Review
Medicine, General & Internal
Wenhao Lu, Wenjie Feng, Jieyu Lai, Dongliang Yuan, Wenfeng Xiao, Yusheng Li
Summary: Sarcopenia is an age-related disease characterized by decreases in muscle mass, strength, and function, and an increase in body fat content, particularly visceral fat. Adipose tissue secretes adipokines, which have regulatory effects on muscle. For example, high levels of leptin decrease muscle function, while adiponectin inhibits muscle atrophy-related genes to prevent muscle mass loss. This article discusses the effects of adipokines such as leptin, adiponectin, resistin, mucin, and lipocalin-2 on muscle and their importance in understanding sarcopenia development.
CHINESE MEDICAL JOURNAL
(2023)
Article
Health Care Sciences & Services
Mohammad Muzaffar Mir, Rashid Mir, Mushabab Ayed Abdullah Alghamdi, Javed Iqbal Wani, Zia Ul Sabah, Mohammed Jeelani, Vijaya Marakala, Shahzada Khalid Sohail, Mohamed O'haj, Muffarah Hamid Alharthi, Mohannad Mohammad S. Alamri
Summary: The study found significantly altered concentrations of four adipokines, adiponectin, leptin, visfatin and chemerin, in the T2DM patient group compared to the controls, with more pronounced alterations in the obese and highly obese patients. This suggests that these four adipokines play a significant role in the onset, progression, and associated complications of T2DM. More research on a larger sample size is needed to further explore the relationship between adipokines and T2DM.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Cell Biology
Alin Garcia-Miranda, Alejandra Garcia-Hernandez, Eduardo Castaneda-Saucedo, Napoleon Navarro-Tito, Paola Maycotte
Summary: Excess body weight and obesity have been identified as significant risk factors for cancer development, with adipokines playing a crucial role in promoting an inflammatory microenvironment conducive to carcinogenesis and tumor progression. Autophagy, a process implicated in both tumor suppression and cancer progression, has been suggested as a therapeutic target in cancer treatment, with its effectiveness potentially influenced by tumor type and microenvironmental conditions influenced by circulating adipokines.
Article
Multidisciplinary Sciences
Andrea Marcinno, Erica Gallo, Fausto Roveta, Silvia Boschi, Alberto Grassini, Innocenzo Rainero, Elisa Rubino
Summary: This study investigated the expression of adiponectin, leptin, and resistin in Alzheimer's disease (AD) and Frontotemporal Dementia (FTD). The results showed that lower resistin concentrations were associated with an increased risk of dementia, particularly in AD. The study suggests that the resistin-linked metabolic profile should be further investigated in AD.
Article
Medicine, General & Internal
Sylwia Sluczanowska-Glabowska, Marzena Staniszewska, Mariola Marchlewicz, Ewa Duchnik, Karolina Luczkowska, Krzysztof Safranow, Boguslaw Machalinski, Andrzej Pawlik
Summary: Psoriasis is a common chronic skin disease characterized by hyperproliferation of keratinocytes, parakeratosis, and T-cell infiltration. Adipose tissue produces adipokines, including leptin, resistin, and adiponectin, which may play a role in the pathogenesis of psoriasis. This study examined the plasma levels of adiponectin, leptin, and resistin in psoriasis patients and their correlation with disease activity parameters and clinical parameters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Physiology
Lubica Cibickova, Michal Grega, Roman Dohnal, Jan Schovanek
Summary: Bariatric procedures, particularly laparoscopic sleeve gastrectomy (LSG), are highly effective in treating obesity. LSG leads to weight loss and metabolic improvement, as well as changes in adipokine levels. Adipokines, including leptin, resistin, visfatin, chemerin, adiponectin, and omentin, play a crucial role in regulating insulin resistance and chronic inflammation, and are significantly altered after LSG.
PHYSIOLOGICAL RESEARCH
(2023)
Article
Environmental Sciences
Xin Wang, Carrie A. Karvonen-Gutierrez, Bhramar Mukherjee, William H. Herman, Sung Kyun Park
Summary: The study found that urinary molybdenum was positively associated with adipokine levels, while cadmium, cesium, and lead were negatively associated with adipokine levels.
ENVIRONMENTAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Kajetan Kielbowski, Estera Bakinowska, Piotr Ostrowski, Bartlomiej Pala, Ewa Gromowska, Klaudia Gurazda, Pawel Dec, Andrzej Modrzejewski, Andrzej Pawlik
Summary: Psoriasis is a chronic skin condition mediated by the immune system, characterized by inflammation and excessive skin cell growth. Dendritic cells, T lymphocytes, and keratinocytes play key roles in the development of psoriasis, while the IL-23/IL-17 pathway contributes to disease progression. Adipokines secreted by adipose tissue, such as adiponectin, leptin, visfatin, and resistin, have immunomodulatory effects and may influence the progression or suppression of psoriasis. Understanding the relationship between psoriasis and adipokines could lead to new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Talitha Abraham, Andrea M. P. Romani
Summary: Obesity has been on the rise in the US and globally, with the prevalence increasing by 2% per decade since 1975. Maternal obesity rates have also increased worldwide, leading to obstetric complications such as gestational diabetes, high blood pressure, and pre-eclampsia. This literature review aims to explore the relationship between obesity and predictive biomarkers for pre-eclampsia in order to improve future prediction and prevention of the condition in at-risk women.
Review
Oncology
Georgios-Ioannis Verras, Levan Tchabashvili, David-Dimitris Chlorogiannis, Francesk Mulita, Maria-Ioanna Argentou
Summary: Breast cancer is a common and deadly disease, with obesity and hormonal changes being known risk factors. Adipokines, which are molecules related to fatty tissue, play a key role in these hormonal changes and have been linked to breast cancer development. This review aims to summarize the evidence and highlight the potential of adipokines as biomarkers, predictive indicators, and therapeutic targets for breast cancer.
Article
Multidisciplinary Sciences
Nadia Obi, Audrey Y. Jung, Tabea Maurer, Marianne Huebner, Theron Johnson, Sabine Behrens, Stefanie Jaskulski, Heiko Becher, Jenny Chang-Claude
Summary: The study aimed to assess the role of post-diagnosis circulating adipokines on long-term prognosis in breast cancer patients. Overall, post-diagnosis adipokines were not associated with long-term outcomes, but higher concentrations of adiponectin in patients with ERPR negative tumors may be associated with increased breast cancer specific mortality.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Kathrine Stenberg, Guy W. Novotny, Thomas A. Lutz, Thomas Mandrup-Poulsen, Charlotte Reinhard Bjornvad
Summary: Indoor-confined cats are prone to obesity due to sedentary lifestyle and excessive energy intake. This study investigated the changes in gene expression related to obesity in cats and found that adiponectin expression was negatively associated with obesity in adipose tissue. In muscle, the expression of peroxisome proliferative activated receptor-gamma 2 and plasminogen activator inhibitor-1 was increased in obese cats compared to normal-weight cats. No significant changes in the expression of inflammatory cytokines were observed. This suggests that feline obesity and insulin resistance may not be solely caused by tissue-derived inflammation, but by multiple factors that require further investigation.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Yisi Shan, Yeting Chen, Haiping Gu, Yadong Wang, Yaming Sun
Summary: Epilepsy is a neurological disorder characterized by impaired glucose metabolism and changes in neuronal excitability. Leptin and adiponectin, as important regulators of glucose metabolism, have been found to be strongly associated with epilepsy. Their role in epilepsy involves various aspects such as inflammation, oxidative damage, and neuronal apoptosis. This paper aims to summarize the signaling pathways and regulation of glucose metabolism related to leptin and adiponectin in epilepsy. It also discusses the dual effects of leptin and the relationship between antiepileptic drugs and the levels of these two adipokines. Understanding their specific involvement in the pathogenesis of epilepsy has practical significance for the personalized treatment of epilepsy according to individual metabolic characteristics.
NEUROCHEMICAL RESEARCH
(2023)
Article
Immunology
Liberato Giardullo, Addolorata Corrado, Nicola Maruotti, Daniela Cici, Natalia Mansueto, Francesco Paolo Cantatore
Summary: Adipokines have diverse effects on the pathogenesis and clinical manifestations of rheumatological diseases. Different adipokines can either promote or inhibit the development and clinical course of these diseases. Further research is needed to fully understand the role of adipokines in rheumatological diseases.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Andreea Roxana Florian, Gheorghe Cruciat, Raluca Maria Pop, Adelina Staicu, Muresan Daniel, Stamatian Florin
Summary: This study revealed that elevated levels of leptin (L) in the early stages of pregnancy are strongly associated with the development of gestational diabetes mellitus (GDM). Meanwhile, adiponectin (AN) and CMPF levels showed no significant correlation with GDM.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)