Review
Biochemistry & Molecular Biology
Alina Scridon
Summary: This article comprehensively explores the complex role of platelets in hemostasis and thrombosis, discussing their importance in clinical medicine, and studying hemostatic platelet-related disorders and antithrombotic therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Carol Dangelmaier, Benjamin Mauri, Akruti Patel, Satya P. Kunapuli, John C. Kostyak
Summary: Platelet functional disorder associated with P2Y12 receptor mutation was identified in a human subject. Knock-in mouse model confirmed the essential role of aspartic acid residue in P2Y12 function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Brian Schnoor, Anne-Laure Papa
Summary: Lyophilized platelets, as a potential hemostatic agent, have long-term ambient storage capabilities and high biocompatibility, which make them a promising platform for drug delivery. The interactions between lyophilized platelets and fresh platelets have paradoxical effects on platelet adhesion and aggregation, which could have an impact for clinical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Hematology
Jiaxin Zhao, Yanyan Xu, Jingyuan Xie, Junling Liu, Ruiyan Zhang, Xiaoxiang Yan
Summary: Roxadustat treatment does not significantly impact platelet production and function, as shown in experiments conducted on both healthy mice and mice with renal impairment. Results indicate that parameters such as platelet aggregation, spreading, clot retraction, and P-selectin/JON/A exposure were similar with or without roxadustat treatment.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Chemistry, Medicinal
Leilei Gao, Fang Wang, Yanjun Chen, Fang Li, Bangxing Han, Dong Liu
Summary: Thrombosis is a major cause of morbidity and mortality globally, and the search for new, efficient, and safer antithrombotic drugs is ongoing. Natural and synthetic coumarins have shown antithrombotic activity, with coumarin-based drugs like warfarin being long used in clinical treatment. Research focuses on the relationship between the chemical structures of coumarins and their therapeutic effectiveness, aiming to discover novel derivatives with high antithrombotic activity.
Article
Biochemical Research Methods
Chi-Ju Kim, Jungmin Kim, Jonathan Sabate del Rio, Dong Yeob Ki, Junyoung Kim, Yoon-Kyoung Cho
Summary: Platelet function tests are crucial in diagnosing inherited platelet function disorders and monitoring antiplatelet therapies. Light transmission aggregometry (LTA) is considered the gold standard, but lacks standardization and requires a large volume of blood. A centrifugal microfluidic disc has been developed to automate LTA testing from a small blood sample, producing more precise results in a shorter time.
Article
Cardiac & Cardiovascular Systems
Tejasvi Dudiki, Manoj Veleeparambil, Irina Zhevlakova, Sudipta Biswas, Eric A. A. Klein, Peter Ford, Eugene A. A. Podrez, Tatiana V. V. Byzova
Summary: Thrombosis is a common complication in cancer patients and platelet hyperactivation plays a critical role. This study found that small extracellular vesicles (sEVs) released by cancer cells are efficiently taken up by platelets, leading to platelet activation and thrombosis. The discovery highlights the diagnostic and prognostic value of platelet-associated cancer markers and identifies new pathways for intervention.
CIRCULATION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Agata Rolnik, Anna Stochmal, Beata Olas
Summary: Extracts from plants of the Asteraceae family, such as dandelion, have been found to possess antioxidant and anti-platelet activity. However, little is known about the effects of extracts from other Asteraceae plants, such as chicory leaves, lettuce leaves, and Jerusalem artichoke roots, on the hemostatic system. The study found that dandelion root extract and fruit extracts have the strongest anti-platelet potential in whole blood, while red lettuce leaves and Jerusalem artichoke roots showed the strongest anti-platelet activity in washed blood platelets.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biotechnology & Applied Microbiology
Yuqi Zhou, Akihiro Isozaki, Atsushi Yasumoto, Ting-Hui Xiao, Yutaka Yatomi, Cheng Lei, Keisuke Goda
Summary: Emerging "intelligent" platelet morphometry is paving the way for a new class of diagnostics, pharmacometrics, and therapeutics.
TRENDS IN BIOTECHNOLOGY
(2021)
Review
Hematology
James I. Hearn, Elizabeth E. Gardiner
Summary: This article discusses the role of platelets in the formation of a hemostatic response and vascular injury repair, as well as their function in flowing blood. The article highlights the importance of platelet adhesion and activation in forming and strengthening adhesive ties, and discusses the challenges faced in research.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Hematology
Oluwamayokun Oshinowo, Sally S. Azer, Jessica Lin, Wilbur A. Lam
Summary: Mechanotransduction is the ability of cells, including platelets, to sense and respond to their mechanical microenvironment. Dysregulation of platelet mechanotransduction can lead to bleeding and thrombosis. Understanding platelet mechanotransduction is crucial for better understanding and treatment of clotting and bleeding disorders.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Urology & Nephrology
Constance C. F. M. J. Baaten, Jonas R. Schroer, Jurgen Floege, Nikolaus Marx, Joachim Jankowski, Martin Berger, Heidi Noels
Summary: Patients with chronic kidney disease (CKD) have a higher risk of cardiovascular and thromboembolic complications, as well as hemorrhages. Altered platelet function may contribute to these complications. Further research is needed to understand the mechanisms behind these abnormalities and optimize antiplatelet treatment strategies for CKD patients.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Hematology
Stefano Ghirardello, Anna Lecchi, Andrea Artoni, Mauro Panigada, Stefano Aliberti, Erica Scalambrino, Silvia La Marca, Marco Boscarino, Andrea Gramegna, Paolo Properzi, Chiara Abruzzese, Francesco Blasi, Giacomo Grasselli, Fabio Mosca, Armando Tripodi, Flora Peyvandi
Summary: The study found that COVID-19 patients displayed impaired platelet thrombus formation in the early phase of the disease compared to later stages and controls, independently from illness severity.
THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Hematology
Elmina Mammadova-Bach, Thomas Gudermann, Attila Braun
Summary: Blood flow-induced hemodynamic changes result in mechanical stress on blood cells and vessel walls. Increased shear stress can activate platelets and other circulating cells, triggering the rapid activation of receptors, calcium channels, and related signaling mechanisms. Mechanosensitive platelet receptors and their cross talk with calcium channels in shear-dependent platelet activation and arterial thrombus formation are discussed in this review.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Lifeng Luo, Zhong Chen, Tong Gong, Qingsong Ye, Hao Li, Yunfei Guo, Jiqiu Wen, Yiqiao Hu, Jinhui Wu
Summary: Thrombosis is a major global health issue. Traditional antiplatelet therapy interferes with platelet activation and carries a risk of bleeding. However, a new approach using cytosolic delivery of nanoscale perfluorocarbon (PFC) via albumin has been developed, which inhibits platelet function without interfering with platelet activation through integrin alpha IIb beta 3. This novel antiplatelet method has shown potential effectiveness and lower bleeding risk in preventing thrombosis in various models.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Erifili Venieri, Constantina Aggeli, Aris Anastasakis, Helen Sambatakou, Christodoulos Stefanadis, Dimitrios Tousoulis
Summary: This study assessed the mitral valve in HCM patients and found that patients with and without obstruction share some common anatomic features, but those with obstruction have unique characteristics that may contribute to LVOT obstruction.
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Review
Pharmacology & Pharmacy
Hassan Yousefi, Ladan Mashouri, Samuel C. Okpechi, Nikhilesh Alahari, Suresh K. Alahari
Summary: The outbreak of the novel coronavirus has caused a major global public health concern, with over 31 million cases confirmed and efforts being made to repurpose existing cancer drugs to treat COVID-19. These drugs target the viral replication cycle and immune response, offering a potential novel approach to combat the virus.
BIOCHEMICAL PHARMACOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Georgios Zakynthinos, Gerasimos Siasos, Evangelos Oikonomou, Maria Gazouli, Konstantinos Mourouzis, Marina Zaromitidou, Vasiliki Tsigkou, Evanthia Bletsa, Panagiota Stampouloglou, Stamatis Tsouroulas, Georgios Marinos, Konstantinos Vlasis, Manolis Vavuranakis, Christodoulos Stefanadis, Dimitris Tousoulis
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Erika Rimondi, Annalisa Marcuzzi, Fabio Casciano, Gianluca Tornese, Agnese Pellati, Barbara Toffoli, Paola Secchiero, Elisabetta Melloni
Summary: This study demonstrates that vitamin D deficiency may contribute to the formation and instability of atheromatous plaques in mice, suggesting a potential role for vitamin D in preventing or delaying atheromatous disease in cardiovascular disorders. Further research is needed to fully understand the impact of vitamin D in cardiovascular diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Eirini Pagkalidou, Athanasios Kordalis, Spyridon Deftereos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: Our network meta-analysis identified the most effective antiarrhythmics for pharmacologic cardioversion over different time settings, with intravenous vernakalant and flecainide showing the highest conversion rate within 4 hours. Flecainide, especially when compared to propafenone, demonstrated superiority for conversion rates within 12 hours, while amiodarone exhibited efficacy within 24 hours, particularly if ranolazine was added.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Gastroenterology & Hepatology
Corey J. Ketchem, Craig C. Reed, Zoe Stefanadis, Evan S. Dellon
Summary: The study evaluated the efficacy of a compounded fluticasone suspension for treating eosinophilic esophagitis, showing significant improvements in symptoms and endoscopic findings, with over a third of patients achieving histologic response.
DISEASES OF THE ESOPHAGUS
(2021)
Article
Pharmacology & Pharmacy
Dimitris Tsiachris, Ioannis Doundoulakis, Panagiotis Tsioufis, Eirini Pagkalidou, Christos-Konstantinos Antoniou, Stefanos M. Zafeiropoulos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This systematic review compares the effectiveness and safety of class Ic agents for cardioversion of paroxysmal AF and finds that intravenous flecainide is the most effective option. Class Ic agents appear to be safe for pharmacologic cardioversion of AF regardless of the presence of SHD.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Economics
Jay Pil Choi, Christodoulos Stefanadis
Summary: This article examines tippy network markets that allow price discrimination and finds that under certain conditions, network competition may lead to a unique subgame-perfect equilibrium where the winner's identity is fully determined by its product features. The concept of the dominant value margin is introduced as a metric for the effectiveness of divide-and-conquer strategies. However, the outcome of a market where suppliers with larger dominant value margins can sell to all customers does not necessarily result in social efficiency.
INTERNATIONAL ECONOMIC REVIEW
(2022)
Letter
Cardiac & Cardiovascular Systems
Christodoulos Stefanadis, Christina Chrysohoou, Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Gerasimos Siasos, Konstantinos Tsioufis, George Panagiotakopoulos, Theoklis Zaoutis, Demosthenes Panagiotakos
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Grigorios Chatzantonis, Christos-Konstantinos Antoniou, Haris Lalos, Gregory C. Bogdanis, Pantelis Nikolaou, Anastasios Spanos, Stefanos Karagiannis, Costas Tsiou, Ali Yilmaz, Christodoulos Stefanadis
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Christos-Konstantinos Antoniou, Eirini Pagkalidou, Stefanos Zafeiropoulos, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of a time to isolation (TTI)-based strategy of cryoballoon ablation (CBA) in the treatment of atrial fibrillation. The results suggest that an individualized CBA dosing strategy based on TTI and extended duration of CBA can reduce recurrence post-AF ablation and decrease procedure time and incidence of phrenic nerve palsy.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Athanasios Kordalis, Dimitrios Konstantinou, Konstantinos Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study compared the clinical outcomes of a three-dimensional electroanatomical mapping (3D-EAM)-based strategy targeting slow pathway (SP) elimination with the conventional fluoroscopic approach in atrioventricular node reentrant tachycardia (AVNRT) ablation. The results showed that 3D-EAM improved procedural parameters, reduced fluoroscopy time and dose, and increased SP elimination frequency. Follow-up results demonstrated lower recurrence rates and redo procedure rates in the 3D-EAM-based group.
JOURNAL OF ARRHYTHMIA
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Peripheral Vascular Disease
Shane A. Phillips, Kendra Osborn, Chueh-Lung Hwang, Ahmad Sabbahi, Mariann R. Piano
Summary: Oxidative stress is implicated in the development of many ethanol-induced pathologies, contributing to endothelial dysfunction and cardiovascular diseases such as hypertension. Ethanol consumption may alter vascular cell function and microvascular function, increasing the risk for hypertension. Data from human investigations have shown an association between alcohol consumption, changes in blood pressure, and hypertension risk.
CURRENT HYPERTENSION REVIEWS
(2021)