Article
Biology
Frida Lona-Durazo, Marla Mendes, Rohit Thakur, Karen Funderburk, Tongwu Zhang, Michael A. Kovacs, Jiyeon Choi, Kevin M. Brown, Esteban J. Parra
Summary: A GWAS study of human hair color in a Canadian population identified candidate causal variants associated with blonde, red, and brown hair color. Colocalization of GWAS hits with expression and methylation QTLs of cultured melanocytes was observed. Additionally, TWAS identified the expression of EDNRB and CDK10 as significantly associated with hair color.
COMMUNICATIONS BIOLOGY
(2021)
Article
Dermatology
Angelique N. Voorberg, Hanna Niehues, Jart A. F. Oosterhaven, Geertruida L. E. Romeijn, Ivonne M. J. J. Vlijmen-Willems, Piet E. J. Erp, Thomas H. A. Ederveen, Patrick L. J. M. Zeeuwen, Marie L. A. Schuttelaar
Summary: Hand eczema is a common inflammatory skin condition of the hands with unknown pathogenesis. Through RNA-sequencing analysis, this study found significantly elevated expression of genes/proteins related to keratinocyte host defense and inflammation in lesional skin of patients with vesicular hand eczema.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jiang Ye, Huabing Liang, Xueyang Zhao, Na Li, Dongji Song, Jiepeng Zhan, Xinfa Wang, Jinxing Tu, Rajeev Kumar Varshney, Jiaqin Shi, Hanzhong Wang
Summary: Heterosis refers to the better performance of cross progeny compared with inbred parents, and its utilization contributes greatly to agricultural production. Several hypotheses have been proposed to explain heterosis mainly including dominance, over-dominance (or pseudo-overdominance) and epistasis. However, systematic dissection and verification of these hypotheses are rarely documented.
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Genetics & Heredity
Zhenming Lu, Li Gong, Yandong Ren, Yongjiu Chen, Zhongkai Wang, Liqin Liu, Haorong Li, Xianqing Chen, Zhenzhu Li, Hairong Luo, Hui Jiang, Yan Zeng, Yifan Wang, Kun Wang, Chen Zhang, Haifeng Jiang, Wenting Wan, Yanli Qin, Jianshe Zhang, Liang Zhu, Wei Shi, Shunping He, Bingyu Mao, Wen Wang, Xiaoyu Kong, Yongxin Li
Summary: Analysis of 11 flatfish genomes indicates that Pleuronectoidei and Psettodoidei are not a monophyletic group. Genomic and transcriptomic data suggest that the WNT and RA pathways played a role in the evolution of the specialized body of flatfish.
Editorial Material
Multidisciplinary Sciences
Dean Hamer, Brian Mustanski, Randall Sell, Stephanie A. Sanders, Justin R. Garcia
Summary: Mixing individuals with different sexual orientations together in research can lead to misleading associations, and it is important to use validated and reliable measures for studying human sexuality.
Article
Plant Sciences
Xiaoyu Lu, Zhu Chen, Buyan Liao, Guomin Han, Dan Shi, Qianzhong Li, Qiuyue Ma, Lu Zhu, Zhiyong Zhu, Xumei Luo, Songling Fu, Jie Ren
Summary: In this study, a chromosome-scale genome for Acer rubrum was obtained using the Oxford Nanopore platform and Hi-C technology. The genome of A. rubrum was found to have 64,644 annotated genes, with a high percentage of functional annotation. The study also revealed the coordinated regulation of non-structural carbohydrates and hormones in the pigmentation of A. rubrum leaves.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Genetics & Heredity
M. Timothy Rabanus-Wallace, Bernd Hackauf, Martin Mascher, Thomas Lux, Thomas Wicker, Heidrun Gundlach, Mariana Baez, Andreas Houben, Klaus F. X. Mayer, Liangliang Guo, Jesse Poland, Curtis J. Pozniak, Sean Walkowiak, Joanna Melonek, Coraline R. Praz, Mona Schreiber, Hikmet Budak, Matthias Heuberger, Burkhard Steuernagel, Brande Wulff, Andreas Boerner, Brook Byrns, Jana Cizkova, D. Brian Fowler, Allan Fritz, Axel Himmelbach, Gemy Kaithakottil, Jens Keilwagen, Beat Keller, David Konkin, Jamie Larsen, Qiang Li, Beata Myskow, Sudharsan Padmarasu, Nidhi Rawat, Ugur Sesiz, Sezgi Biyiklioglu-Kaya, Andy Sharpe, Hana Simkova, Ian Small, David Swarbreck, Helena Toegelova, Natalia Tsvetkova, Anatoly V. Voylokov, Jan Vrana, Eva Bauer, Hanna Bolibok-Bragoszewska, Jaroslav Dolezel, Anthony Hall, Jizeng Jia, Viktor Korzun, Andre Laroche, Xue-Feng Ma, Frank Ordon, Hakan Ozkan, Monika Rakoczy-Trojanowska, Uwe Scholz, Alan H. Schulman, Dorthe Siekmann, Stefan Stojalowski, Vijay K. Tiwari, Manuel Spannagl, Nils Stein
Summary: Rye is a climate-resilient cereal crop used for hybrid breeding to improve wheat varieties, possessing necessary genes for hybridization. Research shows cultivated rye is genetically linked to wild relatives, offering potential applications in disease resistance, low-temperature tolerance, and more.
Article
Genetics & Heredity
Johann S. Hawe, Rory Wilson, Katharina T. Schmid, Li Zhou, Lakshmi Narayanan Lakshmanan, Benjamin C. Lehne, Brigitte Kuehnel, William R. Scott, Matthias Wielscher, Yik Weng Yew, Clemens Baumbach, Dominic P. Lee, Eirini Marouli, Manon Bernard, Liliane Pfeiffer, Pamela R. Matias-Garcia, Matias Autio, Stephane Bourgeois, Christian Herder, Ville Karhunen, Thomas Meitinger, Holger Prokisch, Wolfgang Rathmann, Michael Roden, Sylvain Sebert, Jean Shin, Konstantin Strauch, Weihua Zhang, Wilson L. W. Tan, Stefanie M. Hauck, Juliane Merl-Pham, Harald Grallert, Eudes G. Barbosa, Thomas Illig, Annette Peters, Tomas Paus, Zdenka Pausova, Panos Deloukas, Roger S. Y. Foo, Marjo-Riitta Jarvelin, Jaspal S. Kooner, Marie Loh, Matthias Heinig, Christian Gieger, Melanie Waldenberger, John C. Chambers
Summary: This study focuses on the relationships between DNA sequence variation and DNA methylation, using blood samples from Europeans and South Asians. The findings reveal numerous SNP-CpG associations (meQTL) that are functionally relevant and associated with gene expression, metabolic variation, and clinical traits. Molecular interaction and colocalization analyses identified regulatory pathways linking meQTL loci to phenotypic variation.
Article
Biochemistry & Molecular Biology
Changjun Peng, Dong-Dong Wu, Jin-Long Ren, Zhong-Liang Peng, Zhifei Ma, Wei Wu, Yunyun Lv, Zeng Wang, Cao Deng, Ke Jiang, Christopher L. Parkinson, Yin Qi, Zhi-Yi Zhang, Jia-Tang Li
Summary: By analyzing 14 newly assembled genomes, we investigated the genetic basis of snake phenotypes and conducted functional experiments to understand their morphological characteristics. We identified genes, regulatory elements, and structural variations that have potentially contributed to the evolution of snakes, such as limb loss, elongated body plan, asymmetrical lungs, sensory systems, and digestive adaptations. We also found genes and regulatory elements that might have shaped the evolution of vision, skeletal system and diet in blind snakes, and thermoreception in infrared-sensitive snakes. Our study provides new insights into the evolution and development of snakes and vertebrates.
Article
Plant Sciences
Sajad Majeed Zargar, Madhiya Manzoor, Basharat Bhat, Amir Bashir Wani, Parvaze Ahmad Sofi, Jebi Sudan, Leonard Barnabas Ebinezer, Stefano Dall'Acqua, Gregorio Peron, Antonio Masi
Summary: This study provides a deeper insight into the genetic architecture of seed metabolome in buckwheat by integrating high throughput metabolomics and genotyping-by-sequencing. Results identified 27 SNPs/QTLs and candidate genes associated with metabolites, paving the way for future research on complex economic traits in buckwheat.
Article
Food Science & Technology
Mohammad Shahadat Hossain, Anik Barua, Mohammad Akramul Hoque Tanim, Mohammad Sharif Hasan, Mohammad Jahedul Islam, Md. Rabiul Hossain, Nazim Uddin Emon, S. M. Moazzem Hossen
Summary: The study revealed that the methanol and aqueous extracts of Ganoderma applanatum have significant antidiabetic, hypolipidemic, and hepatoprotective effects in alloxan-induced diabetic rats. In the docking study, Myrocin C showed the highest binding score.
FOOD SCIENCE & NUTRITION
(2021)
Article
Biology
DongAhn Yoo, Junhee Park, Chul Lee, Injun Song, Young Ho Lee, Tery Yun, Hyemin Lee, Adriana Heguy, Jae Yong Han, Jeremy S. Dasen, Heebal Kim, Myungin Baek
Summary: By comparing the transcriptomes of motor neurons in mouse, skate, and chicken, shared and divergent gene expression profiles were identified, and shared and divergent transcription factor motifs were predicted, which may contribute to the understanding of the conserved and divergent molecular mechanisms in MN development in vertebrates.
Editorial Material
Multidisciplinary Sciences
Andrea Ganna, Karin J. H. Verweij, Michel G. Nivard, Robert Maier, Robbee Wedow, Alexander S. Busch, Abdel Abdellaoui, Shengru Guo, J. Fah Sathirapongsasuti, Paul Lichtenstein, Sebastian Lundstrom, Niklas Langstrom, Adam Auton, Kathleen Mullan Harris, Gary W. Beecham, Eden R. Martin, Alan R. Sanders, John R. B. Perry, Benjamin M. Neale, Brendan P. Zietsch
Summary: The complexity of human sexuality cannot be fully captured by a single variable, and genetic influences show substantial overlap between the variable and more nuanced measures of sexual behavior, attraction, and identity.
Article
Genetics & Heredity
Eden Avnat, Guy Shapira, Shelly Shoval, Ifat Israel-Elgali, Anna Alkelai, Alan R. Shuldiner, Claudia Gonzaga-Jauregui, Jamal Zidan, Taiseer Maray, Noam Shomron, Eitan Friedman
Summary: Through variant analysis of whole-genome sequencing of 40 Druze individuals (HGDP cohort) and whole exome sequencing of 118 Druze individuals (WES cohort), several pathogenic variants associated with autosomal recessive and autosomal dominant disorders were identified. These newly identified pathogenic variants should be considered for inclusion in prenatal screening options, but further validation in a larger study is required.
Article
Biochemistry & Molecular Biology
Mengmeng Liu, Cheng Li, Tang Jiang, Ruipu Wang, Yong Wang, Wen'e Zhang, Xuejun Pan
Summary: A high-quality chromosome-scale genome assembly was successfully built for Canna indica using PacBio sequencing and Hi-C genome scaffolding. The genome was predicted to contain 31,130 genes, with 30,816 genes functionally annotated. Transcriptome analysis revealed the genes involved in petal coloration and co-expression network analysis identified key genes regulating deep red and yellow petal coloration. This study provides insights into the molecular basis of flower coloration in Canna indica and has implications for the conservation and breeding of ornamental plants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)