Article
Cardiac & Cardiovascular Systems
Kiran Sarathy, George A. Wells, Kuljit Singh, Etienne Couture, Aun Yeong Chong, Fraser Rubens, Marie Lordkipanidze, Jean-Francois Tanguay, Derek So
Summary: For patients with acute coronary syndromes requiring coronary artery bypass surgery, a more potent antiplatelet regimen may reduce mortality rates. There are potential clinical benefits in terms of platelet quiescence.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Cardiac & Cardiovascular Systems
He Jiao, Jinghui Li, Yunpeng Bai, Zhigang Guo
Summary: This study compared the outcomes of sequential and individual saphenous vein grafts in coronary artery bypass grafting. The results showed that sequential grafts had higher rates of graft failure and long-term mortality, but also an increased risk of perioperative repeat revascularization. Based on the study, the selection of surgical techniques should be based on patients and surgeons.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Muhammad Owais Khan, Justin S. Tran, Han Zhu, Jack Boyd, Rene R. Sevag Packard, Ronald P. Karlsberg, Andrew M. Kahn, Alison L. Marsden
Summary: Biomechanical forces may play a key role in saphenous vein graft disease after coronary artery bypass graft surgery. Computational fluid dynamic modeling has the potential to identify high-risk patients who may benefit from more aggressive medical therapy and closer surveillance. Further studies are needed to develop clinically available tools for predicting SVG failure post-CABG.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Takuma Mikami, Masato Furuhashi, Akiko Sakai, Ryosuke Numaguchi, Ryo Harada, Syuichi Naraoka, Takeshi Kamada, Yukimura Higashiura, Marenao Tanaka, Shunsuke Ohori, Taku Sakurada, Masanori Nakamura, Yutaka Iba, Joji Fukada, Tetsuji Miura, Nobuyoshi Kawaharada
Summary: The perivascular adipose tissue (PVAT) surrounding the saphenous vein (SV) has distinct phenotypes compared to PVATs of other vessels, with larger adipocytes, less fibrosis, and lower levels of inflammation. This unique characteristic may contribute to the high long-term patency of grafting when the novel no-touch technique of SV harvesting is used.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Mario Gaudino, Katia Audisio, Antonino Di Franco, John H. Alexander, Paul Kurlansky, Andreas Boening, Joanna Chikwe, P. J. Devereaux, Anno Diegeler, Arnaldo Dimagli, Marcus Flather, Andre Lamy, Jennifer S. Lawton, Derrick Y. Tam, Wilko Reents, Mohamed Rahouma, Leonard N. Girardi, David L. Hare, Stephen E. Fremes, Umberto Benedetto
Summary: Based on the pooled analysis of 4 large coronary bypass surgery trials, the use of radial artery was associated with better clinical outcomes compared to saphenous vein graft and right internal thoracic artery.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Mario Gaudino, Katia Audisio, Antonino Di Franco, John H. Alexander, Paul Kurlansky, Andreas Boening, Joanna Chikwe, P. J. Devereaux, Anno Diegeler, Arnaldo Dimagli, Marcus Flather, Andre Lamy, Jennifer S. Lawton, Derrick Y. Tam, Wilko Reents, Mohamed Rahouma, Leonard N. Girardi, David L. Hare, Stephen E. Fremes, Umberto Benedetto
Summary: The use of radial artery in coronary bypass surgery showed better clinical outcomes compared to saphenous vein graft and right internal thoracic artery, based on a pooled analysis of four large trials.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Katia Audisio, M. Scott Halbreiner, David Chadow, Mario Gaudino
Summary: Coronary artery disease (CAD) is a common cardiovascular disease worldwide, affecting over 18 million American adults. For patients with multivessel CAD, the use of the radial artery (RA) may be a better choice for coronary artery bypass grafting (CABG) than the saphenous vein (SV).
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Alistair Royse, Justin Ren, Colin Royse, David H. Tian, Stephen Fremes, Mario Gaudino, Umberto Benedetto, Y. Joseph Woo, Andrew B. Goldstone, Piroze Davierwala, Michael Borger, Michael Vallely, Christopher M. Reid, Rodolfo Rocha, David Glineur, Juan Grau, Richard Shaw, Hugh Paterson, Doa El-Ansary, Stuart Boggett, Nilesh Srivastav, Zulfayandi Pawanis, David Canty, Rinaldo Bellomo
Summary: The study suggests that avoiding the use of saphenous vein grafts in total arterial revascularization (TAR) surgery can reduce patients' late survival rate and has a positive impact on reducing all-cause mortality.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Iosif Xenogiannis, Marco Zenati, Deepak L. Bhatt, Sunil V. Rao, Josep Rodes-Cabau, Steven Goldman, Kendrick A. Shunk, Kreton Mavromatis, Subhash Banerjee, Khaldoon Alaswad, Ilias Nikolakopoulos, Evangelia Vemmou, Judit Karacsonyi, Dimitrios Alexopoulos, M. Nicholas Burke, Vinayak N. Bapat, Emmanouil S. Brilakis
Summary: Despite advances in surgical techniques and pharmacotherapy, SVG remain the most frequently used conduits in CABG, but the failure rates remains high. Multiple strategies, including no-touch SVG harvesting technique and careful selection of target vessels, can reduce SVG failure. Redo CABG has higher perioperative mortality compared to PCI, making PCI the preferred option for most patients.
Review
Medicine, General & Internal
Huiru Chen, Zilan Wang, Ke Si, Xiaoxiao Wu, Hanyu Ni, Yanbing Tang, Wei Liu, Zhong Wang
Summary: This study evaluated the efficacy of external stenting for SVGs in CABG and found that it significantly reduced intimal hyperplasia area and thickness, improved lumen uniformity, and did not increase SVG failure rate.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Eleonora Mezzetti, Aniello Maiese, Federica Spina, Fabio Del Duca, Alessandra De Matteis, Marco Di Paolo, Raffaele La Russa, Emanuela Turillazzi, Vittorio Fineschi
Summary: Saphenous vein graft (SVG) is a cardiac surgical practice that creates a cardiac bypass in cases of coronary artery obstruction. This paper presents a rare case of SVG aneurysmal rupture that occurred 24 h after surgery. A systematic review of the literature was also conducted to provide a general overview.
Article
Medicine, General & Internal
Lars Saemann, Lena Wernstedt, Sabine Pohl, Markus Stiller, Jan Willsch, Britt Hofmann, Gabor Veres, Andreas Simm, Gabor Szabo
Summary: This study found that endothelial function of saphenous vein grafts decreases with age in patients treated with coronary artery bypass grafting. Age should be taken into consideration when maintaining grafts.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Sleiman Sebastian Aboul-Hassan, Tomasz Stankowski, Bartlomiej Perek, Anna Olasinska-Wisniewska, Tomasz Urbanowicz, Marek Jemielity, Lukasz Moskal, Weronika Majchrowicz, Michel Pompeu Sa, Ahmed K. Awad, Gianluca Torregrossa, Romuald Cichon
Summary: This study aimed to compare the long-term outcomes of multiple arterial grafts (MAG) and total arterial grafting (TAG) in addition to saphenous vein graft (SVG) after multivessel coronary artery bypass grafting. The results showed no significant differences in early outcomes and long-term survival and freedom from adverse cardiac and cerebral events between MAG + SVG and TAG groups.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Davide Maselli, Gloria Garoffolo, Giada Andrea Cassanmagnago, Rosa Vono, Matthijs S. Ruiter, Anita C. Thomas, Paolo Madeddu, Maurizio Pesce, Gaia Spinetti
Summary: Mechanical stress promotes molecular phenotypic switching of saphenous vein progenitors and increases their responsiveness to extracellular environment alterations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Francesca Toto, Tiziano Torre, Lucia Turchetto, Viviana Lo Cicero, Sabrina Soncin, Catherine Klersy, Stefanos Demertzis, Enrico Ferrari
Summary: This study compared the efficacy of three solutions in preserving the endothelial cell integrity of saphenous vein grafts. The results showed that DuraGraft better protected the grafts against ischemic-induced apoptosis compared to saline solution. Prolonged ischemia was associated with extended endothelium damage, and none of the studied solutions protected the vein grafts.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Guowei Li, Monica Taljaard, Edwin R. Van den Heuvel, Mitchell A. H. Levine, Deborah J. Cook, George A. Wells, Philip J. Devereaux, Lehana Thabane
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2017)
Article
Substance Abuse
Kerri A. Mullen, Douglas G. Manuel, Steven J. Hawken, Andrew L. Pipe, Douglas Coyle, Laura A. Hobler, Jaime Younger, George A. Wells, Robert D. Reid
Review
Cardiac & Cardiovascular Systems
Manuja Premaratne, Mohabbat Shamsaei, Jonathan D. H. Chow, Tony Haddad, Fernanda Erthal, Helen Curran, Yeung Yam, Agnieszka Szczotka, Lisa Mielniczuk, George A. Wells, Rob S. Beanlands, Alomgir Hossain, Benjamin J. W. Chow
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2017)
Article
Immunology
Sizheng Zhao, Eduardo Mysler, Robert J. Moots
Article
Cardiac & Cardiovascular Systems
Louise Y. Sun, Anan Bader Eddeen, Marc Ruel, Erika MacPhee, Thierry G. Mesana
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Cardiac & Cardiovascular Systems
Lara Gharibeh, Katsuhiro Hosoyama, David Glineur, Richard E. Shaw, Harry Lapierre, Marc Ruel, Juan B. Grau
Summary: This study compared the early outcomes of full coronary revascularization using Y-composite grafts in coronary artery bypass grafting, showing advantages of Y-RIMA/RA groups in the number of distal anastomoses. There were no significant differences in mortality and major adverse cardiac and cerebrovascular events among the groups during hospitalization or at 30-day follow-up.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Marc Ruel, Michael Fischbein
Editorial Material
Cardiac & Cardiovascular Systems
Marc Ruel, Anne Williams, Maral Ouzounian, Louise Sun, Jean-Francois Legare, Paul Poirier, Tarek Malas, Michael E. Farkouh, Edgar Chedrawy, Ansar Hassan, Jennifer Higgins, Kim Connelly, R. Scott McClure, David Bewick, Richard Whitlock, Michelle Graham, Rakesh C. Arora
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Marc Ruel, Anne Williams
Article
Cardiac & Cardiovascular Systems
Michael W. A. Chu, Marc Ruel, Allen Graeve, Marc W. Gerdisch, Ralph J. Damiano Jr, Robert L. Smith II, William Brent Keeling, Michael A. Wait, Robert C. Hagberg, Reed D. Quinn, Gulshan K. Sethi, Rosario Floridia, Christopher J. Barreiro, Andrew L. Pruitt, Kevin D. Accola, Francois Dagenais, Alan H. Markowitz, Jian Ye, Michael E. Sekela, Ryan Y. Tsuda, David A. Duncan, Daniel G. Swistel, Lacy E. Harville III, Joseph J. DeRose, Eric J. Lehr, John H. Alexander, John D. Puskas
Summary: This study aimed to assess the safety and efficacy of low-dose warfarin in patients with mechanical mitral valve replacement. The results showed that low-dose warfarin did not achieve noninferiority for the composite primary end point compared to standard-dose warfarin. The difference in the annual incidence rate between the two groups was very small during the 4.1 years of follow-up. Therefore, the current target international normalized ratio range (2.5-3.5) may still be the recommended treatment range for patients with mechanical mitral valve replacement.
ANNALS OF THORACIC SURGERY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Marc Ruel, Michael P. Fischbein, James A. de Lemos
Article
Emergency Medicine
Justin W. Yan, Katherine M. Gushulak, Melanie P. Columbus, Kristine van Aarsen, Alexandra L. Hamelin, George A. Wells, Ian G. Stiell
INTERNATIONAL JOURNAL OF EMERGENCY MEDICINE
(2017)
Article
Rheumatology
Laurianne Loew, Lucie Brosseau, Glen P. Kenny, Natalie Durand-Bush, Stephane Poitras, Gino De Angelis, George A. Wells
CLINICAL RHEUMATOLOGY
(2017)
Letter
Cardiac & Cardiovascular Systems
F. Daniel Ramirez, Pouya Motazedian, Richard G. Jung, Pietro Di Santo, Zachary MacDonald, Trevor Simard, Aisling A. Clancy, Juan J. Russo, Vivian Welch, George A. Wells, Benjamin Hibbert
Review
Medicine, General & Internal
Mahir Fidahic, Antonia Jelicic Kadic, Mislav Radic, Livia Puljak
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2017)