Article
Endocrinology & Metabolism
Maria Caroline Martins de Araujo, Daniela Frizon Alfieri, Ana Lucia Cruz Furstenberger Lehmann, Tamires Flauzino Luz, Emmanuelle Roberto Trevisani, Maisa Rocha Nagao, Leonardo Bodner de Freitas, Andrea Name Colado Simao, Edna Maria Vissoci Reiche
Summary: This study aimed to investigate the association between cellular adhesion molecules (CAMs) and acute ischemic stroke (IS), as well as to identify biomarkers for predicting short-term mortality after IS. The results showed that a combination of baseline IS severity and soluble vascular cellular adhesion molecule 1 (sVCAM-1) levels could early predict the prognosis of IS patients. Additionally, this study suggests that VCAM-1 might be a potential target for therapeutic strategies in IS.
METABOLIC BRAIN DISEASE
(2023)
Article
Medicine, Research & Experimental
Ana Lucia Cruz Furstenberger Lehmann, Daniela Frizon Alfieri, Maria Caroline Martins de Araujo, Emanuelle Roberto Trevisani, Maisa Rocha Nagao, Francisco Spessatto Pesente, Jair Roberto Gelinski, Leonardo Bodner de Freitas, Tamires Flauzino, Marcio Francisco Lehmann, Marcell Alysson Batisti Lozovoy, Jose Wander Bregano, Andrea Name Colado Simao, Michael Maes, Edna Maria Vissoci Reiche
Summary: This study evaluated the prognostic validity of a combination of clinical, imaging, and laboratory biomarkers in predicting 1-year mortality of IS, finding that non-survivors showed significant differences in multiple indicators including IS severity, carotid intima-media thickness, coagulation factors, and inflammatory factors.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Sakiko Honda, Koji Ikeda, Ryota Urata, Ekura Yamazaki, Noriaki Emoto, Satoaki Matoba
Summary: Senescent endothelial cells play a causal role in atherosclerosis by increasing inflammation-mediated VCAM-1 induction, leading to enhanced monocyte adhesion. The NF-kappa B signaling pathway is crucial for regulating inflammatory responses in senescent endothelial cells, and this regulation is achieved through epigenetic alterations involving active histone H3 trimethylation on lysine 4.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Sandra Marinovic Kulisic, Marta Takahashi, Marta Himelreich Peric, Vedrana Muzic Radovic, Ruzica Jurakic Toncic
Summary: This study evaluated the expression of E-selectin, ICAM-1, and VCAM-1 in skin biopsy specimens of patients with AD using a computer program. The results showed that the number of ICAM-1 and VCAM-1 positive cells decreased, while the E-selectin positive epidermal surface area increased in AD patients. The endothelial area positive for E-selectin and ICAM1 was significantly larger in AD-affected skin. In addition, strong signals of E-selectin were detected in skin macrophages and ICAM-1 in dermal vessel endothelium. VCAM-1 signal could not be found in the endothelial cells of AD-affected skin. The expression of E-selectin, ICAM-1, and VCAM-1 shows significant changes in AD-affected skin compared to control skin.
Article
Immunology
Jian Chen, An-Xiang Dai, Hai-Liang Tang, Chang-Hao Lu, Hao-Xin Liu, Ting Hou, Zhi-Jie Lu, Nan Kong, Xin-Yuan Peng, Kai-Xun Lin, Zi-Dong Zheng, Sheng-Liang Xu, Xiao-Fang Ying, Xiao-Yu Ji, Hui Pan, Jie Wu, Xin Zeng, Nai-Li Wei
Summary: This study evaluated the clinical significance of ALCAM, VCAM-1, NCAM, and ICAM-1 levels in plasma of participants with cognitive impairment and identified ALCAM and VCAM-1 as reliable indicators of Alzheimer's disease. ALCAM and VCAM-1 were found to be correlated with age, severity of cognitive decline, and atrophy in the medial temporal lobe structure. They also showed significant correlations with various inflammatory factors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Julie M. Davies, Kristen J. Radford, Jakob Begun, Jean-Pierre Levesque, Ingrid G. Winkler
Summary: The study revealed that E-selectin plays a role in the early stages of immune activation by inducing phosphorylation of AKT and nuclear factor-kappa B in mouse macrophages, leading to enhanced activation and modulation of immune responses.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xinyu Zhu, Jiangtong Peng, Liuye Yang, Yi Guo, Pengchao Wang, Kaiyuan Liu, Jingbo Zhu, Shan Deng, Minglu Liang
Summary: This study demonstrates the inhibitory effect of 7-Mif on endothelial inflammation by reducing the expression of endothelial adhesion molecules and monocyte adhesion.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pediatrics
Danfeng Zhang, Lingjuan Liu, Yuxing Yuan, Tiewei Lv, Xupei Huang, Jie Tian
Summary: Sera from KD patients stimulate OXPHOS levels and enhance E-selectin expression in HCAECs, contributing to the development of CAL in KD patients.
FRONTIERS IN PEDIATRICS
(2021)
Article
Cell Biology
Peter J. Zwiers, Jacqueline P. F. E. Lucas, Rianne M. Jongman, Matijs van Meurs, Eliane R. Popa, Grietje Molema
Summary: Endothelial cells (ECs) in the microvasculature in organs play a role in the pathophysiology of sepsis. The role of Tyrosine protein kinase receptor Tie2 (Tek; Tunica interna Endothelial cell Kinase) in their inflammatory response is not well understood. This study investigated the changes in Tie2 expression and inflammation-associated endothelial adhesion molecules in kidneys and lungs of mice with EC-specific Tie2 knockout. The results revealed heterogeneous effects of Tie2 absence in ECs in kidney and lung microvasculature, calling for further research into the role of Tie2 in EC behavior.
Article
Cardiac & Cardiovascular Systems
Karin Hochrainer, Wei Yang
Summary: Stroke proteomics studies in both animal and human specimens are comprehensively reviewed in this article, with discussions on the limitations, challenges, and future perspectives in the field. The authors also provide a unique resource by presenting extensive lists of proteins identified as altered by stroke in proteomic studies, and perform post-analysis to reveal stroke-related cellular processes and pathways.
CIRCULATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Lazzaro di Biase, Adriano Bonura, Pasquale Maria Pecoraro, Simona Paola Carbone, Vincenzo Di Lazzaro
Summary: Stroke, a complex and heterogeneous disease, poses challenges for early diagnosis and treatment due to the lack of specific diagnostic biomarkers. This review identifies four promising biomarkers for early diagnosis, differentiation between ischemic and hemorrhagic stroke, and prediction of hemorrhagic transformation. Integration of these biomarkers could significantly improve stroke patients' detection and treatment. However, further research and validation are needed to demonstrate their clinical utility in routine stroke treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mobin Khoshbin, Seyyed Amir Yasin Ahmadi, Mostafa Cheraghi, Negar Nouryazdan, Mehdi Birjandi, Gholamreza Shahsavari
Summary: The T allele in the C1901T polymorphism of the E-selectin gene is associated with an increased risk of atherosclerosis, while the G98T polymorphism is not significantly associated. Additionally, the serum level of soluble E-selectin is significantly higher in patients with coronary artery disease compared to the control group, suggesting its association with increased risk of the disease.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Clinical Neurology
Joan Marti-Fabregas, Daniel Guisado-Alonso, Raquel Delgado-Mederos, Alejandro Martinez-Domeno, Luis Prats-Sanchez, Marina Guasch-Jimenez, Pere Cardona, Ana Nunez-Guillen, Manuel Requena, Marta Rubiera, Marta Olive, Alejandro Bustamante, Meritxell Gomis, Sergio Amaro, Laura Llull, Xavier Ustrell, Gislaine Castilho de Oliveira, Laia Sero, Manuel Gomez-Choco, Luis Mena, Joaquin Serena, Saima Bashir Viturro, Francisco Purroy, Mikel Vicente, Ana Rodriguez-Campello, Angel Ois, Esther Catena, Maria Carmen Garcia-Carreira, Oriol Barrachina, Ernest Palomeras, Jerzky Krupinski, Marta Almeria, Josep Zaragoza, Patricia Esteve, Dolores Cocho, Antia Moreira, Cecile van Eendenburg, Javier Emilio Codas, Natalia Perez de la Ossa, Merce Salvat, Pol Camps-Renom
Summary: The study evaluated the impact of COVID-19 infection on patients with ischemic stroke, finding that infected patients had more severe strokes and higher mortality rates, but similar functional outcomes compared to the non-infected group.
Article
Urology & Nephrology
Yan Li, Qingsheng Huang, Mingxing Fang, Mengyao Liu, Jianying Guo, Zhiyong Wang
Summary: This study investigates the expression of various adhesion factors in different stages of AKI and analyzes their relationship with the prognosis of patients with S-AKI. The results suggest that CD62L and CD62E can serve as indicators for different stages of S-AKI, while VCAM-1 is the best predictor of early renal function recovery in S-AKI patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Review
Medical Laboratory Technology
Jean Alex Matos Ribeiro, Luisa Fernanda Garcia-Salazar, Cassia Regina Saade-Pacheco, Erika Shirley Moreira Silva, Simone Garcia Oliveira, Ana Flavia Silveira, Adriana Sanches Garcia-Araujo, Thiago Luiz Russo
Summary: By synthesizing the potential predictive molecular biomarkers for motor recovery following acute hemorrhagic stroke, it was found that 61 independent prognostic molecular biomarkers could predict motor functional recovery. The results of this study suggest that these biomarkers assessed in the acute phase are valuable for predicting motor functional recovery.
CLINICA CHIMICA ACTA
(2021)
Article
Multidisciplinary Sciences
Linnea Lagerstedt, Juan Jose Egea-Guerrero, Alejandro Bustamante, Joan Montaner, Ana Rodriguez-Rodriguez, Amir El Rahal, Natacha Turck, Manuel Quintana, Roser Garcia-Armengol, Carmen Melinda Prica, Elisabeth Andereggen, Lara Rinaldi, Asita Sarrafzadeh, Karl Schaller, Jean-Charles Sanchez
Article
Multidisciplinary Sciences
Linnea Lagerstedt, Juan Jose Egea-Guerrero, Ana Rodriguez-Rodriguez, Alejandro Bustamante, Joan Montaner, Amir El Rahal, Elisabeth Andereggen, Lara Rinaldi, Asita Sarrafzadeh, Karl Schaller, Jean-Charles Sanchez
Article
Multidisciplinary Sciences
Sebastien Richard, Vanessa Lapierre, Nicolas Girerd, Mathieu Bonnerot, Pierre R. Burkhard, Linnea Lagerstedt, Serge Bracard, Marc Debouverie, Natacha Turck, Jean-Charles Sanchez
Scientific Reports
(2016)