Article
Biochemistry & Molecular Biology
Cong Li, Houliang Chen, Minghong Wang, Shujie Zhang, Yujuan Jiang, Zhihong Xian, Cuiqin Shen, Jingzhen Guo, Chengli Song, Hui Gong, Nan Ye, Xue Zhao
Summary: This study observed intimal injuries related to stent retrieval in the iliac artery of a canine. The stent was mainly covered by depositional fibrin after 28 days and by typical neointima after 42 days. The stent retrieval procedure did not induce injury to vascular smooth muscle, and intima repair was performed 14 days after stent retrieval.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Clinical Neurology
Basil E. Gruter, Stefan Wanderer, Fabio Strange, Gwendoline Boillat, Dominik Taschler, Jeannine Rey, Davide M. Croci, Denis Grandgirard, Stephen L. Leib, Michael von Gunten, Stefano Di Santo, Hans Rudolf Widmer, Luca Remonda, Lukas Andereggen, Edin Nevzati, Daniel Coluccia, Javier Fandino, Serge Marbacher
Summary: Through a rat saccular aneurysm model, it was found that neointima formation and thrombus organization are concurrent processes during aneurysm healing, with thrombus-organizing cells predominantly originating in the parent artery. Neointima formation relies more on cell migration from the aneurysm wall in coiled aneurysms.
Review
Plant Sciences
Yuan Yee Lee, Sung Dae Kim, Seung-Chun Park, Man Hee Rhee
Summary: This article summarizes the therapeutic effects of ginseng on cardiovascular diseases, focusing on its influence on platelet aggregation, plaque formation, and thrombus formation.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Surgery
Houman Jalaie, Karina Schleimer, Irwin M. Toonder, Alexander Gombert, Mamdouh Afify, Suat Doganci, Ali Modabber, Mahmood K. Razavi, Mohammad E. Barbati
Summary: This study investigated the impact of stent design on endothelial coverage by implanting segmented self-expanding bare nitinol stents with different gap sizes in the inferior vena cava of sheep. The findings suggest that stent designs with larger gaps between scaffold materials lead to faster and more complete endothelial coverage as well as a thinner intimal layer.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Gastroenterology & Hepatology
Ellen G. Driever, Fien A. von Meijenfeldt, Jelle Adelmeijer, Robbert J. de Haas, Marius C. van den Heuvel, Chandrasekaran Nagasami, John W. Weisel, Constantino Fondevila, Robert J. Porte, Anabel Blasi, Nigel Heaton, Stephen Gregory, Pauline Kane, William Bernal, Yoh Zen, Ton Lisman
Summary: The study found that portal vein thrombosis in cirrhotic patients is mainly composed of intimal fibrosis, with fibrin-rich thrombus present in only one-third of cases. Clinical characteristics showed no significant association with the presence of fibrin-rich thrombi.
Article
Cardiac & Cardiovascular Systems
Xianglan Liu, Ruoxi Zhang, Guosheng Fu, Yong Sun, Jian Wu, Maomao Zhang, Jinwei Tian, Xia Gu, Yang Zheng, Chengming Shi, Jingbo Hou, Bo Yu
Summary: The study found that low-dose methotrexate can promote cell coverage and vascular healing, reduce the number of uncovered struts, and inhibit the inflammatory response by targeting inflammatory pathways. In vitro experiments also showed that low-dose MTX can inhibit HUVEC apoptosis and promote proliferation.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Tim Walter, Tim Berger, Stoyan Kondov, Roman Gottardi, Julia Benk, Bartosz Rylski, Martin Czerny, Maximilian Kreibich
Summary: This study aimed to investigate the occurrence and clinical consequences of postoperative in-stent thrombus formation following the frozen elephant trunk (FET) procedure. The results showed that new postoperative in-stent thrombus was detected in 6% of the patients, with older age, predominantly female, and commonly treated for aortic aneurysms. The thrombi were mainly located in the distal half of the FET stent-graft. Distal embolisation occurred in 21% of the patients, leading to one in-hospital death. Female sex and aortic aneurysm were identified as significant predictors for thrombus development. More research is needed to identify patients at risk and improve perioperative treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
Carlos Torres, Cheemun Lum, Paulo Puac-Polanco, Grant Stotts, Michel Christopher Frank Shamy, Dylan Blacquiere, Ronda Lun, Prasham Dave, Aditya Bharatha, Bijoy K. Menon, Rebecca Thornhill, Franco Momoli, Dar Dowlatshahi
Summary: This study validated the use of a filling defect length threshold of >3.8 mm on CTA to accurately discriminate between free-floating thrombus and plaque. The sensitivity and specificity of this threshold were high, with an optimal length threshold of >3.64 mm. Adjusted logistic regression revealed that an increase in filling defect length is associated with increased odds of free-floating thrombus.
Review
Cardiac & Cardiovascular Systems
Peter Kulyassa, Marie Anne Engh, Peter Vamosi, Peter Fehervari, Peter Hegyi, Bela Merkely, Istvan Ferenc Edes
Summary: Drug-coated balloon (DCB) therapy shows promising results in reducing the need for recurrent revascularization in drug-eluting stent in-stent restenosis (DES-ISR). In this meta-analysis, the occurrence of major cardiac adverse events (MACE) and target lesion revascularization (TLR) after DCB treatment was assessed. The results support the effectiveness of DCB treatment in early or late DES-ISR.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Juhwan Lee, Justin N. Kim, Yazan Gharaibeh, Vladislav N. Zimin, Luis A. P. Dallan, Gabriel T. R. Pereira, Armando Vergara-Martel, Chaitanya Kolluru, Ammar Hoori, Hiram G. Bezerra, David L. Wilson
Summary: A software called OCTOPUS has been developed to provide highly automated and comprehensive analysis of coronary plaques and stents in IVOCT images. It includes important algorithmic steps such as pre-processing, deep learning plaque segmentation, machine learning stent strut identification, and registration for sequential comparisons. The software offers intuitive visualizations, manual editing capabilities, and quantitative measurements. It has been shown to yield excellent results and significantly reduce analysis time.
Article
Neurosciences
Hatice Tosun, Suat Kamisli, Mehmet Tecellioglu, Saadet Alan, Fahriye Secil Tecellioglu, Mustafa Namik Oztanir, Yuksel Kablan
Summary: The study compared the characteristics of red and white thrombi in patients undergoing carotid endarterectomy, finding that red thrombi were more unstable and associated with a higher risk of ischemic cerebrovascular events.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Hematology
Natalie J. Jooss, Christopher W. Smith, Alexandre Slater, Samantha J. Montague, Ying Di, Christopher O'Shea, Mark R. Thomas, Yvonne M. C. Henskens, Johan W. M. Heemskerk, Steve P. Watson, Natalie S. Poulter
Summary: This study emphasizes the critical difference in GPVI-mediated platelet activation by plaque and collagen, highlighting the importance of GPVI clustering for downstream signaling and thrombus formation. Labeled Nb28 is a novel tool for providing mechanistic insight into this process, and the data suggest Nb2 warrants further investigation as a potential anti-thrombotic agent.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
Trevor Simard, Richard Jung, Pietro Di Santo, Alisha Labinaz, Spencer Short, Pouya Motazedian, Shan Dhaliwal, Dhruv Sarma, Adil Rasheed, F. Daniel Ramirez, Michael Froeschl, Marino Labinaz, David R. Holmes, Mohamad Alkhouli, Benjamin Hibbert
Summary: Dipyridamole can reduce restenosis and improve stent healing in a pre-clinical model. However, its efficacy is attenuated in the presence of atherosclerosis. In vitro experiments show that dipyridamole can reduce smooth muscle cell migration and proliferation, leading to reduced neointimal tissue proliferation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Vikrant Rai, Devendra K. Agrawal
Summary: The study demonstrated the immunomodulatory effect of vitamin D on the expression of IL-33 and IL-37 in neointimal tissue, indicating a potential role in reducing inflammation and neointima formation. Decreased IL-33 expression in microswine supplemented with vitamin D may contribute to controlling coronary artery luminal narrowing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Xiaoqing Cheng, Zheng Dong, Jia Liu, Hongxia Li, Changsheng Zhou, Fandong Zhang, Churan Wang, Zhiqiang Zhang, Guangming Lu
Summary: This study aimed to identify predictive features for in-stent restenosis (ISR) after carotid artery stenting (CAS) and develop predictive models. The study analyzed clinical and imaging data and found that carotid plaque length and thickness were independently associated with ISR. Traditional and radiomics-based models showed high predictive accuracy, and the combined model performed the best.
JOURNAL OF CLINICAL MEDICINE
(2022)