Review
Medicine, General & Internal
Ou Xu, Jan Hartmann, Yi-Da Tang, Joao Dias
Summary: Dual antiplatelet therapy is crucial for preventing ischemic events after acute coronary syndrome. Thromboelastography shows promise in assessing therapy response and guiding individualized treatment. This systematic review evaluates the utility of thromboelastography in ACS/PCI in East Asia, finding that it may be better than other techniques in detecting low treatment response and guiding therapy escalation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Davide Cao, Rishi Chandiramani, Mauro Chiarito, Bimmer E. Claessen, Roxana Mehran
Summary: Since its introduction in 1977, percutaneous coronary intervention has become one of the most commonly performed therapeutic procedures worldwide, with antithrombotic agents playing a crucial role in patient management. The past 40 years have seen significant advancements in interventional cardiology in both drug therapies and device technologies.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Yunnan Zhang, Wenxing Peng, Xiujin Shi, Jialun Han, Yifan Wang, Zhenwei Fang, Yang Lin
Summary: This study compared the clinical outcomes of clopidogrel and ticagrelor in older patients with acute coronary syndrome. The findings suggest that clopidogrel and ticagrelor have comparable clinical benefits in patients aged 65 and above, with clopidogrel associated with a lower risk of major bleeding.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Claudio Laudani, Antonio Greco, Giovanni Occhipinti, Salvatore Ingala, Dario Calderone, Lorenzo Scalia, Federica Agnello, Marco Legnazzi, Maria Sara Mauro, Carla Rochira, Sergio Buccheri, Roxana Mehran, Stefan James, Dominick J. Angiolillo, Davide Capodanno
Summary: This study compares the effectiveness of short dual antiplatelet therapy (DAPT) and de-escalation in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). The results suggest that de-escalation reduces the risk of adverse cardiovascular events, while short DAPT decreases the occurrence of major bleeding.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Pharmacology & Pharmacy
Yi Zhang, Xiu-Jin Shi, Wen-Xing Peng, Jia-Lun Han, Bai-Di Lin, Ru Zhang, Yun-Nan Zhang, Jia-Lin Yan, Juan-Juan Wei, Yi-Fan Wang, Su-Wei Chen, Nan Nan, Zhen-Wei Fang, Yong Zeng, Yang Lin
Summary: The study found that prescribing ticagrelor for patients with CYP2C19 loss-of-function alleles can reduce the risk of major adverse cardiac or cerebrovascular events, supporting the implementation of CYP2C19 gene-guided antiplatelet therapy in clinical practice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Carlos E. Vergara-Uzcategui, Victor H. Moreno, Breda Hennessey, Rafael Sanchez-del-Hoyo, Jose H. Donis, Jorgelys Gonzalez-Rojas, Pablo Salinas, Luis Nombela-Franco, Nieves Gonzalo, Pilar Jimenez-Quevedo, Hernan Mejia-Renteria, Javier Escaned, Antonio Fernandez Ortiz, Carlos Macaya Miguel, Ivan J. Nunez-Gil
Summary: This study retrospectively analyzed 750 patients with acute coronary syndrome and found that patients with longer dual antiplatelet therapy (DAPT) had a higher rate of major adverse cardiovascular events and new revascularization. However, there was no significant difference in major bleeding. The results suggest the need for further randomized controlled trials to confirm these findings.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Mohamed Farag, Visvesh Jeyalan, Jose Luis Ferreiro, Young-Hoon Jeong, Tobias Geisler, Diana A. Gorog
Summary: This article evaluates the studies on the de-escalation of dual antiplatelet therapy (DAPT) intensity and duration in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). The limitations of current studies and recommendations for future research are summarized.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Niels M. R. van der Sangen, Rik Rozemeijer, Dean R. P. P. Chan Pin Yin, Marco Valgimigli, Stephan Windecker, Stefan K. James, Sergio Buccheri, Jurrien M. ten Berg, Jose P. S. Henriques, Michiel Voskuil, Wouter J. Kikkert
Summary: Dual antiplatelet therapy is the standard of care for patients with chronic coronary syndrome and acute coronary syndrome undergoing percutaneous coronary intervention, but selecting the optimal duration and composition of treatment poses a major challenge. Current guidelines recommend risk stratification for tailoring treatment, yet various risk scoring methods and testing approaches have not been widely adopted in clinical practice. Further research and validation are needed to determine the effectiveness of these risk stratification methods in improving clinical outcomes.
EUROPEAN HEART JOURNAL
(2021)
Article
Multidisciplinary Sciences
Jeffrey Chidester, Daniel Bennett, Chris Mathew, Tiffany Denkins, Rebecca Vigen, Tayo Addo, Sandeep Das
Summary: A telephone-based reminder system was developed to improve DAPT adherence post-PCI, leading to directed interventions in nearly 1 in 10 patients contacted. However, the system did not significantly improve PDC levels compared to a contemporary sample, highlighting the ongoing difficulty in detecting barriers to adherence.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Arun Kumar, Pamela L. Lutsey, Wendy L. St. Peter, Jon C. Schommer, Jeremy R. Van't Hof, Abhijeet Rajpurohit, Joel F. Farley
Summary: In acute coronary syndrome following percutaneous coronary intervention, newer P2Y12 inhibitors (ticagrelor and prasugrel) reduce cardiovascular outcomes compared to clopidogrel, but have a higher bleeding risk. This study examines the safety of each inhibitor in a real-world population.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Hematology
Emanuela Falcinelli, Marcella De Paolis, Enrico Boschetti, Paolo Gresele
Summary: This study aimed to assess the time-course of MMP-2 release during PCI and the contribution of platelets to its release. The results showed that PCI triggers the release of MMP-2 in ACS patients but not in SA patients.
THROMBOSIS RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Kaivan Vaidya, Bradley Tucker, Rahul Kurup, Chinmay Khandkar, Elvis Pandzic, Jennifer Barraclough, Joshua Machet, Ashish Misra, Mary Kavurma, Gonzalo Martinez, Kerry-Anne Rye, Blake J. Cochran, Sanjay Patel
Summary: The study found that colchicine suppresses NET formation in patients with ACS post-PCI by restoring cytoskeletal dynamics. These findings warrant further investigation in randomized trials powered for clinical end points.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Cardiac & Cardiovascular Systems
Mattia Galli, Dominick J. Angiolillo
Summary: Dual antiplatelet treatment (DAPT) combining aspirin and a potent P2Y(12) inhibitor has been the recommended regimen for antithrombotic therapy in patients with acute coronary syndrome (ACS) for nearly a decade. However, this treatment is associated with an increased risk of bleeding, leading to the development of a de-escalation strategy aimed at reducing bleeding without compromising ischemic events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Clara Bonanad, Francisca Esteve-Claramunt, Sergio Garcia-Blas, Ana Ayesta, Pablo Diez-Villanueva, Jose-Angel Perez-Rivera, Jose Luis Ferreiro, Joaquim Canoves, Francisco Lopez-Fornas, Albert Ariza Sole, Sergio Raposerias, David Vivas, Regina Blanco, Daznia Bompart Berroteran, Alberto Cordero, Julio Nunez, Lorenzo Facila, Ivan J. Nunez-Gil, Jose Luis Gorriz, Vicente Bodi, Manuel Martinez-Selles, Juan Miguel Ruiz Nodar, Francisco Javier Chorro
Summary: The treatment of acute coronary syndrome (ACS) in elderly patients is challenging due to their characteristics and lack of specific recommendations. This review summarizes the current evidence on oral antithrombotic therapy in elderly patients, discussing peculiarities of dual antiplatelet therapy (DAPT) in ACS management and analyzing antithrombotic strategies in patients with atrial fibrillation (AF) and coronary artery disease (CAD).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Chieh-Ju Chao, Anusha Shanbhag, Chia-Chun Chiang, Marlene E. Girardo, Amith R. Seri, Muhammad U. Khalid, Corbin Rayfield, Michael P. O'Shea, Olubadewa Fatunde, F. David Fortuin
Summary: This study found that baseline thrombocytopenia in patients with acute coronary syndrome is associated with increased all-cause mortality and bleeding events. With the severity of thrombocytopenia increasing, the all-cause mortality also increases.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Correction
Oncology
Lukas Marcelis, Asier Antoranz, Anne-Marie Delsupehe, Pauline Biesemans, Julio Finalet Ferreiro, Koen Debackere, Peter Vandenberghe, Gregor Verhoef, Paul Clement, Steven De Vleeschouwer, Olivier Gheysens, Giorgio Cattoretti, Francesca Maria Bosisio, Xavier Sagaert, Daan Dierickx, Thomas Tousseyn
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Alberto Cordero, Belen Cid-Alvarez, Eduardo Alegria, Agustin Fernandez-Cisnal, David Escribano, Jenniffer Bautista, Maria Juskova, Ramiro Trillo, Vicente Bertomeu-Gonzalez, Jose Luis Ferreiro
Summary: This study aimed to validate the effectiveness of the DDTA score in selecting the most suitable patients for manual thrombectomy (MT) in P-PCI. The results indicated that a DDTA score ≥ 4 was associated with TIMI 3 after MT, lower no-reflow, and in-hospital complications. Patients with a DDTA score ≥ 4 and Zwolle risk score 0-3 had the lowest incidence of in-hospital mortality or MACE.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
[Anonymous]
REVISTA ESPANOLA DE CARDIOLOGIA
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
D. Calvo, M. Pombo, Begona Benito, Oscar Cano, Maria Luisa Fidalgo Andres, Manuel Gomez-Bueno, F. Javier Jimenez Candil, Isabel M. Lillo, Pablo Morina-Vazquez, Pablo Penafiel-Verdu, Luis M. Rincon, Jose Maria Tolosana, Pablo Avanzas, Gemma Berga Congost, Araceli Boraita, Hector Bueno, David Calvo, Raquel Campuzano, Victoria Delgado, Laura Dos, Ignacio Ferreira-Gonzalez, Juan Jose Gomez Doblas, Domingo Pascual Figal, Antonia Sambola, Ana Viana Tejedor, Jose Luis Ferreiro, Fernando Alfonso
REVISTA ESPANOLA DE CARDIOLOGIA
(2022)
Article
Cardiac & Cardiovascular Systems
Diana A. Gorog, Ying X. Gue, Tze-Fan Chao, Laurent Fauchier, Jose Luis Ferreiro, Kurt Huber, Stavros Konstantinidis, Deirdre A. Lane, Francisco Marin, Jonas Oldgren, Tatjana Potpara, Vanessa Roldan, Andrea Rubboli, Dirk Sibbing, Hung-Fat Tse, Gemma Vilahur, Gregory Y. H. Lip
Summary: This article comprehensively reviews the published evidence on bleeding risk assessments in patients with atrial fibrillation (AF) and venous thromboembolism (VTE) and proposes consensus statements to summarize 'best practice' in antithrombotic therapy for these patients. The article discusses the epidemiology and size of the bleeding risk problem in AF and VTE, reviews established bleeding risk factors, and summarizes bleeding definitions. It also reviews the importance of patient values and preferences and balancing the risk of bleeding against thromboembolism.
Review
Medicine, General & Internal
Clara Bonanad, Francisca Esteve-Claramunt, Sergio Garcia-Blas, Ana Ayesta, Pablo Diez-Villanueva, Jose-Angel Perez-Rivera, Jose Luis Ferreiro, Joaquim Canoves, Francisco Lopez-Fornas, Albert Ariza Sole, Sergio Raposerias, David Vivas, Regina Blanco, Daznia Bompart Berroteran, Alberto Cordero, Julio Nunez, Lorenzo Facila, Ivan J. Nunez-Gil, Jose Luis Gorriz, Vicente Bodi, Manuel Martinez-Selles, Juan Miguel Ruiz Nodar, Francisco Javier Chorro
Summary: The treatment of acute coronary syndrome (ACS) in elderly patients is challenging due to their characteristics and lack of specific recommendations. This review summarizes the current evidence on oral antithrombotic therapy in elderly patients, discussing peculiarities of dual antiplatelet therapy (DAPT) in ACS management and analyzing antithrombotic strategies in patients with atrial fibrillation (AF) and coronary artery disease (CAD).
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Pablo Avanzas, Javier Bermejo, Manuel Barreiro-Perez, Belen Cid, Victoria Delgado, J. Alberto San Roman, Arturo Evangelista, Pastora Gallego, Francisco Javier Garcia Aranda, Jose Lopez-Menendez, Marta Sitges, Isidre Vilacosta, Pablo Avanzas, Gemma Berga Congost, Araceli Boraita, Hevtor Bueno, David Calvo, Raquel Campuzano, Victoria Delgado, Laura Dos, Ignacio Ferreira-Gonzalez, Juan Jose Gomez Doblas, Domingo Pascual Figal, Antonia Sambola, Ana Viana Tejedor, Jose Luis Ferreiro, Fernando Alfonso
REVISTA ESPANOLA DE CARDIOLOGIA
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Domingo Pascual Figal, Jose Ramon Gonzalez-Juanatey, Antoni Bayes-Genis, Marta Cobo, Juan Delgado, Beatriz Diaz-Molina, Jose Gonzalez Costello, Silvia Lopez-Fernandez, Rafael Mesa Rico, Julio Nunez Villota, Alfonso Valle, Jose Luis Zamorano, Pablo Avanzas, Gemma Berga Congost, Araceli Boraita, Hector Bueno, David Calvo, Raquel Campuzano, Victoria Delgado, Laura Dos, Ignacio Ferreira-Gonzalez, Juan Jose Gomez Doblas, Domingo Pascual Figal, Antonia Sambola, Ana Viana Tejedor, Jose Luis Ferreiro, Fernando Alfonso
REVISTA ESPANOLA DE CARDIOLOGIA
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Vicente Arrarte, Raquel Campuzano, Jose Antonio Alarcon Duque, Guillermo Aldama, Vivencio Barrios, Clara Bonanad, Almudena Castro Conde, Rosa Fernandez Olmo, Jose M. Gamez, Gabriela Guzman-Martinez, Carmen Neiro Rey, David Vivas, Pablo Avanzas, Gemma Berga Congost, Araceli Boraita, Hector Bueno, David Calvo, Victoria Delgado, Laura Dos, Ignacio Ferreira-Gonzalez, Juan Jose Gomez Doblas, Domingo Pascual Figal, Antonia Sambola, Ana Viana Tejedor, Jose Luis Ferreiro, Fernando Alfonso
REVISTA ESPANOLA DE CARDIOLOGIA
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Joan Antoni Gomez-Hospital, Jose Luis Ferreiro
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Hematology
Diana A. Gorog, Ying X. Gue, Tze-Fan Chao, Laurent Fauchier, Jose Luis Ferreiro, Kurt Huber, Stavros V. Konstantinidis, Deirdre A. Lane, Francisco Marin, Jonas Oldgren, Tatjana Potpara, Vanessa Roldan, Andrea Rubboli, Dirk Sibbing, Hung-Fat Tse, Gemma Vilahur, Gregory Y. H. Lip
Summary: This article summarizes the consensus on bleeding risk assessments in patients with atrial fibrillation (AF) and venous thromboembolism (VTE), including bleeding risk factors, definitions, and the consideration of patient values and preferences in balancing bleeding against thromboembolism risks.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
Sunil Rao, Bodo Kirsch, Deepak L. Bhatt, Andrzej Budaj, Rosa Coppolecchia, John Eikelboom, Stefan K. James, W. Schuyler Jones, Bela Merkely, Lars Keller, Renicus S. Hermanides, Gianluca Campo, Jose Luis Ferreiro, Taro Shibasaki, Hardi Mundl, John H. Alexander
Summary: This study investigated the pharmacodynamics, safety, and efficacy of the oral FXIa inhibitor asundexian for secondary prevention after acute myocardial infarction (MI). The results showed that asundexian effectively inhibited coagulation activity without increasing the risk of bleeding or ischemic events.
Review
Cardiac & Cardiovascular Systems
Mohamed Farag, Visvesh Jeyalan, Jose Luis Ferreiro, Young-Hoon Jeong, Tobias Geisler, Diana A. Gorog
Summary: This article evaluates the studies on the de-escalation of dual antiplatelet therapy (DAPT) intensity and duration in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). The limitations of current studies and recommendations for future research are summarized.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ana Lucrecia Marcano, Montserrat Gracida, Gerard Roura, Josep Gomez-Lara, Rafael Romaguera, Luis Teruel, Lara Fuentes, Guillem Muntane-Carol, Oona Merono, Silvia Gabriela Sosa, Joan Antoni Gomez-Hospital, Josep Comin-Colet, Jose Luis Ferreiro
Summary: Patients with diabetes mellitus have increased platelet reactivity and diminished responsiveness to clopidogrel. Ticagrelor is more effective in inhibiting platelet function compared to clopidogrel in patients with chronic coronary syndromes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Diana A. Gorog, Jose Luis Ferreiro, Ingo Ahrens, Junya Ako, Tobias Geisler, Sigrun Halvorsen, Kurt Huber, Young-Hoon Jeong, Eliano P. Navarese, Andrea Rubboli, Dirk Sibbing, Jolanta M. Siller-Matula, Robert F. Storey, Jack W. C. Tan, Jurrien M. ten Berg, Marco Valgimigli, Christophe Vandenbriele, Gregory Y. H. Lip
Summary: Dual antiplatelet therapy (DAPT) reduces the risk of ischaemic events but increases bleeding risk in patients with acute coronary syndrome undergoing percutaneous coronary intervention. Strategies to reduce bleeding include de-escalation of DAPT intensity or abbreviation of DAPT duration, which both require individual assessment of ischaemic and bleeding risks.
NATURE REVIEWS CARDIOLOGY
(2023)
