Article
Cardiac & Cardiovascular Systems
Guangyu Zhang, Xiaoding Wang, Chao Li, Qinfeng Li, Yu A. An, Xiang Luo, Yingfeng Deng, Thomas G. Gillette, Philipp E. Scherer, Zhao Wang
Summary: The study demonstrates the significant role of the ISR in myocardial ischemia/reperfusion injury by selectively suppressing mitochondrial protein synthesis and reducing oxidative stress to improve cell survival and mitigate reperfusion damage.
Article
Biochemistry & Molecular Biology
Amanda B. Abildgaard, Vasileios Voutsinos, Soren D. Petersen, Fia B. Larsen, Caroline Kampmeyer, Kristoffer E. Johansson, Amelie Stein, Tommer Ravid, Claes Andreasson, Michael K. Jensen, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
Summary: Protein quality control (PQC) degrons are short protein segments that target misfolded proteins for proteasomal degradation, and chaperone-binding regions may function as PQC degrons. A canonical Hsp70-binding motif, the APPY peptide, functions as a dose-dependent PQC degron in yeast and human cells. The number of exposed Hsp70-binding sites in the yeast proteome correlates with reduced protein abundance and half-life.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Neurosciences
Mimi Wu, Xiaoping Gu, Zhengliang Ma
Summary: Ischemic stroke is a major cause of death and disability worldwide. Reperfusion therapy is standard for ischemic stroke, but can exacerbate neuronal damage through mitochondrial dysfunction. Mitochondrial quality control and mitophagy play crucial roles in preventing neuronal damage and maintaining a healthy mitochondrial network in cerebral I/R injury.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Olga M. Rusiecka, Filippo Molica, Morten S. Nielsen, Axel Tollance, Sandrine Morel, Maud Frieden, Marc Chanson, Kerstin Boengler, Brenda R. Kwak
Summary: This study found that deletion of the Pannexin1 (Panx1) gene in cardiac endothelial cells can alleviate cardiac ischaemia/reperfusion (I/R) injury and improve left ventricular function recovery. This cardioprotective effect seems to be mediated through its influence on cardiac mitochondria rather than reducing the inflammatory response. Therefore, Panx1 may represent a new target for controlling cardiac reperfusion damage.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Csaba Horvath, Megan Young, Izabela Jarabicova, Lucia Kindernay, Kristina Ferenczyova, Tanya Ravingerova, Martin Lewis, M. Saadeh Suleiman, Adriana Adameova
Summary: RIP3 is a central point of multiple signaling pathways, but the acute myocardial ischemia/reperfusion injury is not mediated by necroptotic cell death. The study shows that RIP3 regulates reperfusion injury through oxidative stress and mitochondrial activity effects, rather than cell loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Kevin J. Ashton, Can J. Kiessling, Jamie-Lee M. Thompson, Aliah Y. Aziz, Walter G. Thomas, John P. Headrick, Melissa E. Reichelt
Summary: Evidence of early cardiac aging and associated mechanisms were found in the hearts of male mice, including declining cardiovascular reserve and stress-resistance, as well as transcriptional changes.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Carolyn Allain Breckel, Mark Hochstrasser
Summary: The proper folding of proteins is vital for their diverse functions, and misfolded proteins can potentially harm cells by forming aggregates. Protein quality control pathways are responsible for repairing or degrading abnormal proteins, with the ubiquitin-proteasome system being commonly employed.
Article
Cardiac & Cardiovascular Systems
Min Xie, Geoffrey W. Cho, Yongli Kong, Dan L. Li, Francisco Altamirano, Xiang Luo, Cyndi R. Morales, Nan Jiang, Gabriele G. Schiattarella, Herman May, Jessica Medina, John M. Shelton, Anwarul Ferdous, Thomas G. Gillette, Joseph A. Hill
Summary: The study tested the use of an autophagy-inducing peptide, TB, to protect against reperfusion injury by reducing reactive oxygen species. It was found that TB reduced infarct size, improved contractile function, and decreased oxidative stress by increasing autophagic flux.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Luyan Yao, Funan He, Quanyi Zhao, Dandan Li, Shufang Fu, Mingzhi Zhang, Xingzhong Zhang, Bingying Zhou, Li Wang
Summary: Imaging mass cytometry was used to characterize the spatial distribution and dynamics of cell phenotypes and communities in the mouse left ventricle following myocardial infarction. H3K9me3 in endothelial cells was identified as a potential therapeutic target for alleviating pathological remodeling of the heart after ischemia-reperfusion injury.
CIRCULATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Lion Borgert, Swadha Mishra, Fabian den Brave
Summary: The nucleus plays an emerging role in cellular quality control by degrading or sequestering aberrant proteins, thus protecting the cellular environment.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Kun-Ling Tsai, Pei-Ling Hsieh, Wan-Ching Chou, Hui-Ching Cheng, Yu-Ting Huang, Shih-Hung Chan
Summary: The study suggests that DAPA may alleviate oxidative stress and cardiac apoptosis induced by ischemia/reperfusion injury through modulation of AMPK, improving cardiac function. Additionally, DAPA may protect cardiac cells by influencing mitochondrial function.
CELL AND BIOSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Ying Yang, Yang Zhang, Jiqin Yang, Manman Zhang, Tao Tian, Yuan Jiang, Xuening Liu, Genlong Xue, Xingda Li, Xiaofang Zhang, Shangxuan Li, Xiang Huang, Zheng Li, Yang Guo, Lexin Zhao, Hairong Bao, Zhiwen Zhou, Jiahui Song, Guohui Yang, Lina Xuan, Hongli Shan, Zhiren Zhang, Yanjie Lu, Baofeng Yang, Zhenwei Pan
Summary: This study found that ASPP1 protein exacerbates cardiac ischemia/reperfusion (I/R) injury by binding to p53 protein and co-translocating to the nucleus through importin-beta 1. The findings imply that interfering the expression of ASPP1 or the interaction between ASPP1 and p53 to block their nuclear trafficking represents an important therapeutic strategy for cardiac I/R injury.
CIRCULATION RESEARCH
(2023)
Article
Critical Care Medicine
Matthias Kohlhauer, Mathieu Panel, Marine Vermot des Roches, Estelle Faucher, Yara Abi Zeid Daou, Emilie Boissady, Fanny Lidouren, Bijan Ghaleh, Didier Morin, Renaud Tissier
Summary: The study found that cardiac and cerebral mitochondrial dysfunction showed similar patterns after cardiac arrest, with initial recovery within the first few hours but a significant increase in dysfunction after 24 hours. Despite greater neurological dysfunction after non-shockable cardiac arrest, mitochondrial dysfunction was still more pronounced after 24 hours.
Review
Biochemistry & Molecular Biology
Jose Lillo-Moya, Catalina Rojas-Sole, Diego Munoz-Salamanca, Emiliano Panieri, Luciano Saso, Ramon Rodrigo
Summary: Ischemic heart disease is a major cause of death globally, and reoxygenation is the primary treatment to restore blood flow, although it can also induce tissue injury. Iron-induced ferroptosis plays a critical role in heart damage, and efforts to inhibit it may improve clinical outcomes for patients.
Review
Biochemistry & Molecular Biology
Christopher Lotz, Johannes Herrmann, Quirin Notz, Patrick Meybohm, Franz Kehl
Summary: Mitochondria play a crucial role in myocardial ischemia/reperfusion injury and pharmacological cardiac conditioning, including maintaining cellular function, regulating calcium balance and cell death, participating in aging and mitochondrial regeneration, etc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
