Review
Pharmacology & Pharmacy
Christian Butter, Martin Seifert, Christian Georgi, Konstantinos Iliodromitis, Harilaos Bogossian
Summary: Cardiac resynchronization therapy (CRT) is recommended for patients with symptomatic systolic heart failure and left bundle branch block, despite optimal medical therapy. The 2021 ESC guidelines emphasize the importance of CRT in heart failure patients with reduced left ventricular ejection fraction, sinus rhythm, and typical left bundle branch block. Other pacing strategies and alternative sites are available if CRT is not feasible or effective.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Elian F. Giordanino
Summary: Although cardiac resynchronization therapy (CRT) is an effective treatment for heart failure patients with reduced ejection fraction, not all patients respond to it, suggesting a lack of understanding of the underlying mechanisms of CRT response.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Review
Medicine, General & Internal
Giuseppe Boriani, Andrea Venturelli, Jacopo F. Imberti, Niccolo Bonini, Davide A. Mei, Marco Vitolo
Summary: This study analyzed the level of evidence and class of recommendations in 50 ESC guidelines released in the past 12 years. The results showed that only 16% of the recommendations had the highest quality of evidence. Although there was a slight increase in LOE A recommendations in recent years, further scientific research efforts are needed to improve the quality of evidence.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Tamila Abdurashidova, Martin Mueller, Sara Schukraft, Nisha Soborun, Barbara Pitta-Gros, John Kikoine, Henri Lu, Zalina Chazymova, Kanzaada Dzhorupbekova, Medet Beishenkulov, Georgios Tzimas, Matthias Kirsch, Peter Vollenweider, Marie Mean, Pierre Monney, Roger Hullin
Summary: Adjusted outcomes for age and LVEF were found to be similar between Central Asian and Western European AHF patients, despite significant ethnic disparities.
Review
Medicine, General & Internal
Henri Lu, Hortense Lu, Christophe Kosinski, Anne Wojtusciszyn, Anne Zanchi, Pierre-Nicolas Carron, Martin Mueller, Philippe Meyer, Jehan Martin, Olivier Muller, Roger Hullin
Summary: SGLT2 inhibitors are a class of antidiabetic treatments used in type 2 diabetes mellitus, particularly in patients with cardiovascular disease, high risk, heart failure, or renal disease. While common adverse events are easily treatable, attention must be paid to some potentially serious adverse events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Novosadova, Lauren Gianchetti, Koji Takagi, Priyanka Morishetty, Lauren Gaeta, Christopher Edwards, Beth A. Davison, Adrien Picod, Alexandre Mebazaa, Gad Cotter
Summary: The study aims to compare standard in-hospital treatment and management of AHF with clinical guidelines and variations across regions. The results show significant differences in how AHF patients are treated and managed, with suboptimal adherence to clinical guidelines in some regions.
Article
Medicine, General & Internal
Marielle Kloosterman, Fenna Daniels, Eva Roseboom, Michiel Rienstra, Alexander H. Maass
Summary: This study aimed to investigate the optimal atrioventricular (AV) delay in cardiac resynchronization therapy (CRT) and to explore a simple intracardiac electrogram-based optimization method. The study found that optimal AV delays vary among patients and differ from nominal settings. The paced AV delay can be easily calculated using the intracardiac electrogram method after optimizing the sensed AV delay.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Paul A. Heidenreich, Biykem Bozkurt, David Aguilar, Larry A. Allen, Joni J. Byun, Monica M. Colvin, Anita Deswal, Mark H. Drazner, Shannon M. Dunlay, Linda R. Evers, James C. Fang, Savitri E. Fedson, Gregg C. Fonarow, Salim S. Hayek, Adrian F. Hernandez, Prateeti Khazanie, Michelle M. Kittleson, Christopher S. Lee, Mark S. Link, Carmelo A. Milano, Lorraine C. Nnacheta, Alexander T. Sandhu, Lynne Warner Stevenson, Orly Vardeny, Amanda R. Vest, Clyde W. Yancy, Joshua A. Beckman, Patrick T. O'Gara, Sana M. Al-Khatib, Anastasia L. Armbruster, Kim K. Birtcher, Joaquin E. Cigarroa, Lisa de las Fuentes, Dave L. Dixon, Lee A. Fleisher, Federico Gentile, Zachary D. Goldberger, Bulent Gorenek, Norrisa Haynes, Mark A. Hlatky, Jose A. Joglar, W. Schuyler Jones, Joseph E. Marine, Daniel B. Mark, Debabrata Mukherjee, Latha P. Palaniappan, Mariann R. Piano, Tanveer Rab, Erica S. Spatz, Jacqueline E. Tamis-Holland, Duminda N. Wijeysundera, Y. Joseph Woo
Summary: The 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure provides patient-centric recommendations for clinicians to prevent, diagnose, and manage patients with heart failure. It is based on contemporary evidence and aims to improve quality of care and align with patients' interests.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Theo Pezel, Etienne Audureau, Jacques Mansourati, Guillaume Baudry, Ahmed Ben Driss, Florence Durup, Marie Fertin, Christian Godreuil, Julien Jeanneteau, Martin Kloeckner, Francois Koukoui, Lamia Kesri-Tartiere, Thierry Laperche, Francois Roubille, Alain Cohen-Solal, Thibaud Damy
Summary: In heart failure patients, there is a high prevalence of iron deficiency, yet only a third of patients undergo diagnostic testing for iron deficiency, and the recommended intravenous iron supplementation for heart failure patients with reduced ejection fraction is underutilized. Cardiologists are encouraged to adhere to ESC guidelines for optimal treatment outcomes.
Article
Cardiac & Cardiovascular Systems
Parag Goyal, Ozan Unlu, Peter J. Kennel, Ross C. Schumacher, Lauren G. Gilstrap, Ashok Krishnaswami, Larry A. Allen, Mathew S. Maurer, Michael W. Rich, Anil Makam
Summary: The majority of recommendations from heart failure CPGs lack information on diagnostic and therapeutic performance parameters and patient context, innovative strategies are needed to optimize CPGs.
JOURNAL OF CARDIAC FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Jan-Per Wenzel, Julius Nikorowitsch, Ramona bei der Kellen, Christina Magnussen, Renate Bonin-Schnabel, Dirk Westermann, Raphael Twerenbold, Paulus Kirchhof, Stefan Blankenberg, Benedikt Schrage
Summary: The prevalence of heart failure (HF) has increased following the new diagnostic algorithm introduced in the 2021 HF guidelines. This study aimed to determine the contemporary prevalence of HF in a representative sample from the general population. The results showed an increase in HF prevalence, particularly in patients with reduced/mildly-reduced ejection fraction. This increase offers opportunities for preventive therapies in HF patients.
Review
Cardiac & Cardiovascular Systems
Gianluigi Savarese, Peter Moritz Becher, Lars H. Lund, Petar Seferovic, Giuseppe M. C. Rosano, Andrew J. S. Coats
Summary: Heart Failure (HF) is a multi-faceted and life-threatening syndrome with significant morbidity and mortality worldwide, affecting over 64 million people. While the incidence of HF has stabilized in industrialized countries, the prevalence is increasing due to population ageing and improved treatment. Developing countries lack substantial data on HF epidemiology, which shows different features compared to the Western world. This review provides updated estimates on global burden of HF including prevalence, incidence, outcomes, and costs.
CARDIOVASCULAR RESEARCH
(2022)
Article
Medicine, General & Internal
Yuji Matsuo, Fumitoshi Yoshimine, Katsuya Fuse, Kazuo Suzuki, Takuya Sakamoto, Kenichi Iijima, Kazuyuki Ozaki, Tohru Minamino
Summary: There are regional disparities in the treatment of chronic heart failure (CHF) in both urban and rural areas in Japan, with lower adherence rates in rural areas. Improving the use of guideline-directed treatment for CHF in rural areas may lead to better outcomes for CHF patients.
Article
Cardiac & Cardiovascular Systems
Michele Massimo Gulizia, Francesco Orso, Andrea Mortara, Donata Lucci, Nadia Aspromonte, Leonardo De Luca, Giuseppe Di Tano, Giuseppe Leonardi, Alessandro Navazio, Giovanni Pulignano, Furio Colivicchi, Andrea Di Lenarda, Fabrizio Oliva
Summary: This study assessed adherence to guideline recommendations among Italian cardiology sites in the management of acute and chronic heart failure, and found that an educational intervention could improve their performance on specific indicators.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Nicholas W. S. Chew, Audrey Zhang, Gwyneth Kong, Kai Lin Lee, Cheng Han Ng, Bryan Chong, J. H. Nicholas Ngiam, Ching Hui Sia, Poay Huan Loh, Yinghao Lim, Ivandito Kuntjoro, Raymond C. C. Wong, William K. F. Kong, Tiong-Cheng Yeo, Kian-Keong Poh
Summary: The study examines the prognosis of patients with significant aortic stenosis (AS) based on the presence of metabolic health and obesity. The results show that metabolically healthy obese patients and metabolically unhealthy obese patients are associated with lower all-cause mortality rates. In contrast, metabolically healthy nonobese patients exhibit the worst survival.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
