Article
Multidisciplinary Sciences
Michele Provenzano, Raffaele Serra, Ashour Michael, Davide Bolignano, Giuseppe Coppolino, Nicola Ielapi, Giuseppe Filiberto Serraino, Pasquale Mastroroberto, Francesco Locatelli, Luca De Nicola, Michele Andreucci
Summary: Studies have shown that smoking is independently associated with cardiovascular events and mortality in CKD patients, and it also amplifies the relationship between other risk factors and renal outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Health Care Sciences & Services
Paivi E. Korhonen, Sem Kiiski, Hannu Kautiainen, Seppo Ojanen, Risto Tertti
Summary: This study investigated the long-term clinical consequences of different eGFR levels calculated by the CKD-EPI equation in apparently healthy cardiovascular risk subjects. It found that subjects with eGFR >= 105 ml/min/1.73 m(2) had an increased risk for all-cause mortality, incident peripheral artery disease, and atrial fibrillation/flutter compared to those with eGFR in the range of 90-104 ml/min. These patients also had a higher mortality rate compared to the general population in Finland. Therefore, close monitoring and timely interventions are necessary for patients with eGFR >= 105 ml/min/1.73 m(2).
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Faiez Zannad, Joao Pedro Ferreira, Stuart J. Pocock, Cordula Zeller, Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Sibylle Jenny Hauske, Martina Brueckmann, Egon Pfarr, Janet Schnee, Christoph Wanner, Milton Packer
Summary: In the EMPEROR-Reduced trial, empagliflozin treatment had beneficial effects on key efficacy outcomes and slowed the rate of kidney function decline in patients with and without chronic kidney disease, regardless of the severity of kidney impairment at baseline.
Article
Medicine, General & Internal
Andrzej Konieczny, Piotr Donizy, Tomasz Golebiowski, Andrzej Tukiendorf, Agnieszka Halon, Mariusz Kusztal, Hanna Augustyniak-Bartosik, Magdalena Krajewska
Summary: This study analyzed clinical and histopathological data from 80 patients with IgA nephropathy, and found that endocapillary hypercellularity and interstitial fibrosis were predictors of eGFR decline, while serum albumin concentration had a protective impact on eGFR deterioration. The presence of endocapillary hypercellularity and extent of interstitial fibrosis also negatively correlated with the reduction in proteinuria below 1.0 g/24 h.
Article
Cardiac & Cardiovascular Systems
Ravi B. Patel, Gregg C. Fonarow, Stephen J. Greene, Shuaiqi Zhang, Brooke Alhanti, Adam D. DeVore, Javed Butler, Paul A. Heidenreich, Joanna C. Huang, Michelle M. Kittleson, Karen E. Joynt Maddox, James J. McDermott, Anjali Tiku Owens, Pamela N. Peterson, Scott D. Solomon, Orly Vardeny, Clyde W. Yancy, Muthiah Vaduganathan
Summary: This study evaluated the care patterns and outcomes in heart failure patients with different degrees of kidney function. It found that patients with comorbid heart failure and kidney disease are not optimally treated with evidence-based medical therapies, leading to increased mortality risk. Further efforts are needed to mitigate the risks in these patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Peripheral Vascular Disease
Mark M. Mitsnefes, Yunwen Xu, Derek K. Ng, Garick Hill, Thomas Kimball, Susan L. Furth, Bradley A. Warady
Summary: Diastolic dysfunction is an early cardiac abnormality in patients with chronic kidney disease, with E/e' ratio being a marker to assess it. Abnormal E/e' ratio is associated with younger age, lower glomerular filtration rate, lower hemoglobin, hypertension, left ventricular hypertrophy, and sustained hypertension. Ambulatory blood pressure may better identify chronic kidney disease in children at risk for subclinical cardiac dysfunction compared to casual blood pressure.
Article
Immunology
Robin Chazot, Elisabeth Botelho-Nevers, Christophe Mariat, Anne Fresard, Etienne Cavalier, Frederic Lucht, Pierre Delanaye, Nicolas Maillard, Amandine Gagneux-Brunon
Summary: In individuals with HIV infection, cystatin C and urine albumin to creatinine ratio are associated with all-cause mortality and/or cardiovascular events independently of baseline mGFR. Biomarkers were not predictive of changes in glomerular filtration rate over time.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Maggie Wang, Samson S. Peter, Chi D. Chu, Delphine S. Tuot, Jonathan H. Chen
Summary: The findings of this study suggest that nearly half of patients with CKD at high risk of progressing to kidney failure do not have a nephrologist visit within 1 year of established risk.
Article
Medicine, General & Internal
Meghann Pasternak, Ping Liu, Robert Quinn, Meghan Elliott, Tyrone Gorden Harrison, Brenda Hemmelgarn, Ngan Lam, Paul Ronksley, Marcello Tonelli, Pietro Ravani
Summary: This study aims to assess the 5-year probability of CKD regression in patients with newly diagnosed CKD, taking into account the competing risks of CKD progression and death, and investigate the association between albuminuria level and CKD regression.
Article
Cardiac & Cardiovascular Systems
Joan Carles Trullas, Jose Luis Morales-Rull, Jesus Casado, Margarita Carrera-Izquierdo, Marta Sanchez-Marteles, Alicia Conde-Martel, Meliton Francisco Davila-Ramos, Pau Llacer, Prado Salamanca-Bautista, David Chivite, Rosa Jordana-Comajuncosa, Maria Villalonga, Maria Inmaculada Paez-Rubio, Luis Manzano, Francesc Formiga
Summary: This study analyzed data from 230 patients with acute heart failure and examined the impact of estimated glomerular filtration rate (eGFR) on the effectiveness of hydrochlorothiazide (HCTZ) and furosemide combination therapy. The results showed that in patients with eGFR below 60 ml/min/1.73m2, the addition of HCTZ significantly improved diuretic response. However, there were no significant differences in diuretic response among patients in other eGFR ranges.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Medicine, General & Internal
Antonio Mirijello, Pamela Piscitelli, Angela de Matthaeis, Michele Inglese, Maria Maddalena D'Errico, Valentina Massa, Antonio Greco, Andrea Fontana, Massimiliano Copetti, Lucia Florio, Maurizio Angelo Leone, Michele Antonio Prencipe, Filippo Aucella, Salvatore De Cosmo
Summary: The clinical course of COVID-19 is more severe in elderly patients with cardio-metabolic co-morbidities, and chronic kidney disease is an independent cardiovascular risk factor. This study aimed to evaluate the impact of reduced eGFR on the composite outcome of admission to ICU and death in a sample of consecutive COVID-19 hospitalized patients. The results showed that patients with reduced eGFR at admission are at high risk for clinical deterioration and death, with age and eGFR being significant independent factors associated with the main outcome.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Transplantation
Hans-Joachim Anders, Gema M. Fernandez-Juarez, Augusto Vaglio, Paola Romagnani, Juergen Floege
Summary: The management of immune-mediated kidney diseases focuses on controlling the underlying immune disease process and the non-immune mechanisms of chronic kidney disease (CKD) progression. Non-pharmacological interventions, such as reducing salt intake and regular physical activity, along with approved drug interventions, can help attenuate CKD progression.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Neurosciences
Ora A. Weisz
Summary: The article describes the mechanism of protein recycling in the renal tubules and its behavior in different states, proposing an integrated new working model that explains the role of fluid phase uptake in recovering high concentrations of protein in conditions of impaired filtration barrier. This model considers the independent pathways of fluid phase and receptor-mediated uptake, as well as the impact of protein load on physiological and pathological states.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Medicine, General & Internal
Hernan Trimarchi, Mark Haas, Rosanna Coppo
Summary: IgA nephropathy is a progressive disease with great variability in clinical course. Crescents, a distinct pathological feature, have been considered as a prognostic indicator of poor outcomes. However, recent guidelines suggest that crescents should not be used to determine disease progression or guide immunosuppression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Mohammed Siddiqui, Lonnie Hannon, Zhixin Wang, Jessica Blair, Suzanne Oparil, Sonya L. Heath, Edgar T. Overton, Paul Muntner
Summary: This study found that the association between hypertension and cardiovascular disease (CVD), including acute myocardial infarction (AMI), stroke, and heart failure, differs between individuals with and without HIV. Hypertension is associated with a higher risk of CVD in individuals with HIV. This study emphasizes the high CVD risk associated with hypertension among individuals with HIV.