Review
Cardiac & Cardiovascular Systems
Rasha K. Al-Lamee, Christopher A. Rajkumar, Sashiananthan Ganesananthan, Allen Jeremias
Summary: Invasive coronary physiology has become established as an important component in guidelines for managing stable coronary artery disease, improving clinical outcomes and cost efficiency. Despite recent doubts from randomized controlled trials, it remains crucial for selecting patients for coronary revascularization.
Article
Biotechnology & Applied Microbiology
Gaurav Chandola, Jun-Mei Zhang, Ru-San Tan, Ping Chai, Lynette Teo, John C. Allen, Ris Low, Weimin Huang, Shuang Leng, Jiang Ming Fam, Chee Yang Chin, Ghassan S. Kassab, Adrian Fatt Hoe Low, Swee Yaw Tan, Terrance Chua, Soo Teik Lim, Liang Zhong
Summary: The study assessed the feasibility and accuracy of a non-invasive FFR calculation based on CTCA for predicting coronary hemodynamics before and after stenting, finding a good correlation and agreement with invasive FFR, especially in predicting the hemodynamic effects post-stenting, indicating its potential as a useful tool in PCI planning.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Damien Collison, Matthaios Didagelos, Muhammad Aetesam-ur-Rahman, Samuel Copt, Robert McDade, Peter McCartney, Thomas J. Ford, John McClure, Mitchell Lindsay, Aadil Shaukat, Paul Rocchiccioli, Richard Brogan, Stuart Watkins, Margaret McEntegart, Richard Good, Keith Robertson, Patrick O'Boyle, Andrew Davie, Adnan Khan, Stuart Hood, Hany Eteiba, Colin Berry, Keith G. Oldroyd
Summary: The study aimed to evaluate the feasibility and efficacy of a post-PCI FFR-guided optimization strategy compared to standard coronary angiography in achieving final post-PCI FFR values >= 0.90. While the FFR-guided optimization strategy did not significantly increase the proportion of patients with final FFR >= 0.90, it did significantly reduce the proportion of patients with final FFR <= 0.80.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Damien Collison, Matthaios Didagelos, Muhammad Aetesam-Ur-Rahman, Samuel Copt, Robert McDade, Peter McCartney, Thomas J. Ford, John McClure, Mitchell Lindsay, Aadil Shaukat, Paul Rocchiccioli, Richard Brogan, Stuart Watkins, Margaret McEntegart, Richard Good, Keith Robertson, Patrick O'Boyle, Andrew Davie, Adnan Khan, Stuart Hood, Hany Eteiba, Colin Berry, Keith G. Oldroyd
Summary: The TARGET-FFR trial examined the importance of FFR value >= 0.90 after PCI, finding that an FFR-guided optimization strategy did not significantly increase this proportion, but did reduce the proportion of patients with FFR value <= 0.80.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Rikuta Hamaya, Shinichi Goto, Doyeon Hwang, Jinlong Zhang, Seokhun Yang, Joo Myung Lee, Masahiro Hoshino, Chang-Wook Nam, Eun-Seok Shin, Joon-Hyung Doh, Shao-Liang Chen, Gabor G. Toth, Zsolt Piroth, Abdul Hakeem, Barry F. Uretsky, Yohei Hokama, Nobuhiro Tanaka, Hong-Seok Lim, Tsuyoshi Ito, Akiko Matsuo, Lorenzo Azzalini, Massoud A. Leesar, Carlos Collet, Bon-Kwon Koo, Bernard De Bruyne, Tsunekazu Kakuta
Summary: This study used machine learning algorithms to predict post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR) based on baseline information and clinical relevance. The study found a moderate correlation between predicted and actual post-PCI FFR, and the deviation of post-PCI FFR from the predicted value was associated with incident target vessel failure.
Article
Cardiac & Cardiovascular Systems
Rikuta Hamaya, Taishi Yonetsu, Kodai Sayama, Kazuki Matsuda, Hiroki Ueno, Tatsuhiro Nagamine, Toru Misawa, Masahiro Hada, Masahiro Hoshino, Tomoyo Sugiyama, Tetsuo Sasano, Tsunekazu Kakuta
Summary: This study investigated the determinants and prognostic implications of changes in coronary flow capacity (CFC) following percutaneous coronary intervention (PCI) in patients with chronic coronary syndrome (CCS). The results showed that changes in CFC were associated with the risk of incident target vessel failure (TVF) and were largely predicted by the pre-PCI CFC status.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Hu Ai, Naixin Zheng, Le Li, Guojian Yang, Hui Li, Guodong Tang, Qi Zhou, Huiping Zhang, Xue Yu, Feng Xu, Ying Zhao, Fucheng Sun
Summary: This study found that caFFR measurements are well-correlated and in agreement with invasive wire-based FFR measurements before and after PCI. Post-PCI caFFR measurements, similar to wire-based FFR measurements, can help identify patients at higher risk for adverse events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Salim Belguidoum, Nicolas Meneveau, Pascal Motreff, Patrick Ohlman, Mohamed Mehdi Boussaada, Johanne Silvain, Benoit Guillon, Vincent Descotes-Genon, Yohann Lefrancois, Olivier Morel, Nicolas Amabile
Summary: This study aimed to analyze the relationship between stent expansion criteria using optical coherence tomography (OCT) analysis and the final PCI functional result. The results showed no relationship between optimal stent expansion according to ILUMIEN III or DOCTORS OCT criteria and final post-PCI FFR values.
Article
Cardiac & Cardiovascular Systems
Jinlong Zhang, Jun Jiang, Xinyang Hu, Yong Sun, Changling Li, Lingjun Zhu, Feng Gao, Liang Dong, Yabin Liu, Jian Shen, Cheng Ni, Kan Wang, Zexin Chen, Haibo Chen, Shiqiang Li, Seokhun Yang, Jeehoon Kang, Doyeon Hwang, Joo-Yong Hahn, Chang-Wook Nam, Joon-Hyung Doh, Bong-Ki Lee, Weon Kim, Jinyu Huang, Fan Jiang, Hao Zhou, Peng Chen, Lijiang Tang, Wenbing Jiang, Xiaomin Chen, Wenming He, Sung Gyun Ahn, Myeong-Ho Yoon, Ung Kim, Joo Myung Lee, You-Jeong Ki, Eun-Seok Shin, Chee Hae Kim, Seung-Jea Tahk, Bon-Kwon Koo, Jian'an Wang
Summary: In cases of intermediate stenosis, women had more favorable outcomes compared to men despite receiving fewer interventions. The use of FFR led to a lower PCI rate but had a similar prognostic value compared to IVUS in both women and men.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Tara Neleman, Alessandra Scoccia, Kaneshka Masdjedi, Mariusz Tomaniak, Jurgen M. R. Ligthart, Karen T. Witberg, Alise Vermaire, Quinten Wolff, Leon Visser, Paul Cummins, Isabella Kardys, Jeroen Wilschut, Roberto Diletti, Wijnand K. Den Dekker, Felix Zijlstra, Nicolas M. Van Mieghem, Joost Daemen
Summary: Lower post-PCI vFFR values are significantly associated with an increased risk of TVF and TVR at 5 years follow-up.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Povilas Budrys, Aaron Peace, Arvydas Baranauskas, Giedrius Davidavicius
Summary: This study compared the effectiveness of FFR and IVUS PCI optimization strategies for long coronary lesions. The results showed that the FFR optimization strategy resulted in poorer functional PCI outcomes and larger myocardial ischemia burden compared to the IVUS optimization strategy. However, this difference did not have a statistically significant impact on clinical outcomes.
Article
Medicine, General & Internal
Ling Hou, Ke Su, Jinbo Zhao, Yuanhong Li
Summary: This study retrospectively analyzed the clinical data of patients who underwent PCI at our hospital and investigated the correlation between COPD and ISR. The results showed that COPD is an independent risk factor for ISR after PCI.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sakura Nagumo, Carlos Collet, Bjarne L. Norgaard, Hiromasa Otake, Brian Ko, Bon-kwon Koo, Jonathon Leipsic, Daniele Andreini, Ward Heggermont, Jesper M. Jensen, Yu Takahashi, Abdul Ihdayhid, Zinlong Zhang, Emanuele Barbato, Michael Maeng, Takuya Mizukami, Jozef Bartunek, Adam Updegrove, Martin Penicka, Campbell Rogers, Charles Taylor, Bernard De Bruyne, Jeroen Sonck
Summary: This study aims to validate the accuracy of FFRCT Planner in predicting post-PCI FFR with invasive FFR as a reference standard. The study includes 127 patients, with 100 patients already enrolled, and the final results are expected in 2021.
CLINICAL CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Takuro Abe, Kensuke Shimazaki, Tetsu Moriyama, Akira Murohashi, Yuji Iwanami, Akihito Sasaki, Katsumi Saito, Kentaro Jujo
Summary: Deferring percutaneous coronary intervention (PCI) for functionally insignificant stenosis with a fractional flow reserve (FFR) > 0.80 is associated with favorable long-term outcomes. This study examined the optimal management of low-density lipoprotein cholesterol (LDL-C) in patients with intermediate coronary stenosis and deferred PCI based on FFR values. The results showed that uncontrolled LDL-C levels were associated with higher major adverse cardiovascular and cerebrovascular events (MACCE) rates in patients with FFR values of 0.81-0.85, highlighting the importance of strict LDL-C-lowering therapy for this high-risk population.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Haseong Chang, Hyun Kuk Kim, Doosup Shin, Kyung Seob Lim, Sun-Uk Kim, Chang-Yeop Jeon, Hwal-Yong Lee, Youngjeon Lee, Jinyoung Won, Seung Hun Lee, Tsunekazu Kakuta, Joo Myung Lee
Summary: This study evaluated the temporal changes of coronary circulatory indexes in tandem stenoses before and after angioplasty for proximal stenosis. The results showed significant changes in coronary circulatory indexes after angioplasty for proximal stenosis, with alterations in blood flow indexes and pressure gradient.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Gabor G. Toth, Masafumi Ono, Eva Buschmann, Xinlei Wu, Dominik Edl, Yoshinobu Onuma, Patrick W. J. C. Serruys, William Wijns
Summary: The study evaluated whether the technical characteristics of the Fantom Encore(R) bioresorbable scaffold allow for bifurcation percutaneous coronary intervention, and found that the device is not suitable for conventional techniques for bifurcation PCI.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Leo Cuenin, Benjamin Honton, Farhang Aminfar, Pierre Meyer, Claude Mariottini, Maelle Haessler, Philippe Vareille, William Wijns, Luc Maillard, Julien Adjedj
Summary: This study demonstrated the feasibility of performing QFR analysis using angiograms obtained by 4-F catheters, showing a good correlation with QFR performed using 6-F catheters and with conventional FFR performed using a pressure guidewire.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Charles Knoery, Katie A. McEwan, Matthew Manktelow, Jonathan Watt, Jamie Smith, Aleeha Iftikhar, Khaled Rjoob, Raymond Bond, Victoria McGilligan, Aaron Peace, Anne McShane, Janet Heaton, Stephen J. Leslie
Summary: Treatment decisions for myocardial infarction (MI) are currently stratified based on the presence or absence of ST elevation on the electrocardiogram. This study aimed to identify features that could help identify occlusive MI (OMI) among non-ST elevation MI (NSTEMI) cases. The study found that OMI patients had fewer comorbidities but higher acute mortality compared to nonocclusive MI. Latent class analysis did not effectively distinguish OMI from non-OMI. Therefore, there is a need for alternative strategies to improve the identification and treatment of OMI patients.
CLINICAL CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Fabio Mangiacapra, Michele Mattia Viscusi, Giuseppe Verolino, Luca Paolucci, Annunziata Nusca, Rosetta Melfi, Gian Paolo Ussia, Francesco Grigioni
Summary: The critical role of the coronary microvascular compartment and its invasive functional assessment have been recognized. However, the diagnosis of coronary microvascular dysfunction (CMD) is challenging due to its small dimensions. Several diagnostic tools are available for assessing the coronary microvascular function, which, when combined with physiological indices, can provide a comprehensive evaluation of the coronary circulation. Physiological-guided management of CMD may offer symptom improvement among patients with angina and ischemic heart disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Robert-Jan van Geuns, Chang Chun-Chin, Margaret B. McEntegart, Evgeny Merkulov, Evgeny Kretov, Maciej Lesiak, Peter O'Kane, Colm G. Hanratty, Erwan Bressollette, Marc Silvestri, Adrian Wlodarczak, Paul Barragan, Richard Anderson, Aleksey Protopopov, Aaron Peace, Ian Menown, Paul Rocchiccioli, Yoshinobu Onuma, Keith G. Oldroyd
Summary: This study aimed to compare the clinical outcomes in patients undergoing PCI of unprotected left main coronary artery disease using a biodegradable polymer-coated stent followed by 4 months of DAPT versus a durable polymer-coated stent followed by 12 months of DAPT. The results showed that after two years of follow-up, the two treatment strategies were similar in terms of the primary endpoint, but patients using the biodegradable polymer-coated stent experienced more bleeding events.
Article
Cardiac & Cardiovascular Systems
Aaron Peace, Salah S. Al-Zaiti, Dewar Finlay, Victoria McGilligan, Raymond Bond
Summary: This commentary paper discusses the use of electrocardiogram in aiding diagnostic and patient referral decisions in acute care settings. It addresses the factors that contribute to variability and noise in the decision-making process, and suggests potential research questions and tools to mitigate these issues and improve the quality of decisions based on electrocardiogram.
JOURNAL OF ELECTROCARDIOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Khaled Rjoob, Raymond Bond, Dewar Finlay, Victoria McGilligan, Stephen J. Leslie, Ali Rababah, Aleeha Iftikhar, Daniel Guldenring, Charles Knoery, Anne McShane, Aaron Peace, Peter W. Macfarlane
Summary: This study reviewed the application of machine learning (ML) in analyzing electrocardiogram (ECG) data and used time series analysis to study the changing popularity of different ML algorithms over the past two decades. The results showed that the use of ML in analyzing ECG data has been increasing, especially in heart abnormality classification. Support vector machine has been the most commonly used technique in the past decade, but deep learning has been trending upwards since 2018 and is likely to become the leading technique in the coming years. Accuracy was the most frequently used evaluation metric in the reviewed studies.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Birgitte Krogsgaard Andersen, Daixin Ding, Lone Juul Hune Mogensen, Shengxian Tu, Niels Ramsing Holm, Jelmer Westra, William Wijns
Summary: This systematic review and study-level meta-analysis investigated the relationship between post-PCI FFR and the rate of major adverse cardiac events (MACE) including all-cause death, myocardial infarction (MI), and target vessel revascularization (TVR). The results showed no clear continuous association between post-PCI FFR and clinical outcomes, but in studies comparing high vs. low post-PCI FFR, high FFR was associated with better clinical outcomes.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Medicine, General & Internal
Markus P. Schlaich, Marc Bellet, Michael A. Weber, Parisa Danaietash, George L. Bakris, John M. Flack, Roland F. Dreier, Mouna Sassi-Sayadi, Lloyd P. Haskell, Krzysztof Narkiewicz, Ji-Guang Wang
Summary: This study evaluated the blood pressure lowering efficacy of the dual endothelin antagonist aprocitentan in patients with resistant hypertension. The results showed that aprocitentan had a blood pressure lowering effect at week 4 and maintained a sustained effect at week 40. The most common adverse event was mild-to-moderate edema or fluid retention.
Article
Cardiac & Cardiovascular Systems
Simon Winther, Theodore Murphy, Samuel Emil Schmidt, Jeroen J. J. Bax, William Wijns, Juhani Knuuti, Morten Bottcher
Summary: This study compared different pretest probability (PTP) models for obstructive coronary artery disease (CAD) and found that the new AHA/ACC-PTP model overestimated the prevalence of CAD. Including symptoms and risk factors in the model improved discrimination and identified more patients with a low likelihood of CAD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Khaled Rjoob, Victoria McGilligan, Roisin McAllister, Raymond Bond, Gemina J. Doolub, Stephen Leslie, Matthew Manktelow, Charles Knoery, James Shand, Aleeha Iftikhar, Anne A. McShane, Mamas Mamas, Aaron Peace
Summary: This study aimed to evaluate the inter-rater agreement in rating the complexity and risk of percutaneous coronary intervention (PCI). An online survey revealed poor agreement in classifying the complexity level (k=0.1) and fair agreement in classifying the risk level (k=0.31). However, there was good agreement among participants in rating 26 factors for classifying complex PCI.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Martine Gilard, William Wijns
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Mattia Lunardi, Mamas A. Mamas, Josepa Mauri, Carmen Medina Molina, Oriol Rodriguez-Leor, Simon Eggington, Jan B. Pietzsch, Natalie L. Papo, Silke Walleser-Autiero, Andreas Baumbach, Francesco Maisano, Flavio L. Ribichini, Darren Mylotte, Emanuele Barbato, Jan J. Piek, William Wijns, Christoph K. Naber
Summary: The untimely or missed revascularization of STEMI patients during the COVID-19 pandemic has led to increased morbidity, mortality, and long-term adverse health outcomes. The analysis shows that the reduced treatment during lockdown led to a significant loss in survival and quality-adjusted life-years, as well as increased costs at the population level. The findings highlight the importance of timely revascularization and the potential long-term implications of delayed treatment for STEMI patients during a pandemic.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Simone Fezzi, Daixin Ding, Roberto Scarsini, Jiayue Huang, Paolo Alberto Del Sole, Qiang Zhao, Gabriele Pesarini, Andrew Simpkin, William Wijns, Flavio Ribichini, Shengxian Tu
Summary: This study demonstrated that angiography-derived physiology can provide a reliable assessment of coronary circulation in patients with severe aortic stenosis, showing good accuracy in predicting FFR and stable evaluation results.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Sigrun Halvorsen, Julinda Mehilli, Salvatore Cassese, Trygve S. Hall, Magdy Abdelhamid, Emanuele Barbato, Stefan De Hert, Ingrid de Laval, Tobias Geisler, Lynne Hinterbuchner, Borja Ibanez, Radoslaw Lenarczyk, Ulrich R. Mansmann, Paul McGreavy, Christian Mueller, Claudio Muneretto, Alexander Niessner, Tatjana S. Potpara, Arsen Ristic, L. Elif Sade, Henrik Schirmer, Stefanie Schuepke, Henrik Sillesen, Helge Skulstad, Lucia Torracca, Oktay Tutarel, Peter Van Der Meer, Wojtek Wojakowski, Kai Zacharowski
GIORNALE ITALIANO DI CARDIOLOGIA
(2023)