Review
Cardiac & Cardiovascular Systems
Andrew Owen, Jaimin M. Patel, Dhruv Parekh, Mansoor N. Bangash
Summary: Prolonged critical care stays can lead to the development of cardiovascular and renal diseases due to the immune response and treatments during severe illness, resulting in inflammation and immunosenescence.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jin-Yue Yang, Lingyu Zhang, Tian-Tian Zhang, Cheng-Cheng Wang, Ying-Cai Zhao, Xiao-Yue Li, Yu-Ming Wang, Chang-Hu Xue
Summary: Previous studies have shown that EPA-PLs can improve glucose and lipid metabolism by increasing CD36 expression. However, the effects of EPA-PLs on glucose and lipid metabolism in CD36 mutation are still unclear. This study used SHR as a CD36 mutation model and found that dietary EPA-PLs could alleviate abnormal lipid levels and adipocyte hypertrophy in SHR. EPA-PLs also reduced triglyceride and cholesterol levels in the liver and improved glucose tolerance and insulin levels through the IRS/PI3K/AKT signaling pathway. These findings suggest that EPA-PLs provide a precise nutrition strategy for individuals with CD36 mutation.
Review
Cell Biology
Daniela Sorriento, Maria Rosaria Rusciano, Valeria Visco, Antonella Fiordelisi, Federica Andrea Cerasuolo, Paolo Poggio, Michele Ciccarelli, Guido Iaccarino
Summary: Insulin resistance is a pathophysiological condition associated with obesity, glucose intolerance, dyslipidemia, and hypertension, leading to type 2 diabetes and cardiovascular diseases. Studies have identified G Protein Coupled Receptor Kinase type 2 (GRK2) as a potential therapeutic target for insulin resistance and its associated phenotypes.
Article
Cardiac & Cardiovascular Systems
Parveen K. Garg, Mary L. Biggs, Jorge R. Kizer, Sanjiv J. Shah, Bruce Psaty, Mercedes Carnethon, John S. Gottdiener, David Siscovick, Kenneth J. Mukamal
Summary: This study evaluated the association between glucose dysregulation and subclinical cardiac dysfunction in an older population. The findings suggest that the relationship between glucose dysregulation and cardiac dysfunction is largely attenuated after adjusting for central adiposity.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Medicine, General & Internal
Teresa Salvatore, Pia Clara Pafundi, Raffaele Galiero, Gaetana Albanese, Anna Di Martino, Alfredo Caturano, Erica Vetrano, Luca Rinaldi, Ferdinando Carlo Sasso
Summary: Research has shown that individuals with diabetes mellitus have a higher risk of heart failure compared to non-diabetic individuals, and diabetic cardiomyopathy may be a key factor. Metabolic abnormalities, mitochondrial damage, oxidative stress, and other factors may lead to extracellular remodeling and hypertrophy in the diabetic heart, resulting in left ventricular diastolic and systolic dysfunction.
FRONTIERS IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Huancong Zheng, Guanzhi Chen, Kuangyi Wu, Weiqiang Wu, Zegui Huang, Xianxuan Wang, Zekai Chen, Zefeng Cai, Zhiwei Cai, Yulong Lan, Shouling Wu, Youren Chen
Summary: The study aimed to determine the relationship between cumulative exposure to high triglyceride-glucose index (TyG) and the risk of heart failure. The results showed that high cumulative TyG index is associated with an increased risk of heart failure. This emphasizes the importance of long-term monitoring of the TyG index in clinical practice.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
David D. Berg, Benjamin L. Freedman, Marc P. Bonaca, Petr Jarolim, Benjamin M. Scirica, Erica L. Goodrich, Marc S. Sabatine, David A. Morrow
Summary: This study found that biomarkers of myocardial injury and hemodynamic stress are independent predictors of heart failure risk in patients with stable atherothrombotic disease, regardless of prior heart failure and/or type 2 diabetes mellitus. These biomarkers can improve heart failure risk assessment and help identify patients who may benefit from heart failure preventive therapies.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Serafino Fazio, Valentina Mercurio, Flora Affuso, Paolo Bellavite
Summary: This opinion article discusses the potential impact of insulin resistance and hyperinsulinemia on the cardiovascular system, specifically heart failure. The incidence of heart failure has been increasing, particularly heart failure with preserved ejection fraction. Insulin resistance may play a significant role in the pathophysiology and progression of heart failure. Early screening and appropriate treatment of insulin resistance could be beneficial for individuals at risk and patients with heart failure.
Article
Biochemistry & Molecular Biology
Maria Perticone, Raffaele Maio, Simona Gigliotti, Ermal Shehaj, Alfredo Francesco Toscani, Antonella Capomolla, Ginevra Fabiani, Angela Sciacqua, Francesco Perticone
Summary: This study investigated the association between endothelial dysfunction and insulin resistance with heart failure, and explored the possible interaction between them. The findings showed that both endothelial dysfunction and insulin resistance are independent predictors of heart failure in hypertensive patients, and they interact with each other.
Review
Biochemistry & Molecular Biology
Nilanjan Ghosh, Leena Chacko, Hiranmoy Bhattacharya, Jayalakshmi Vallamkondu, Sagnik Nag, Abhijit Dey, Tanushree Karmakar, P. Hemachandra Reddy, Ramesh Kandimalla, Saikat Dewanjee
Summary: Diabetes mellitus (DM) and cardiovascular complications often occur together, creating a challenging situation. The development of diabetic cardiomyopathy (DCM) involves complex pathophysiological pathways at the metabolic and molecular level, leading to structural and functional alterations of the heart. Glucagon-like peptide-1 (GLP-1) analogues and sodium-glucose cotransporter-2 (SGLT-2) inhibitors have shown promising results in improving cardiovascular outcomes in diabetes. This article highlights the pathways contributing to DCM and discusses potential future therapies.
Article
Cardiac & Cardiovascular Systems
Vinithra Varadarajan, Samuel S. Gidding, Colin Wu, J. Jeffrey Carr, Joao A. C. Lima
Summary: The increasing prevalence of obesity, hypertension, and diabetes, along with worsening environmental factors, has led to a growing burden of cardiovascular diseases worldwide. Noninvasive imaging techniques, including vascular ultrasound, echocardiography, and magnetic resonance imaging, play a significant role in identifying early cardiovascular disease phenotypes. This article reviews the various imaging modalities used for the evaluation, characterization, and quantification of early subclinical cardiovascular diseases.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Rihua Huang, Yifen Lin, Xiaomin Ye, Xiangbin Zhong, Peihan Xie, Miaohong Li, Xiaodong Zhuang, Xinxue Liao
Summary: The study aimed to investigate the association between the triglyceride-glucose (TyG) index and the development of heart failure (HF) and left ventricular (LV) dysfunction. The results showed that an increase in the TyG index was significantly associated with a higher risk of HF and impaired LV structure and function.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Plant Sciences
Jingyu Ni, Zhihao Liu, Miaomiao Jiang, Lan Li, Jie Deng, Xiaodan Wang, Jing Su, Yan Zhu, Feng He, Jingyuan Mao, Xiumei Gao, Guanwei Fan
Summary: This study confirms the protective effect of ginsenoside Rg3 on heart function in TAC-induced heart failure mice and reveals the molecular mechanisms involved in regulating glucose metabolism and improving insulin resistance.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Endocrinology & Metabolism
Luli Xu, Mingyang Wu, Shuohua Chen, Yingping Yang, Youjie Wang, Shouling Wu, Yaohua Tian
Summary: This study investigated the association between TyG index and heart failure (HF). The results showed a positive relationship between TyG index and the risk of HF, with a dose-response relationship. This association was observed in both men and participants with or without abdominal obesity.
DIABETES & METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Hui Ye, Yanan He, Chuan Zheng, Fang Wang, Ming Yang, Junzhi Lin, Runchun Xu, Dingkun Zhang
Summary: Type 2 diabetes mellitus (T2DM) and heart failure (HF) are diseases with high morbidity and mortality. Their combination is common in middle-aged and elderly individuals, making treatment challenging. Abnormal insulin signaling pathway, a common pathogenic mechanism, could serve as a specific target for the treatment of T2DM patients with HF.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Goro Katsuumi, Ippei Shimizu, Yohko Yoshida, Yuka Hayashi, Ryutaro Ikegami, Masayoshi Suda, Takayuki Wakasugi, Masaaki Nakao, Tohru Minamino
INTERNATIONAL HEART JOURNAL
(2018)
Article
Cardiac & Cardiovascular Systems
Hiromi Kayamori, Ippei Shimizu, Yohko Yoshida, Yuka Hayashi, Masayoshi Suda, Ryutaro Ikegami, Coro Katsuumi, Takayuki Wakasugi, Tohru Minamino
INTERNATIONAL HEART JOURNAL
(2018)
Article
Cardiac & Cardiovascular Systems
Yuji Okura, Sumika Ishigaki, Satoko Sakakibara, Chika Yumoto, Mitsue Hashitate, Chika Sekine, Tomomi Fujita, Tsugumi Takayama, Kazuyuki Ozaki, Nobuaki Sato, Tohru Minamino
INTERNATIONAL HEART JOURNAL
(2018)
Article
Medicine, Research & Experimental
Toshiaki Teratani, Kengo Tomita, Takahiro Suzuki, Hirotaka Furuhashi, Rie Irie, Makoto Nishikawa, Junji Yamamoto, Toshifumi Hibi, Soichiro Miura, Tohru Minamino, Yuichi Oike, Ryota Hokari, Takanori Kanai
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Letter
Cardiac & Cardiovascular Systems
Sou Otuki, Daisuke Izumi, Masayoshi Suda, Akinori Sato, Yuki Hasegawa, Nobue Yagihara, Kenichi Iijima, Masaomi Chinushi, Ichiro Fuse, Tohru Minamino
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2018)
Article
Oncology
Yuji Okura, Tsugumi Takayama, Kazuyuki Ozaki, Hiroshi Tanaka, Hiroshi Seki, Tatsuya Takenouchi, Nobuaki Sato, Tohru Minamino
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Cell Biology
Ryutaro Ikegami, Ippei Shimizu, Takeshi Sato, Yohko Yoshida, Yuka Hayashi, Masayoshi Suda, Goro Katsuumi, Ji Li, Takayuki Wakasugi, Yasuhiko Minokoshi, Shiki Okamoto, Eiichi Hinoi, Soren Nielsen, Naja Zenius Jespersen, Camilla Scheele, Tomoyoshi Soga, Tohru Minamino
Article
Multidisciplinary Sciences
Kentaro Fukuda, Shinya Okazaki, Masayuki Shiozaki, Iwao Okai, Akihisa Nishino, Hiroshi Tamura, Kenji Inoue, Masataka Sumiyoshi, Hiroyuki Daida, Tohru Minamino
Summary: This study retrospectively reviewed 366 endovascular treatment procedures for femoropopliteal lesions in 335 patients with claudication and 69 patients with critical limb ischemia. The predictors of bleeding-associated complications were age ≥ 80 years and antegrade cannulation of the common femoral artery. Ultrasound-guided puncture was found to reduce bleeding complications at the approach site.
Editorial Material
Cardiac & Cardiovascular Systems
Hiroshi Iwata, Tohru Minamino
EUROPEAN HEART JOURNAL
(2022)
Article
Multidisciplinary Sciences
Yusuke Joki, Hakuoh Konishi, Hiroyuki Ebinuma, Kiyoshi Takasu, Tohru Minamino
Summary: The study found that sLR11 is significantly associated with the severity of PH in patients with left heart disease and can serve as a strong predictor for patients with severe mitral regurgitation after surgery.
Article
Substance Abuse
Takuro Okada, Shiro Matsuo, Kazunori Shimada, Tohru Minamino
Summary: Athletes face disciplinary action for unintentional doping. This study evaluated the effectiveness of prior checks on athletes' drug regimens by medical personnel with anti-doping knowledge to prevent unintentional doping and found that approximately 10% of the drugs elite athletes wanted to use were not allowed.
SUBSTANCE USE & MISUSE
(2022)
Article
Multidisciplinary Sciences
Ryo Furuuchi, Ippei Shimizu, Yohko Yoshida, Goro Katsuumi, Masayoshi Suda, Yoshiaki Kubota, Kenneth Walsh, Tohru Minamino
Summary: This study found that capillary density decreases in brown adipose tissue during dietary obesity, and boysenberry polyphenols can reduce endothelial cell apoptosis, enhance capillarization, and improve the response to dietary changes.
Article
Multidisciplinary Sciences
Yumi Kuroda, Tomohiro Kaneko, Hitomi Yoshikawa, Saori Uchiyama, Yuichi Nagata, Yasushi Matsushita, Makoto Hiki, Tohru Minamino, Kazuhisa Takahashi, Hiroyuki Daida, Nobuyuki Kagiyama
Summary: The study investigated the effectiveness of an artificial intelligence-based automated pneumonia detection method using point-of-care lung ultrasound for COVID-19. The results showed that the AI-POCUS had high accuracy and sensitivity in detecting CT-validated pneumonia.
Article
Cardiac & Cardiovascular Systems
Taishi Dotare, Daichi Maeda, Yuya Matsue, Tohru Minamino
Summary: This case report suggests that methotrexate may have a direct anti-inflammatory effect in patients with cardiac sarcoidosis refractory to regular corticosteroid therapy.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Yuki Hasegawa, Daisuke Izumi, Takeshi Kashimura, Tohru Minamino
Summary: AMA-positive myositis can lead to myocardial involvement, resulting in severe left ventricular dysfunction and life-threatening ventricular arrhythmias over time.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2021)
