Article
Cardiac & Cardiovascular Systems
Hilary C. Bowman, Kevin M. Shannon, Reshma Biniwale, Jeremy P. Moore
Summary: In adult congenital heart disease (ACHD) patients, overall dysfunction and reintervention rates of cardiac implantable electronic devices (CIEDs) are similar between transvenous (TV) and epicardial (EPI) approaches, but lead dysfunction is more severe in EPI devices.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Tam Dan N. Pham, Frank Cecchin, Edward O'Leary, Francis Fynn-Thompson, John K. Triedman, Kimberlee Gauvreau, Douglas Y. Mah
Summary: This study evaluated the safety and efficacy of transvenous lead extraction (TLE) at a single pediatric/congenital heart disease (CHD) center, demonstrating that TLE can be performed successfully and safely in this setting.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jamil Bashir, Arthur J. Lee, Francois Philippon, Blandine Mondesert, Andrew D. Krahn, Mouhannad M. Sadek, Derek Exner, Melissa Pak, Jean Francois Legare, Shahzad Karim, Lynn Fedoruk, Defen Peng, Robert J. Cusimano, Ratika Parkash, G. Frank O. Tyers, Jason Andrade
Summary: This study aims to identify factors associated with cardiac or vascular perforation and death in patients undergoing lead extraction, as well as to characterize the lead extraction procedure in a large population.
Article
Cardiac & Cardiovascular Systems
Ziad F. Issa, Tariq Z. Issa
Summary: This study assessed the management approach and outcome of subacute and delayed cardiac perforation by pacemaker or ICD leads. Percutaneous repositioning or replacement of the perforating lead was found to be a safe and effective management approach in this study.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Moris Topaz, Ehud Chorin, Arie Lorin Schwartz, Aviram Hochstadt, Avraham Shotan, Itamar Ashkenazi, Mark Kazatsker, Narin-Nard Carmel, Guy Topaz, Yoram Oron, Gilad Margolis, Eyal Nof, Roy Beinart, Michael Glikson, Anna Mazo, Anat Milman, Michal Dekel, Shmuel Banai, Raphael Rosso, Sami Viskin
Summary: This study evaluated the efficacy of delivering continuous, in situ-targeted, ultrahigh concentration of antibiotics (CITA) into the infected device pocket as an alternative to device extraction. It was found that CITA is a safe and effective treatment for patients with pocket infections who are unable or unwilling to undergo extraction.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Douglas Darden, Bendelyn Asante Boateng, Andrew S. Tseng, Laith Alshawabkeh, Travis Pollema, Yong-Mei Cha, Ulrika Birgersdotter-Green
Summary: This study examined the outcomes of transvenous lead extraction (TLE) in patients with congenital complete heart block (CCHB) with cardiac implantable electronic devices. The results showed a high risk and the need for experienced centers in lead management for CCHB patients.
Article
Cardiac & Cardiovascular Systems
Simon Pecha, Heiko Burger, Da-Un Chung, Viviane Moeller, Tomas Madej, Alaa Maali, Brigitte Osswald, Raffaele De Simone, Nadeja Monsefi, Virgilijus Ziaukas, Stefan Erler, Hamdi Elfarra, Mathias Perthel, Mahmoud S. Wehbe, Naser Ghaffari, Tim Sandhaus, Henning Busk, Jan D. Schmitto, Volker Baersch, Jerry Easo, Marc Albert, Hendrik Treede, Herbert Naegele, Dieter Zenker, Yasser Hegazy, Donja Ahmadi, Nele Gessler, Wolfgang Ehrlich, Gabriele Romano, Michael Knaut, Hermann Reichenspurner, Stephan Willems, Christian Butter, Samer Hakmi
Summary: The GALLERY study investigates the safety and effectiveness of laser lead extraction procedures in Germany. The results show high success rate and low complication rate. Predictors for complications include female sex and the presence of abandoned leads, while predictors for all-cause mortality include systemic infection, age ≥ 75 years, and chronic kidney disease.
Article
Cardiac & Cardiovascular Systems
Roland Heck, Bjoern Peters, Pia Lanmueller, Joachim Photiadis, Felix Berger, Volkmar Falk, Christoph Starck, Peter Kramer
Summary: This retrospective cohort study analyzed the use of transvenous lead extraction (TLE) with powered mechanical dissection sheaths in children. The study found that TLE with mechanical powered rotational dissection sheaths is feasible and safe in pediatric patients. However, the success and complexity of the procedure varied between different lead types.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Linhong Song, Qiang Meng, Changgen Liu, Gang Wang, Hui Wang, Gengxu Zhou, Zhichun Feng
Summary: This study retrospectively analyzed the clinical data and follow-up results of nine children with congenital complete atrioventricular block (CCAVB). The results showed that early implantation of a pacemaker in newborns and infants diagnosed with CCAVB can significantly improve clinical symptoms without affecting their growth and development. Further studies are needed to confirm these findings.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Massimo Stefano Silvetti, Luc Bruyndonckx, Alice Maltret, Roman Gebauer, Joanna Kwiatkowska, Laszlo Kornyei, Sonia Albanese, Cristina Raimondo, Christian Paech, Maciej Kempa, Gabor Fesus, Reinoud E. Knops, Nico Andreas Blom, Fabrizio Drago
Summary: This study aims to investigate the indications, complications, and outcomes of subcutaneous-implantable cardiac defibrillators (S-ICDs) in young patients. The results showed that S-ICDs had good efficacy and safety in young patients, with better outcomes in patients with BMI > 20 and newer implantation techniques.
Article
Cardiac & Cardiovascular Systems
Ziad F. Issa
Summary: This study evaluated an intraprocedural risk stratification approach for elective transvenous lead extraction, which proved successful in the majority of patients and can potentially optimize the balance between efficacy, safety, and efficiency in lead extraction.
Article
Public, Environmental & Occupational Health
Marie Tindborg, Anders Koch, Mikael Andersson, Klaus Juul, Uka Wilhjelm Geisler, Bolette Soborg, Sascha Wilk Michelsen
Summary: The incidence rates of heart disease (HD) and congenital heart disease (CHD) were compared between young Inuit populations in Greenland and Denmark. It was found that the incidence rate of HD was lower in Greenland compared to Denmark, while the incidence rates of CHD were similar in both countries. Individuals of Inuit/mixed ethnicity had a higher risk of both HD and CHD compared to non-Inuit individuals in both countries.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ying Huang, Joseph A. Dearani, Brian D. Lahr, Elizabeth H. Stephens, Malini Madhavan, Bryan C. Cannon, Hartzell Schaff
Summary: The objective of this study was to evaluate outcomes of surgical management of lead-induced tricuspid regurgitation (TR) in patients with congenital heart disease. The study found that early mortality was low after tricuspid valve surgery, and survival and rate of tricuspid valve reintervention were comparable for repair and replacement groups. However, repair surgery was associated with progressive TR during intermediate follow-up, especially in patients with severe preoperative TR.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Biology
Igor Diemberger, Luca Segreti, Christopher A. Rinaldi, Jesper Hastrup Svendsen, Andrzej Kutarski, Arwa Younis, Cecile Laroche, Christophe Leclercq, Barbara Malecka, Przemyslaw Mitkowski, Maria Grazia Bongiorni
Summary: According to the analysis of patients with infection of implantable pacemakers/defibrillators, about one-third of the cases showed systemic infection, which is associated with increased complications and mortality during hospitalization. Patients with systemic infection have different characteristics compared to those with local infection, suggesting that some infections may be systemic from the beginning. These findings have important implications for further research and treatment.
Article
Cardiac & Cardiovascular Systems
Joseph Boone Muhlestein, Elizabeth Dranow, Jason Chaney, Leenhapong Navaravong, Benjamin A. Steinberg, Roger A. Freedman
Summary: The tandem femoral-superior approach to lead extraction was found to be safe and effective, effectively eliminating superior vena cava injury.
Article
Cardiac & Cardiovascular Systems
Andrew B. Goldstone, Michael Baiocchi, David Wypij, Christian Stopp, Dean B. Andropoulos, Joseph Atallah, Andrew M. Atz, John Beca, Mary T. Donofrio, Kim Duncan, Nancy S. Ghanayem, Caren S. Goldberg, Hedwig Hoevels-Guerich, Fukiko Ichida, Jeffrey P. Jacobs, Robert Justo, Beatrice Latal, Jennifer S. Li, William T. Mahle, Patrick S. McQuillen, Shaji C. Menon, Nancy A. Pike, Christian Pizarro, Lara S. Shekerdemian, Anne Synnes, Ismee A. Williams, David C. Bellinger, Jane Newburger, J. William Gaynor
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Jayani B. Abeysekera, Dora L. Gyenes, Joseph Atallah, Charlene M. T. Robertson, Gwen Y. Bond, Ivan M. Rebeyka, Elham Khodayari Moez, Irina A. Dinu, Heather N. Switzer, Lisa K. Hornberger
Summary: In fetal transposition of the great arteries and hypoplastic left heart syndrome, a higher UA-PI in the third trimester, suggestive of placental insufficiency but not MCA-PI, is associated with worse 2-year growth and neurodevelopment outcomes.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Correction
Cardiac & Cardiovascular Systems
Joseph Atallah, M. Cecilia Gonzalez Corcia, Edward P. Walsh
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jeffrey A. Robinson, Martin J. LaPage, Joseph Atallah, Gregory Webster, Christina Y. Miyake, Christopher Ratnasamy, Nicholas J. Ollberding, Shaun Mohan, Nicholas H. Von Bergen, Christopher L. Johnsrude, Jason M. Garnreiter, David S. Spar, Richard J. Czosek
Summary: ICD is recommended for secondary prevention after SCA, but its outcomes in pediatric patients remain unclear. The study found that pediatric patients receiving an ICD after SCA are at high risk for future device therapy, with factors such as genetic predisposition and cardiac function playing a role. Lack of a definitive diagnosis after SCA does not reduce the risk of subsequent events, highlighting the importance of continued prophylactic measures.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Susan Christian, Alicia Welsh, Jeremy Yetman, Patrician Birch, Kirsten Bartels, Lindsay Burnell, Fiona Curtis, Cathleen Huculak, Laura Zahavich, Laura Arbour, Julien Marcadier, Joseph Atallah
Summary: This study developed and evaluated 4 cardiac decision aids for families with genetic diagnoses of certain heart conditions. The response to the aids was positive, with high acceptability and understandability scores. These tools can be used before, during, or after genetic counseling appointments to help guide discussions and provide a balanced approach to decision-making.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Dania Kallas, Thomas M. Roston, Sonia Franciosi, Laura Brett, Krystien V. V. Lieve, Sit-Yee Kwok, Prince J. Kannankeril, Andrew D. Krahn, Martin J. LaPage, Susan Etheridge, Allison Hill, Christopher Johnsrude, James Perry, Linda Knight, Peter Fischbach, Seshadri Balaji, Svjetlana Tisma-Dupanovic, Ian Law, Joseph Atallah, David Backhoff, Anna Kamp, Peter Kubus, Adam Kean, Peter F. Aziz, Joshua Kovach, Yung Lau, Jordana Kron, Sally-Ann Clur, Georgia Sarquella-Brugada, Arthur A. M. Wilde, Shubhayan Sanatani
Summary: In this study of pediatric CPVT patients, it was found that proband status is an independent predictor of time to first cardiac event. Age at symptom onset and sex were not identified as predictive factors. Treatment and strategies can influence event risk for both probands and relatives.
Review
Cardiac & Cardiovascular Systems
Drake A. Comber, Brianna Davies, Jason D. Roberts, Rafik Tadros, Martin S. Green, Jeffrey S. Healey, Christopher S. Simpson, Shubhayan Sanatani, Christian Steinberg, Ciorsti MacIntyre, Paul Angaran, Henry Duff, Robert Hamilton, Laura Arbour, Richard Leather, Colette Seifer, Anne Fournier, Joseph Atallah, Shane Kimber, Bhavanesh Makanjee, Wael Alqarawi, Julia Cadrin-Tourigny, Jacqueline Joza, Karen Gibbs, Laura Robb, Laura Zahavich, Martin Gardner, Mario Talajic, Alice Virani, Andrew D. Krahn, Anna Lehman, Zachary W. M. Laksman
Summary: Research teams developing biobanks and genomic databases must establish policies for disclosing and reporting potentially actionable genomic results to research participants. There are various approaches to returning results, requiring decisions on informed consent, disclosure practices, and clinical validation.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Puck J. Peltenburg, Dania Kallas, Johan M. Bos, Krystien V. V. Lieve, Sonia Franciosi, Thomas M. Roston, Isabelle Denjoy, Katrina B. Sorensen, Seiko Ohno, Ferran Roses-Noguer, Takeshi Aiba, Alice Maltret, Martin J. LaPage, Joseph Atallah, John R. Giudicessi, Sally-Ann B. Clur, Nico A. Blom, Michael Tanck, Fabrice Extramiana, Koichi Kato, Julien Barc, Martin Borggrefe, Elijah R. Behr, Georgia Sarquella-Brugada, Jacob Tfelt-Hansen, Esther Zorio, Heikki Swan, Janneke A. E. Kammeraad, Andrew D. Krahn, Andrew Davis, Frederic Sacher, Peter J. Schwartz, Jason D. Roberts, Jonathan R. Skinner, Maarten P. van den Berg, Prince J. Kannankeril, Fabrizio Drago, Tomas Robyns, Kristina Haugaa, Terezia Tavacova, Christopher Semsarian, Jan Till, Vincent Probst, Ramon Brugada, Wataru Shimizu, Minoru Horie, Antoine Leenhardt, Michael J. Ackerman, Shubhayan Sanatani, Christian van der Werf, Arthur A. M. Wilde
Summary: Selective beta-blockers are associated with a higher risk of arrhythmic events in symptomatic children with CPVT compared to nonselective beta-blockers, especially nadolol. Nadolol, or propranolol if nadolol is unavailable, should be the preferred beta-blocker for treating symptomatic children with CPVT.
Article
Biochemistry & Molecular Biology
Kaveh Rayani, Brianna Davies, Matthew Cheung, Drake Comber, Jason D. Roberts, Rafik Tadros, Martin S. Green, Jeffrey S. Healey, Christopher S. Simpson, Shubhayan Sanatani, Christian Steinberg, Ciorsti MacIntyre, Paul Angaran, Henry Duff, Robert Hamilton, Laura Arbour, Richard Leather, Colette Seifer, Anne Fournier, Joseph Atallah, Shane Kimber, Bhavanesh Makanjee, Wael Alqarawi, Julia Cadrin-Tourigny, Jacqueline Joza, Martin Gardner, Mario Talajic, Richard D. Bagnall, Andrew D. Krahn, Zachary W. M. Laksman
Summary: Variants in splice sites of cardiac genes may increase the risk of potentially lethal arrhythmias. Screening of 1315 patients and relatives revealed that 10% of patients carried variants near the splice sites, and these variants were classified and evaluated using nine in silico tools. Among these tools, CADD showed good sensitivity, dbscSNV was highly sensitive, and SpliceAI exhibited high specificity. Splice variants remain an important consideration in inherited arrhythmia syndromes.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Lauren A. Yee, Hui-Chen Han, Brianna Davies, Charles M. Pearman, Zachary W. M. Laksman, Jason D. Roberts, Christian Steinberg, Rafik Tadros, Julia Cadrin-Tourigny, Christopher S. Simpson, Martin Gardner, Ciorsti MacIntyre, Laura Arbour, Richard Leather, Anne Fournier, Martin S. Green, Shane Kimber, Paul Angaran, Shubhayan Sanatani, Jacqueline Joza, Habib Khan, Jeffrey S. Healey, Joseph Atallah, Colette Seifer, Andrew D. Krahn
Summary: The study confirmed the high predictive value of the 3-step algorithm based on exercise response for diagnosing LQTS in a more representative population, with better accuracy in confirming the condition in female patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Amol A. Moray, Charlene M. T. Robertson, Gwen Y. Bond, Jayani B. Abeysekera, Parsa Mohammadian, Irina A. Dinu, Joseph Atallah, Heather N. Switzer, Lisa K. Hornberger
Summary: This study examines the relationships between umbilical and middle cerebral artery pulsatility index (PI) in fetuses with major congenital heart disease (CHD) and neurodevelopment (ND) outcomes. The results show an inverse relationship between third trimester umbilical artery PI and cognitive, motor, and language domains of neurodevelopment at 2 years, indicating impaired neurodevelopment in these fetuses.
PEDIATRIC CARDIOLOGY
(2023)
Article
Psychology, Clinical
Richelle C. Waldner, Manpreet Doulla, Joseph Atallah, Sarah Rathwell, Chelsey Grimbly
Summary: This study aimed to determine the proportion of gender-diverse youth with QTc prolongation on leuprolide acetate therapy. A retrospective chart review revealed that none of the gender-diverse youth receiving leuprolide acetate therapy showed clinically significant QTc prolongation (QTc >460 milliseconds) at a tertiary care pediatric hospital in Alberta, Canada.
TRANSGENDER HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Mikyla L. Janzen, Brianna Davies, Zachary W. M. Laksman, Jason D. Roberts, Shubhayan Sanatani, Christian Steinberg, Rafik Tadros, Julia Cadrin-Tourigny, Ciorsti Macintyre, Joseph Atallah, Anne Fournier, Martin S. Green, Robert Hamilton, Habib R. Khan, Shane Kimber, Steven White, Jacqueline Joza, Bhavanesh Makanjee, Erkan Ilhan, David Lee, Simon Hansom, Alexios Hadjis, Laura Arbour, Richard Leather, Colette Seifer, Paul Angaran, Christopher S. Simpson, Jeffrey S. Healey, Martin Gardner, Mario Talajic, Andrew D. Krahn
Summary: Inherited arrhythmia syndromes are rare genetic conditions that increase the risk of sudden cardiac arrest and death in seemingly healthy individuals. The Hearts in Rhythm Organization is a Canadian network that aims to improve care for patients and families affected by these conditions. This review provides consensus care pathways for common inherited cardiac conditions, as well as guidelines for investigating and managing sudden cardiac arrest and related cases.
Article
Cardiac & Cardiovascular Systems
Jeremy P. Moore, Natasja M. S. de Groot, Matthew Connor, Daniel Cortez, Jonathan Su, Austin Burrows, Kevin M. Shannon, Edward T. O. Leary, Maully Shah, Paul Khairy, Joseph Atallah, Tom Wong, Michael S. Lloyd, Yannick J. H. J. Taverne, Anne M. Dubin, Jens C. Nielsen, Reinder Evertz, Richard J. Czosek, Malini Madhavan, Philip M. Chang, Alper Aydin, Oscar Cano
Summary: This study compared the clinical outcomes of cardiac conduction system pacing (CSP) versus conventional cardiac resynchronization therapy (CRT) in congenital heart disease (CHD) patients with biventricular, systemic left ventricular anatomy. The results showed that CSP achieved similar improvement in left ventricular ejection fraction (LVEF) but greater QRS narrowing compared to conventional CRT.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Khoury, Morteza Hajihosseini, Charlene M. T. Robertson, Gwen Bond, Darren Freed, Irina Dinu, Sue Makarchuk, Ari Joffe, Joseph Atallah
Summary: This study aimed to evaluate the prevalence and factors associated with optimal neurodevelopmental outcomes in 4-to 6-year-old children with Fontan circulation. Factors such as female sex, years of maternal schooling, age at Fontan surgery, need for concomitant atrioventricular valve intervention, and time for lactate normalization were found to be associated with optimal neurodevelopmental outcomes.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)