Article
Public, Environmental & Occupational Health
Nan Zhang, Ziheng Jia, Tianshu Gu, Yi Zheng, Yunpeng Zhang, Wenhua Song, Ziliang Chen, Guangping Li, Gary Tse, Tong Liu
Summary: This study explores the causal relationships between genetically predicted risk factors and frailty, finding significant associations between genetic liability to certain diseases and lifestyle factors with increased risk of frailty. It also identifies a negative association between college education and high-density lipoprotein cholesterol level with frailty risk.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Multidisciplinary Sciences
Rodney Plat, Maria Vasile, Francois Roubille, Gregoire Mercier
Summary: Worldwide, there has been a decrease in hospitalizations for acute coronary syndrome (ACS) during the COVID-19 pandemic. ACS is known to be associated with socioeconomic status. This study aims to assess the impact of COVID-19 on ACS admissions in France during the first national lockdown and investigate the factors contributing to its spatial heterogeneity.
Article
Cardiac & Cardiovascular Systems
Tripti Rastogi, Frederick K. Ho, Patrick Rossignol, Thomas Merkling, Javed Butler, Andrew Clark, Timothy Collier, Christian Delles, J. Wouter Jukema, Stephane Heymans, Roberto Latini, Alexandre Mebazaa, Pierpaolo Pellicori, Peter Sever, Jan A. Staessen, Lutgarde Thijs, John G. Cleland, Naveed Sattar, Faiez Zannad, Nicolas Girerd
Summary: This study compares the clinical characteristics associated with the progression to heart failure (HF) in patients with and without a prior history of myocardial infarction (MI). The results show that the importance of risk factors for HF onset is dependent on whether the patient has had a prior MI. Lower renal function is strongly associated with HF onset in patients with prior MI, while higher body mass index (BMI), systolic blood pressure, and blood glucose are significantly associated with HF onset only in patients without prior MI.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Laila A. Hopstock, Bente Morseth, Sarah Cook, Anne Elise Eggen, Sameline Grimsgaard, Marie W. Lundblad, Maja-Lisa Lochen, Ellisiv Mathiesen, Amalie Nilsen, Inger Njolstad
Summary: This study investigated the achievement of European guideline treatment targets for cardiovascular risk factors in Norwegian women and men after myocardial infarction (MI) or ischemic stroke. The study found that secondary prevention of cardiovascular disease was suboptimal, with only a negligible proportion of participants achieving all treatment targets for cardiovascular risk factors.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Adele Perrin, Gergis Abdalla, Marie Viprey, Francois Delahaye, Nathan Mewton, Michel Ovize, Laurent Sebbag, Thomas Bochaton, Alexandra L. Dima, Estelle Bravant, Anne-Marie Schott, Julie Haesebaert
Summary: This study aimed to estimate the prevalence of low health literacy (HL) in patients hospitalized for acute myocardial infarction (AMI) or acute decompensated heart failure (ADHF) and explore the determinants of low HL. The results showed that ADHF patients had a significantly higher prevalence of low HL compared to AMI patients, requiring more support to access healthcare services.
Article
Cardiac & Cardiovascular Systems
Catarina Schiborn, Daniela Weber, Tilman Grune, Ronald Biemann, Susanne Jager, Natascha Neu, Marie Muller von Blumencron, Andreas Fritsche, Cornelia Weikert, Matthias B. Schulze, Clemens Wittenbecher
Summary: This study found differences in the association of retinol and RBP4 (retinol binding protein 4) with cardiovascular diseases and type 2 diabetes. The association was modified by hypertension state, liver function, kidney function, and sex. These findings suggest a complex relationship between retinol, RBP4, and cardiometabolic risk.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Samuel S. Gidding, Laura A. Colangelo, Chike C. Nwabuo, Cora E. Lewis, David R. Jacobs, Pamela J. Schreiner, Joao A. C. Lima, Norrina B. Allen
Summary: The PDAY risk score based on post-mortem measurements was found to be highly predictive of future ASCVD events in young adults. The presence of coronary artery calcium improved risk prediction only if the score was 0. Cumulative risk exposure and PDAY score at age 18-30 were also significant factors for predicting ASCVD.
EUROPEAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Ida Juul Rasmussen, Ruth Frikke-Schmidt
Summary: Dementia is a major global challenge, but 40% of cases can be prevented. Prevention measures, such as reducing cardiovascular risk factors, are crucial for reducing the incidence of dementia. Genome-wide association studies can be useful for identifying novel pathogenic pathways and high-risk individuals.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Ivana Skrlec, Zrinka Biloglav, Jasminka Talapko, Snjezana Dzijan, Danijela Daus-Sebedak, Vera Cesar
Summary: This study investigated the association between MTNR1B gene polymorphisms, chronotype, and susceptibility to myocardial infarction. The case-control study included 199 myocardial infarction patients and 198 control participants without previous cardiovascular diseases, who were genotyped for MTNR1B polymorphisms. Chi-square tests revealed no significant association between allele and genotype distribution in myocardial infarction patients and controls. Additionally, there was no association between MTNR1B polymorphisms and chronotype in myocardial infarction patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Marcelo Munoz, Cagla Eren Cimenci, Keshav Goel, Maxime Comtois-Bona, Mahir Hossain, Christopher McTiernan, Matias Zuniga-Bustos, Alex Ross, Brenda Truong, Darryl R. Davis, Wenbin Liang, Benjamin Rotstein, Marc Ruel, Horacio Poblete, Erik J. Suuronen, Emilio Alarcon
Summary: This article reports on the development and testing of a sprayable nanotherapeutic that can improve cardiac function and conductivity, reduce infarct size, and increase the number of blood vessels and cardiomyocytes in infarcted myocardium.
Article
Peripheral Vascular Disease
Zhongyu Jian, Chi Yuan, Yucheng Ma
Summary: This study reveals that higher levels of urinary uromodulin (uUMOD) are associated with an increased risk of myocardial infarction (MI), while no causal effects of uUMOD on other cardiovascular disease (CVD) outcomes were found. Blood pressure mediates the effect of uUMOD on MI risk.
Article
Peripheral Vascular Disease
Zegui Huang, Zekai Chen, Xianxuan Wang, Xiong Ding, Zefeng Cai, Weijian Li, Zhiwei Cai, Yulong Lan, Guanzhi Chen, Wei Fang, Shouling Wu, Youren Chen
Summary: In hypertensive patients, high-stable cardiovascular health score (CHS) or improvement in CHS is associated with a lower risk of incident myocardial infarction (MI), when compared with low-stable CHS trajectory over time.
Article
Clinical Neurology
Gad Abraham, Loes Rutten-Jacobs, Michael Inouye
Summary: Genetic factors play a significant role in the prediction of cardiovascular diseases, including stroke, and the development of polygenic risk scores has shown potential to improve risk prediction for stroke.
Article
Rheumatology
Tsai-Hung Yen, Yun-Wen Chen, Tsu-Yi Hsieh, Yi-Ming Chen, Wen-Nan Huang, Yi-Hsing Chen, Hsin-Hua Chen
Summary: This study aimed to assess the incidence and risk factors of major adverse cardiovascular events (MACEs) in patients with systemic sclerosis (SSc). A nationwide cohort study was conducted in Taiwan, including 1379 SSc patients and 2758 non-SSc individuals. The study found that SSc was associated with increased risk of myocardial infarction and peripheral arterial occlusion disease, but not of ischaemic stroke. Age, gender, residential area, valvular heart disease, rheumatoid arthritis, and the use of clopidogrel and aspirin were identified as independent risk factors for MACEs in SSc patients. The findings of this study are clinically significant in understanding the risk factors for MACEs in SSc patients.
Article
Medicine, General & Internal
Luke C. Pilling, Deniz Turkmen, Hannah Fullalove, Janice L. Atkins, Joao Delgado, Chia-Ling Kuo, George A. Kuchel, Luigi Ferrucci, Jack Bowden, Jane A. H. Masoli, David Melzer
Summary: The study found that in UK primary care patients, individuals carrying CYP2C19 loss-of-function alleles had a higher risk of ischemic stroke and myocardial infarction when prescribed clopidogrel. Therefore, genotype-guided selection of antiplatelet medications may improve outcomes in patients with CYP2C19 genetic variants.
Article
Cardiac & Cardiovascular Systems
Marianne Benn, Sarah C. W. Marott, Anne Tybjaerg-Hansen, Borge G. Nordestgaard
Summary: High BMI causally increases the risk of both heart failure incidence and mortality.
CARDIOVASCULAR RESEARCH
(2023)
Article
Psychology, Developmental
Sofie Have Hoffmann, Veronica Sofie Clara Pisinger, Johanne Aviaja Rosing, Janne S. Tolstrup
Summary: The objectives of this study were to assess the prevalence of worries and symptoms of distress among young Danes during the first COVID-19 lockdown, as well as the perceived change in these symptoms based on sociodemographic factors and preexisting vulnerabilities. The results showed that females reported a higher frequency of distress symptoms compared to males during the lockdown, and individuals with pre-pandemic anxiety symptoms, mental health disorders, and economic hardships were more likely to perceive an increase in distress symptoms during the lockdown.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Signe Skovgaard Hviid, Veronica Pisinger, Sofie Have Hoffman, Johanne Aviaja Rosing, Janne Shurmann Tolstrup
Summary: This study aimed to explore the effects of restrictions during the first Danish COVID-19 lockdown on alcohol use among adolescents aged 15-20. The findings revealed that Danish adolescents drank less during the lockdown, and there was a close relationship between in-person social interactions and frequency of drinking. Drinking episodes when meeting online were rare and were not consistently associated with changes in drinking during the lockdown.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Kamilla Kragelund, Janne S. Tolstrup, Cathrine J. Lau, Anne Christensen, Maja B. Jorgensen
Summary: This study found that smokers are at a higher risk of unemployment and sickness absence, and have a lower chance of getting re-employed compared to never smokers. Thus, more efforts should be put into smoking prevention and cessation in relation to job seeking and absence.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Sanne Pagh Moller, Janne S. Tolstrup, Signe Skovgaard Hviid, Pernille Bendtsen
Summary: There is a strong association between parental alcohol norms and alcohol intake among high school students, and this association persists across different levels of school alcohol intake and level of trustful communication with parents.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Mie Balling, Borge G. Nordestgaard, Anette Varbo, Anne Langsted, Pia R. Kamstrup, Shoaib Afzal
Summary: This study explored the association between high levels of small dense low-density lipoprotein (sdLDL) and the risk of ischemic stroke in a large prospective study. The findings revealed a robust relationship between elevated sdLDL cholesterol levels and increased risk of ischemic stroke.
ANNALS OF NEUROLOGY
(2023)
Article
Gastroenterology & Hepatology
Helene Gellert-Kristensen, Anne Tybjaerg-Hansen, Borge G. Nordestgaard, Jonas Ghouse, Andreas Fuchs, Jorgen T. Kuhl, Per E. Sigvardsen, Klaus F. Kofoed, Stefan Stender
Summary: Observational epidemiological studies have shown that fatty liver disease is associated with higher all-cause mortality, liver-related mortality, ischemic heart disease-related mortality, and extrahepatic cancer-related mortality. In this genetic study, we found that seven genetic variants associated with fatty liver disease were significantly correlated with liver-related mortality. Using a Mendelian randomization framework, we further demonstrated that hepatic steatosis and elevated plasma ALT, as genetically determined factors, are associated with liver-related mortality.
LIVER INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Jacob Louis Marott, Magnus T. Jensen, Marianne Benn, Martina Chantal de Knegt, James H. O'Keefe, Carl J. Lavie, Peter Schnohr, Berge Gronne Nordestgaard, Gorm Boje Jensen
Summary: This study aimed to test the hypothesis that the increased risk of atrial fibrillation in men compared with women is explained by height. The results showed that the higher risk of atrial fibrillation in men can indeed be explained by differences in height. The study also suggested that height is one of the most important risk factors for atrial fibrillation in both men and women.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Health Care Sciences & Services
Caroline Holt Udesen, Signe Skovgaard Hviid, Ulrik Becker, Janne S. Tolstrup
Summary: Adolescents and young adults aged 15-24 years are disproportionately affected by alcohol-related deaths. This study aimed to explore the extent and circumstances surrounding these deaths, as well as the potential differences in socioeconomic background and ethnicity compared to the general population.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Cardiac & Cardiovascular Systems
Katrine L. Rasmussen, Jiao Luo, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: The structural genetic variations in the APOE gene are associated with vascular diseases. APOE variants with high apoE, triglycerides, and remnant cholesterol are associated with peripheral arterial disease (PAD), while common APOE variants with high LDL cholesterol, triglycerides, and remnant cholesterol are associated with ischemic heart disease (IHD). APOE variants with low apoE are associated with increased risk of ischemic cerebrovascular disease (ICVD).
Article
Cardiac & Cardiovascular Systems
Nawar Dalila, Ruth Frikke-Schmidt, Borge G. Nordestgaard, Anne Tybjaerg-Hansen
Summary: This study found that low levels of thyroid stimulating hormone (TSH) are associated with increased risk of cardiovascular diseases (such as atrial fibrillation, myocardial infarction, stroke) both observationally and genetically. These findings suggest a potential causal relationship.
Article
Cardiac & Cardiovascular Systems
Laerke Kristine Kyhl, Borge Gronne Nordestgaard, Anne Tybjaerg-Hansen, Sune Fallgaard Nielsen
Summary: High levels of plasma triglycerides, BMI, and waist circumference, individually and combined, are associated with an increased risk of clinically diagnosed non-alcoholic fatty liver disease. This study found that the risk of non-alcoholic fatty liver disease increased in individuals with higher plasma triglycerides, BMI, and waist circumference over a 9.2-year follow-up period.
Article
Endocrinology & Metabolism
Berit Storgaard Hedegaard, Borge Gronne Nordestgaard, Helle Lynge Kanstrup, Kristian Korsgaard Thomsen, Jan Bech, Lia Evi Bang, Finn Lund Henriksen, Lars Juel Andersen, Thomas Gohr, Linnea Hornbech Larsen, Anne Merete Boas Soja, Frank-Peter Elpert, Tomas Joen Jakobsen, Anette Sjol, Albert Marni Joensen, Ib Christian Klausen, Erik Berg Schmidt, Christian Sorensen Bork
Summary: This study investigated the presence of lipoprotein(a) in individuals referred to Danish lipid clinics and found that elevated lipoprotein(a) played a role in a quarter of individuals who met the diagnosis criteria for clinical familial hypercholesterolemia (FH).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris Jansen, Eric Yu, Aude Nicolas, Itziar de Rojasj, Thiago Peixoto Leal, Akinori Miyashita, Celine Bellenguez, Michelle Mulan Lian, Kayenat Parveen, Takashi Morizono, Hyeonseul Park, Benjamin Grenier-Boley, Tatsuhiko Naito, Fahri Kucukali, Seth D. Talyansky, Selina Maria Yogeshwar, Vicente Sempere, Wataru Satake, Victoria Alvarez, Beatrice Arosio, Michael E. Belloy, Luisa Benussi, Anne Boland, Barbara Borroni, Maria J. Bullido, Paolo Caffarra, Jordi Clarimon, Antonio Daniele, Daniel Darling, Stephanie Debette, Jean-Francois Deleuze, Martin Dichgans, Carole Dufouil, Emmanuel During, Emrah Duzel, Daniela Galimberti, Guillermo Garcia-Ribas, Jose Maria Garcia-Alberca, Pablo Garcia-Gonzalez, Vilmantas Giedraitis, Oliver Goldhardt, Caroline Graff, Edna Grunblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Heimbach, Henne Holstege, Jakub Hort, Yoo Jin Jung, Deckert Jurgen, Silke Kern, Teemu Kuulasmaa, Kun Ho Lee, Ling Lin, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre de Mendonca, Merce Boada, Pablo Mir, Susanne Moebus, Fermin Moreno, Benedetta Nacmias, Gael Nicolas, Shumpei Niida, Borge G. Nordestgaard, Goran Papenberg, Janne Papma, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Oliver Peters, Yolande A. L. Pijnenburg, Gerard Pinol-Ripoll, Julius Popp, Laura Molina Porcel, Raquel Puertaj Jordi Perez-Tur, Innocenzo Rainero, Inez Ramakers, Luis M. Real, Steffi Riedel-Heller, Eloy Rodriguez-Rodriguez, Owen A. Ross, Jose Luis Royo, Dan Rujescu, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Ingmar Skoog, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John van Swieten, Raquel Sanchez-Valle, Eng-King Tan, Thomas Tegos, Charlotte Teunissen, Jesper Qvist Thomassen, Lucio Tremolizzo, Martin Vyhnalek, Frans Verhey, Margda Waern, Jens Wiltfang, Jing Zhangc, Henrik Zetterberg, Kaj Blennow, Zihuai He, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick G. Kehoe, Ole A. Andreassen, Cornelia Van Duin, Magda Tsolaki, Pascual Sanchez-Juan, Ruth Frikke-Schmidt, Kristel Sleegers, Tatsushi Todau, Anna Zettergren, Martin Ingelsson, Yukinori Okada, Giacomina Rossi, Mikko Hiltunen, Jungsoo Gim, Kouichi Ozaki, Rebecca Sims, Jia Nee Foo, Wiesje van der Fliere, Takeshi Ikeuchi, Alfredo Ramirez, Ignacio Mata, Agustin Ruiz, Ziv Gan-Or, Jean-Charles Lambert, Michael D. Greicius, Emmanuel Mignot
Summary: We analyzed the HLA associations in individuals with Parkinson's disease and Alzheimer's disease across different ancestry groups and found that these two diseases share a common protective association at the HLA locus. Fine-mapping showed that specific subtypes of HLA-DRB1*04 were responsible for this association, with HLA-DRB1*04:04 and HLA-DRB1*04:07 showing the strongest association. This protective effect was also associated with decreased neurofibrillary tangles in the brain and reduced levels of tau protein in cerebrospinal fluid.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cardiac & Cardiovascular Systems
Jiao Luo, Jesper Qvist Thomassen, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: This study investigated the associations between neutrophil counts and nine cardiovascular endpoints using observational and genetic approaches. The results showed that high neutrophil counts were associated with an increased risk of all cardiovascular outcomes. Genetic studies also supported this finding. No robust associations were found for other types of leukocytes in the two-sample MR analysis.
EUROPEAN HEART JOURNAL
(2023)
