Article
Biochemistry & Molecular Biology
Dongxia Wang, Jiaying Li, Gang Luo, Juan Zhou, Ning Wang, Shanshan Wang, Rui Zhao, Xin Cao, Yuxia Ma, Gang Liu, Liping Hao
Summary: This review provides an overview of the role and regulatory mechanisms of Nox4 in diabetic microangiopathy, with a special emphasis on its upregulation in diabetic nephropathy. It also presents novel perspectives, such as epigenetics, on how Nox4 regulates diabetic microangiopathy. Additionally, the review discusses Nox4 as a therapeutic target and highlights drugs, inhibitors, and dietary components that target Nox4 for the prevention and treatment of diabetic microangiopathy.
Review
Genetics & Heredity
Philip Duesing, Andreas Zietzer, Philip Roger Goody, Mohammed Rabiul Hosen, Christian Kurts, Georg Nickenig, Felix Jansen
Summary: CKD and CVD are interlinked, with CKD increasing the risk of cardiovascular disease mainly due to accumulation of uremic toxins, chronic inflammation, and oxidative stress. Vascular alterations, especially atherosclerosis and vascular calcification, play a significant role in the association between CKD and cardiovascular mortality.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Immunology
Barbara Dymek, Piotr Sklepkiewicz, Michal Mlacki, Nazan Cemre Guner, Patrycja Nejman-Gryz, Katarzyna Drzewicka, Natalia Przysucha, Aleksandra Rynnaszewska, Magdalena Paplinska-Goryca, Agnieszka Zagozdzon, Malgorzata Proboszcz, Lukasz Krzeminski, Jan H. von der Thusen, Katarzyna Gorska, Karolina Dzwonek, Zbigniew Zaslona, Pawel Dobrzanski, Rafal Krenke
Summary: In this study, increased activity of CHIT1 was found in sarcoidosis patients, and a first-in-class CHIT1 inhibitor called OATD-01 showed efficacy in mouse models, providing proof-of-concept for its clinical evaluation in sarcoidosis.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Vicente Javier Clemente-Suarez, Alexandra Martin-Rodriguez, Rodrigo Yanez-Sepulveda, Jose Francisco Tornero-Aguilera
Summary: Mitochondrial dysfunction is a common feature of various diseases, and mitochondrial transfer has emerged as a potential therapeutic approach for restoring mitochondrial function. This review summarizes the current understanding of mitochondrial transfer, its mechanisms, therapeutic applications, and impact on cell death pathways. The future directions and challenges in using mitochondrial transfer as a novel therapeutic approach in disease diagnosis and treatment are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Yunfeng Pan, Jia Liu, Jiahui Ren, Yun Luo, Xiaobo Sun
Summary: This study reviews the regulatory effects of Epac on various vascular diseases, including cardiovascular disease, cerebrovascular disease, and cancer. It suggests that Epac could serve as a promising therapeutic target for the treatment of vascular diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Engineering, Biomedical
Jacob S. Brenner, Samir Mitragotri, Vladimir R. Muzykantov
Summary: Red blood cell hitchhiking is a drug delivery method that increases drug concentration in target organs by adsorbing drug-loaded nanoparticles onto red blood cells. This method has been successfully demonstrated in multiple species and organs, highlighting its versatility and potential clinical applications in various preclinical disease models.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021
(2021)
Article
Urology & Nephrology
Joshua A. Walker, Sean Richards, Stephen A. Whelan, Sung Bok Yoo, Teresa L. Russell, Nkiruka Arinze, Saran Lotfollahzadeh, Marc A. Napoleon, Mostafa Belghasem, Norman Lee, Laura M. Dember, Katya Ravid, Vipul C. Chitalia
Summary: The study found that patients with chronic kidney disease are at increased risk of thrombosis after vascular injury, with indoleamine 2,3-dioxygenase-1 (IDO-1) playing a key role in this process. Inhibiting IDO-1 expression can reduce tissue factor expression in blood vessels, thereby reducing the risk of thrombosis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Medical Laboratory Technology
Xiaojuan Zhang, David A. Ostrov, Haoming Tian
Summary: This review summarizes the potential therapeutic role of AAT in metabolic syndrome associated diseases and type 1 diabetes, as well as studies demonstrating its potential use as a novel biomarker.
CLINICA CHIMICA ACTA
(2022)
Review
Biochemistry & Molecular Biology
Qin Fang, Yang Bai, Shuiqing Hu, Jie Ding, Lei Liu, Meiyan Dai, Jie Qiu, Lujin Wu, Xiaoquan Rao, Yan Wang
Summary: This review article explores the role and mechanism of Nrf2 in pulmonary vascular remodeling associated with PH, as well as summarizes the therapeutic potential of Nrf2 inducers.
Article
Oncology
Ali Ghoochani, En-Chi Hsu, Merve Aslan, Meghan A. Rice, Holly M. Nguyen, James D. Brooks, Eva Corey, Ramasamy Paulmurugan, Tanya Stoyanova
Summary: The study found that mediators of ferroptosis are expressed in treatment-resistant prostate cancer, and treatment with ferroptosis inducers such as erastin and RSL3 can significantly reduce prostate cancer cell growth and migration, potentially serving as novel therapeutic strategies.
Article
Biochemistry & Molecular Biology
Jiaxin Chen, Hongjiao Yu, Xiao Tan, Simon Wing Fai Mok, Yuchen Xie, Yueheng Wang, Xueyan Jiang, Vicky E. Macrae, Lan Lan, Xiaodong Fu, Dongxing Zhu
Summary: The study investigates the role of PFKFB3, a critical enzyme of glycolysis, in vascular calcification and finds that its expression is upregulated in calcified mouse VSMCs and arteries. Overexpression of miR-26a/b-5p significantly inhibits PFKFB3 expression in VSMCs, and pharmacological inhibition of PFKFB3 or knockdown of PFKFB3 ameliorates vascular calcification in vivo or in vitro. The study suggests that PFKFB3 may be a promising therapeutic target for the treatment of vascular calcification.
Review
Biochemistry & Molecular Biology
Alesandra Florescu, Florin Liviu Gherghina, Anca Emanuela Musetescu, Vlad Padureanu, Anca Rosu, Mirela Marinela Florescu, Cristina Criveanu, Lucian-Mihai Florescu, Anca Bobirca
Summary: This review discusses interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA), including its patterns, molecular mechanisms, and therapeutic challenges. Biomarkers have been found to be useful in identifying high-risk patients and guiding personalized treatment.
Review
Pharmacology & Pharmacy
Miriam Bettinetti-Luque, Laura Trujillo-Estrada, Eduardo Garcia-Fuentes, Juana Andreo-Lopez, Raquel Sanchez-Varo, Lourdes Garrido-Sanchez, Angela Gomez-Mediavilla, Manuela G. Lopez, Melissa Garcia-Caballero, Antonia Gutierrez, David Baglietto-Vargas
Summary: Adipose tissue is an important endocrine organ that plays a crucial role in energy metabolism and immune response. Recent studies have shown that the adipose tissue can affect brain function through adipokines, which may have implications for the development and treatment of Alzheimer's disease.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Immunology
Manlian Zhu, Xia Liu, Yiru Ye, Xiumei Yan, Yiwen Cheng, Longyou Zhao, Feng Chen, Zongxin Ling
Summary: Parkinson's disease is a common neurodegenerative disease characterized by motor dysfunction. Gut dysbiosis is involved in the development and progression of PD, and the gut microbiota can be considered as a potential diagnostic and therapeutic target. Gut dysbiosis influences the progression and onset of PD by increasing intestinal permeability, aggravating neuroinflammation, aggregating abnormal levels of alpha-synuclein fibrils, increasing oxidative stress, and decreasing neurotransmitter production.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Paramjit S. Tappia, Brett Hiebert, Rohan Sanjanwala, Paul Komenda, Chris Sathianathan, Amarjit S. Arneja, Bram Ramjiawan
Summary: This study suggests that bathing in CO2-enriched water may accelerate the healing of foot ulcers, although no significant differences were observed in the group/time interaction effect.
APPLIED SCIENCES-BASEL
(2021)
Article
Cell & Tissue Engineering
Conrad P. Hodgkinson, Richard E. Pratt, Imke Kirste, Sophie Dal-Pra, John P. Cooke, Victor J. Dzau
Article
Cell Biology
Gianfranco Matrone, Rajarajan A. Thandavarayan, Brandon K. Walther, Shu Meng, Anahita Mojiri, John P. Cooke
Review
Hematology
John P. Cooke, Shu Meng
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
John P. Cooke
Article
Cardiac & Cardiovascular Systems
Shu Meng, Jie Lv, Palas K. Chanda, Iris Owusu, Kaifu Chen, John P. Cooke
Review
Cell Biology
Palas K. Chanda, Roman Sukhovershin, John P. Cooke
Summary: mRNA has emerged as a key biomolecule for therapy development during the COVID-19 pandemic, with potential applications ranging from cancer immunotherapy to vaccine development. Recent advancements in RNA therapeutics have overcome challenges associated with this drug molecule, enabling its use in stem cell generation and cardiovascular regeneration.
Article
Genetics & Heredity
Guangyu Wang, Bo Xia, Man Zhou, Jie Lv, Dongyu Zhao, Yanqiang Li, Yiwen Bu, Xin Wang, John P. Cooke, Qi Cao, Min Gyu Lee, Lili Zhang, Kaifu Chen
Summary: The study explores the role of MACMIC analysis in identifying feature pairs with maximal colocalization and minimal correlation in the epigenomic landscape. It reveals a dual role of CTCF in epigenetic regulation of cell identity genes.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2021)
Article
Cardiac & Cardiovascular Systems
Brian H. Annex, John P. Cooke
Summary: PAD is a significant global cause of disability and mortality, primarily due to atherosclerotic obstructions in the large arteries to the leg(s). Despite advances in surgical and endovascular procedures, treatment outcomes may be suboptimal at times due to comorbid conditions or severe microvascular disease.
CIRCULATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Gianfranco Matrone, Bo Xia, Kaifu Chen, Martin A. Denvir, Andrew H. Baker, John P. Cooke
Summary: This study identified novel up-regulated genes during endothelial development and highlighted the crucial role of PRDM16 in regulating endothelial cell differentiation and angiogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cardiac & Cardiovascular Systems
Alyssa M. Flores, Alejandro Schuler, Anne Verena Eberhard, Jeffrey W. Olin, John P. Cooke, Nicholas J. Leeper, Nigam H. Shah, Elsie G. Ross
Summary: This study used unsupervised machine learning to analyze data of patients with coronary artery disease and identified four subgroups with different clinical trajectories. In terms of risk assessment, cluster membership was more informative than the pooled cohort equations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Ahmed Ibrahim Ahmed, Mahmoud Al Rifai, Fares Alahdab, Jean Michel Saad, Yushui Han, Moath Said Alfawara, Malek Nayfeh, Maan Malahfji, Faisal Nabi, John J. Mahmarian, John P. Cooke, William A. Zoghbi, Mouaz H. Al-Mallah
Summary: This study aimed to determine the effects of prior COVID-19 on coronary microvasculature. By considering factors such as time from infection, disease severity, SARS-CoV-2 variants, and subgroups of patients with diabetes and those with no known coronary artery disease, the study compared the myocardial flow reserve (MFR) between patients with previous COVID-19 and controls. The results showed that patients with prior COVID-19 had a significantly higher risk of impaired MFR.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Engineering, Biomedical
David F. Chang, Karem A. Court, Rhonda Holgate, Elizabeth A. Davis, Katie A. Bush, Andrew P. Quick, Aldona J. Spiegel, Maham Rahimi, John P. Cooke, Biana Godin
Summary: Using autologous hSCS to treat deep skin wounds requires less donor skin and can prevent the decline of therapeutic effect caused by skin aging. Utilizing hTERT mRNA LNP can enhance the engraftment and proliferation of hSCS, reducing cellular senescence and DNA damage.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Multidisciplinary Sciences
Roderic I. Pettigrew, John P. Cooke
Summary: There has been a significant transformation in the scientific world, with accelerated discovery and innovation driven by interdisciplinary collaboration. The concept of Pasteur's quadrant, which combines fundamental understanding and application, has been expanded to include other quadrants contributing to scientific progress. The reimagined Pasteur's quadrant schema highlights the continuous fluid interchange among quadrants, leading to transformative advancements.
Article
Biochemical Research Methods
Brandon K. Walther, Navaneeth Krishna Rajeeva Pandian, Karli A. Gold, Ecem S. Kilic, Vineeth Sama, Jianhua Gu, Akhilesh K. Gaharwar, Anthony Guiseppi-Elie, John P. Cooke, Abhishek Jain
Summary: The study discusses the importance of endothelial mechanobiology in vascular dysfunction, focusing on the effects of shear stress and matrix stiffness on endothelial cell responses. By utilizing vessel-chip systems, researchers were able to model and validate the mechanobiological behaviors of endothelial cells in response to different mechanical stimuli, providing insights into the progression of diseases like atherosclerosis.
Article
Cardiac & Cardiovascular Systems
Renfang Mao, Shu Meng, Qilin Gu, Raquel Araujo-Gutierrez, Sandeep Kumar, Qing Yan, Felicidad Almazan, Keith A. Youker, Yingbin Fu, Henry J. Pownall, John P. Cooke, Yury I. Miller, Longhou Fang
CIRCULATION RESEARCH
(2017)
