Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Article
Cardiac & Cardiovascular Systems
Julia Aschauer, Robert Zilberszac, Andreas Gleiss, Christian Colizzi, Thomas Binder, Piergiorgio Bruno, Guenther Laufer, Massimo Massetti, Harald Gabriel, Raphael Rosenhek
Summary: Bicuspid aortic valve (BAV) disease is associated with a high rate of cardiac events, but modern care leads to good survival with low rates of infective endocarditis, aortic dissection, and sudden death. Gradual degrees of aortic stenosis and regurgitation, the presence of aortic dilatation, and age are predictive factors for cardiac events.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Christian M. Beusch, Oscar E. Simonson, Johan O. Wedin, Pierre Sabatier, Ulrika Felldin, Sandeep Kadekar, Cecilia Osterholm, Akos Vegvari, Roman A. Zubarev, Karin Fromell, Bo Nilson, Stefan James, Elisabeth Stahle, Karl-Henrik Grinnemo, Sergey Rodin
Summary: By comparing the extracellular matrix proteins in valve tissues from patients with isolated aortic valve degeneration, the study identified differences in the molecular cues and aetiologies between patients with tricuspid and bicuspid aortic valves, suggesting the need for different treatments and providing insights into the molecular basis of the condition.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Byung Joo Sun, Jae-Kwan Song
Summary: Bicuspid aortic valve is a common congenital anomaly with various morphological phenotypes and clinical presentations. The use of a unified classification system can help in studying and understanding this condition.
Article
Cardiac & Cardiovascular Systems
Michelle S. Lim, Geoff Strange, David Playford, Simon Stewart, David S. Celermajer
Summary: The study aimed to describe the echocardiographic characteristics of bicuspid aortic valve (BAV) and compare patients with BAV with moderate-to-severe aortic stenosis (AS) with those with tricuspid aortic valve (TAV) stenosis. Patients with BAV were more likely to have moderate-to-severe AS, larger ascending aortas, and were younger at the time of AS diagnosis compared to those with TAV. Despite this, patients with BAV had a more favorable prognosis when AS develops.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Jun Shi, Lai Wei, Yucheng Chen, Xu Wang, Jian Ye, Chaoyi Qin, Lulu Liu, Hong Qian, Chunsheng Wang, Yingqiang Guo
Summary: The study showed good midterm outcomes of transcatheter aortic valve implantation with the J-Valve system in treating patients with aortic stenosis or pure aortic insufficiency, suggesting it as a promising alternative therapy for high-risk patients.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Angela Lopez, Ilaria Dentamaro, Laura Galian, Francisco Calvo, Josep M. Alegret, Violeta Sanchez, Rodolfo Citro, Antonella Moreo, Fabio Chirillo, Paolo Colonna, Maria Celeste Carrero, Eduardo Bossone, Sergio Moral, Augusto Sao-Aviles, Laura Gutierrez, Gisela Teixido-Tura, Jose Rodriguez-Palomares, Arturo Evangelista
Summary: The study aimed to assess the progression of aortic dilation and valve dysfunction in BAV patients. Results showed that rapid aortic root dilation was associated with male sex, hypertension, presence of raphe, and aortic regurgitation, while rapid ascending aorta dilation was only related to hypertension.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Waqas Ullah, Abdul-Rahman M. Suleiman, Heba Osman, Sairamya Bodempudi, Hamza Zahid Ullah Muhammadzai, Salman Zahid, Mohamed Zghouzi, Yasar Sattar, Salim S. Virani, David L. Fischman, M. Chadi Alraies
Summary: This study analyzed data from the Nationwide Readmissions Database and found that patients undergoing transcatheter aortic valve implantation (TAVI) for aortic insufficiency had higher rates of in-hospital clinical events, mortality, major bleeding, and valvular complications compared to those undergoing TAVI for aortic stenosis. However, there were no significant differences in these complications at 30-day and 180-day follow-up.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Annastiina Husso, Juhani Airaksinen, Tatu Juvonen, Mika Laine, Sebastian Dahlbacka, Marko Virtanen, Matti Niemela, Timo Makikallio, Mikko Savontaus, Markku Eskola, Peter Raivio, Antti Valtola, Fausto Biancari
Summary: This study compared the outcomes of surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR) in patients with severe stenosis of bicuspid aortic valve. The results showed that TAVR achieved similar early and mid-term outcomes compared to SAVR.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Taishi Okuno, Caglayan Demirel, Daijiro Tomii, Gabor Erdoes, Dik Heg, Jonas Lanz, Fabien Praz, Rainer Zbinden, David Reineke, Lorenz Raber, Stefan Stortecky, Stephan Windecker, Thomas Pilgrim
Summary: This study aimed to evaluate the risk of noncardiac surgery after TAVI. The results suggest that noncardiac surgery can be performed early after successful TAVI, and device performance may impact the risk of adverse outcomes after surgery.
Article
Cardiac & Cardiovascular Systems
Steele C. Butcher, Francesca Prevedello, Federico Fortuni, William K. F. Kong, Gurpreet K. Singh, Arnold C. T. Ng, Rebecca Perry, Kian Keong Poh, Ana G. Almeida, Ariana Gonzalez, Mylene Shen, Tiong Cheng Yeo, Miriam Shanks, Bogdan A. Popescu, Laura Galian Gay, Marcin Fijalkowski, Michael Liang, Nina Ajmone Marsan, Joseph B. Selvanayagam, Fausto Pinto, Jose L. Zamorano, Philippe Pibarot, Arturo Evangelista, Jeroen J. Bax, Victoria Delgado
Summary: The aim of this study was to determine the prevalence and prognostic implications of significant mitral regurgitation (MR) in patients with bicuspid aortic valve (BAV). The study found that significant MR is uncommon in patients with BAV, and it is only associated with adverse prognosis in patients with moderate to severe aortic regurgitation.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Medicine, General & Internal
Hanyi Dai, Jiaqi Fan, Yuxin He, Jun Chen, Dao Zhou, Abuduwufuer Yidilisi, Xinrui Qi, Ranxi Li, Xianbao Liu, Jian'an Wang
Summary: This study aimed to compare the technical success and clinical outcomes between patients with bicuspid and tricuspid aortic stenosis (AS) receiving transcatheter aortic valve replacement. It was found that bicuspid AS patients were younger with a lower prevalence of hypertension and peripheral vascular diseases. Technical failure was primarily due to the high incidence of second valve implantation. The technical success rates were comparable between the two groups, and technical failure increased the risk of all-cause mortality at both 30 days and 1 year.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yang Liu, Mengen Zhai, Yu Mao, Chennian Xu, Yanyan Ma, Lanlan Li, Ping Jin, Jian Yang
Summary: This study examines the early experience with transcatheter aortic valve replacement (TAVR) in patients with quadricuspid aortic valve (QAV). The results demonstrate that TAVR is a feasible treatment option for QAV patients with acceptable early outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sebastien Hecht, Steele C. Butcher, Stephan M. Pio, William K. F. Kong, Gurpreet K. Singh, Arnold C. T. Ng, Rebecca Perry, Kian Keong Poh, Ana G. Almeida, Ariana Gonzalez, Mylene Shen, Tiong Cheng Yeo, Miriam Shanks, Bogdan A. Popescu, Laura Galian Gay, Marcin Fijalkowski, Michael Liang, Edgar Tay, Nina Ajmone Marsan, Joseph Selvanayagam, Fausto Pinto, Jose L. Zamorano, Arturo Evangelista, Victoria Delgado, Jeroen J. Bax, Philippe Pibarot
Summary: This study found that in patients with BAV disease, the risk of adverse clinical outcomes significantly increases when the LVEF is less than 60%. These findings suggest that the proposed LVEF cutoff values for intervention should be raised from 50% to 60% in AS or AR, and 55% in MAVD.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jiajun Zhang, Xiaoxing Li, Rui Tian, Mengzhi Zong, Xinghua Gu, Feng Xu, Yuguo Chen, Chuanbao Li
Summary: This retrospective cohort study found that the use of cerebral embolic protection during transcatheter aortic valve replacement (TAVR) for patients with bicuspid aortic valve stenosis was associated with a lower incidence of in-hospital stroke without increasing the cost of hospitalization or the risk of vascular complications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)