Article
Medicine, General & Internal
Camilla Kjellstad Larsen, Otto A. Smiseth, Jurgen Duchenne, Elena Galli, John Moene Aalen, Mathieu Lederlin, Jan Bogaert, Erik Kongsgaard, Cecilia Linde, Martin Penicka, Erwan Donal, Jens-Uwe Voigt, Einar Hopp
Summary: This study investigates the feasibility of using CMR as a single-image modality to identify CRT responders, and found that the combined assessment of septal scar and septal flash can accurately predict CRT response and long-term survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Lei Fan, Jenny S. S. Choy, Farshad Raissi, Ghassan S. Kassab, Lik Chuan Lee
Summary: Cardiac resynchronization therapy (CRT) response is affected by pacing site and coronary perfusion, which may have clinical implications in improving treatment outcomes.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Review
Medicine, General & Internal
Frans A. van Nieuwenhoven, Blanche Schroen, Lucio Barile, Lars van Middendorp, Frits W. Prinzen, Angelo Auricchio
Summary: Cardiac resynchronization therapy (CRT) is a valuable addition to heart failure treatment options, especially for patients with electrical conduction disturbances causing regional contraction patterns (dyssynchrony). Experimental studies have shown extensive molecular and cellular remodeling in dyssynchronous hearts. Increasing evidence suggests that several miRNAs are involved in this remodeling process. Measurement of myocardium-derived miRNAs in extracellular vesicles (EVs) in peripheral blood may provide new insights into investigating and monitoring (reverse) remodeling in dyssynchronous and resynchronized hearts of patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Erick Alexanderson-Rosas, Nilda Espinola-Zavaleta, Ernest V. Garcia, Amalia Peix, Teresa Massardo, Luz M. Pabon, Neftali Eduardo Antonio-Villa, Isabel Carvajal-Juarez, Claudio T. Mesquita, Amelia Jimenez-Heffernan, Chetan Patel, Ganesan Karthikeyan, Alka Kumar, Sadaf Butt, Mani Kalaivani, Victor Marin, Olga Morozova, Diana Paez
Summary: CRT improves both systolic and diastolic dyssynchrony values at 6-month follow-up. LVDD at baseline is correlated with cardiac functionality at follow-up, but not with overall favorable clinical outcomes.
JOURNAL OF NUCLEAR CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jeremy Layec, Marie Decroocq, Francois Delelis, Ludovic Appert, Yves Guyomar, Clemence Riolet, Helene Dumortier, Amandine Mailliet, Christophe Tribouilloy, Sylvestre Marechaux, Aymeric Menet
Summary: This study evaluated the relationship between preprocedural echocardiographic parameters of electromechanical dyssynchrony (EMD) and outcome following cardiac resynchronization therapy (CRT) in heart failure patients. The results showed that certain echocardiographic parameters were associated with treatment response and patient prognosis. Therefore, echocardiographic assessment can help select patients who will benefit from CRT.
JACC-CARDIOVASCULAR IMAGING
(2023)
Review
Cell Biology
Eleonora Russo, Giulio Russo, Mauro Cassese, Maurizio Braccio, Massimo Carella, Paolo Compagnucci, Antonio Dello Russo, Michela Casella
Summary: Functional mitral regurgitation (FMR) is caused by alterations in the left ventricle and left atrium geometry, resulting in an imbalance between closing and tethering forces. FMR affects quality of life and increases mortality, and there is no clear treatment approach. Left ventricle dyssynchrony may contribute to the onset and worsening of FMR, and is an important target for treatment.
Article
Cardiac & Cardiovascular Systems
Scott M. Koerber, Michael E. Field, Daniel B. Cobb, Mathew J. Gregoski, John L. Sturdivant, Michael R. Gold
Summary: This study found a close correlation between Delta RV-LV and Delta QLV in LBBB patients, suggesting that selecting proximal bipoles as pacing sites is recommended. In non-LBBB patients, a greater variation in activation pattern was observed, indicating the need for individualized pacing site selection.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Christopher D. Brown, Kevin V. Burns, Michelle M. Harbin, Emanuel A. Espinosa, Matthew D. Olson, Alan J. Bank
Summary: This study demonstrates the effect of CRT optimization using electrical dyssynchrony mapping on left ventricular function, size, and dyssynchrony in selected patients with nonresponse/incomplete response to CRT.
Review
Medicine, General & Internal
Cristian Statescu, Carina Ureche, Stefana Enachi, Rodica Radu, Radu A. Sascau
Summary: Non-ischemic cardiomyopathy presents a heterogeneous group of diseases with an unfavorable long-term prognosis. Cardiac resynchronization therapy (CRT) is beneficial for symptomatic heart failure patients, especially in non-ischemic dilated cardiomyopathy. Multimodality cardiac imaging shows promise in refining CRT selection criteria and improving response rates.
Article
Cardiac & Cardiovascular Systems
Odette A. E. Salden, Alwin Zweerink, Philippe Wouters, Cornelis P. Allaart, Bastiaan Geelhoed, Frederik J. de Lange, Alexander H. Maass, Michiel Rienstra, Kevin Vernooy, Marc A. Vos, Mathias Meine, Frits W. Prinzen, Maarten J. Cramer
Summary: Evaluation of systolic septal rebound stretch (SRSsept) may enhance patient selection for cardiac resynchronization therapy (CRT) and provides additional predictive information over ApRock assessment in patients without left bundle branch block (LBBB).
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Biophysics
Pim J. A. Oomen, Thien-Khoi N. Phung, Seth H. Weinberg, Kenneth C. Bilchick, Jeffrey W. Holmes
Summary: Cardiac resynchronization therapy (CRT) is effective for heart failure patients, but response rate is limited. Computational models can predict remodeling outcomes to help clinicians tailor personalized treatment strategies.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Cheng Wang, Jianzhou Shi, Jiacheng Ge, Haipeng Tang, Zhuo He, Yanyun Liu, Zhongqiang Zhao, Chunxiang Li, Kai Gu, Xiaofeng Hou, Minglong Chen, Jiangang Zou, Lei Zhou, Ernest Garcia, Dianfu Li, Weihua Zhou
Summary: The study found that both systolic LVMD and diastolic LVMD have important predictive values for CRT response in patients with DCM. Furthermore, pacing at LV segments with both late contraction and late relaxation has the potential to increase CRT response.
JOURNAL OF NUCLEAR CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Andra Gurgu, Constantin-Tudor Luca, Cristina Vacarescu, Lucian Petrescu, Emilia-Violeta Goanta, Mihai-Andrei Lazar, Diana-Aurora Arnautu, Dragos Cozma
Summary: This study evaluates the outcome of LV diastolic dyssynchrony in fusion pacing CRT and identifies the cut-off values of diastolic dyssynchrony parameters as predictors of favorable outcomes in responders and super-responder patients.
Article
Medicine, General & Internal
Tariel A. Atabekov, Mikhail S. Khlynin, Anna I. Mishkina, Roman E. Batalov, Svetlana I. Sazonova, Sergey N. Krivolapov, Victor V. Saushkin, Yuliya V. Varlamova, Konstantin V. Zavadovsky, Sergey V. Popov
Summary: This study aimed to determine the role of left ventricular mechanical dyssynchrony and scar burden as predictors of cardiac resynchronization therapy (CRT) response. The results showed that left ventricular anterior-wall standard deviation, summed rest score, and nonischemic etiology of heart failure were independent predictors of CRT response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Xu Gao, Mohamad Abdi, Daniel A. Auger, Changyu Sun, Christopher A. Hanson, Austin A. Robinson, Christopher Schumann, Pim J. Oomen, Sarah Ratcliffe, Rohit Malhotra, Andrew Darby, Oliver J. Monfredi, J. Michael Mangrum, Pamela Mason, Sula Mazimba, Jeffrey W. Holmes, Christopher M. Kramer, Frederick H. Epstein, Michael Salerno, Kenneth C. Bilchick
Summary: This study aimed to investigate the feasibility and effectiveness of CMR cine and strain imaging before and after CRT for assessing patient response and determining the optimal resynchronization pacing strategy. The results showed that CMR evaluation with assessment of multiple pacing modes after CRT is feasible and provides valuable information for patient care.
JACC-CARDIOVASCULAR IMAGING
(2021)
