Article
Cardiac & Cardiovascular Systems
Anand Desai, James D. Thomas, Robert O. Bonow, Jane Kruse, Adin-Cristian Andrei, James L. Cox, Patrick M. McCarthy
Summary: The study shows that mitral repair in asymptomatic patients with mitral regurgitation is safe and durable, with low rates of reoperation and high survival rates at 10 years. While NYHA class did not significantly affect freedom from regurgitation, patients classified as NYHA III/IV had worse overall survival compared to class II.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Multidisciplinary Sciences
Robert Zilberszac, Andreas Gleiss, Massimo Massetti, Wilfried Wisser, Thomas Binder, Harald Gabriel, Raphael Rosenhek
Summary: Patients with severe asymptomatic primary mitral regurgitation can be safely managed with active surveillance. Left atrial size is a predictor of event-free survival in asymptomatic severe primary MR patients.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jens Sorensen, Johannes Bergsten, Tomasz Baron, Lovisa Holm Orndahl, Tanja Kero, Tomas Bjerner, Eva -Maria Hedin, Hendrik J. Harms, Rafael Astudillo, Frank A. Flachskampf
Summary: Patients with asymptomatic moderate-to-severe or severe primary mitral regurgitation are closely monitored for progression and symptoms. This study found that myocardial metabolic function, measured by MEE, can independently predict the time to surgical intervention in these patients.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Soongu Kwak, Seung-Ah Lee, Jaehyun Lim, Seokhun Yang, Doyeon Hwang, Hyun-Jung Lee, Hong-Mi Choi, In-Chang Hwang, Sahmin Lee, Yeonyee E. Yoon, Jun-Bean Park, Hyung-Kwan Kim, Yong-Jin Kim, Jong-Min Song, Goo-Yeong Cho, Duk-Hyun Kang, Dae-Hee Kim, Seung-Pyo Lee
Summary: In this study, a risk prediction model for post-mitral valve replacement mortality in severe degenerative mitral regurgitation patients was developed using machine learning. The model considered multiple risk factors such as age, hemoglobin, valve replacement, glomerular filtration rate, left atrial dimension, and left ventricular end-systolic diameter, and a simple scoring system was constructed for risk stratification.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Heemoon Lee, Dong Seop Jeong, Wook Sung Kim, Kiick Sung, Keumhee Chough Carriere, Sung-Ji Park, Pyo Won Park
Summary: The study found that prophylactic TAP in patients with mild TR who underwent mitral valve repair may not have a beneficial effect on TR progression. Further large studies are necessary to define the role of prophylactic TAP in mild TR.
ANNALS OF THORACIC SURGERY
(2021)
Review
Cardiac & Cardiovascular Systems
Myriam Carpenito, Martina Gelfusa, Simona Mega, Valeria Cammalleri, Giovanni Benfari, Domenico De Stefano, Gian Paolo Ussia, Christophe Tribouilloy, Maurice Enriquez-Sarano, Francesco Grigioni
Summary: The most common cause of mitral regurgitation is degenerative mitral valve prolapse (MVP). The complications of MVP often include volume overload due to mitral regurgitation. Surgery is recommended before irreparable consequences of volume overload occur, although there is a risk of mortality for asymptomatic patients. However, the post-surgical outcome for symptomatic patients is poor and affects life expectancy. In this article, we propose a watchful surgery approach that combines watchful waiting and early surgery to optimize patient outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Giovanni Benfari, Paul Sorajja, Giovanni Pedrazzini, Maurizio Taramasso, Mara Gavazzoni, Luigi Biasco, Benjamin Essayagh, Francesco Grigioni, Richard Bae, Christophe Tribouilloy, Jean-Louis Vanoverschelde, Hector Michelena, Vinayak N. Bapat, David Vancraynest, Catherine Klersy, Moreno Curti, Prabin Thapa, Maurice Enriquez-Sarano
Summary: This study compared the outcome of older patients with degenerative mitral regurgitation (DMR) treated with transcatheter edge-to-edge repair (TEER) vs. unoperated DMR. The results showed that TEER was associated with higher survival and successful control of mitral regurgitation was key to survival improvement.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Aeshah Althunayyan, Sahar Alborikan, Sveeta Badiani, Kit Wong, Rakesh Uppal, Nikhil Patel, Steffen E. Petersen, Guy Lloyd, Sanjeev Bhattacharyya
Summary: Current guidelines recommend intervention in severe degenerative mitral regurgitation (MR) in symptomatic patients or asymptomatic patients with left ventricular dilatation or dysfunction. The role of exercise testing for symptoms in MR is not clearly defined. Exercise-induced symptoms predict the development of subsequent spontaneous symptoms and mitral valve intervention in primary asymptomatic degenerative MR patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Seth Uretsky, Islamiyat Babs Animashaun, Sakul Sakul, Lillian Aldaia, Leo Marcoff, Konstantinos Koulogiannis, Edgar Argulian, Mark Rosenthal, Steven D. Wolff, Linda D. Gillam
Summary: The study aimed to compare the American Society of Echocardiography (ASE) algorithm with cardiac magnetic resonance (CMR) and left ventricular (LV) remodeling in assessing mitral regurgitation (MR) and the impact of mitral intervention. The results showed suboptimal agreement between CMR and the ASE algorithm in patients with degenerative MR, and CMR was a better predictor for post mitral intervention LV reverse remodeling.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Steele C. Butcher, Benjamin Essayagh, Ewout W. Steyerberg, Giovanni Benfari, Clemence Antoine, Francesco Grigioni, Thierry Le Tourneau, Jean-Christian Roussel, Aniek van Wijngaarden, Nina Ajmone Marsan, Christophe Tribouilloy, Dan Rusinaru, Aviram Hochstadt, Yan Topilsky, Hector Michelena, Victoria Delgado, Jeroen J. Bax, Maurice Enriquez-Sarano
Summary: This study examined the impact of secondary outcome determinants on post-operative survival in patients with degenerative mitral regurgitation (DMR) and found that the number of these determinants was independently associated with increased mortality after surgery, providing better outcome discrimination than traditional indications for surgery.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Boyang Liu, Desley A. H. Neil, Moninder Bhabra, Ramesh Patel, Thomas A. Barker, Nicolas Nikolaidis, J. Stephen Billing, Manvir Hayer, Shanat Baig, Anna M. Price, Ravi Vijapurapu, Thomas A. Treibel, Nicola C. Edwards, Richard P. Steeds
Summary: This study investigated myocardial fibrosis in patients undergoing mitral valve repair, finding reductions in fibrotic markers postoperatively and preoperative iECV predicting postoperative ventricular remodeling.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Bartlomiej Imielski, S. Chris Malaisrie, Duc Thinh Pham, Jane Kruse, Adin-Cristian Andrei, Menghan Liu, James L. Cox, Patrick M. McCarthy
Summary: The study found that residual mild mitral regurgitation was uncommon, with late progression to moderate or greater mitral regurgitation being rare and never leading to late mitral reoperation. Experienced surgeons may be better able to determine repairs likely to remain stable, and most cases of mild residual mitral regurgitation do not require re-repair.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Review
Cardiac & Cardiovascular Systems
Pierre Vladimir Ennezat, Marie Christine Malergue, Thierry H. Le Jemtel, Eric Abergel
Summary: Aortic stenosis, a common valvular heart disease in older adults, requires prompt aortic valve replacement for symptomatic patients. The management of asymptomatic patients has shifted towards early aortic valve replacement, but evidence is limited and further randomized trials are needed to determine its clinical outcomes. Less interventional medicine and healthcare resource utilization may lead to better health outcomes.
ARCHIVES OF CARDIOVASCULAR DISEASES
(2021)
Article
Medicine, General & Internal
Mark Kheifets, Filippo Angelini, Fabrizio D'Ascenzo, Stefano Pidello, Haya Engelstein, Pier Paolo Bocchino, Paolo Boretto, Simone Frea, Amos Levi, Hana Vaknin-Assa, Mordehay Vaturi, Yaron Shapira, Ran Kornowski, Leor Perl
Summary: This study compared the prognosis of patients with degenerative mitral regurgitation (DMR) and functional mitral regurgitation (FMR) after transcatheter edge-to-edge repair (TEER). The results showed higher rates of death and major adverse cardiac events (MACE) in the FMR group. FMR was identified as an independent predictor of MACE rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Hidetake Kawajiri, Hartzell Schaff, Joseph A. Dearani, Richard C. Daly, Kevin L. Greason, Arman Arghami, Philip G. Rowse, Jason K. Viehman, Brian D. Lahr, Carlos Gallego-Navarro, Juan A. Crestanello
Summary: This study analyzes the safety and outcomes of mitral valve repair for degenerative mitral valve regurgitation in patients 75 years of age or older. The results show that mitral valve repair in elderly patients can be achieved with low operative mortality and complications. Older age, smoking, and over and underweight are associated with increased risk of mortality, while higher left ventricular ejection fraction and hypertension are associated with reduced risk.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
