Article
Pharmacology & Pharmacy
Jade Gauvin, Genevieve Fregeau, Hanan Elimam, Liliane Menard, David Huynh, Catherine Le, Ahsanullah Ahsanullah, William D. Lubell, Huy Ong, Sylvie Marleau
Summary: Atherosclerosis is a chronic inflammatory disease that occurs at vulnerable sites in the arterial walls. It is a major risk factor for adverse cardiovascular events such as myocardial infarction and stroke, often due to the rupture of unstable atherosclerotic plaques. Macrophage uptake of modified lipoproteins and metabolic dysfunction significantly contribute to the development and progression of atherosclerotic lesions. The CD36 receptor plays a crucial role in the progression of atherosclerotic lesions and acts as a molecule in the resolution of advanced plaques. This study demonstrates that a novel and selective macrocyclic azapeptide CD36 ligand, MPE-298, effectively protects against the progression of atherosclerosis in mice fed a high-fat high-cholesterol diet, leading to increased plaque stability after 8 weeks of daily injections.
FRONTIERS IN PHARMACOLOGY
(2023)
Editorial Material
Immunology
Gaetan Juban, Benedicte Chazaud
Summary: A recent study reveals that dendritic cells inhibit the clearance of skin debris during the uptake of apoptotic cells, and the elimination of this inhibition can accelerate wound healing.
Review
Biochemistry & Molecular Biology
Wenxue Zheng, Zhengjie Zhou, Xiaoping Guo, Xu Zuo, Jiaqi Zhang, Yiming An, Haoyu Zheng, Yuan Yue, Guoqiang Wang, Fang Wang
Summary: Cells are the fundamental units of living organisms and undergo processes like proliferation and differentiation. Dead cells need to be removed through efferocytosis to maintain organism homeostasis. This review explores the relevance of faulty efferocytosis in respiratory diseases, discussing the process, mechanisms, regulation methods, and treatment approaches. Additionally, it summarizes drugs that target efferocytosis for potential treatment of lung diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Jiayi Zhao, Weiqi Zhang, Tingting Wu, Hongyi Wang, Jialiang Mao, Jian Liu, Ziheng Zhou, Xianfeng Lin, Huige Yan, Qingqing Wang
Summary: This article discusses the impacts of efferocytosis on homeostasis, the mechanism of efferocytosis, the associations of efferocytosis failure and CNS diseases, and the current clinical applications of efferocytosis. The study identifies efferocytosis as a novel potential target for exploring the causes and treatments of CNS diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Xinbo Zhang, Jonathan Sun, Alberto Canfran-Duque, Binod Aryal, George Tellides, Ying Ju Chang, Yajaira Suarez, Timothy F. Osborne, Carlos Fernandez-Hernando
Summary: Epigenetic modifications, particularly SETDB2, play a crucial role in regulating immune response during atherosclerosis. Upregulation of SETDB2 is associated with proinflammatory macrophages, while its deficiency exacerbates vascular inflammation. Loss of SETDB2 affects monocyte population and gene expression related to inflammation in atherosclerotic plaques.
Article
Multidisciplinary Sciences
Lilan Zhao, Anastasios D. Giannou, Yang Xu, Ahmad Mustafa Shiri, Imke Liebold, Babett Steglich, Tanja Bedke, Tao Zhang, Joean Lueke, Pasquale Scognamiglio, Jan Kempski, Anna Woestemeier, Jing Chen, Theodora Agalioti, Dimitra E. Zazara, Diana Lindner, Melanie Janning, Jan K. Hennigs, Rajesh M. Jagirdar, Ourania S. Kotsiou, Sotirios G. Zarogiannis, Yasushi Kobayashi, Jacob R. Izbicki, Sourav Ghosh, Carla V. Rothlin, Lidia Bosurgi, Samuel Huber, Nicola Gagliani
Summary: The study found that efferocytosis by pleural cavity macrophages through AXL and MERTK receptors led to the production of IL-10, which then influenced dendritic cells to produce TIMP1, thereby facilitating MPE progression. Targeting this inflammatory cascade offers potential therapeutic strategies for MPE.
Review
Cell Biology
Gaetan Juban, Benedicte Chazaud
Summary: Efferocytosis, the engulfment of dead cells by macrophages, plays a crucial role in tissue repair post-injury by delineating the transition from the pro-inflammatory phase to the recovery phase. In the context of skeletal muscle regeneration, efferocytosis is essential for sterile tissue injury followed by complete regeneration, with molecular mechanisms and metabolic control playing a significant role in this process.
Review
Cell Biology
Jana Krystofova Mike, Donna Marie Ferriero
Summary: Neonatal brain hypoxia-ischemia (HI) is a major cause of morbidity and long-term disabilities in children. Efferocytosis, the process of immune regulation and clearance of cellular debris, has therapeutic potential in neurodegenerative diseases and could be a promising target for new HI therapies after stroke.
Article
Pharmacology & Pharmacy
Ke Xu, Yu Liu, Huiyan Luo, Tengfei Wang
Summary: This study highlights the importance of efferocytosis in the progression of hepatocellular carcinoma (HCC) and develops a predictive model based on efferocytosis-related genes (ERGs) for assessing patient risk and prognosis. The results also reveal the presence of distinct immune environments and prognostic stratification within HCC based on ERGs. These findings contribute to the development of personalized treatment strategies, including immunotherapy and chemotherapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Lili Wang, Hongxia Li, Yuhan Tang, Ping Yao
Summary: Atherosclerosis is the main pathological basis for cardio-cerebrovascular diseases, with abnormal accumulation of apoptotic and necrotic cells leading to plaque formation and rupture. The efficiency of phagocytosis of apoptotic cells in AS is low, and recent research has made progress in understanding the molecular mechanisms involved.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bo-Min Kim, Ye-Ji Lee, Youn-Hee Choi, Eun-Mi Park, Jihee Lee Kang
Summary: The research shows that administration of recombinant Gas6 (rGas6) can reduce inflammation and apoptosis in bleomycin (BLM)-induced acute lung injury (ALI), including decreased secretion of inflammatory cytokines, improved apoptotic cell clearance, and reduced levels of inflammation and cell apoptosis in the lungs.
Review
Oncology
Yifan Zhang, Yiru Wang, Jie Ding, Ping Liu
Summary: Efferocytosis, the phagocytosis of apoptotic cells, plays a crucial role in tissue repair and homeostasis. Defective efferocytosis can lead to various diseases, including atherosclerosis, lung damage, fatty liver, and neurodegenerative diseases. This review provides insights into the mechanisms of efferocytosis and its implications in disease pathogenesis and discusses potential treatment strategies.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Pharmacology & Pharmacy
Jing Cheng, Fei Xue, Cheng Cheng, Wenhai Sui, Meng Zhang, Lei Qiao, Jing Ma, Xiaoping Ji, Wenqiang Chen, Xiao Yu, Bo Xi, Feng Xu, Guohai Su, Yuxia Zhao, Panpan Hao, Yun Zhang, Cheng Zhang
Summary: ADAM17 knockdown alleviates cardiac fibrosis in diabetic mice by regulating ACE2 shedding and myofibroblast transformation through the TGF-beta 1/Smad3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Charles Yin, Bryan Heit
Summary: The efficient clearance of apoptotic cells, known as efferocytosis, plays a critical role in maintaining tissue homeostasis by preventing secondary necrosis and inflammation. Efferocytosis differs from phagocytosis in its immunologically silent nature and induction of tissue repair response. This review discusses recent advances in understanding cellular responses to apoptotic cell uptake, signaling events, and the role of efferocytosis in host defense.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Maria Shoykhet, Jens Waschke, Sunil Yeruva
Summary: ADAM family proteins, especially ADAM17, play a role in cardiac diseases, and inhibiting ADAM17 can enhance cardiomyocyte cohesion by stabilizing desmosomal adhesion. In a murine AC model, elevated levels of p38MAPK were found, suggesting an activation of ADAM17. However, ADAM17 levels were unaffected. Acute inhibition of ADAM17 enhanced the localization of DSG2 and DP at the cell membrane, leading to increased cardiomyocyte cohesion. This study suggests the potential therapeutic use of ADAM17 inhibition in AC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Kristofor Glinton, Matthew DeBerge, Xin-Yi Yeap, Jenny Zhang, Joseph Forbess, Xunrong Luo, Edward B. Thorp
SEMINARS IN IMMUNOPATHOLOGY
(2018)
Article
Multidisciplinary Sciences
Tarun Pant, Anuradha Dhanasekaran, Xiaowen Bai, Ming Zhao, Edward B. Thorp, Joseph M. Forbess, Zeljko J. Bosnjak, Zhi-Dong Ge
SCIENTIFIC REPORTS
(2019)
Article
Pathology
Hannah L. Wiesolek, Triet M. Bui, Joseph J. Lee, Prarthana Dalal, Ariel Finkielsztein, Ayush Batra, Edward B. Thorp, Ronen Sumagin
AMERICAN JOURNAL OF PATHOLOGY
(2020)
Article
Surgery
Shuangjin Yu, Anil Dangi, Melanie Burnette, Michael M. Abecassis, Edward B. Thorp, Xunrong Luo
Summary: Acute CMV infection disrupts established transplantation tolerance in 50%-60% of recipients during the maintenance stage and leads to recipient allo-sensitization. This disruption reverts allo-specific T cells to a non-tolerant state and promotes their differentiation into allo-specific memory cells, resulting in accelerated rejection of a second same-donor islet allograft. Close monitoring for allo-sensitization is recommended in previously tolerant transplant recipients with disrupted tolerance maintenance due to acute CMV infection.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Paul W. Burridge, Edward B. Thorp
CIRCULATION RESEARCH
(2020)
Article
Urology & Nephrology
Longhui Qiu, Xingqiang Lai, Jiao-jing Wang, Xin Yi Yeap, Shulin Han, Feibo Zheng, Charlie Lin, Zhuoli Zhang, Daniele Procissi, Deyu Fang, Lin Li, Edward B. Thorp, Michael M. Abecassis, Yashpal S. Kanwar, Zheng J. Zhang
KIDNEY INTERNATIONAL
(2020)
Article
Multidisciplinary Sciences
Connor Lantz, Behram Radmanesh, Esther Liu, Edward B. Thorp, Jennie Lin
SCIENTIFIC REPORTS
(2020)
Article
Medicine, Research & Experimental
Anil Dangi, Naveen R. Natesh, Irma Husain, Zhicheng Ji, Laura Barisoni, Jean Kwun, Xiling Shen, Edward B. Thorp, Xunrong Luo
Article
Multidisciplinary Sciences
Xiaolei Liu, Ester De la Cruz, Xiaowu Gu, Laszlo Balint, Michael Oxendine-Burns, Tamara Terrones, Wanshu Ma, Hui-Hsuan Kuo, Connor Lantz, Trisha Bansal, Edward Thorp, Paul Burridge, Zoltan Jakus, Joachim Herz, Ondine Cleaver, Miguel Torres, Guillermo Oliver
Article
Multidisciplinary Sciences
Tarun Pant, Anuradha Dhanasekaran, Ming Zhao, Edward B. Thorp, Joseph M. Forbess, Zeljko J. Bosnjak, Ivor J. Benjamin, Zhi-Dong Ge
Summary: This study identified five circulating lncRNAs that play a crucial role in the pathogenesis of diabetic cardiomyopathy, suggesting their high potential as diagnostic biomarkers for DCM.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Matthew DeBerge, Kristofor Glinton, Manikandan Subramanian, Lisa D. Wilsbacher, Carla Rothlin, Ira Tabas, Edward B. Thorp
Summary: In response to myocardial ischemia/reperfusion injury, AXL receptor in myeloid cells plays a maladaptive role leading to increased inflammation, adverse ventricular remodeling, and impaired contractile function. Inhibiting AXL alone can improve cardiac healing, and combination with blocking MerTK cleavage enhances the efficacy further, suggesting macrophage TAM receptors as potential therapeutic targets for myocardial infarction.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Adovich S. Rivera, Arjun Sinha, Faraz S. Ahmad, Edward Thorp, Jane E. Wilcox, Donald M. Lloyd-Jones, Matthew J. Feinstein
Summary: The study revealed distinct patterns of left ventricular ejection fraction trajectories associated with specific individual CIDs among patients with HF, highlighting the diversity of HF subtypes and changes over time across different CIDs.
CIRCULATION-HEART FAILURE
(2021)
Article
Endocrinology & Metabolism
Laurent Yvan-Charvet, Edward Benjamin Thorp
Summary: Glycolysis fuels inflammatory response in macrophages and produces pyruvate. However, a study in Nature Metabolism by Ran et al. shows that transporting pyruvate to the mitochondria for Krebs cycle is not necessary for inflammation.
Review
Medicine, Research & Experimental
Edward B. Thorp
Summary: Interest in cardioimmunology has grown as researchers explore the potential of immunotherapy for clinical care. The role of cardiac macrophages, which modulate cardiac function, has become a focus of study. After a heart attack, myeloid macrophages can both protect and harm the heart. The outcomes depend on factors such as myeloid ontogeny, heterogeneity, and cellular plasticity. The extracellular milieu and nutrient limitations also play a role.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Kristofor E. Glinton, Wanshu Ma, Connor Lantz, Lubov S. Grigoryeva, Matthew DeBerge, Xiaolei Liu, Maria Febbraio, Mark Kahn, Guillermo Oliver, Edward B. Thorp
Summary: Clearance of dying cells by efferocytosis is crucial for cardiac repair after myocardial infarction (MI). In this study, it was found that defective efferocytosis by macrophages after MI led to a reduction in cardiac lymphangiogenesis and Vegfc expression. Cardiac macrophages promoted myocardial lymphangiogenesis and suppressed inflammatory cytokines through the production of Vegfc.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
