Review
Chemistry, Analytical
Xiaohua Jia, Guodong Shen, Jia Jia, Yan Zhang, Dan Zhang, Wanjun Li, Jianjun Zhang, Xinglu Huang, Jie Tian
Summary: This article introduces the importance of cancer stem cells and the method of lineage tracing, as well as the application of molecular imaging in the dynamic detection of cancer stem cells. The article analyzes the current situation and looks forward to the future development of cancer stem cell detection.
Article
Cell & Tissue Engineering
Keyu Zhuang, Rocco Romagnuolo, Tamilla Sadikov Valdman, Kyle D. W. Vollett, Daniel A. Szulc, Hai-Ying Mary Cheng, Michael A. Laflamme, Hai-Ling Margaret Cheng
Summary: This study successfully applied a novel ferritin-based MRI platform for longitudinal tracking of human embryonic stem cells (hESCs) in vivo.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Xin Gao, Fang Hong, Zhenyu Hu, Zilong Zhang, Yang Lei, Xiaoyun Li, Tao Cheng
Summary: ABC portal is a database and web portal that contains 198 single-cell transcriptomic datasets related to the development, differentiation, and disorders of blood/immune cells. It provides interactive analysis modules and customized analysis functions, facilitating the exploration and re-analysis of single-cell data by researchers and clinicians.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Yuki Murata, Jun-ichiro Jo, Yasuhiko Tabata
Summary: Metabolic pathways of energy production play a crucial role in cell function. Stem cell differentiation is closely associated with their metabolic profiles. However, current technology lacks the ability to directly assess the metabolic profile of individual living cells. This study developed an imaging system using cationized gelatin nanospheres (cGNS) incorporating molecular beacons (MB) to visualize key regulators in energy metabolism and discriminate the differentiation state of cells.
Review
Biology
Julien Issa, Mazen Abou Chaar, Bartosz Kempisty, Lukasz Gasiorowski, Raphael Olszewski, Paul Mozdziak, Marta Dyszkiewicz-Konwinska
Summary: This systematic scoping review aims to identify and map the available artificial-intelligence-based techniques for imaging analysis, stem cell differentiation, and trans-differentiation pathways. The study found that artificial intelligence has the potential to assist in stem cell imaging but is still considered a developing field. Researchers highlight limitations in factors such as image quality, sample size, and prediction of unexpected events.
Article
Chemistry, Physical
Jianqiao Chang, Yu Zhang, Yike Li, Ziwei Han, Fei Tian, Chao Liu, Qiang Feng, Yuguang Wang, Jiashu Sun, Lu Zhang
Summary: This study introduces a multilayer ratiometric fluorescent nanomachine for live-cell perturbation and imaging of mRNA at single cell resolution, offering great potential for quantifying mRNA expression and modulating and imaging intratumoral mRNA.
Article
Chemistry, Multidisciplinary
Min Hao, He Xia, Jiazhi Duan, Hengxing Zhou, Gaorui Zhang, Dong Li, Xin Chen, Wenhan Wang, Yuanhua Sang, Shiqing Feng, Hong Liu
Summary: This study reports a living material constructed from living stem cells, nanocarriers, and drugs to achieve targeted delivery with real-time monitoring. The material has high drug loading, tumor targeting ability, and can be monitored using magnetic resonance imaging.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Donatella Coradduzza, Giuseppe Garroni, Antonella Congiargiu, Francesca Balzano, Sara Cruciani, Stefania Sedda, Alessandra Nivoli, Margherita Maioli
Summary: Bipolar disorder is a severe neuropsychiatric disorder characterized by recurrent mood disturbances. The etiology involves both biological and epigenetic factors, with microRNAs and neural stem cells playing crucial roles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Hematology
Zahi A. Fayad, Philip M. Robson
Summary: Calcification is an important component in the development of atherosclerotic plaque, with CT imaging being a well-established tool for noninvasive assessment in the coronary arteries. PET imaging with 18F-sodium fluoride is gaining popularity as a method for assessing atherosclerosis activity and providing insight into future clinical events. Molecular imaging can provide additional information, adding a color dimension to CT or MRI images.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Spectroscopy
Ewelina Matuszyk, Adriana Adamczyk, Basseem Radwan, Anna Pieczara, Piotr Szczesniak, Jacek Mlynarski, Katarzyna Kaminska, Malgorzata Baranska
Summary: Raman imaging with molecular reporters is a novel method for subcellular visualization, offering improved selectivity and sensitivity; this study aimed to visualize organelles in endothelial cells using established and new reporters, and to investigate changes in organelle distribution after induced dysfunction, highlighting drawbacks of established reporters.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biophysics
Seungmin Han, Byunghoon Kang, Hye Young Son, Yuna Choi, Moo-Kwang Shin, Jongjin Park, Jeong-Ki Min, Daewon Park, Eun-Kyung Lim, Yong-Min Huh, Seungjoo Haam
Summary: The study developed a new technology using manganese-based magnetic nanoparticles and anti-human integrin beta 1 antibody to minimally invasively monitor transplanted human stem cells. This method does not require modification of stem cells for monitoring their therapeutic capability. The technology was demonstrated to specifically target and transplant stem cells through experimental verification.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Jeff W. M. Bulte, Chao Wang, Ali Shakeri-Zadeh
Summary: Superparamagnetic iron oxide (SPIO)-labeling of cells for magnetic resonance imaging (MRI) cell tracking has a long history, but studies have shown that the labeled cells may have different behaviors compared to unlabeled cells. With the emergence of magnetic particle imaging (MPI) cell tracking, there has been a renaissance in the formulation of SPIO nanoparticles optimized for MPI. Lessons learned from past experiences with SPIO-labeling for MRI could potentially facilitate the clinical translation of (combined) MRI/MPI cell tracking.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Brett Z. Fite, Virginia Hinostroza, Lisa States, Alexandria Hicks-Nelson, Lucia Baratto, Kimberly Kallianos, Marina Codari, Brenda Yu, Priyanka Jha, Mana Shams, Tanya Stoyanova, Fanny F. Chapelin, Anna Liu, Ali Rashidi, Fernando Soto, Yuri Quintana, Guido Alejandro Davidzon, Krzysztof Marycz, Iris C. Gibbs, Daniel B. Chonde, Chirag B. Patel, Heike Elisabeth Daldrup-Link
Summary: The conference aimed to promote and enhance diversity in the STEM field, discussing issues such as racial diversity, the role of women in STEM, and global health to find ways to address these challenges. Participants engaged in discussions on how to increase representation of URM and women in STEM, support existing members in their career pursuits, and improve global health, among other topics.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Article
Engineering, Biomedical
Gyunggyu Lee, Hyemin Kim, Ji Young Park, Gyeongmin Kim, Jiyou Han, Seok Chung, Ji Hun Yang, Jang Su Jeon, Dong-Hun Woo, Choongseong Han, Sang Kyum Kim, Han-Jin Park, Jong-Hoon Kim
Summary: Advances in pluripotent stem cell technology have led to the efficient and reproducible generation of hepatocyte-like cell spheroids in various sizes using microwell culture platforms. These spheroids show high expressions of hepatic marker genes, enhanced drug-metabolizing activity, and increased sensitivity to hepatotoxicants compared to traditional hepatocytes. This imaging-based toxicity screening system holds promise for predicting drug-induced hepatotoxicity in the early stages of drug discovery.
Article
Medicine, Research & Experimental
Tie-Jun Yuan, Xue-Han Xu, Nan Zhou, Ge Yan, Ting-Wei Gu, Li-Hua Peng
Summary: This study identified 11 natural compounds from medicinal plants that have both proliferative and anti-senescence abilities in stem cells. Mechanistic analysis revealed their involvement with growth factors and senescence-related pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
