Article
Cardiac & Cardiovascular Systems
Karrie F. Downing, Wendy N. Nembhard, Charles E. Rose, Jennifer G. Andrews, Anthony Goudie, Scott E. Klewer, Matthew E. Oster, Sherry L. Farr
Summary: Between 1980 and 1997, 8 out of 10 individuals with congenital heart defects (CHDs) in the US survived until 35 years of age, with survival rates varying based on the severity of CHDs, presence of noncardiac anomalies, birth weight, and maternal race and ethnicity. Among individuals without noncardiac anomalies, those with nonsevere CHDs had similar mortality rates between 1 and 35 years of age as the general population, and those with any CHD had similar mortality rates between 10 and 35 years of age as the general population.
Article
Obstetrics & Gynecology
Matheus Sarabion Vilela Pereira, Daniela Koeller Rodrigues Vieira, Maria de Fatima M. P. Leite, Maria Auxiliadora Monteiro Villar, Carla Verona Barreto Farias
Summary: Most patients with omphalocele have other malformations, especially congenital heart disease. The presence of concurrent defects has a significant impact on prognosis. An effective perinatal plan should be developed to minimize maternal morbidity and improve care for the newborn.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Immunology
Ulrika Snygg-Martin, Kok Wai Giang, Mikael Dellborg, Josefina Robertson, Zacharias Mandalenakis
Summary: Patients with congenital heart disease have a higher cumulative incidence of infective endocarditis compared to controls, and this incidence increases with age. The incidence of infective endocarditis varies by age but not by birth year.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Fred H. Rodriguez, Cheryl L. Raskind-Hood, Trenton Hoffman, Sherry L. Farr, Jill Glidewell, Jennifer S. Li, Alfred D'Ottavio, Lorenzo Botto, Matthew R. Reeder, Daphne Hsu, George K. Lui, Anaclare M. Sullivan, Wendy M. Book
Summary: CDC's Surveillance of Congenital Heart Defects Across the Lifespan project aims to understand the epidemiology and outcomes of congenital heart defects (CHD) using large databases. The study found acceptable positive predictive values (PPV) for CHD identification based on ICD-9-CM codes, but further evaluation and algorithm development are needed for accurate identification.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Eva Havers-Borgersen, Jawad H. Butt, Lauge ostergaard, Jeppe K. Petersen, Christian Torp-Pedersen, Lars Kober, Emil L. Fosbol
Summary: Patients with congenital heart disease (CHD) have a higher risk of infective endocarditis (IE) compared to the general population. This observational cohort study in Denmark found that the risk of IE varied among different types of CHD. Factors associated with IE in CHD patients included male sex, cyanosis, cardiac prostheses, chronic kidney disease, and cardiac implantable electronic devices. This highlights the importance of implementing preventive measures for CHD patients.
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Eva Havers-Borgersen, Jawad H. Butt, Morten Smerup, Gunnar H. Gislason, Christian Torp-Pedersen, Mathis Groning, Michael Rahbek Schmidt, Lars Sondergaard, Lars Kober, Emil L. Fosbol
Summary: Patients with tetralogy of Fallot (ToF) are at increased risk of infective endocarditis (IE), particularly those who undergo pulmonary valve replacement (PVR). Limited data exist on the long-term risk of IE, but the study confirms an association between PVR and increased incidence of IE.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Kimberley G. Miles, Dora Kormendine Farkas, Kristina Laugesen, Henrik Toft Sorensen, Nadine A. Kasparian, Nicolas Madsen
Summary: The incidence of mental health conditions among children with congenital heart disease (CHD) is higher than the general population, particularly among males and those with severe or single-ventricle CHD. Early intervention and mental health support may be especially important for these at-risk populations.
Article
Pediatrics
Abeer A. Hasan, Naser Aldain A. Abu Lehyah, Moath K. Al Tarawneh, Mahmoud Y. Abbad, Areen G. Fraijat, Razan A. Al-Jammal, Dania M. Moamar, Qasem A. Shersheer, Scott O. Guthrie, Joseph R. Starnes
Summary: This study investigated the epidemiology and identification methods of CHD in Jordan. The results showed a high incidence of CHD in Jordan, and prenatal and perinatal screening could facilitate early detection.
FRONTIERS IN PEDIATRICS
(2023)
Article
Public, Environmental & Occupational Health
Xingdi Yang, Jianjuan Zeng, Yiping Gu, Yiming Fang, Caiyun Wei, Shengkui Tan, Xiaoying Zhang
Summary: This hospital-based study in Guilin, China, aimed to determine the prevalence of birth defects in the region and classify them based on clinical presentation and causation. Of the 147,817 births recorded, 2,003 infants were diagnosed with BDs, with a total prevalence rate of 13.55 per 1,000 births. The study found that congenital heart defects, polydactyly, syndactyly, malformations of the external ear, and talipes equinovarus were the most common BD types.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Graziella Eshuis, Julia Hock, Gideon Marchie du Sarvaas, Hiske van Duinen, Rhoia Neidenbach, Freek van den Heuvel, Hans Hillege, Rolf M. F. Berger, Alfred Hager
Summary: This study aimed to provide a perspective for the interpretation of exercise capacity in patients with repaired Tetralogy of Fallot by describing the course of peakVO(2) from patients aged 6-63 years. The peakVO(2) of patients with rTOF was reduced at all ages, originating from childhood and declining over time. Sex differences in patients with rTOF were similar to natural existing sex differences.
Article
Cardiac & Cardiovascular Systems
Xuelian Yuan, Fengchao Liang, Jun Zhu, Keyong Huang, Li Dai, Xiaohong Li, Yanping Wang, Qi Li, Xiangfeng Lu, Jianfeng Huang, Lihui Liao, Yang Liu, Dongfeng Gu, Hanmin Liu, Fangchao Liu
Summary: This study investigated the association between maternal exposure to fine particulate matter (PM2.5) and fetal congenital heart defects (CHDs) in China. The results showed that higher maternal PM2.5 exposure, especially during the preconception period, increased the risk of certain types of CHDs in offspring. The findings highlight the importance of improving air quality in China and other highly polluted regions for CHD prevention.
Article
Cardiac & Cardiovascular Systems
Markus Schwerzmann, Francisco Javier Ruperti-Repilado, Helmut Baumgartner, Berto Bouma, Judith Bouchardy, Werner Budts, Laurence Campens, Massimo Chessa, Maria Jesus del Cerro Marin, Harald Gabriel, Pastora Gallego, Rocio Garcia-Orta, Ana Elvira Gonzalez, Annette Schophuus Jensen, Magalie Ladouceur, Berta Miranda-Barrio, Marielle Morissens, Agnes Pasquet, Joaquin Rueda, Annemien E. van den Bosch, Heleen Berdina van der Zwaan, Daniel Tobler, Matthias Greutmann
Summary: This study aimed to collect clinical outcome data and identify risk factors for a complicated course of COVID-19 in patients with adult congenital heart disease (ACHD). Risk factors such as age, obesity, and multiple comorbidities were associated with an increased risk of a complicated COVID-19 course in ACHD patients. Cyanotic heart disease, including unrepaired cyanotic defects or Eisenmenger syndrome, were identified as particularly high-risk congenital cardiac defects in ACHD patients.
Article
Cardiac & Cardiovascular Systems
Joost P. van Melle, Jolien W. Roos-Hesselink, Manish Bansal, Otto Kamp, Marwa Meshaal, Jiri Pudich, Vlatka Reskovic Luksic, Regino Rodriguez-Alvarez, Anita Sadeghpour, Jadranka Separovic Hanzevacki, Rouguiatou Sow, Ana Teresa Tim, Marisa Trabulo Morgado, Michele De Bonis, Cecile Laroche, Eric Boersma, Patrizio Lancellotti, Gilbert Habib
Summary: Congenital heart disease (CHD) patients with infective endocarditis (IE) have better survival rates compared to non-CHD patients. CHD patients are younger and have fewer comorbidities. Positive blood cultures for Streptococcus viridans and a higher prevalence of dental procedures were observed in CHD patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Cell Biology
Yuwen Chen, Deyong Xiao, Lu Zhang, Chen-Leng Cai, Bai-Yan Li, Ying Liu
Summary: Tbx20, a member of the T-box gene family, plays crucial roles in cardiovascular development and homeostasis, as well as cardiac remodeling in response to pathophysiological stresses. Mutations and genetic variants in TBX20 are associated with a wide spectrum of congenital heart defects and heart diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alexandra Arvanitaki, Wasyla Ibrahim, Darryl Shore, Gerhard-Paul Diller, Wei Li, Isma Rafiq, Michael Gatzoulis, Claudia Montanaro
Summary: This study analyzed the epidemiology, clinical characteristics, and in-hospital management of SAIE in ACHD patients. The results showed that SAIE remains a life-threatening complication, requiring cardiac surgery in the majority of ACHD patients. Early surgery was associated with a shorter hospital stay.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Letter
Endocrinology & Metabolism
Steven D. Stovitz, Hailey R. Banack, Jay S. Kaufman
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Pediatrics
Andrew S. Mackie, Kathryn N. Rankin, Maryna Yaskina, Jody Gingrich, Elina Williams, Michelle Schuh, Adrienne H. Kovacs, Brian W. McCrindle, David Nicholas, Gwen R. Rempel
Summary: This study evaluated the impact of a novel nurse-led transition intervention program on young adolescents (aged 13-14 years) with congenital heart disease (CHD). The results showed that the intervention significantly improved the participants' self-management skills and CHD knowledge.
JOURNAL OF PEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Saeid Safiri, Nahid Karamzad, Jay S. Kaufman, Seyed Aria Nejadghaderi, Nicola Luigi Bragazzi, Mark J. M. Sullman, Amir Almasi-Hashiani, Mohammad Ali Mansournia, Gary S. Collins, Ali-Asghar Kolahi, Ahmedin Jemal
Summary: This study provides a comprehensive report on the levels and trends of 13 cancers attributable to excess body weight (EBW) from 1990 to 2019 in 204 countries and territories. The findings suggest that the burden of EBW-attributable cancers has been increasing globally over the past three decades. There are significant variations between countries and regions, highlighting the need for tailored preventive interventions.
Review
Cardiac & Cardiovascular Systems
Andrew S. Mackie, Gruschen R. Veldtman, Lene Thorup, Vibeke E. Hjortdal, Yoav Dori
Summary: Plastic bronchitis (PB) and protein-losing enteropathy (PLE) are rare but serious complications of the Fontan circulation. Both diseases involve the disruption of the lymphatic system and lymphatic drainage to abnormal pathways. Advances in imaging and lymphatic interventions have greatly improved our understanding of these diseases.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Rubee Dev, Valeria Raparelli, Simon L. Bacon, Kim L. Lavoie, Louise Pilote, Colleen M. Norris
Summary: This study aims to examine the association between sociocultural gender factors and the public's adherence to COVID-19-recommended protective health behaviors. The findings suggest that while females show greater adherence, factors such as employment status and high gender inequality at the country level are independently associated with non-adherence among females.
Article
Environmental Sciences
Megan Kirby-McGregor, Chen Chen, Hong Chen, Tarik Benmarhnia, Jay S. Kaufman
Summary: This study found that ambient PM2.5 concentrations in Canada decreased from 2001 to 2016, but disadvantaged communities with lower income, education, and higher proportions of aboriginal population did not benefit equally. This highlights the need to address environmental injustice in air pollution policies.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Peripheral Vascular Disease
Zahra Azizi, Pouria Alipour, Valeria Raparelli, Colleen M. M. Norris, Louise Pilote
Summary: Gender-based factors play a significant role in the manifestation and control of hypertension, with different impacts on men and women. Women are more affected by factors like life stressors and mental health. Marital status and social support also influence hypertension differently. Socioeconomic status has an impact on blood pressure control.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Multidisciplinary Sciences
Hong Chen, Matthew Quick, Jay S. Kaufman, Chen Chen, Jeffrey C. Kwong, Aaron van Donkelaar, Jun Meng, Randall V. Martin, JinHee Kim, Eric Lavigne, Li Bai, Yi Li, Michael Tjepkema, Tarik Benmarhnia, Richard T. Burnett
Summary: Reducing anthropogenic contributions to PM2.5 could lead to significant health benefits, even in a country like Canada where PM2.5 levels are already low. A 10% annual reduction in PM2.5 contributions from transportation and power generation sources could prevent a substantial number of deaths per million by 2016.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Letter
Pediatrics
Francesca del Giorgio, Merieme Habti, Joanna Merckx, Jay S. Kaufman, Jocelyn Gravel, Nelson Piche, Esli Osmanlliu, Olivier Drouin
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Li Bai, Tarik Benmarhnia, Chen Chen, Jeffrey C. Kwong, Richard T. Burnett, Aaron van Donkelaar, Randall Martin, JinHee Kim, Jay S. Kaufman, Hong Chen
Summary: This study investigates the mediation effect of diabetes and cardiovascular diseases on the relationship between long-term exposure to PM2.5 and mortality. The results suggest that a significant portion of the effect of PM2.5 on deaths can be attributed to its impact on diabetes and cardiovascular diseases, emphasizing the importance of PM2.5 on cardiovascular health deterioration.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Psychology, Clinical
Yi Li, Kazuki Yoshida, Jay S. Kaufman, Maya B. Mathur
Summary: This article provides an overview of regression-based causal mediation analysis in the field of traumatic stress and offers guidance on conducting mediation analysis using the R package regmedint. The authors discuss the causal interpretations of the estimated quantities in causal mediation analysis, including total, direct, and indirect effects, especially when there is an interaction between exposure and mediator. They also discuss the necessary assumptions and suitable study designs for valid estimation of these causal quantities, as well as the differences between causal mediation analysis and traditional methods of mediation. By using data from a published longitudinal study, the authors illustrate how to conduct and interpret mediation analysis using regmedint and compare the results to those obtained using traditional methods, highlighting the importance of accounting for exposure-mediator interaction.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2023)
Article
Peripheral Vascular Disease
Marina G. Birck, Cristiano S. Moura, Marina A. A. Machado, Jia Li Liu, Michal Abrahamowicz, Louise Pilote, Sasha Bernatsky
Summary: The evaluation using 3 different cohorts, including adjustment for race/ethnicity, did not establish a clear difference between hydrochlorothiazide and ACE inhibitor in terms of skin cancer risk.
Article
Cardiac & Cardiovascular Systems
Uri Bender, Colleen M. Norris, Rachel P. Dreyer, Harlan M. Krumholz, Valeria Raparelli, Louise Pilote
Summary: Gender-related factors are associated with the length of hospital stay in patients with non-ST-segment-elevation myocardial infarction, independent of sex. Age, unemployment, and country of hospitalization were independent predictors of hospital stay. Sociocultural factors may play a role in improving healthcare expenditure and resource allocation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Zahra N. N. Sohani, Hassan Behlouli, Cristiano Soares de Moura, Michal Abrahamowicz, Louise Pilote
Summary: The study found that sacubitril-valsartan was more effective in women with preserved ejection fraction in heart failure. This treatment reduced the risk of death and hospitalization for heart failure in both men and women, especially those with systolic dysfunction. However, further investigation is needed to understand the effectiveness in diastolic dysfunction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Public, Environmental & Occupational Health
Doris Duran, Renzo Calderon Anyosa, Belinda Nicolau, Jay S. Kaufman
Summary: The COVID-19 pandemic has had a significant impact on cancer mortality rates and place of death in Brazil, Chile, and Peru. The implementation of lockdown measures resulted in a decrease in overall cancer mortality rates and an increase in at-home deaths, with a corresponding decrease in hospital deaths observed only in Chile.
CADERNOS DE SAUDE PUBLICA
(2023)