidity and mortality compared to patients without heart failure, emphasizing the importance of this phenotype.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Mingming Yang, Toru Kondo, Jawad H. Butt, William T. Abraham, Inder S. Anand, Akshay S. Desai, Lars Kober, Milton Packer, Marc A. Pfeffer, Jean L. Rouleau, Marc S. Sabatine, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Pardeep S. Jhund, John J. McMurray
Summary: Patients with heart failure who have a history of stroke are at a high risk of subsequent cardiovascular events, regardless of ejection fraction. This study investigated the prevalence of stroke history in patients with heart failure and found that they had more vascular comorbidity and worse heart failure compared to those without stroke history. Targeting underutilization of guideline-recommended treatments might improve outcomes in this high-risk population.
EUROPEAN HEART JOURNAL
(2023)
Article
Health Care Sciences & Services
Akshay Khunte, Veer Sangha, Evangelos K. Oikonomou, Lovedeep S. Dhingra, Arya Aminorroaya, Bobak J. Mortazavi, Andreas Coppi, Cynthia A. Brandt, Harlan M. Krumholz, Rohan Khera
Summary: Artificial intelligence (AI) can detect left ventricular systolic dysfunction (LVSD) from noisy electrocardiograms (ECGs) obtained from wearable and portable devices. A novel strategy was developed to automate the detection of hidden cardiovascular diseases, such as LVSD, by training AI models on ECGs augmented with real-world noise sources. The noise-adapted model outperforms the standard model on ECGs augmented with portable ECG device noise at multiple signal-to-noise ratios (SNRs).
NPJ DIGITAL MEDICINE
(2023)
Review
Physiology
Gustavo Jose Justo da Silva, Raffaele Altara, George W. Booz, Alessandro Cataliotti
Summary: Atrial natriuretic peptide is a crucial cardiac hormone that helps maintain heart function through potent natriuretic, diuretic, and vasodilating actions. Its main effects involve promoting the function of different tissues and organs in the body, and it shows potential in cardiorenal protective actions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medical Laboratory Technology
Giuseppe Pinto, Barbara Colombo, Adriano Autieri, Luca Foppoli, Roberto Spoladore, Valentina Ardizzone, Alberto Margonato, Angelo Corti, Gabriele Fragasso
Summary: In patients with chronic systolic heart failure, vasostatin-1 and chromogranin A may serve as prognostic markers for cardiovascular events, providing complementary information to NT-proBNP and age, distinct from the association with left ventricular ejection fraction.
CLINICA CHIMICA ACTA
(2022)
Article
Cardiac & Cardiovascular Systems
Emil Wolsk, Brian Claggett, Rafael Diaz, Kenneth Dickstein, Hertzel C. Gerstein, Lars Kober, Eldrin F. Lewis, Aldo P. Maggioni, John J. McMurray, Jeffrey L. Probstfield, Matthew C. Riddle, Scott D. Solomon, Jean-Claude Tardif, Marc A. Pfeffer
Summary: Serial NP measurements can improve the prediction of imminent cardiovascular death or heart failure hospitalization in patients with coronary artery disease and type 2 diabetes. The absolute risk estimates provided can aid clinicians in decision-making and help patients understand their short-term risk profile.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Biochemistry & Molecular Biology
Riccardo Sarzani, Massimiliano Allevi, Chiara Di Pentima, Paola Schiavi, Francesco Spannella, Federico Giulietti
Summary: Cardiac natriuretic peptides are true hormones produced by cardiomyocytes, exerting systemic effects and contributing to cardiovascular health. They also have paracrine and autocrine activities on the heart, preventing cardiac dysfunction and promoting heart protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Abdulaziz Joury, Hector Ventura, Selim R. Krim
Summary: Early detection and risk stratification are crucial for patients with heart failure (HF). Various biomarkers have been investigated for their diagnostic, prognostic, and therapeutic roles in HF, including markers of myocardial stretch, neurohormonal activation, inflammation and oxidative stress, as well as cardiac hypertrophy, fibrosis, and remodeling. This paper summarizes the current evidence supporting the use of selected biomarkers in HF management, discusses potential factors limiting their use in clinical practice, and highlights the challenges of adopting a multi-biomarker strategy.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Biology
Tomoko Ichiki, Atsushi Jinno, Yoshihisa Tsuji
Summary: This review discusses the role of natriuretic peptides and their receptors in cardiovascular protection and bone growth. The natriuretic peptide system is useful in the treatment of conditions such as heart failure, hypertension, and dwarfism. Optimization of therapeutics for each disease state requires consideration of drug metabolism, delivery systems, and target receptors.
Article
Cardiac & Cardiovascular Systems
Antoni Bayes-Genis, Kieran F. Docherty, Mark C. Petrie, James L. Januzzi, Christian Mueller, Lisa Andreson, Biykem Bozkurt, Javed Butler, Ovidiu Chioncel, John G. F. Cleland, Ruxandra Christodorescu, Stefano Del Prato, Finn Gustafsson, Carolyn S. P. Lam, Brenda Moura, Rodica Pop-Busui, Petar Seferovic, Maurizio Volterrani, Muthiah Vaduganathan, Marco Metra, Giuseppe Rosano
Summary: Diagnosing heart failure is often difficult due to non-specific symptoms. This document explores the use of NT-proBNP as a biomarker for diagnosing heart failure in different clinical scenarios. Validated cut-points are provided for ruling in or ruling out acute and de novo heart failure. The concept of 'heart stress' is introduced, and a simple acronym FIND-HF is proposed for early diagnosis of heart failure.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Engineering, Biomedical
Vien T. Truong, Satya Shreenivas, Wojciech Mazur, Gregory F. Egnaczyk, Cassady Palmer, Sriram D. Rao, J. Eduardo Rame, Eugene S. Chung
Summary: The study suggests that preoperative end-diastolic left ventricular dimension (preLVEDD) is an independent predictor of mortality and adverse events in patients treated with centrifugal continuous-flow left ventricular assist device (CF-LVAD).
Article
Engineering, Biomedical
Robert S. Zhang, Thomas C. Hanff, Carli J. Peters, Peter T. Evans, Judy Marble, J. Eduardo Rame, Pavan Atluri, Kimberly Urgo, Monique S. Tanna, Jeremy A. Mazurek, Michael A. Acker, Marisa Cevasco, Edo Y. Birati, Joyce W. Wald
Summary: This study analyzed the characteristics and outcomes of patients who underwent continuous-flow left ventricular assist device (CF-LVAD) explantation at a large academic center. The overall survival rate for eligible patients during the follow-up period was 52%, and there were changes in left ventricular size and ejection fraction.
Review
Surgery
Diana C. Jimenez, Eric D. Warner, Danial Ahmad, Jake L. Rosen, Nawar Al-Rawas, Rohinton J. Morris, Rene Alvarez, J. Eduardo Rame, John W. Entwistle, H. Todd Massey, Vakhtang Tchantchaleishvili
Summary: This systematic review investigated the use of heparin in patients with heparin-induced thrombocytopenia undergoing orthotopic heart transplantation. The results showed that heparin use may be associated with fewer adverse effects compared to other anticoagulants, with no difference in 30-day mortality.
CLINICAL TRANSPLANTATION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Senthil Selvaraj, Kenneth B. Margulies, Supritha Dugyala, Erin Schubert, Ann Tierney, Zoltan Arany, Daniel A. Pryma, Svati H. Shah, J. Eduardo Rame, Daniel P. Kelly, Paco E. Bravo
Summary: This study examines whether exogenous ketone administration is noninferior to the ketogenic diet in achieving myocardial glucose suppression and whether serum beta-hydroxybutyrate levels can predict this suppression. The results suggest that exogenous ketones are less effective than the ketogenic diet, while serum BHB levels can predict myocardial glucose suppression.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sophie Trefely, Katharina Huber, Joyce Liu, Michael Noji, Stephanie Stransky, Jay Singh, Mary T. Doan, Claudia D. Lovell, Eliana von Krusenstiern, Helen Jiang, Anna Bostwick, Hannah L. Pepper, Luke Izzo, Steven Zhao, Jimmy P. Xu, Kenneth C. Bedi, J. Eduardo Rame, Juliane G. Bogner-Strauss, Clementina Mesaros, Simone Sidoli, Kathryn E. Wellen, Nathaniel W. Snyder
Summary: This study developed a stable isotope labeling technique for quantifying acyl-CoA thioesters in subcellular compartments. The researchers found that oxygen tension, cellular differentiation, and nutrient availability have compartmentalized effects on subcellular metabolism. Importantly, they discovered a significant enrichment of propionyl-CoA in the nuclear compartment and identified isoleucine as a major metabolic source for nuclear propionyl-CoA and histone propionylation, revealing a new mechanism of crosstalk between metabolism and the epigenome.
Review
Immunology
Andrew M. Jordan, Robert Tatum, Danial Ahmad, Sonali V. J. Patel, Elizabeth P. Maynes, Matthew Weber, Sean L. Moss, Tricia Royer, Vakhtang J. Tchantchaleishvili, H. Todd Massey, J. Eduardo Rame, John Zurlo, Nana Aburjania
Summary: Infective endocarditis (IE) following heart transplantation (HTx) is rare but potentially fatal, with fungal organisms causing poorer prognosis than bacterial ones. Surgical management, including valve surgery, is observed in a portion of patients.
TRANSPLANTATION REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
E. Wilson Grandin, Gaurav Gulati, Jose Nunez, Kevin Kennedy, J. Eduardo Rame, Pavan Atluri, Francis D. Pagani, James K. Kirklin, Robert L. Kormos, Jeffrey Teuteberg, Michael S. Kiernan
Summary: Adult CF-LVAD patients receiving early PDE5i showed similar rates of late right heart failure, mortality and major bleeding compared to those who did not receive early PDE5i.
CIRCULATION-HEART FAILURE
(2022)
Article
Biochemistry & Molecular Biology
Mary T. Doan, Michael D. Neinast, Erika L. Varner, Kenneth C. Bedi, David Bartee, Helen Jiang, Sophie Trefely, Peining Xu, Jay P. Singh, Cholsoon Jang, J. Eduardo Rame, Donita C. Brady, Jordan L. Meier, Kenneth B. Marguiles, Zoltan Arany, Nathaniel W. Snyder
Summary: Research has shown that mammals can synthesize a six-carbon compound through the metabolism of propionate, and this reaction has been confirmed in humans and mice.
JOURNAL OF LIPID RESEARCH
(2022)
Review
Engineering, Biomedical
Sophie A. A. Leon, Jake L. L. Rosen, Danial Ahmad, Melissa A. A. Austin, Alec Vishnevsky, Indranee N. N. Rajapreyar, Nicholas J. J. Ruggiero, J. Eduardo Rame, John W. W. Entwistle, Howard T. T. Massey, Vakhtang Tchantchaleishvili
Summary: This systematic review and meta-analysis compared the baseline characteristics, periprocedural data, and outcomes of microaxial support before and after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction complicated by cardiogenic shock. The study found that the pre-PCI group had better early survival compared to the post-PCI group.
Article
Cardiac & Cardiovascular Systems
Amrita Sukhavasi, Danial Ahmad, Melissa Austin, J. Eduardo Rame, John W. Entwistle, Howard T. Massey, Vakhtang Tchantchaleishvili
Summary: Predicting cardiac mass (PCM) has been validated for size matching donor hearts in heart transplantation recipients. This study found that cardiothoracic ratio (CTR) could reflect recipient-specific limits of oversizing and evaluated the utility of donor to recipient PCM ratio (PCMR) and CTR in predicting delayed sternal closure after heart transplantation.
THORACIC AND CARDIOVASCULAR SURGEON
(2023)
Review
Surgery
Colin C. Yost, Diana C. Jimenez, Matthew P. Weber, Elizabeth J. Maynes, Katherine A. Belden, Vakhtang Tchantchaleishvili, H. Todd Massey, David A. Sass, J. Eduardo Rame, John J. Zurlo, Nana Aburjania
Summary: Expanding the heart donor pool to include HBV-positive patients could help address the organ shortage in heart transplantation. A systematic review and meta-analysis found that HBV D+/R- heart transplantation had fewer active hepatitis infections and lower hepatitis-related mortality compared to D-/R+ transplantation, with comparable survival at 1 year.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Engineering, Biomedical
James W. Schurr, Ian Sigal, Asad Usman, Prakash Patel, Benedicte Lefebvre, Kristy Kurcik, Pavan Atluri, Michael Acker, Christian Bermudez, J. Eduardo Rame, Thomas Hanff, Marisa Cevasco, Joyce Wald
Summary: Right ventricular dysfunction is common after left ventricular assist device implantation and is associated with right heart failure. Anesthesia induction during surgery may contribute to the development of right ventricular dysfunction. This study examined intraoperative RV hemodynamics and echocardiographic parameters and observed the occurrence of postoperative clinical right heart failure.
Article
Communication
Jesus Rame
Summary: This article analyzes the concept of love and its development in modern social networks, and explores the impact of information and communication technologies on affective practices.
COMUNICACION Y HOMBRE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Melissa A. Austin, Jake L. Rosen, Danial Ahmad, Matthew P. Weber, Indranee Rajapreyar, Jesus Eduardo Rame, Rene J. Alvarez, John W. Entwistle, Howard T. Massey, Vakhtang Tchantchaleishvili
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Rachel Debenham, Indranee Rajapreyar, Rene J. Alvarez, Jesus Eduardo Rame, John Entwistle, Howard Todd Massey, Vakhtang Tchantchaleishvili, Konstadinos Plestis, Mahek Shah, Yevgeniy Brailovsky, David L. Fischman, Nicholas J. Ruggiero, Michael P. Savage, Praveen Mehrotra, Eric Gnall, Alec Vishnevsky
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)