Article
Cardiac & Cardiovascular Systems
Vivek Jani, M. Imran Aslam, Axel J. Fenwick, Weikang Ma, Henry Gong, Gregory Milburn, Devin Nissen, Ilton M. Cubero M. Salazar, Olivia Hanselman, Monica Mukherjee, Marc K. Halushka, Kenneth B. Margulies, Kenneth S. Campbell, Thomas C. Irving, David A. Kass, Steven Hsu
Summary: Right ventricular contractile dysfunction commonly occurs in patients with heart failure with reduced ejection fraction and pulmonary hypertension. Standard clinical indices may not reflect aspects of underlying myocyte dysfunction. This study investigates the mechanical properties of RV myocytes in HFrEF-PH patients and identifies potential underlying mechanisms.
Article
Peripheral Vascular Disease
Yongfa Huang, Chuxiang Lei, Wenjun Xie, Li Yan, Yanru Wang, Su Yuan, Jing Wang, Yan Zhao, Zhaojian Wang, Xiaoying Yang, Xiaohan Qin, Quan Fang, Ligang Fang, Xiaoxiao Guo
Summary: The study identified that in a rat model of pulmonary arterial hypertension, the development of RV failure can be divided into stages of normal, compensated, and decompensated. In the decompensated stage, diastolic SR Ca2+ leakage via oxidized RyR2 was found to facilitate the progression of RV failure. Dantrolene was proven to inhibit this Ca2+ leakage, delaying right cardiac dysfunction and improving the survival rate of animals with pulmonary arterial hypertension.
Article
Cardiac & Cardiovascular Systems
Riccardo M. Inciardi, Martin Abanda, Amil M. Shah, Maja Cikes, Brian Claggett, Hicham Skali, Muthiah Vaduganathan, Narayana Prasad, Sheldon Litwin, Bela Merkely, Annamaria Kosztin, Klaudia Vivien Nagy, Sanjiv J. Shah, Wilfred Mullens, Michael R. Zile, Carolyn S. P. Lam, Marc A. Pfeffer, John J. V. McMurray, Scott D. Solomon, PARAGON HF Investigators
Summary: This study aimed to evaluate the clinical implications of right ventricular function and its association with NT-proBNP, as well as its risk for adverse events in patients with HFpEF. The results demonstrated that worsening RV function and its ratio to pulmonary pressure were significantly associated with an increased risk of HF hospitalizations and cardiovascular death in these patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Catherine G. Ireland, Rachel L. Damico, Todd M. Kolb, Stephen C. Mathai, Monica Mukherjee, Stefan L. Zimmerman, Ami A. Shah, Fredrick M. Wigley, Brian A. Houston, Paul M. Hassoun, David A. Kass, Ryan J. Tedford, Steven Hsu
Summary: The study found that measuring RV contractile reserve during exercise by changes in RV Ees and dilation can better predict occult RV dysfunction, with RV ejection fraction during exercise proving to be a robust surrogate. This parameter was found to predict clinical outcomes more effectively than resting measures of RV function.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Respiratory System
Stanislav Keranov, Oliver Doerr, Leili Jafari, Christian Troidl, Christoph Liebetrau, Steffen Kriechbaum, Till Keller, Sandra Voss, Timm Bauer, Jakob Lorenz, Manuel J. Richter, Khodr Tello, Henning Gall, Hossein A. Ghofrani, Eckhard Mayer, Christoph B. Wiedenroth, Stefan Guth, Holger Loerchner, Jochen Poeling, Prakash Chelladurai, Soni Savai Pullamsetti, Thomas Braun, Werner Seeger, Christian W. Hamm, Holger Nef
Summary: The study revealed that CILP1 is a novel biomarker associated with maladaptive RV function and PH, with significant differences in its concentrations among different cardiac pathology groups, showing potential in predicting maladaptive RV function.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tilman Emrich, Veronica Bordonaro, U. Joseph Schoepf, Aniela Petrescu, Gabrielle Young, Moritz Halfmann, Theresia Schoeler, Josua Decker, Ibukun Abidoye, Anna Lena Emrich, Karl-Friedrich Kreitner, Kai Helge Schmidt, Akos Varga-Szemes, Aurelio Secinaro
Summary: The study aimed to test the feasibility of T2 mapping for detecting left-to-right shunts. Results indicated that the T2 ratio can serve as an imaging biomarker capable of detecting or ruling out left-to-right shunts.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Cardiac & Cardiovascular Systems
Ross Arena, Cemal Ozemek, Justin M. Canada, Carl J. Lavie, Audrey Borghi-Silva, Samantha Bond, Dejana Popovic, Paola Argiento, Marco Guazzi
Summary: Cardiorespiratory fitness is an important predictor of health trajectory and quality of life, supported by evidence. The role of right ventricular cardiac output in peak oxygen consumption response is often overlooked.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Max Berrill, Eshan Ashcroft, David Fluck, Isaac John, Ian Beeton, Pankaj Sharma, Aigul Baltabaeva
Summary: This study aimed to assess the predictive value of echocardiographic parameters of left and right ventricular function on the long-term prognosis of acute heart failure (AHF). The results showed that several parameters of right ventricular function were predictive of the 2-year outcome, while left ventricular ejection fraction could not identify patients at risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jessie van Wezenbeek, Azar Kianzad, Arno van de Bovenkamp, Jeroen Wessels, Sophia A. Mouratoglou, Natalia J. Braams, Samara M. A. Jansen, Eva Meulblok, Lilian J. Meijboom, J. Tim Marcus, Anton Vonk Noordegraaf, Marie Jose Goumans, Harm Jan Bogaard, M. Louis Handoko, Frances S. de Man
Summary: This study compared cardiac function in HFpEF, HFpEF-PH, and PAH patients and found that despite similar pressure overload, RV/RA function was less compromised in HFpEF-PH compared to PAH. The increased RA pressure and stiffness in HFpEF-PH were explained by left atrial/RA interaction.
CIRCULATION-HEART FAILURE
(2022)
Review
Cardiac & Cardiovascular Systems
Youn-Hoa Jung, Xianfeng Ren, Giancarlo Suffredini, Jeffery M. Dodd-o, Wei Dong Gao
Summary: This manuscript reviews issues related to right ventricular diastolic dysfunction and failure, including diagnosis, mechanisms, clinical impact, and management, highlighting its importance as a sensitive marker of end-organ dysfunction.
HEART FAILURE REVIEWS
(2022)
Review
Cardiac & Cardiovascular Systems
Michael I. Brener, Amirali Masoumi, Vivian G. Ng, Khodr Tello, Marcelo B. Bastos, William K. Cornwell, Steven Hsu, Ryan J. Tedford, Philipp Lurz, Karl-Philipp Rommel, Karl-Patrik Kresoja, Sherif F. Nagueh, Manreet K. Kanwar, Navin K. Kapur, Gurumurthy Hiremath, Mohammad Sarraf, Antoon J. M. Van Den Enden, Nicolas M. Van Mieghem, Paul M. Heerdt, Rebecca T. Hahn, Susheel K. Kodali, Gabriel T. Sayer, Nir Uriel, Daniel Burkhoff
Summary: Right ventricular pressure-volume analysis is a method independent of loading conditions to evaluate myocardial chamber performance and is becoming increasingly common in clinical and research settings. This review summarizes the basic techniques for PV loop measurement, analysis, and interpretation, as well as its application in clinically relevant topics.
CIRCULATION-HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Chih-Hsin Hsu, Jun-Neng Roan, Shih-Yuan Fang, Meng-Hsuan Chiu, Tzu-Ting Cheng, Chien-Chi Huang, Ming-Wei Lin, Chen-Fuh Lam
Summary: This study found that transplantation of viable mitochondria can reverse vascular and cardiac structural and functional damage in rats with pulmonary hypertension. By improving the contractile ability of the pulmonary artery and inhibiting abnormal proliferation, mitochondrial transplantation may be a revolutionary approach for treating pulmonary hypertension.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Lucas R. Celant, Jeroen N. Wessels, Azar Kianzad, J. Tim Marcus, Lilian J. Meijboom, Harm Jan Bogaard, Frances S. de Man, Anton Vonk Noordegraaf
Summary: This study aimed to investigate the relationship between reaching or maintaining a 45% threshold of right ventricular ejection fraction (RVEF) and treatment response, long-term functional stability, and prognosis in patients with pulmonary arterial hypertension (PAH). The findings demonstrated that patients who reached or maintained the 45% RVEF threshold had favorable prognosis and long-term stable RV function.
Article
Cardiac & Cardiovascular Systems
Ze Ming Goh, Nithin Balasubramanian, Samer Alabed, Krit Dwivedi, Yousef Shahin, Alexander M. K. Rothman, Pankaj Garg, Allan Lawrie, David Capener, A. A. Roger Thompson, Faisal Alandejani, Jim M. Wild, Christopher S. Johns, Robert A. Lewis, Rebecca Gosling, Michael Sharkey, Robin Condliffe, David G. Kiely, Andrew J. Swift
Summary: This study investigated the prognostic value of patterns of right ventricular adaptation in patients with pulmonary arterial hypertension (PAH) using cardiac magnetic resonance imaging. The results showed that patients in different volume/mass groups had different survival outcomes, with those in the high-volume-low-mass group having a higher risk of treatment failure.
Editorial Material
Emergency Medicine
Tobias Kummer, Arun Nagdev
Summary: Assessing right ventricular function is crucial in patients with submassive pulmonary embolism to determine the appropriate treatment pathway. The use of intravenous saline contrast may help detect impending right ventricular collapse and prompt more aggressive intervention.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
