Article
Cardiac & Cardiovascular Systems
Fiorenzo Gaita, Natascia Cerrato, Carla Giustetto, Annamaria Martino, Laura Bergamasco, Michele Millesimo, Lorella Barbonaglia, Paula Carvalho, Domenico Caponi, Andrea Saglietto, Giacomo Bonacchi, Francesca Bianchi, Elisa Silvetti, Cinzia Crescenzi, Stefano Canestrelli, Melissa De Maio, Gaetano Maria De Ferrari, Giuseppe Musumeci, Francesco Rametta, Marco Scaglione, Leonardo Calo
Summary: The study evaluated the long-term prognosis of a large cohort of asymptomatic patients with Brugada ECG pattern. The entire population of asymptomatic patients with BrECG exhibited a relatively low event rate per year, with those having spontaneous type-1 BrECG and positive EPS showing higher risk. Asymptomatic patients with drug-induced-only BrECG had minimal arrhythmic risk, but ongoing follow-up was recommended to detect the appearance of spontaneous type-1 BrECG pattern.
Article
Cardiac & Cardiovascular Systems
Vincent Portero, Thomas Nicol, Svitlana Podliesna, Gerard A. Marchal, Antonius Baartscheer, Simona Casini, Rafik Tadros, Jorien L. Treur, Michael W. T. Tanck, I. Jane Cox, Fay Probert, Tertius A. Hough, Sara Falcone, Leander Beekman, Martina Muller-Nurasyid, Gabi Kastenmuller, Christian Gieger, Annette Peters, Stefan Kaab, Moritz F. Sinner, Andrew Blease, Arie O. Verkerk, Connie R. Bezzina, Paul K. Potter, Carol Ann Remme
Summary: This study identified a mouse line with a high incidence of sudden death at a young age due to a nonsense mutation in the Bcat2 gene, leading to elevated levels of branch chain amino acids. The elevated BCAA levels were found to be positively correlated with arrhythmia-related indices and calcium dysregulation in both mouse models and human cardiomyocytes. The involvement of the mTOR pathway activation was demonstrated in preventing pro-arrhythmic events induced by high BCAA concentrations, suggesting a potential link between elevated BCAAs and arrhythmia in conditions like diabetes and heart failure.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Shohreh Honarbakhsh, Rui Providencia, Jorge Garcia-Hernandez, Claire A. Martin, Ross J. Hunter, Wei Y. Lim, Claire Kirkby, Adam J. Graham, Ardalan Sharifzadehgan, Victor Waldmann, Eloi Marijon, Carmen Munoz-Esparza, Javier Lacunza, Juan Ramon Gimeno-Blanes, Benedicte Ankou, Philippe Chevalier, Natalia Antonio, Luis Elvas, Silvia Castelletti, Lia Crotti, Peter Schwartz, Mauricio Scanavacca, Francisco Darrieux, Luciana Sacilotto, Johanna Mueller-Leisse, Christian Veltmann, Alessandro Vicentini, Andrea Demarchi, Nuno Cortez-Dias, Pedro Silverio Antonio, Joao de Sousa, Pedro Adragao, Diogo Cavaco, Francisco Morosco Costa, Ziad Khoueiry, Serge Boveda, Mario Joao Sousa, Zeynab Jebberi, Patrick Heck, Sarju Mehta, Giulio Conte, Tardu Ozkartal, Angelo Auricchio, Martin D. Lowe, Richard J. Schilling, David Prieto-Merino, Pier D. Lambiase
Summary: This study aimed to develop a risk score model for patients with Brugada syndrome, utilizing a multicenter international cohort to evaluate and predict ventricular arrhythmias/sudden cardiac death. The study identified four risk factors associated with higher risk of VA/SCD in BrS patients, and a risk score model was created with effective validation through cross-validation.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Mehul Adhaduk, Bishow Paudel, Kan Liu, Mahi Ashwath, Michael Giudici
Summary: The study found that EPS is an effective risk stratification tool in patients with cardiac sarcoidosis (CS) across all subgroups with high sensitivity and specificity, making it valuable for predicting adverse clinical outcomes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Sara D'Imperio, Michelle M. Monasky, Emanuele Micaglio, Giuseppe Ciconte, Luigi Anastasia, Carlo Pappone
Summary: Brugada syndrome (BrS) is a hereditary disorder characterized by a specific ECG pattern and associated with an increased risk of sudden cardiac death. The syndrome has been linked to a systemic effect involving various organ systems beyond just the heart, with potential triggers for arrhythmic events in patients including large meals and alcohol consumption. Further research using a multi-omics approach may lead to the development of biomarkers and minimally invasive diagnostic tests for BrS, reducing the risks associated with current diagnostic methods.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Pattara Rattanawong, Jakrin Kewcharoen, Chanavuth Kanitsoraphan, Timothy Barry, Anusha Shanbhag, Nway L. Ko Ko, Wasawat Vutthikraivit, Madhurima Home, Pradyumna Agasthi, Hasan Ashraf, Wataru Shimizu, Win-Kuang Shen
Summary: The study revealed that a history of SCD among family members under the age of 40 is associated with a higher risk of MAE. Additionally, a history of SCD in younger family members was significantly linked to a higher risk of MAE when stratified by the age cutoff points of 50, 45, 40, and 35 years old.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Andrew E. Radbill, Lucy Y. Lei, Sachin Y. Paranjape, Daniel J. Blackwell, Robert L. Abraham, Derek S. Chew, Satish R. Raj, Bjorn C. Knollmann
Summary: This study aimed to assess rate-dependence of clinical surrogates of contractility and repolarization in humans with hypertrophic cardiomyopathy. Findings show that rapid pacing trains triggered ventricular ectopy in hypertrophic cardiomyopathy patients, but not controls. However, there were no significant differences observed in surrogate measures for cardiac contractility, suggesting that altered length-dependent myofilament activation may not have significant clinical implications in these patients.
Review
Medicine, General & Internal
Shixu Liu, Hongsheng Xia, Xiaoyan Yao, Hengyuan Liu, Yanyi Liu, Xiao Xia, Dandan Wang, Xiaohong Liu, Guangxi Li
Summary: By conducting bibliometric analysis, this study revealed the characteristics, hotspots, and trends in Brugada syndrome research. The results showed that research on Brugada syndrome has been increasing over time, with the United States being the leading country and the University of Amsterdam being the most prolific and influential institution. Researchers Pedro Brugada, Arthur Wilde, and Charles Antzelevitch have made significant contributions in the field. Keywords analysis indicated that the mechanism, diagnosis, risk stratification, and management of Brugada syndrome are the hot research topics, while future research may focus on the underlying pathophysiology, novel therapies, and personalized risk assessment.
Article
Cardiac & Cardiovascular Systems
Michelle M. Monasky, Emanuele Micaglio, Emanuela T. Locati, Carlo Pappone
Summary: The evolution of the current dogma surrounding Brugada syndrome has sparked a significant debate about the true utility of genetic testing in this syndrome. While genetic testing can provide valuable insights into the genetics of BrS, it should not be used solely for diagnostic purposes. BrS is no longer seen as a pure autosomal dominant disorder, but rather as an oligogenic condition, with the need for further research to understand the effects of specific genetic variants.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Genetics & Heredity
Chiara Di Resta, Jan Berg, Andrea Villatore, Marianna Maia, Gianluca Pili, Francesco Fioravanti, Rossella Tomaiuolo, Simone Sala, Sara Benedetti, Giovanni Peretto
Summary: Having a new and more precise definition of BrS may be crucial to improve the clinical management of patients, at diagnostic, prognostic, and therapeutic levels. The evidence of myocardial structural and functional abnormalities in patients with BrS challenges the definition of the disease as a channelopathy.
Article
Cardiac & Cardiovascular Systems
Vincent Probst, Thomas Goronflot, Soraya Anys, Romain Tixier, Jean Briand, Pauline Berthome, Olivier Geoffroy, Nicolas Clementy, Jacques Mansourati, Laurence Jesel, Jean-Marc Dupuis, Paul Bru, Florence Kyndt, Matthieu Wargny, Beatrice Guyomarch, Aurelie Thollet, Philippe Mabo, Pierre-Antoine Gourraud, Nathalie Behar, Frederic Sacher, Jean-Baptiste Gourraud
Summary: The study aimed to investigate the accuracy of Brugada syndrome patients' sudden cardiac arrest risk scores. The research found that risk scores were unable to accurately stratify the risk of arrhythmic events in intermediate-risk patients, based on a cohort of 1613 patients.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Koonlawee Nademanee, Fa-Po Chung, Frederic Sacher, Akihiko Nogami, Hiroshi Nakagawa, Chenyang Jiang, Meleze Hocini, Elijah Behr, Gumpanart Veerakul, Jaap Jan Smit, Arthur A. M. Wilde, Shih-Ann Chen, Kohei Yamashiro, Yuichiro Sakamoto, Itsuro Morishima, Mithilesh K. Das, Apichai Khongphatthanayothin, Saran Vardhanabhuti, Michel Haissaguerre
Summary: This study reports the results of the BRAVO registry, which showed that catheter ablation is a safe and highly effective treatment for preventing VF recurrence in high-risk Brugada syndrome. The study suggests that ablation treatment may be an alternative to implantable cardioverter-defibrillator implantation for selected patients with BrS.
Article
Biology
Bin Zeng, Xiang Zhang, Rainer Schimpf, Andrew Powers, Michael Glikson, Charles Antzelevitch, Dan Hu, Hector Barajas-Martinez
Summary: J wave syndrome (JWS) is a cardiac channelopathy associated with malignant ventricular arrhythmias and sudden cardiac death. This study explores the association between variants in the L-type calcium channel gene subunits, CACNA1C and CACNB2b, and the JWS phenotype. Through genetic sequencing, mutations in these genes were identified in individuals with JWS, suggesting a loss-of-function effect on the cardiac calcium channel current. These findings further support the hypothesis that variants in CACNA1C and CACNB2b are associated with JWS and should be included in genetic screening protocols.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Chin-Feng Tsai, Yao-Tsung Chuang, Jing-Yang Huang, Kwo-Chang Ueng
Summary: Fever may trigger Brugada syndrome electrocardiogram pattern and ventricular tachyarrhythmias in susceptible individuals. The prognostic value of fever-induced Brugada ECG pattern remains unclear, but is associated with factors such as white cell count, tumour markers, adenovirus detection, etc.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Camilla H. B. Jespersen, Johanna Kroll, Priya Bhardwaj, Bo Gregers Winkel, Peter Karl Jacobsen, Christian Jons, Jens Haarbo, Jens Kristensen, Jens Brock Johansen, Berit T. Philbert, Sam Riahi, Christian Torp-Pedersen, Lars Kober, Jacob Tfelt-Hansen, Peter E. Weeke
Summary: This study aimed to investigate the association between a diagnosis of Brugada syndrome (BrS) and symptomatic disease presentation with new-onset depression or anxiety and all-cause mortality. The results showed that symptomatic BrS disease manifestation was significantly associated with new-onset depression or anxiety, while the overall mortality rate in these patients was low.
Review
Cardiac & Cardiovascular Systems
Arthur A. M. Wilde, Ahmad S. Amin, Pieter G. Postema
Summary: Congenital long QT syndrome (LQTS) is a heart condition with 75% of cases linked to genetic mutations, leading to various subtypes, yet 25% of cases remain genotype elusive. The large variability in disease severity and uncertainty in identifying familial risk factors are key challenges in research.
Review
Cardiac & Cardiovascular Systems
E. Madelief J. Marsman, Pieter G. Postema, Carol Ann Remme
Summary: Brugada syndrome is an inherited cardiac disorder with a typical ECG pattern and increased risk of arrhythmias and sudden cardiac death. Diagnosis and risk prediction are challenging, but with the rise in asymptomatic patients and family screenings, the incidence is expected to increase.
Article
Computer Science, Information Systems
Hongxu Yang, Caifeng Shan, Arthur Bouwman, Lukas R. C. Dekker, Alexander F. Kolen, Peter H. N. de With
Summary: In this article, a semi-supervised learning framework is proposed for instrument segmentation in 3D ultrasound, which requires less annotation effort and achieves better segmentation results and inference time compared to existing methods.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Cardiac & Cardiovascular Systems
Luc J. H. J. Theunissen, Henricus-Paul Cremers, Dennis van Veghel, Pepijn H. van der Voort, Peter E. Polak, Sylvie F. A. M. S. de Jong, Geert Smits, Jos Dijkmans, Hareld M. C. Kemps, Jeroen A. A. van de Pol
Summary: This study investigated the relationship between AF-related quality of life at diagnosis and the improvement of perceived symptoms and general state of health after 12 months for AF patients in different age categories. The results showed that AF patients with lower quality of life at diagnosis were more likely to improve their EHRA score after 12 months. This effect was most prominent in patients aged 65 and above and patients aged below 75. Further research should focus on defining characteristics of these age groups for age-tailored treatment implementation.
JOURNAL OF ARRHYTHMIA
(2022)
Article
Health Policy & Services
Gijs J. van Steenbergen, Paul Cremers, Lukas Dekker, Dennis van Veghel
Summary: Healthcare expenditure is increasing globally and value-based healthcare (VBHC) is a strategy aimed at improving outcomes and controlling costs. However, current outcome monitoring practices lack variation and fail to connect clinical outcomes with costs. Incorporating cost parameters into routine outcome monitoring would enhance patient value.
INTERNATIONAL JOURNAL OF HEALTHCARE MANAGEMENT
(2023)
Review
Cardiac & Cardiovascular Systems
Lisa A. Gottlieb, Ruben Coronel, Lukas R. C. Dekker
Summary: Atrial fibrillation (AF) is a common cardiac arrhythmia associated with increased mortality. Heart failure, hypertension, valvular disease, and obstructive sleep apnea are risk factors for AF as they increase atrial wall stretch. Experimental studies confirm the proarrhythmic effect of atrial stretch, suggesting that targeted reduction of atrial stretch could be a therapeutic target for AF prevention.
Editorial Material
Cardiac & Cardiovascular Systems
Alexandre Ouss, Loes van Stratum, Pepijn van der Voort, Lukas Dekker
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Article
Medical Laboratory Technology
Jonna A. van der Stam, Sjoerd Bouwmeester, Saskia L. M. van Loon, Natal A. W. van Riel, Lukas R. Dekker, Arjen-Kars Boer, Patrick Houthuizen, Volkher Scharnhorst
Summary: This study aimed to combine HF biomarkers into an objective classification system for risk stratification of patients with HF. The NT-proBNP, ST2, and GDF-15 were identified as independent predictors and combined as the Heartmarker score, which was found to be better at discriminating different risk classes and had a comparable relationship to functional capacity than the widely used NYHA classification.
ANNALS OF LABORATORY MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Luc Theunissen, Henricus-Paul Cremers, Lukas Dekker, Hans Janssen, Martijn Burg, Ellen Huijbers, Pascale Voermans, Hareld Kemps, Dennis van Veghel
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
F. E. Vervaat, A. van Der Gaag, C. Smetsers, P. C. Barneveld, M. Van't Veer, K. Teeuwen, H. van Suijlekom, L. Dekker, I. F. Wijnbergen
Summary: This study aims to investigate the efficacy of high density spinal cord stimulation in patients with refractory angina pectoris. The primary outcome is the reduction in myocardial ischemia measured by myocardial perfusion positron emission tomography scan. The study uses a randomized crossover design with a 1-year follow-up period.
CLINICAL CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jasper Vermeer, Tineke Vinck, Bianca de Louw, Stacey Slingerland, Marcel van't Veer, Marta Regis, Jos-marien Jansen, Edwin van den Heuvel, Lukas Dekker
Summary: Modifiable risk factors have a strong impact on the progression of atrial fibrillation (AF) and outcomes of ablation therapy. The POP trial aims to evaluate the effects of a dedicated nurse-led AF lifestyle outpatient clinic on clinical outcomes in patients with symptomatic AF. This randomized controlled trial will assess the efficacy and cost-effectiveness of an integrated technology-supported lifestyle therapy in AF patients. The trial is funded by the Netherlands Organisation for Health Research and Development and uses home sleep apnea testing devices provided by Itamar Medical, Ltd.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Health Care Sciences & Services
Luc J. H. J. Theunissen, Jeroen A. A. van de Pol, Gijs J. van Steenbergen, Henricus-Paul Cremers, Dennis van Veghel, Pepijn H. van der Voort, Peter E. Polak, Sylvie F. A. M. S. de Jong, Jaap Seelig, Geert Smits, Hareld M. C. Kemps, Lukas R. C. Dekker
Summary: This study assessed the prognostic value of AF-related quality of life (AFEQT) at baseline on Major Adverse Cardiovascular Events (MACE) and improvement of perceived symptoms (EHRA), as well as the relationship between quality of life and AF-related hospitalizations. The results showed that AF patients with a lower quality of life at diagnosis were more likely to experience MACE, improvement in symptoms, and hospitalizations.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Rik J. C. van Esch, Iris C. Cramer, Xian Li, Cindy Verstappen, Carla Kloeze, Marcel van 't Veer, Angelique Dierick, Susan Hommerson, Leon Montenij, Lukas Dekker, R. Arthur Bouwman, Erik Korsten, Jan Bergmans, Sander Stuijk, Svitlana Zinger
Summary: Remote PPG enables contactless monitoring of cardiac rhythm using an RGB camera in a regular hospital environment. Three machine learning models were developed to detect atrial fibrillation (AF), classify if a cardiac arrhythmia (AF or Aflutter) is present, and classify the data into AF, Aflutter, and sinus rhythm. While the performance of detecting arrhythmia is close to the second model, distinguishing between AF and Aflutter remains a challenge.
MEDICAL IMAGING 2023
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Shuhao Que, Rik J. C. van Esch, Iris C. Cramer, Cindy Verstappen, Carla Kloeze, Marcel van 't Veer, Angelique Dierick, Susan Hommerson, Fokke van Meulen, Sebastiaan Overeem, Leon Montenij, Lukas Dekker, R. Arthur Bouwman, Erik Korsten, Jan Bergmans, Svitlana Zinger, Sander Stuijk
Summary: In this study, we investigated the feasibility of extracting continuous respiratory parameters using a single RGB camera in a short-stay ward. We implemented two algorithms, chest optical flow (COF) and energy variance maximization (EVM), to extract respiration from the patient's thoracic and facial areas, respectively. The results showed that COF and EVM achieved errors within 3 breaths per minute and 3.5 breaths per minute, respectively, for average breath-to-breath rate estimation. Furthermore, using respiratory features extracted from COF measurements, we achieved an average AUC value of 0.64 for detecting atrial fibrillation (AF) in the respiratory signal. This highlights the potential of using camera-based respiratory parameters as predictors for AF or as surrogate predictors when facial area extraction is not possible.
MEDICAL IMAGING 2023
(2023)
Letter
Cardiac & Cardiovascular Systems
Gijs J. van Steenbergen, Lukas Dekker, Dennis van Veghel
ANNALS OF THORACIC SURGERY
(2023)
